Molecular mechanisms of diabetic renal hypertrophy

Kidney International

Volumn 56, Issue 2, 1999, Pages 393-405

  Wolf, Gunter ^a,b   Ziyadeh, Fuad N ^a,b,c  

^a UNIVERSITY OF HAMBURG   (Germany)

^b 1150 Vagelos Laboratories   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Angiotensin; Cell cycle; Cyclin; Diabetes mellitus; Glomerulopathy; Glucose; TGF

Indexed keywords

ANGIOTENSIN; CHEMOKINE; CYCLIN DEPENDENT KINASE; ENDOTHELIN 1; PLATELET DERIVED GROWTH FACTOR B; PROTEIN P27; SOMATOMEDIN C; THROMBOXANE; TRANSFORMING GROWTH FACTOR BETA;

CELL CYCLE G1 PHASE; CELL PROLIFERATION; CYTOKINE PRODUCTION; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; GLOMERULOSCLEROSIS; HEMODYNAMICS; KIDNEY CELL CULTURE; KIDNEY HYPERTROPHY; KIDNEY TUBULE CELL; MESANGIUM CELL; MOLECULAR DYNAMICS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; REVIEW;

EID: 0032815449     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1999.00590.x     Document Type: Article

References (153)

1. 1. MAJOR RH: Classic Descriptions of Disease. Springfield, Charles C. Thomas, 1932, pp 185-213
2. 2. BRIGHT P: Dr. Richard Bright (1789-1858). London, The Bodley Head, 1983, pp 131-142
3. th century: The impact of Richard Bright on the continent. Am J Nephrol 9:167-172, 1989
4. 4. WOLF G: Changing concepts of compensatory renal growth: From humoral pathology to molecular biology. Am J Nephrol 12:369-373, 1992
5. 5. JOSLIN EP: Treatment of Diabetes Mellitus. Philadelphia, Lea & Filbinger, 1917, p 419
6. 6. ZIYADEH FN: The extracellular matrix in diabetic nephropathy. Am J Kidney Dis 22:736-744, 1993
7. 7. KIMMELSTIEL P, WILSON C: Intercapillary lesions in glomeruli of the kidney. Am J Pathol 12:83-97, 1936
8. 8. MOGENSEN CE, ANDERSEN MJ: Increased kidney size and glomerular filtration rate in early juvenile diabetes. Diabetes 22:706-712, 1973
9. 9. SEYER-HANSEN K: Renal hypertrophy in streptozotocin-diabetic rats. Clin Sci Mol Med 51:551-555, 1976
10. 10. OSTERBY R, GUNDERSEN HJG: Glomerular size and structure in diabetes mellitus. I. Early abnormalities. Diabetologia 11:225-229, 1975
11. 11. OSTERBY R: Morphometric studies of the peripheral glomerular basement membrane in early juvenile diabetes. I. Development of initial basement membrane thickening. Diabetologia 8:84-92, 1972
12. 12. RITZ E, STEFANSKI A: Diabetic nephropathy in type II diabetes. Am J Kidney Dis 27:167-194, 1996
13. 13. SCHMITZ A, GUNDERSEN HJ, OSTERBY R: Glomerular morphology by light microscopy in non-insulin-dependent diabetes mellitus. Diabetes 37:38-43, 1988
14. 14. RODBY RA: Type II diabetic nephropathy. Its clinical course and therapeutic implications. Semin Nephrol 17:132-147, 1997
15. 15. WIRTA OR, PASTERNACK AI: Glomerular filtration rate and kidney size in type 2 (non-insulin-dependent) diabetes mellitus. Clin Nephrol 44:1-7, 1995
16. 16. PAGTALUNAN ME, MILLER PL, JUMPING-EAGLE, S, NELSON RG, MYERES BD, RENNKE HG, COPLON NS, SUN L, MEYER TW: Podocyte loss and progressive glomerular injury in type II diabetes. J Clin Invest 99:342-348, 1997
17. 17. IBRAHIM HN, HOSTETTER TH: Diabetic nephropathy. J Am Soc Nephrol 8:487-493, 1997
18. 18. HOSTETTER TH, TROY JL, BRENNER BM: Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int 19:410-415, 1981
