Association and direct activation of signal transducer and activator of transcription1α by platelet-derived growth factor receptor

Journal of Clinical Investigation

Volumn 101, Issue 12, 1998, Pages 2751-2760

  Ghosh Choudhury, Goutam ^a,b   Ghosh Choudhury, Nandini ^a   Abboud, Hanna E ^a  

^a University of Texas Health Science Center   (United States)

^b Audie L Murphy Memorial Veterans Administration Center   (United States)

Author keywords

Mesangial cells; PDGFR; STAT1

Indexed keywords

PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR RECEPTOR; STAT1 PROTEIN; TYROSINE;

ARTICLE; CELL DAMAGE; CONTROLLED STUDY; DNA PROTEIN COMPLEX; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MESANGIUM CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION;

EID: 0343200750     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/jci1044     Document Type: Article

References (43)

1. Abboud, H.E. 1995. Role of platelet-derived growth factor in renal injury. Annu. Rev. Physiol. 57:297-309.
2. Soriano, P. 1994. Abnormal kidney development and hematological disorders in PDGF β-receptor mutant mice. Genes & Dev. 8:1886-1896.
3. Leveen, P., M. Pekny, S. Gebre-Medhin, B. Swolin, E. Larson, and C. Betsholtz. 1994. Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes & Dev. 8:1875-1887.
4. Kazlauskas, A. 1994. Receptor tyrosine kinases and their targets. Curr. Opin. Genet. & Dev. 4:5-14.
5. Abboud, H.E., B. Bhandari, and G. Ghosh Choudhury. 1995. Cell biology of platelet-derived growth factor. In Molecular Nephrology: Kidney Function in Health and Disease. J. Bonventre and D. Schlondorff, editors. Marcel Dekker Inc., New York. 573-590.
6. Arvidsson, A.-N., E. Rupp, E. Nanberg, J. Downward, L. Ronnstrand, S. Wennstrom, J. Schlessinger, C.-H. Heldin, and L. Claesson-Welsh. 1994. Tyr-716 in the platelet-derived growth factor β receptor kinase insert is involved in Grb-2 binding and Ras activation. Mol. Cell. Biol. 14:6715-6726.
7. Yokote, K., S. Mori, K. Hansen, J. McGlade, T. Pawson, C.-H. Heldin, and L. Claesson-Welsh. 1994. Direct interaction between Shc and platelet-derived growth factor beta-receptor. J. Biol. Chem. 269:15337-15343.
8. Nishimura, R., W. Li, A. Kashishian, A. Mondino, M. Zhou, J. Cooper, and J. Schlessenger. 1993. Two signaling molecules share a phosphotyrosine containing binding site in the platelet-derived growth factor receptor. Mol. Cell. Biol. 13:6889-6896.
9. Darnell, J.E., I.M. Kerr, and G.R. Stark. 1994. JAK-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 264:1415-1421.
10. Ihle, J.N. 1996. STATs: signal transducers and activators of transcription. Cell. 84:331-334.
11. Leaman, D.W., S. Leung, X. Li, and G.R. Stark. 1996. Regulation of STAT-dependent pathways by growth factors and cytokines. FASEB J. 10: 1578-1588.
12. Muller, M., C. Laxton, J. Briscoe, C. Schindler, T. Improta, J.E. Darnell, G.R. Stark, and I.M. Kerr. 1993. Complementation of A mutant cell line: central role of the 91 kd polypeptide of the ISGF3 in the interferon α and γ-signal transduction pathway. EMBO J. 12:4221-4228.
13. Horvath, C.M., and J.E. Darnell. 1996. The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein. J. Virol. 70:647-650.
14. Sadowski, H.B., K. Shuai, J.E. Darnell, and M.Z. Gilman. 1993. A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science. 261:1739-1743.
15. Ruff-Jamison, S.K. Chen, and S. Cohen. 1993. Induction of EGF and interferon -γ of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei. Science. 261:1733-1736.
16. Vignais, M.-L., B. Sadowski, D. Watling, N.L. Rogers, and M. Gilman. 1996. Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins. Mol. Cell. Biol. 16:1759-1769.
17. Ghosh Choudhury, G., F. Marra, H. Kiyomoto, and H.E. Abboud. 1996. PDGF stimulates tyrosine phosphorylation of JAK 1 protein tyrosine kinase in human mesangial cells. Kidney Int. 49:19-25.
18. Silver, B., F.E. Jaffer, and H.E. Abboud. 1989. Platelet-derived growth factor synthesis in mesangial cells: induction by multiple peptide mitogens. Proc. Natl. Acad. Sci. USA. 186:1046-1050.
19. Ghosh Choudhury, G., L.-M. Wang, J. Pierce, S.A. Harvey, and A.Y. Sakaguchi. 1991. A mutational analysis of phosphatidylinositol 3 kinase activation by human colony stimulating factor 1 receptor. J. Biol. Chem. 266:8068-8072.
20. Marra, F., G. Ghosh Choudhury, and H.E. Abboud. 1996. Interferon γ-mediated activation of STAT1α regulates growth factor-induced mitogenesis. J. Clin. Invest. 98:1218-1230.
