Stoichiometric inhibition of amyloid β-protein aggregation with peptides containing alternating α,α-disubstituted amino acids

Journal of the American Chemical Society

Volumn 128, Issue 11, 2006, Pages 3522-3523

  Etienne, Marcus A ^a   Aucoin, Jed P ^a   Fu, Yanwen ^a   McCarley, Robin L ^a   Hammer, Robert P ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMYLOID BETA PROTEIN; PEPTIDE;

ARTICLE; BETA SHEET; FIBER; HYDROPHOBICITY; IN VITRO STUDY; INTERCALATION COMPLEX; MOLECULAR SIZE; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; SCANNING FORCE MICROSCOPY; SPECTROSCOPY; STOICHIOMETRY;

AMINO ACIDS; AMYLOID BETA-PROTEIN; CIRCULAR DICHROISM; HYDROPHOBICITY; OLIGOPEPTIDES; POLYLYSINE; PROTEIN STRUCTURE, SECONDARY;

EID: 33645384655     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0600678     Document Type: Article

References (22)

1. (a) Iversen, L. L.; Mortishire-Smith, R. J.; Pollack, S. J.; Shearman, M. S. Biochem. J. 1995, 311, 1.
2. (b) Walsh, D. M.; Selkoe, D. J. Neuron 2004, 44, 181.
3. Walsh, D. M.; Hartley, D. M.; Condron, M. M.; Selkoe, D. J.; Teplow, D. B. Biochem. J. 2001, 355, 869.
4. (a) Kayed, R.; Head, E.; Thompson, J. L.; McIntire, T. M.; Milton, S. C.; Cotman, C. W.; Glabe, C. G. Science 2003, 300, 486.
5. (b) Bucciantini, M.; Giannoni, E.; Chiti, F.; Baroni, F.; Formigli, L.; Zurdo, L.; Taddei, N.; Ramponi, G.; Dobson, C. M.; Stefani, M. Nature 2002, 416, 507.
6. (a) Wood, S. J.; Wetzel, R.; Martin, J. D.; Hurle, M. R. Biochemistry 1995, 34, 724.
7. (b) Soto, C.; Kindy, M. S.; Baumann, M.; Frangione, B. Biochem. Biophys. Res. Commun. 1996, 226, 672.
8. Tjernberg, L. O.; Naeslund, J.; Lindqvist, F.; Johansson, J.; Karlstrom, A. R.; Thyberg, J.; Terenius, L.; Nordstedt, C. J. Biol. Chem. 1996, 271, 8545.
9. Gordon, D. J.; Sciarretta, K. L.; Meredith, S. C. Biochemistry 2001, 40, 8237.
10. (a) Findeis, M. A.; Musso, G. M.; Arico-Muendil, C. C.; Benjamin, H. W.; Hundal, A. M.; Lee, J.; Chin, J.; Kelley, M.; Wakefield, J.; Hayward, N. J.; Molineaux, S. M. Biochemistry 1999, 38, 6791.
11. (b) Findeis, M. A. Biochim. Biophys. Acta 2000, 1502, 76.
12. (a) Pallitto, M. M.; Ghanta, J.; Heinzelman, P.; Kiessling, L. L.; Murphy, R. M. Biochemistry 1999, 38, 3570.
13. (b) Lowe, T. L.; Strzelec, A.; Kiessling, L. L.; Murphy, R. M. Biochemistry 2001, 40, 7882.
14. Toniolo, C.; Crisma, M.; Formaggio, F.; Peggion, C. Biopolymers 2001, 60, 396.
15. (a) Fu, Y.; Hammer, R. P. Org. Lett. 2002, 4, 237.
16. (b) Fu, Y.; Etienne, M. A.; Hammer, R. P. J. Org. Chem. 2003, 68, 9854.
17. Harper, J. D.; Wong, S. S.; Lieber, C. M.; Lunsbury, P. T., Jr. Chem. Biol. 1997, 4, 119.
18. -1). This CD response is invariant over weeks after initial dissolution of AMY-1.
19. The dynamic range of the SFM does not allow the imaging of particles of the size (> 10 μm) found in Figure 2A by TEM. The tree-like structure in Figure 2A is presumably formed by self-association of fibrils over the long period of the incubation.
20. Chennamsetty, N.; Bock, H.; Seanu, L. F.; Siperstein, F. R.; Gubbins, K. E. J. Chem. Phys. 2005, 122, 094710.
21. Schmechel, A.; Zentgraf, H.; Scheuermann, S.; Fritz, G.; Pipkorn, R.; Reed, J.; Beyreuther, K.; Bayer, T. A.; Multhaup G. J. Biol. Chem. 2003, 37, 35317.
22. Morimoto, A.; Irie, K.; Murakami, K.; Masuda, Y.; Ohigashi, H.; Nagao, M.; Fukuda, H.; Shimizu, T.; Shirasawa, T. J. Biol. Chem. 2004, 50, 52781.