19. 19. O'BRYAN GT, HOSTETTER TH: The renal hemodynamic basis of diabetic nephropathy. Semin Nephrol 17:93-100, 1997
20. 20. ZATZ R: Haemodynamically mediated glomerular injury: The end of a 15-year-old controversy? Curr Opin Nephrol Hypertens 5:468-475, 1996
21. 21. STOCKLAND JD, SAMSON SC: Regulation of filtration rate by glomerular mesangial cells in health and diabetic renal disease. Am J Kidney Dis 29:971-981, 1997
22. 22. CORTES P, ZHAO X, RISER BL, NARINS RG: Role of glomerular mechanical strain in the pathogenesis of diabetic nephropathy. Kidney Int 51:57-68, 1997
23. 23. HARRIS RC, HARALSON MA, BADR KF: Continuous stretch-relaxation in culture alters rat mesangial cell morphology, growth characteristics and metabolic activity. Lab Invest 66:548-554, 1992
24. 24. YASUDA KONDO S, HOMMA T, HARRIS RC: Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells. J Clin Invest 98:1991-2000, 1996
25. 25. FLOEGE J, BURNS MW, ALPERS CE, YOSHIMURA A, PRITZL P, GORDON K, SEIFFERT RA, BOWEN-POPE DF, COUSER WG, JOHNSON RJ: Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model. Kidney Int 41:297-309, 1992
26. 26. WOLF G, NEILSON EG: Molecular mechanisms of tubulointerstitial hypertrophy and hyperplasia. Kidney Int 39:401-420, 1991
27. 27. EDDY AA: Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol 7:2495-2508, 1996
28. 28. FOGO A, ICHIKAWA I: Evidence for the central role of glomerular growth promoters in the development of sclerosis. Semin Nephrol 9:329-342, 1989
29. 29. EL NAHAS AM: Growth factors and glomerular sclerosis. Kidney Int 41(Suppl 36):S15-S20, 1992
30. 30. WOLF G, ZIYADEH FN: Renal tubular hypertrophy induced by angiotensin II. Semin Nephrol 17:448-454, 1997
31. 31. WOLF G: Molecular mechanisms of angiotensin II in the kidney: Emerging role in the progression of renal disease beyond haemodynamics. Nephrol Dial Transplant 13:1131-1142, 1998
32. 32. SHARMA K, ZIYADEH FN: Biochemical events and cytokine interactions linking glucose metabolism to the development of diabetic nephropathy. Semin Nephrol 17:80-92, 1997
33. 33. WOLF G, THAISS F: Hyperglycaemia-pathophysiological aspects at the cellular level. Nephrol Dial Transplant 10:1109-1112, 1995
34. 34. SCHRIER RW, HARRIS DC, CHAN L, SHAPIRO JI, CARAMELO C: Tubular hypermetabolism as a factor in the progression of chronic renal failure. Am J Kidney Dis 12:243-249, 1988
35. 35. CULPEPPER RM, SCHOOLWERTH AC: Remnant kidney oxygen consumption: Hypermetabolism or hyperbole? J Am Soc Nephrol 3:151-156, 1992
36. 36. MAUER SM, STEFFES MW, ELLIS EN, SUTHERLAND DER, BROWN DM, GOETZ FC: Structural-functional relationships in diabetic nephropathy. J Clin Invest 74:1143-1155, 1984
37. 37. LANE PH, STEFFES MW, FIORETTO P, MAUER SM: Renal interstitial expansion in insulin-dependent diabetes mellitus. Kidney Int 43:661-667, 1993
38. 38. ZIYADEH FN, GOLDFARB S: The renal tubulointerstitium in diabetes mellitus. Kidney Int 39:464-475, 1991
39. 39. NATH KA: Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 20:1-17, 1992
40. 40. SCHWIEGER J, FINE LG: Renal hypertrophy, growth factors, and nephropathy in diabetes mellitus. Semin Nephrol 10:242-253, 1990
