-
1
-
-
54049085754
-
Imatinib therapy blocks cerebellar apoptosis an improves neurological symptoms in a mouse model of Niemann-Pick type C disease
-
Alvarez AR, Klein A, Castro J, Cancino GI, Amigo J, Mosqueira M, Vargas LM, Yévenes LF, Bronfman FC, Zanlungo S. 2008. Imatinib therapy blocks cerebellar apoptosis an improves neurological symptoms in a mouse model of Niemann-Pick type C disease. FASEB J 10:3617-3627.
-
(2008)
FASEB J
, vol.10
, pp. 3617-3627
-
-
Alvarez, A.R.1
Klein, A.2
Castro, J.3
Cancino, G.I.4
Amigo, J.5
Mosqueira, M.6
Vargas, L.M.7
Yévenes, L.F.8
Bronfman, F.C.9
Zanlungo, S.10
-
2
-
-
56049101608
-
Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP, APP+PS1 transgenic mouse brains
-
Amritraj A, Hawkes C, Phinney AL, Mount HT, Scott CD, Westaway D, Kar S. 2009a. Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP, APP+PS1 transgenic mouse brains. Neurobiol Aging 30:54-70.
-
(2009)
Neurobiol Aging
, vol.30
, pp. 54-70
-
-
Amritraj, A.1
Hawkes, C.2
Phinney, A.L.3
Mount, H.T.4
Scott, C.D.5
Westaway, D.6
Kar, S.7
-
3
-
-
73549105909
-
Increased activity and altered subcellular distribution of lysosomal enzymes determine neuronal vulnerability in Niemann-Pick type C1-deficient mice
-
Amritraj A, Peake K, Kodam A, Salio C, Merighi A, Vance JE, Kar S. 2009b. Increased activity and altered subcellular distribution of lysosomal enzymes determine neuronal vulnerability in Niemann-Pick type C1-deficient mice. Am J Pathol 175:2540-2556.
-
(2009)
Am J Pathol
, vol.175
, pp. 2540-2556
-
-
Amritraj, A.1
Peake, K.2
Kodam, A.3
Salio, C.4
Merighi, A.5
Vance, J.E.6
Kar, S.7
-
4
-
-
0028980771
-
Glial expression of the β-amyloid precursor protein (APP) in global ischemia
-
Banati RB, Gehrmann J, Wiessner C, Hossmann KA, Kreutzberg GW. 1995. Glial expression of the β-amyloid precursor protein (APP) in global ischemia. J Cereb Blood Flow Metab 15:647-654.
-
(1995)
J Cereb Blood Flow Metab
, vol.15
, pp. 647-654
-
-
Banati, R.B.1
Gehrmann, J.2
Wiessner, C.3
Hossmann, K.A.4
Kreutzberg, G.W.5
-
5
-
-
0842320913
-
Postnatal development of inflammation in a murine model of Niemann-Pick type C disease: Immunohistochemical observations of microglia and astroglia
-
DOI 10.1016/S0014-4886(03)00345-5
-
Baudry M, Yao Y, Simmons D, Liu J, Bi X. 2003. Postnatal development of inflammation in a murine model of Niemann-Pick type C disease: Immunohistochemical observations of microglia and astroglia. Exp Neurol 184:887-903. (Pubitemid 38182817)
-
(2003)
Experimental Neurology
, vol.184
, Issue.2
, pp. 887-903
-
-
Baudry, M.1
Yao, Y.2
Simmons, D.3
Liu, J.4
Bi, X.5
-
6
-
-
0028323567
-
Differential distribution of amyloid protein precursor immunoreactivity in the rat brain studied by using five different antibodies
-
Beeson JG, Shelton ER, Chan HW, Gage FH. 1994. Differential distribution of amyloid protein precursor immunoreactivity in the rat brain studied by using five different antibodies. J Comp Neurol 342:78-96.
