Novel mechanisms of protein synthesis in diabetic nephropathy - Role of mRNA translation

Reviews in Endocrine and Metabolic Disorders

Volumn 9, Issue 4, 2008, Pages 255-266

  Kasinath, B S ^a,b   Mariappan, M M ^a,b   Sataranatarajan, K ^a,b   Lee, M J ^a,b   Ghosh Choudhury, G ^a,b   Feliers, D ^a,b  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

Angiotensin II; Glucose; Insulin; MicroRNA; Protein synthesis; Signaling reactions; Vascular endothelial growth factor

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENYLATE KINASE; ADIPONECTIN; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MATRIX PROTEIN; METFORMIN; MICRORNA; NEUTRALIZING ANTIBODY; RAPAMYCIN; RESVERATROL; VASCULOTROPIN ANTIBODY;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; DIABETIC NEPHROPATHY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; KIDNEY HYPERTROPHY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REVIEW; RNA PROCESSING; RNA STRUCTURE; RNA TRANSLATION; TRANSLATION REGULATION;

AMP-ACTIVATED PROTEIN KINASES; ANGIOTENSIN II; ANIMALS; DIABETIC NEPHROPATHIES; EUKARYOTIC INITIATION FACTORS; EXTRACELLULAR MATRIX; HUMANS; HYPERTROPHY; KIDNEY; MICRORNAS; MODELS, BIOLOGICAL; PEPTIDE CHAIN ELONGATION, TRANSLATIONAL; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 54949158939     PISSN: 13899155     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11154-008-9091-3     Document Type: Review

References (84)