41. 41. WOLF G: Cellular mechanisms of tubule hypertrophy and hyperplasia in renal injury. Miner Electrolyte Metab 21:303-316, 1995
42. 42. ROMEN W, TAKAHASHI A: Autoradiographic studies on the proliferation of glomerular and tubular cells of the rat kidney in early diabetes. Virchows Arch B 40:339-345, 1982
43. 3H-thymidine uptake in diabetic and uninephrectomized rats. Diabetologia 25:280-287, 1983
44. 44. YOUNG BA, JOHNSON RJ, ALPERS CA, ENG E, GORDON K, FLOEGE J, COUSER WG: Cellular events in the evolution of experimental diabetic nephropathy. Kidney Int 47:935-944, 1995
45. 2 and hyaluronan on mesangial cell proliferation: A potential contribution to glomerular hypercellularity in diabetes. Diabetes 45:44-50, 1996
46. 46. WOLF G, SHARMA K, CHEN Y, ERICKSEN M, ZIYADEH FN: High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β. Kidney Int 42:647-656, 1992
47. 47. NAHMAN NS, LEONHARDT KL, COSIO FG, HEBERT CL: Effects of high glucose on cellular proliferation and fibronectin production by cultured human mesangial cells. Kidney Int 41:396-402, 1992
48. 48. COSIO FG: Effects of high glucose concentrations on human mesangial cell proliferation. J Am Soc Nephrol 5:1600-1609, 1995
49. 49. MARCUSSEN N, NYENGAARD JR, CHRISTENSEN S: Compensatory growth of glomeruli is accomplished by an increased number of glomerular capillaries. Lab Invest 70:868-874, 1994
50. 50. OSTERBY R, GUNDERSEN HJG: Fast accumulation of basement membrane material and the rate of morphological changes in acute experimental diabetic glomerular hypertrophy. Diabetologia 18:493-500, 1980
51. 51. NYENGAARD JR, RASCH R: The impact of experimental diabetes mellitus in rats on glomerular capillary number and size. Diabetologia 36:189-194, 1993
52. 52. SEYER-HANSEN K: Renal hypertrophy in experimental diabetes mellitus. Kidney Int 23:643-646, 1983
53. 53. CURCIO F, CERIELLO A: Decreased cultured endothelial cell proliferation in high glucose medium is reversed by antioxidants: New insights on the pathophysiological mechanisms of diabetic vascular complications. In Vitro Cell Dev Biol 28:787-790, 1992
54. 54. HAYASHI JN, ITO H, KANAYASU T, ASUWA N, MORITA I, ISHII T, MUROTA SI: Effects of glucose on migration, proliferation and tube formation by vascular endothelial cells. Virchows Arch B Cell Pathol Incl Mol Pathol 60:245-252, 1991
55. 55. FEENER EP, KING GL: Vascular dysfunction in diabetes mellitus, Lancet 350:S9-S13, 1997
56. 56. VAN DET NF, VERHAGEN NAM, TAMSMA JT, BERDEN JHM, BRUIJN JA, DAHA MR, VAN DER WOUDE FJ: Regulation of glomerular epithelial cell production of fibronectin and transforming growth factor-β by high glucose, not by angiotensin II. Diabetes 46:834-840, 1997
57. 57. KRIZ W: Progressive renal failure-inability of podocytes to replicate and the consequences for development of glomerulosclerosis. Nephrol Dial Transplant 11:1738-1742, 1996
58. 58. WOLF G, NEILSON EG: Morphogenic cues that modulate podocyte growth. Kidney Int 53:1087-1088, 1998
59. 59. RENNKE HG: How does glomerular epithelial cell injury contribute to progressive glomerular damage? Kidney Int 45(Suppl 45):S58-S63, 1994
60. 60. SEYER-HANSEN K, GUNDERSEN HJG: Renal hypertrophy in experimental diabetes: A morphometric study. Diabetologia 18:501 505, 1980