-
(1994)
J Comp Neurol
, vol.342
, pp. 78-96
-
-
Beeson, J.G.1
Shelton, E.R.2
Chan, H.W.3
Gage, F.H.4
-
8
-
-
0016275478
-
Staining of cholesterol with the fluorescent antibiotic "filipin."
-
Bornig H, Geyer G. 1974. Staining of cholesterol with the fluorescent antibiotic "filipin." Acta Histochem 50:110-115.
-
(1974)
Acta Histochem
, vol.50
, pp. 110-115
-
-
Bornig, H.1
Geyer, G.2
-
9
-
-
0038045571
-
Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo
-
Burns M, Gaynor K, Olm V, Mercken M, LaFrancois J, Wang L, Mathews PM, Noble W, Matsuoka Y, Duff K. 2003. Presenilin redistribution associated with aberrant cholesterol transport enhances β-amyloid production in vivo. J Neurosci 23:5645-5649. (Pubitemid 36807842)
-
(2003)
Journal of Neuroscience
, vol.23
, Issue.13
, pp. 5645-5649
-
-
Burns, M.1
Gaynor, K.2
Olm, V.3
Mercken, M.4
LaFrancois, J.5
Wang, L.6
Mathews, P.M.7
Noble, W.8
Matsuoka, Y.9
Duff, K.10
-
10
-
-
0030863352
-
Niemann-Pick C1 disease gene: Homology to mediators of cholesterol homeostasis
-
DOI 10.1126/science.277.5323.228
-
Carstea ED, Morris JA, Coleman KG, Loftus SK, Zhang D, Cummings C, Gu J, Rosenfeld MA, Pavan WJ, Krizman DB, Nagle J, Polymeropoulos MH, Sturley SL, Ioannou YA, Higgins ME, Comly M, Cooney A, Brown A, Kaneski CR, Blanchette-Mackie EJ, Dwyer NK, Neufeld EB, Chang TY, Liscum L, Strauss JF III, Ohno K, Zeigler M, Carmi R, Sokol J, Markie D, O'Neill RR, van Diggelen OP, Elleder M, Patterson M, Brady RO, Vanier MT, Pentchev PG, Tagle DA. 1997. Niemann-Pick C1 disease gene: Homology to mediators of cholesterol homeostasis. Science 277:228-231. (Pubitemid 27446076)
-
(1997)
Science
, vol.277
, Issue.5323
, pp. 228-231
-
-
Carstea, E.D.1
Morris, J.A.2
Coleman, K.G.3
Loftus, S.K.4
Zhang, D.5
Cummings, C.6
Gu, J.7
Rosenfeld, M.A.8
Pavan, W.J.9
Krizman, D.B.10
Nagle, J.11
Polymeropoulos, M.H.12
Sturley, S.L.13
Ioannou, Y.A.14
Higgins, M.E.15
Comly, M.16
Cooney, A.17
Brown, A.18
Kaneski, C.R.19
Blanchette-Mackie, E.J.20
Dwyer, N.K.21
Neufeld, E.B.22
Chang, T.-Y.23
Liscum, L.24
Strauss III, J.F.25
Ohno, K.26
Zeigler, M.27
Carmi, R.28
Sokol, J.29
Markie, D.30
O'Neill, R.R.31
Van Diggelen, O.P.32
Elleder, M.33
Patterson, M.C.34
Brady, R.O.35
Vanier, M.T.36
Pentchev, P.G.37
Tagle, D.A.38
more..
-
11
-
-
0034961205
-
The amyloid-β peptide and its role in Alzheimer's disease
-
Clippingdale AB, Wade JD, Barrow CJ. 2001. The amyloid-β peptide and its role in Alzheimer's disease. J Pept Sci 7:227-249.
-
(2001)
J Pept Sci
, vol.7
, pp. 227-249
-
-
Clippingdale, A.B.1
Wade, J.D.2
Barrow, C.J.3
-
12
-
-
57649217285
-
The role of amyloid precursor protein processing by BACE1, the β-secretase in Alzheimer's disease pathology
-
Cole SL, Vassar R. 2008. The role of amyloid precursor protein processing by BACE1, the β-secretase in Alzheimer's disease pathology. J Biol Chem 283:29621-29625.