1. Kasinath B, Lee MJ, Feliers D, Sonenberg N. 2006. mRNA Translation in Diabetic Nephropathy. In: Contemporary Diabetes: The Diabetic Kidney. pp 97-116.
2. G Chen TG Gharib CC Huang JM Taylor DE Misek SL Kardia 2002 Discordant protein and mRNA expression in lung adenocarcinomas Mol Cell Proteomics 1 304 313
3. SP Gygi Y Rochon BR Franza R Aebersold 1999 Correlation between protein and mRNA abundance in yeast Mol Cell Biol 19 1720 1730
4. M Kozak 2007 Some thoughts about translational regulation: forward and backward glances J Cell Biochem 102 280 290
5. BS Kasinath MM Mariappan K Sataranatarajan MJ Lee D Feliers 2006 mRNA translation: unexplored territory in renal science J Am Soc Nephrol 17 3281 3292
6. MK Holz BA Ballif SP Gygi J Blenis 2005 mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events Cell 123 569 580
7. CG Proud 2007 Signalling to translation: how signal transduction pathways control the protein synthetic machinery Biochem J 403 217 234
8. B Berkhout KT Jeang 2007 RISCy business: MicroRNAs, pathogenesis, and viruses J Biol Chem 282 26641 26645
9. MD Sheets CA Fox T Hunt G Woude Vande M Wickens 1994 The 3′-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation Genes Dev 8 926 938
10. A Kahvejian YV Svitkin R Sukarieh MN M'Boutchou N Sonenberg 2005 Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms Genes Dev 19 104 113
11. N Sonenberg AG Hinnebusch 2007 New modes of translational control in development, behavior, and disease Mol Cell 28 721 729
12. PV Alone TE Dever 2006 Direct binding of translation initiation factor eIF2gamma-G domain to its GTPase-activating and GDP-GTP exchange factors eIF5 and eIF2B epsilon J Biol Chem 281 12636 12644
13. NL Korneeva BJ Lamphear FL Hennigan RE Rhoads 2000 Mutually cooperative binding of eukaryotic translation initiation factor (eIF) 3 and eIF4A to human eIF4G-1 J Biol Chem 275 41369 41376
14. T von der Haar JD Gross G Wagner JE McCarthy 2004 The mRNA cap-binding protein eIF4E in post-transcriptional gene expression Nat Struct Mol Biol 11 503 511
15. M Stoneley AE Willis 2004 Cellular internal ribosome entry segments: structures, trans-acting factors and regulation of gene expression Oncogene 23 3200 3207
16. S Thornton N Anand D Purcell J Lee 2003 Not just for housekeeping: protein initiation and elongation factors in cell growth and tumorigenesis J Mol Med 81 536 548
17. G Hirokawa MC Kiel A Muto G Kawai K Igarashi H Kaji 2002 Binding of ribosome recycling factor to ribosomes, comparison with tRNA J Biol Chem 277 35847 35852
18. M Ceci C Gaviraghi C Gorrini LA Sala N Offenhauser PC Marchisio 2003 Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly Nature 426 579 584
19. A Pause GJ Belsham AC Gingras O Donze TA Lin JC Lawrence Jr 1994 Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function Nature 371 762 767
20. NT Redpath NT Price KV Severinov CG Proud 1993 Regulation of elongation factor-2 by multisite phosphorylation Eur J Biochem 213 689 699
21. W Filipowicz SN Bhattacharyya N Sonenberg 2008 Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9 102 114
22. H Grosshans W Filipowicz 2008 Molecular biology: the expanding world of small RNAs Nature 451 414 416
23. DT Humphreys BJ Westman DI Martin T Preiss 2005 MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function Proc Natl Acad Sci U S A 102 16961 16966
24. RS Pillai SN Bhattacharyya CG Artus T Zoller N Cougot E Basyuk 2005 Inhibition of translational initiation by Let-7 MicroRNA in human cells Science 309 1573 1576
25. M Wakiyama K Takimoto O Ohara S Yokoyama 2007 Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system Genes Dev 21 1857 1862
26. TH Hostetter 1995 Progression of renal disease and renal hypertrophy Annu Rev Physiol 57 263 278
27. HC Huang PA Preisig 2000 G1 kinases and transforming growth factor-beta signaling are associated with a growth pattern switch in diabetes-induced renal growth Kidney Int 58 162 172
28. R Rasch JO Norgaard 1983 Renal enlargement: comparative autoradiographic studies of 3H-thymidine uptake in diabetic and uninephrectomized rats Diabetologia 25 280 287
29. J Satriano 2007 Kidney growth, hypertrophy and the unifying mechanism of diabetic complications Amino Acids 33 331 339