61. 61. RASCH R: Tubular lesions in streptozotocin-diabetic rats. Diabetologia 27:32-37, 1984
62. 62. ZIYADEH FN, SNIPES ER, WATANABE M, ALVAREZ RJ, GOLDFARB S, HAVERTY TP: High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule. Am J Physiol 259:F704-F714, 1990
63. 63. JAIN SK, MORSHED KM, KANNAN K, MCMARTIN KE, BOCHINI JA: Effect of elevated glucose concentration on cellular lipid peroxidation and growth of cultured human kidney proximal tubule cells. Mol Cell Biochem 162:11-16, 1996
64. 64. FLYVBERG A, GRONBAEK H, BAK M, NILESEN B, CHRISTIANSIN T, HILL C, LOGAN A, ORSKOV H: Diabetic kidney disease: The role of growth factors. Nephrol Dial Transplant 13:1104-1107, 1998
65. 65. ABBOUD HE: Growth factors and diabetic nephropathy: An overview. Kidney Int 52(Suppl 60):S3-S6, 1997
66. 66. SHARMA K, ZIYADEH FN: Hyperglycemia and diabetic kidney disease: The case for transforming growth factor-β as a key mediator. Diabetes 44:1139 1146, 1995
67. 67. BORDER WA, RUOSLAHTI E: Transforming growth factor-β in disease: The dark side of tissue repair. J Clin Invest 90:1-7, 1992
68. 68. SHARMA K, ZIYADEH FN, ALZAHABI B, MCGOWAN TA, KAPOOR S, KURNICK BRC, WEISBERG LS: Increased renal production of transforming growth factor-β1 in patients with type II diabetes mellitus. Diabetes 46:854-859, 1997
69. 69. SHANKLAND SJ, SCHOLEY JW: Expression of transforming growth factor-β1 during diabetic renal hypertrophy. Kidney Int 46:430-442, 1994
70. 70. PARK IS, KIYOMOTO H, ABBOUD SL, ABBOUD HE: Expression of transforming growth factor-β and type IV collagen in early streptozotocin-induced diabetes. Diabetes 46:473-480, 1997
71. 71. YAMAMOTO T, NAKAMURA T, NOBLE NA, RUOSLAHTI E, BORDER WA: Expression of transforming growth factor β is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci USA 90:1814-1818, 1993
72. 72. SHARMA K, ZIYADEH FN: Renal hypertrophy is associated with upregulation of TGF-β1 gene expression in diabetic BB rat and NOD mouse. Am J Physiol 267:F1094-F1101, 1994
73. 73. PANKEWYCZ OG, GUAN JX, BOLTON WK, GOMEZ A, BENEDICT JF: Renal TGF-β regulation in spontaneously diabetic NOD mice with correlations in mesangial cells. Kidney Int 46:748-758, 1994
74. 74. ROCCO MV, CHEN Y, GOLDFARB S, ZIYADEH FN: Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule. Kidney Int 41:107-114, 1992
75. 75. MOGYOROSI A, ZIYADEH FN: Increased decorin mRNA in diabetic mouse kidney and in mesangial and tubular cells cultured in high glucose. Am J Physiol 275(5 Pt 2):F827-F832, 1998
76. 76. KOLM-LITTY V, SAUER U, NERLICH A, LEHMANN R, SCHLEICHER ED: High glucose-induced transforming growth factor β1 production is mediated by the hexoseamine pathway in porcine glomerular mesangial cells. J Clin Invest 101:160-169, 1998
77. 77. WOLF G, MUELLER E, STAHL RAK, ZIYADEH FN: Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-β. J Clin Invest 92:1366-1372, 1993
78. 78. NEGRETE H, STUDER RK, CRAVEN PA, DERUBERTIS FR: Role for transforming growth factor β in thromboxane-induced increases in mesangial cell fibronectin synthesis. Diabetes 44:335-339, 1995
79. 79. PUGLIESE G, PRICCI F, ROMEO G, PUGLIESE F, MENÉ P, GIANNINI S, CRESCI B, GALLI G, ROTELLA CM, VLASSARA H, DI MARIO U: Upregulation of mesangial growth factor and extracellular matrix synthesis by advanced glycation end products via a receptor-mediated mechanisms. Diabetes 46:1881-1887, 1997
