Mutagenesis and peptide analysis of the DRY motif in the α2A adrenergic receptor: Evidence for alternate mechanisms in G protein-coupled receptors

Biochemical and Biophysical Research Communications

Volumn 293, Issue 4, 2002, Pages 1233-1241

  Chung, Duane A ^a,b   Wade, Susan M ^b   Fowler, Carol B ^a   Woods, Danielle D ^b   Abada, Paolo B ^b   Mosberg, Henry I ^a   Neubig, Richard R ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Adrenergic receptor; Circular dichroism; Constitutive activation; DRY motif; G protein coupled receptor; Muscarinic receptor; Mutagenesis; Peptides

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ARGININE; ASPARTIC ACID; G PROTEIN COUPLED RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CIRCULAR DICHROISM; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; KIDNEY CELL; MOLECULAR MODEL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE;

ADRENERGIC ALPHA-AGONISTS; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ARGININE; BINDING, COMPETITIVE; CATALYSIS; CELL LINE; CIRCULAR DICHROISM; CYCLIC AMP; CYTOPLASM; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE BIOSYNTHESIS; PEPTIDES; PLASMIDS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; QUINOXALINES; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, ALPHA-2; TRANSFECTION;

EID: 0036078874     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00357-1     Document Type: Article

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