30. S Thompson JA Latham GA Turner 1987 A simple, reproducible and cheap batch method for the analysis of serum glycoproteins using sepharose-coupled lectins and silver staining Clin Chim Acta 167 217 223
31. D Senthil GG Choudhury C McLaurin BS Kasinath 2003 Vascular endothelial growth factor induces protein synthesis in renal epithelial cells: a potential role in diabetic nephropathy Kidney Int 64 468 479
32. M Awazu S Omori K Ishikura M Hida H Fujita 2003 The lack of cyclin kinase inhibitor p27(Kip1) ameliorates progression of diabetic nephropathy J Am Soc Nephrol 14 699 708
33. G Wolf A Schanze RA Stahl SJ Shankland K Amann 2005 p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency Kidney Int 68 1583 1589
34. MJ Lee D Feliers MM Mariappan K Sataranatarajan L Mahimainathan N Musi 2007 A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy Am J Physiol Renal Physiol 292 F617 F627
35. DG Hardie 2004 The AMP-activated protein kinase pathway-new players upstream and downstream J Cell Sci 117 5479 5487
36. B Viollet F Andreelli SB Jorgensen C Perrin D Flamez J Mu 2003 Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models Biochem Soc Trans 31 216 219
37. S Kovacic CL Soltys AJ Barr I Shiojima K Walsh JR Dyck 2003 Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart J Biol Chem 278 39422 39427
38. EA Goncharova DA Goncharov A Eszterhas DS Hunter MK Glassberg RS Yeung 2002 Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM) J Biol Chem 277 30958 30967
39. J Jozwiak 2006 Hamartin and tuberin: working together for tumour suppression Int J Cancer 118 1 5
40. K Inoki T Zhu KL Guan 2003 TSC2 mediates cellular energy response to control cell growth and survival Cell 115 577 590
41. JK Chen J Chen EG Neilson RC Harris 2005 Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy J Am Soc Nephrol 16 1384 1391
42. MJ Lee MM Mariappan K Sataranatarajan M Li D Feliers G Ghosh Choudhury 2007 Resveratrol ameliorates renal hypertrophy in diabetic mice J Am Soc Nephrol 18 170A
43. SP Hong FC Leiper A Woods D Carling M Carlson 2003 Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases Proc Natl Acad Sci U S A 100 8839 8843
44. KT Howitz KJ Bitterman HY Cohen DW Lamming S Lavu JG Wood 2003 Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan Nature 425 191 196
45. JA Baur KJ Pearson NL Price HA Jamieson C Lerin A Kalra 2006 Resveratrol improves health and survival of mice on a high-calorie diet Nature 444 337 342
46. M Lagouge C Argmann Z Gerhart-Hines H Meziane C Lerin F Daussin 2006 Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha Cell 127 1109 1122
47. Y Matsuzawa 2006 Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease Nat Clin Pract Cardiovasc Med 3 35 42
48. K Sharma S Ramachandrarao G Qiu HK Usui Y Zhu SR Dunn 2008 Adiponectin regulates albuminuria and podocyte function in mice J Clin Invest 118 1645 1656
49. L Mahimainathan F Das B Venkatesan GG Choudhury 2006 Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN Diabetes 55 2115 2125
50. KD Burns 2000 Angiotensin II and its receptors in the diabetic kidney Am J Kidney Dis 36 449 467
51. DJ Leehey AK Singh N Alavi R Singh 2000 Role of angiotensin II in diabetic nephropathy Kidney Int Suppl 77 S93 S98
52. EJ Lewis LG Hunsicker RP Bain RD Rohde 1993 The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group N Engl J Med 329 1456 1462
53. S Kagami WA Border DE Miller NA Noble 1994 Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells J Clin Invest 93 2431 2437
54. AS de Vriese RG Tilton M Elger CC Stephan W Kriz NH Lameire 2001 Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes J Am Soc Nephrol 12 993 1000
55. A Flyvbjerg F Dagnaes-Hansen AS De Vriese BF Schrijvers RG Tilton R Rasch 2002 Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody Diabetes 51 3090 3094
56. D Feliers S Duraisamy JL Barnes G Ghosh-Choudhury BS Kasinath 2005 Translational regulation of vascular endothelial growth factor expression in renal epithelial cells by angiotensin II Am J Physiol Renal Physiol 288 F521 F529
57. D Feliers Y Gorin G Ghosh-Choudhury HE Abboud BS Kasinath 2006 Angiotensin II stimulation of VEGF mRNA translation requires production of reactive oxygen species Am J Physiol Renal Physiol 290 F927 F936
58. DH Ostareck A Ostareck-Lederer M Wilm BJ Thiele M Mann MW Hentze 1997 mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3′ end Cell 89 597 606