80. 80. COHEN MP, SHARMA K, JIN Y, HUD E, WU VY, TOMASZEWSKI J, ZIYADEH FN: Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists: A novel treatment strategy. J Clin Invest 95:2338-2345, 1995
81. 81. ZIYADEH FN, HAN DC, COHEN J, GUO J, COHEN MP: Glycated albumin stimulates fibronectin gene expression in glomerular mesangial cells: Involvement of the TGF-β system. Kidney Int 53:631-638, 1998
82. 82. RISER BL, CORTES P, HEILIG C, GRONDIN J, LADSON-WOFFORD S, PATTERSON D, NARINS RG: Cyclic stretching force selectively upregulates transforming growth factor-β isoforms in cultured rat mesangial cells. Am J Pathol 148:1915-1923, 1996
83. 83. HIRAKATA M, KANAME S, CHUNG UG, JOKI N, HORI Y, NODA M, TAKUWA Y, OKAZAKI T, FUJITA T, KATOH T, KUROKAWA K: Tyrosine kinase dependent expression of TGF-β induced by stretch in mesangial cells. Kidney Int 51:1028-1036, 1997
84. 84. ZIYADEH FN, SHARMA K, ERICKSEN M, WOLF G: Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by activation of transforming growth factor-β. J Clin Invest 93:536 542, 1994
85. 1 cells partly by decreasing transforming growth factor-β receptor protein expression. J Am Soc Nephrol 7:1207-1215, 1996
86. 86. SHARMA K, JIN Y, GUO J, ZIYADEH FN: Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 45:522-530, 1996
87. 87. NAKAMURA T, FUKUI M, EBIHARA I, OSADA S, NAGAOKA I, TOMINO Y, KOIDE H: mRNA expression of growth factors in glomeruli from diabetic rats. Diabetes 42:450-456, 1993
88. 88. INABA T, ISHIBASHI S, GOTODA T, KAWAMURA M, MORINO N, NOJIMA Y, KAWAKAMI M, YAZAKI Y, YAMADA N: Enhanced expression of platelet-derived growth factor-β receptor by high glucose. Involvement of platelet-derived growth factor in diabetic angiopathy. Diabetes 45:507-512, 1996
89. 89. THROCKMORTON DC, BRODGEN AP, MIN B, RASMUSSEN H, KASHGARIAN M: PDGF and TGF-β mediate collagen production by mesangial cells exposed to advanced glycosylation end products. Kidney Int 48:111-117, 1995
90. 90. LIU Y, TOLBERT WM, SUN AM, DWORKIN LD: In vivo and in vitro evidence for increased expression of HGF receptor in kidney of diabetic rats. Am J Physiol 271:F1202-F1210, 1996
91. 91. MORISHITA R, NAKAMURA S, NAKAMURA Y, AOKI M, MORIGUCHI A, KIDA I, YO Y, MATSUMOTO K, NAKAMURA T, HIGAKI J, OGIHARA T: Potential role of an endothelium-specific growth factor, hepatocyte growth factor, on endothelial damage in diabetes. Diabetes 46:138-142, 1997
92. 92. ISHIBASHI K, SASAKI S, SAKAMOTO H, NAKAMURA Y, HATA T, NAKAMURA T, MARUMO F: Hepatocyte growth factor is a paracrine factor for renal epithelial cells: Stimulation of DNA synthesis and Na,K-ATPase activity. Biochim Biophys Res Commun 182:960-965, 1992
93. 93. FLYVBJERG A, ORSKOV H: Kidney tissue insulin-like growth factor I and initial renal growth in diabetic rats: Relation to severity of diabetes. Acta Endocrinol 122:374-378, 1990
94. 94. HAMMERMAN MR: The growth hormone-insulin-like growth factor axis in kidney. Am J Physiol 257:F503-F514, 1989
95. 95. FLYVBJERG A, BORNFELDT KE, MARSHALL SM, ARNQVIST ORSKOV H: Kidney IGF-I mRNA in initial renal hypertrophy in experimental diabetes in rats. Diabetologia 33:334-338, 1990
