Structure?activity relationships in peptide modulators of β-amyloid protein aggregation: Variation in α,α-disubstitution results in altered aggregate size and morphology

ACS Chemical Neuroscience

Volumn 1, Issue 9, 2010, Pages 608-626

  Bett, Cyrus K ^a   Ngunjiri, Johnpeter N ^b   Serem, Wilson K ^a   Fontenot, Krystal R ^a   Hammer, Robert P ^c   McCarley, Robin L ^a   Garno, Jayne C ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b NANOINK INC   (United States)

^c New England Peptide   (United States)

Author keywords

, disubstituted amino acids; Amyloid; Alzheimer's disease; amyloid aggregation mitigating peptides; fibrils; spherical aggregates

Indexed keywords

AMYLOID; AMYLOID AGGREGATION MITIGATING PEPTIDE 1; AMYLOID AGGREGATION MITIGATING PEPTIDE 2; AMYLOID AGGREGATION MITIGATING PEPTIDE 3; AMYLOID AGGREGATION MITIGATING PEPTIDE 4; AMYLOID AGGREGATION MITIGATING PEPTIDE 6; AMYLOID AGGREGATION MITIGATING PEPTIDE 7; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; UNCLASSIFIED DRUG;

ARTICLE; ATOMIC FORCE MICROSCOPY; GENE DISRUPTION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TRANSMISSION ELECTRON MICROSCOPY;

Α,Α-DISUBSTITUTED AMINO ACIDS; Β-AMYLOID; ALZHEIMER'S DISEASE; AMYLOID AGGREGATION MITIGATING PEPTIDES; FIBRILS; SPHERICAL AGGREGATES;

AMYLOID BETA-PEPTIDES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICROSCOPY, ATOMIC FORCE; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956685965     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn100045q     Document Type: Article

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