59. D Feliers MJ Lee G Ghosh-Choudhury K Bomsztyk BS Kasinath 2007 Heterogeneous nuclear ribonucleoprotein K contributes to angiotensin II stimulation of vascular endothelial growth factor mRNA translation Am J Physiol Renal Physiol 293 F607 F615
60. K Sataranatarajan MJ Lee MM Mariappan D Feliers 2008 PKCdelta regulates the stimulation of vascular endothelial factor mRNA translation by angiotensin II through hnRNP K Cell Signal 20 969 977
61. FN Ziyadeh 2004 Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator J Am Soc Nephrol 15 Suppl 1 S55 S57
62. D Fraser N Brunskill T Ito A Phillips 2003 Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-beta 1 synthesis via an autocrine PDGF loop Am J Pathol 163 2565 2574
63. RM Mason NA Wahab 2003 Extracellular matrix metabolism in diabetic nephropathy J Am Soc Nephrol 14 1358 1373
64. AR Saltiel CR Kahn 2001 Insulin signalling and the regulation of glucose and lipid metabolism Nature 414 799 806
65. MH Shanik Y Xu J Skrha R Dankner Y Zick J Roth 2008 Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse? Diabetes Care 31 Suppl 2 S262 S268
66. KP Hummel MM Dickie DL Coleman 1966 Diabetes, a new mutation in the mouse Science 153 1127 1128
67. TS Ha JL Barnes JL Stewart CW Ko JH Miner DR Abrahamson 1999 Regulation of renal laminin in mice with type II diabetes J Am Soc Nephrol 10 1931 1939
68. BK Bhandari D Feliers S Duraisamy JL Stewart AC Gingras HE Abboud 2001 Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells Kidney Int 59 866 875
69. D Feliers S Duraisamy JL Faulkner J Duch AV Lee HE Abboud 2001 Activation of renal signaling pathways in db/db mice with type 2 diabetes Kidney Int 60 495 504
70. T Kondo CR Kahn 2004 Altered insulin signaling in retinal tissue in diabetic states J Biol Chem 279 37997 38006
71. HG Zecchin RM Bezerra JB Carvalheira MA Carvalho-Filho K Metze KG Franchini 2003 Insulin signalling pathways in aorta and muscle from two animal models of insulin resistance-the obese middle-aged and the spontaneously hypertensive rats Diabetologia 46 479 491
72. JH Miner BL Patton SI Lentz DJ Gilbert WD Snider NA Jenkins 1997 The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform J Cell Biol 137 685 701
73. MM Mariappan D Feliers S Mummidi GG Choudhury BS Kasinath 2007 High glucose, high insulin, and their combination rapidly induce laminin-beta1 synthesis by regulation of mRNA translation in renal epithelial cells Diabetes 56 476 485
74. S Wullschleger R Loewith MN Hall 2006 TOR signaling in growth and metabolism Cell 124 471 484
75. F Das N Ghosh-Choudhury L Mahimainathan B Venkatesan D Feliers DJ Riley 2008 Raptor-rictor axis in TGFbeta-induced protein synthesis Cell Signal 20 409 423
76. K Sataranatarajan MM Mariappan MJ Lee D Feliers GG Choudhury JL Barnes 2007 Regulation of elongation phase of mRNA translation in diabetic nephropathy: amelioration by rapamycin Am J Pathol 171 1733 1742
77. X Wang W Li M Williams N Terada DR Alessi CG Proud 2001 Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase EMBO J 20 4370 4379
78. N Lloberas JM Cruzado M Franquesa I Herrero-Fresneda J Torras G Alperovich 2006 Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats J Am Soc Nephrol 17 1395 1404
79. M Sakaguchi M Isono K Isshiki T Sugimoto D Koya A Kashiwagi 2006 Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice Biochem Biophys Res Commun 340 296 301
80. N Embi DB Rylatt P Cohen 1980 Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase Eur J Biochem 107 519 527
81. DP Hanger K Hughes JR Woodgett JP Brion BH Anderton 1992 Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase Neurosci Lett 147 58 62
82. H Cui Y Meng RF Bulleit 1998 Inhibition of glycogen synthase kinase 3beta activity regulates proliferation of cultured cerebellar granule cells Brain Res Dev Brain Res 111 177 188
83. R Kerkela K Woulfe T Force 2007 Glycogen synthase kinase-3beta-actively inhibiting hypertrophy Trends Cardiovasc Med 17 91 96
84. MM Mariappan G Ghosh Choudhury BS Kasinath 2007 Role of GSK3 beta (GSK3b) inactivation in high glucose (HG)- and high insulin (HI)-inducedextra cellular matrix protein synthesis in proximal tubular epithelial (MCT) cells J Am Soc Nephrol 18 651A