96. 96. PHILLIP M, SEGEVE Y, ZUNG A, KOWARSKI AA, WERNER H, ROBERTS CT, LEROTTH D, LADAS J, MULRONEY SE: The accumulation of IGF-I in kidneys of streptozotocin-diabetic adult rats is not associated with elevated plasma GH or IGF-I levels. Endocrine 3:689-693, 1995
97. 97. WERNER H, SHEN-ORR Z, STANNARD B, BURGUERA B, ROBERTS CT, LFROITH D: Experimental diabetes increases insulinlike growth factor I and II receptor concentration and gene expression in kidney. Diabetes 39:1490-1497, 1990
98. 98. SUGIMOTO H, SHIKATA K, MAKINO H, OTA K, OTA Z: Increased gene expression of insulin-like growth factor-I receptor in experimental diabetic rat glomeruli. Nephron 72:648-653, 1996
99. 99. FLYVBJERG A, MARSHALL SM, FRYSTYK J, HANSEN KW, HARRIS AG, ORSKOV H: Octreotide administration in diabetic rats: Effects on renal hypertrophy and urinary albumin excretion. Kidney Int 41:805-812, 1992
100. 100. FELD SM, HIRSCHBERG R, ARTISHEVSKY A, NAST C, ADLER SG: Insulin-like growth factor I induces mesangial proliferation and increases mRNA and secretion of collagen. Kidney Int 48:45-51, 1995
101. 101. BLAZER-YOST BL, WATANABE M, HAVERTY TP, ZIYADEH FN: Role of insulin and IGF1 receptors in proliferation of cultured renal proximal tubule cells. Biochim Biophys Acta 113:329-335, 1992
102. 102. HIRSCHBERG R: Bioactivity of glomerular ultrafiltrate during heavy proteinuria may contribute to renal tubulo-interstitial lesions: Evidence for a role for insulin-like growth factor I. J Clin Invest 98:116-124, 1996
103. 103. TEMARU R, URAKAZE M, SATOU A, YAMAZAKI K, NAKAMURA N, KOBAYASHI M: High glucose enhances the gene expression of interleukin-8 in human endothelial cells, but not in smooth muscle cells: Possible role of interleukin-8 in diabetic macroangiopathy. Diabetologia 40:610-613, 1997
104. 104. IHM CG: Monocyte chemotactic peptide-1 in diabetic nephropathy. Kidney Int 52(Suppl 60):S20-S22, 1997
105. 105. STAHL RAK, WOLF G, THAISS F: The possible role of chemotactic cytokines in renal disease. Clin Invest 72:711-712, 1994
106. 106. WOLF G: Vasoactive substances as regulators of renal growth. Exp Nephrol 1:141-151, 1993
107. 107. WOLF G, ZIYADEH FN: The role of angiotensin II in diabetic nephropathy: Emphasis on nonhemodynamic mechanisms. Am J Kidney Dis 29:153-163, 1997
108. 108. KENNEFICK TM, ANDERSON S: Role of angiotensin II in diabetic nephropathy. Semin Nephrol 17:441-447, 1997
109. 109. WOLF G, NEILSON EG, GOLDFARB S, ZIYADEH FN: The influence of glucose concentration on angiotensin II-induced hypertrophy of proximal tubular cells in culture. Biochem Biophys Res Commun 176:902-909, 1991
110. 110. WOLF G, NEILSON EG: Angiotensin II induces cellular hypertrophy in cultured murine proximal tubular cells. Am J Physiol 259:F768-F777, 1990
111. 111. WOLF G, NEILSON EG: Angiotensin II as a renal growth factor. J Am Soc Nephrol 3:1531-1540, 1993
112. 1 cells. Nephrol Dial Transplant 10:1305-1312, 1995
113. 113. BECKER BN, KONDO S, CHENG HF, HARRIS RC: Effect of glucose, pyruvate, and insulin on type 1 angiotensin II receptor expression in SV40-immortalized rabbit proximal tubule epithelial cells. Kidney Int 52:87-92, 1997