21. Ghosh Choudhury, G., P. Biswas, G. Grandaliano, B. Fouqueray, S.A. Harvey, and H.E. Abboud. 1994. PDGF-mediated activation of phosphatidylinositol 3 kinase in human mesangial cells. Kidney Int. 46:37-47.
22. Wagner, B.J., T.E. Hayes, C.J. Hoban, and B.H. Cochran. 1990. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J. 9:4477-4484.
23. Kaplan, D.R., D.K. Morrison, G. Wong, F. McCormick, and L.T. Williams. 1990. PDGF β receptor stimulates tyrosine phosphorylation of GAP and association of GAP with signaling complex. Cell. 61:125-133.
24. Klinghoffer, R.A., B. Duckworth, M. Valius, L. Cantley, and A. Kazlauskas. 1996. Platelet-derived growth factor dependent activation of phosphatidylinositol 3 kinase is regulated by binding of SH2-domain containing proteins which influence Ras activity. Mol. Cell. Biol. 16:5905-5914.
25. Winston, L.A., and T. Hunter. 1995. JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone. J. Biol. Chem. 270:30837-30840.
26. Wang X.-Y., D.K. Fuhrer, M.S. Marshall, and Y.-C. Yang. 1995. Interleukin 11 induces complex formation of Grb2, Fyn, and JAK2 in 3T3L1 cells. J. Biol. Chem. 270:27999-28002.
27. Meydan, N., T. Grunberger, H. Dadi, M. Shahar, E. Arpaia, Z. Lapidot, J.S. Leeder, M. Freedman, A. Cohen, A. Gazit, et al. 1996. Inhibition of acute lymphoblastic leukemia by Jak-2 inhibitor. Nature. 379:645-648.
28. Marrero, M.B., B. Schieffer, B. Li, J. Sun, J.B. Harp, and B.N. Ling. 1997. Role of Janus kinase/signal transducer and activator of transcription and mitogen activated protein kinase cascades in angiotensin II- and platelet-derived growth factor-induced vascular smooth muscle cell proliferation. J. Biol. Chem. 272:24684-24690.
29. Margolis, B. 1992. Proteins with SH2 domains: transducers in the tyrosine kinase signaling pathway. Cell Growth & Diff. 3:73-80.
30. Shuai, K., C.M. Horvath, L.H.T. Huang, S.A. Qureshi, D. Cowburn, and J.E. Darnell. 1994. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell. 76: 821-828.
31. Kypta, R.M., Y. Goldberg, E.T. Ulug, and S.A Courtneidge. 1990. Association between the PDGF receptor and members of the src family tyrosine kinases. Cell. 62:481-492.
32. Mori, S., L. Ronnstrand, K. Yokote, A. Engstrom, S.A. Courtneidge, L. Claesson-Welsh, and C.-H. Heldin. 1993. Identification of two juxtamembrane autophosphorylation sites in the PDGFβ receptor: involvement in the interaction with Src family tyrosine kinases. EMBO J. 12:2257-2264.
33. Twamley-Stein, G., R. Pepperkok, W. Ansorge, and S.A. Courtneidge. 1993. The src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells. Proc. Natl. Acad. Sci. USA. 90:7696-7700.
34. Chao-Lan, Y., D.B. Meyer, G.S. Campbell, A.C. Larner, C. Carter-Su, J. Schwartz, and R. Jove. 1995. Enhanced DNA binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science. 269:81-83.
35. Cao, X., A. Tay, G.R. Guy, and Y.H. Tan. 1996. Activation and association of Stat3 with Src in v-Src transformed cell lines. Mol. Cell. Biol. 16:1595-1603.
36. Stahl, N., T.J. Farruggella, T.G. Boulton, Z. Zhong, J.E. Darnell, and G.D. Yancopoulos. 1995. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptor. Science. 267:1349-1353.
37. Heim, M.H., I.M. Kerr, G.R. Stark, and J.E. Darnell. 1995. Contribution of STAT SH2 groups to specific interferon signaling by JAK-STAT pathway. Science. 267:1347-1349.
38. Fu, X.-Y., and J.-J. Zhang. 1993. Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter. Cell. 74:1135-1145.
39. Leaman, D.W., S. Pisharody, T.W. Flickinger, M.A. Commane, J. Schlessinger, I.M. Kerr, D.E. Levy, and G.R. Stark. 1996. Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor. Mol. Cell. Biol. 16:369-175.
40. Quelle, F.W., W. Thierfelder, B.A. Witthuhn, B. Tang, S. Cohen, and J. Ihle. 1995. Phosphorylation and activation of the DNA binding activity of purified Stal1 by Janus protein tyrosine kinases and the epidermal growth factor receptor. J. Biol. Chem. 270:20775-20780.
41. Zilong, W., Z. Zhong, and J.E. Darnell, Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell. 82:241-250.
42. Zhang, X., J. Blenis, H. C. Li, C. Schindler, and S. Chen-Kiang.1995. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science. 267: 1990-1994.
43. Johnson, R.L. 1993. Cytokine networks and the pathogenesis of glomerulonephritis. J. Lab. Clin. Med. 121:190-192.