114. 114. THAISS F, WOLF G, ASSAD N, ZAHNER G, STAHL RAK: Angiotensinase A gene expression and enzyme activity in isolated glomeruli of diabetic rats. Diabetologia 39:275-280, 1996
115. 115. HAIJINAZARIAN M, COSIO FG, NAHMAN NS, MAHAN JD: Angiotensin-converting enzyme inhibition partially prevents diabetic organomegaly. Am J Kidney Dis 23:105-117, 1994
116. 116. SASSY-PRIGENT C, HEUDES D, JOUQUEY S, AUBERVAI D, BELAIR MF, MICHEL O, HAMON G, BARIETY J, BRUNEVAL P: Morphometric detection of incipient glomerular lesions in diabetic nephropathy in rats: Protective effects of ACE inhibition. Lab Invest 73:64-71, 1995
117. 117. REMUZZI A, PERICO N, AMUCHASTEGUI CS, MALANCHINI B, MAZERSKA M, BATTAGLIA C, BERTANIN T, REMUZZI G: Short-and long-term effect of angiotensin II receptor blockade in rats with experimental diabetes. J Am Soc Nephrol 4:40-49, 1993
118. 118. WILLIAMS ME: Angiotensin converting enzyme inhibitors in the prevention of diabetic renal disease. Curr Opin Endocrinol Diabetes 4:10-15, 1997
119. 119. NAKAMURA T, EBIHARA I, FUKUI M, TOMINO Y, KOIDE H: Effect of a specific endothelin receptor A antagonist on mRNA levels for extracellular matrix components and growth factors in diabetic glomeruli. Diabetes 44:895-899, 1995
120. 120. NAKAMURA T, EBIHARA I, TOMINO T, KOIDE H: Alteration of growth-related proto-oncogene expression in diabetic glomeruli by a specific endothelin receptor A antagonist. Nephrol Dial Transplant 11:1528-1531, 1996
121. 2 pathway in the mediation of increased prostaglandin synthesis by glomeruli from diabetic rats. Diabetes 37:429-435, 1988
122. 122. OLBRICHT CJ, GEISSINGER B: Renal hypertrophy in streptozotocin diabetic rats: Role of proteolytic lysosomal enzymes. Kidney Int 11:966-972, 1992
123. 123. SCHAEFER L, SCHAEFER RM, LING H, TESCHNER M, HEIDLAND A: Renal proteinases and kidney hypertrophy in experimental diabetes. Diabetologia 37:567-571, 1994
124. 124. SCHERBERICH JE, WOLF G, ALBERS C, NOWACK A, STUCKHARDT C, SCHOEPPE W: Glomerular and tubular membrane antigens reflecting cellular adaptation in human renal failure. Kidney Int 36(Suppl 27):S38-S51, 1989
125. 125. DERUBERTIS FR, CRAVEN PA: Activation of protein kinase C in glomerular cells in diabetes: Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy. Diabetes 43:1-8, 1994
126. 126. ISHII H, KOYA D, KING GL: Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus. J Mol Med 76:21-31, 1998
127. 127. KIKKAWA R, HANEDA M, UZU T, KOYA D, SUGIMOTO T, SHIGETA Y: Translocation of protein kinase α and ζ in rat glomerular mesangial cells cultured under high glucose conditions. Diabetologia 37:838-841, 1994
128. 128. BABAZONO T, KAPOR-DREZGIC J, DLUGOSZ JA, WHITESIDE C: Altered expression and subcellular localization of diacylglycerolsensitive protein kinase C isoforms in diabetic rat glomerular cells. Diabetes 47:668-676, 1998
129. 129. STUDER RK, NEGRETE H, CRAVEN PA, DERUBERTIS FR: Protein kinase C signals thromboxane induced increases in fibronectin synthesis and TGF-β bioactivation in mesangial cells. Kidney Int 48:422-430, 1995
130. 130. KREISBERG JI, AYO SH: The glomerular mesangium in diabetes mellitus. Kidney Int 43:109-113, 1993
131. 131. ZIYADEH FN, FUMO P, RODENBERGER CH, KUNCIO GS, NEILSON EG: Role of protein kinase C and cyclic AMP/protein kinase A in high glucose-stimulated transcriptional activation of collagen α1 (IV) in glomerular mesangial cells. J Diabetes Compl 9:255-261, 1995
132. 132. ZHOU X, LI C, DLUGOSZ J, KAPOR-DRESZIG J, MUNK S, WHITESIDE C: Mesangial cell actin disassembly in high glucose mediated by protein kinase C and the polyol pathway. Kidney Int 51:1797-1808, 1997
133. 133. HANEDA M, ARAKI S, TOGAWA M, SUGIMOTO T, ISONO M, KIKKAWA R: Activation of mitogen-activated protein kinase cascade in diabetic glomeruli and mesangial cells cultured under high glucose conditions. Kidney Int 52(Suppl 60):S66-S69, 1997
134. 134. HANEDA M, ARAKI S, TOGAWA M, SUGIMOTO T, ISONO M, KIKKAWA R: Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions. Diabetes 46:847-853, 1997
135. 1. FEBS Lett 410:481-484, 1997
136. 136. PEDERSEN SB, FLYVBJERG A, GRONBAEK H, RICHELSEN B: Increased ornithine decarboxylase activity in kidneys undergoing hypertrophy in experimental diabetes. Mol Cell Endocrinol 86:67-72, 1992
137. 137. PEDERSEN SB, FLYVBJERG A, RICHELSEN B: Inhibition of renal ornithine decarboxylase activity prevents kidney hypertrophy in experimental diabetes. Am J Physiol 264:C453-C456, 1993
138. 138. ZADOR IZ, DESHMUKH GD, KUNKEL R, JOHNSON K, RADIN NS, SHAYMAN JA: A role for glycosphingolipid accumulation in the renal hypertrophy of streptozotocin-induced diabetes mellitus. J Clin Invest 91:797-803, 1993
139. 139. SHANKLAND SJ: Cell-cycle control and renal disease. Kidney Int 52:294-308, 1997
140. 140. PETER M, HERSKOWITZ I: Joining the complex: Cyclin-dependent inhibitory proteins and the cell cycle. Cell 78:181-184, 1994
141. 141. SHANKLAND SJ, SCHOLEY JW: Expression of growth related protooncogenes during diabetic renal hypertrophy. Kidney Int 47:782-788, 1995
142. 142. KREISBERG JI, RADNIK RA, AYO SH, GARONI J, SAIKUMAR P: High glucose elevates c-fos and c-jun transcripts and proteins in mesangial cell culture. Kidney Int 46:105-112, 1994
143. 143. INGRAM AJ, SCHOLEY JW: Protooncogene expression and diabetic kidney injury. Kidney Int 52(Suppl 60):S70-S76, 1997
144. 144. WILMER WA, COSIO FG: DNA binding of activator protein-1 is increased in human mesangial cells cultured in high glucose concentrations. Kidney Int 53:1172-1181, 1998
145. Kip1 in cultured mouse mesangial cells: Relationship to hypertrophy. Am J Physiol 273:348-356, 1997
146. Kip1 in diabetic db/db mouse: Role of hyperglycemia. Kidney Int 53:869-879, 1998
147. WAF1,CIP1 is increased in experimental diabetic nephropathy: Potential role in glomerular hypertrophy. J Am Soc Nephrol 9:986-1003, 1998
148. Kip1. Kidney Int 50:2112-2119, 1996
149. 149. NAGATA S: Apoptosis by death factor. Cell 88:355-365, 1997
150. 150. REED J: Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1-6, 1994
151. 151. ORTIZ A, ZIYADEH FN, NEILSON EG: Expression of apoptosis-regulatory genes in renal proximal tubular epithelial cells exposed to high ambient glucose and in diabetic kidneys. J Invest Med 45:50-56, 1997
152. Kip1. J Clin Invest 103:597-604, 1999
153. 153. OSLER W: The evolution of internal medicine, in The Collected Essays of Sir William Osler (vol II), New York, Gryphon Editions, 1985, pp 303-322