-
(2008)
J Biol Chem
, vol.283
, pp. 29621-29625
-
-
Cole, S.L.1
Vassar, R.2
-
13
-
-
53549091866
-
The cholesterol transport inhibitor U18666a regulates amyloid precursor protein metabolism and trafficking in N2aAPP "Swedish" cells
-
Davis W. 2008. The cholesterol transport inhibitor U18666a regulates amyloid precursor protein metabolism and trafficking in N2aAPP "Swedish" cells. Curr Alzheimer Res 5:448-456.
-
(2008)
Curr Alzheimer Res
, vol.5
, pp. 448-456
-
-
Davis, W.1
-
14
-
-
0037097247
-
Studies on neuronal death in the mouse model of Niemann-Pick C disease
-
DOI 10.1002/jnr.10257
-
Erickson RP, Bernard O. 2002. Studies on neuronal death in the mouse model of Niemann-Pick C disease. J Neurosci Res 68:738-744. (Pubitemid 34594990)
-
(2002)
Journal of Neuroscience Research
, vol.68
, Issue.6
, pp. 738-744
-
-
Erickson, R.P.1
Bernard, O.2
-
15
-
-
0001504829
-
Simvastatin strongly reduces Alzheimer's disease Aβ42 and Aβ40 levels in vitro and in vivo
-
Fassbender K, Simons M, Bergmann C. 2001. Simvastatin strongly reduces Alzheimer's disease Aβ42 and Aβ40 levels in vitro and in vivo. Proc Natl Acad Sci USA 98:5856-5861.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 5856-5861
-
-
Fassbender, K.1
Simons, M.2
Bergmann, C.3
-
16
-
-
0033519601
-
The role of cholesterol in the biosynthesis of β-amyloid
-
Frears ER, Stephens DJ, Walters CE, Davies H, Austen BM. 1999. The role of cholesterol in the biosynthesis of β-amyloid. Neuroreport 10:1699-1705.
-
(1999)
Neuroreport
, vol.10
, pp. 1699-1705
-
-
Frears, E.R.1
Stephens, D.J.2
Walters, C.E.3
Davies, H.4
Austen, B.M.5
-
17
-
-
0035821438
-
Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann-Pick C disease
-
German DC, Quintero EM, Liang CL, Ng B, Punia S, Xie C, Dietschy JM. 2001. Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann-Pick C disease. J Comp Neurol 433:415-425.
-
(2001)
J Comp Neurol
, vol.433
, pp. 415-425
-
-
German, D.C.1
Quintero, E.M.2
Liang, C.L.3
Ng, B.4
Punia, S.5
Xie, C.6
Dietschy, J.M.7
-
18
-
-
0037440474
-
Astrocytic expression of the Alzheimer's disease β-secretase (BACE1) is stimulus-dependent
-
Hartlage-Rubsamen M, Zeitschel U, Apelt J, Gartner U, Franke H, Stahl T, Gunther A, Schliebs R, Penkowa M, Bigl V, Rossner S. 2003. Astrocytic expression of the Alzheimer's disease β-secretase (BACE1) is stimulus-dependent. Glia 41:169-179.
-
(2003)
Glia
, vol.41
, pp. 169-179
-
-
Hartlage-Rubsamen, M.1
Zeitschel, U.2
Apelt, J.3
Gartner, U.4
Franke, H.5
Stahl, T.6
Gunther, A.7
Schliebs, R.8
Penkowa, M.9
Bigl, V.10
Rossner, S.11
-
19
-
-
1242316263
-
Intracellular Accumulation of Amyloidogenic Fragments of Amyloid-beta Precursor Protein in Neurons with Niemann-Pick Type C Defects Is Associated with Endosomal Abnormalities
-
Jin L, Maezawa I, Vincent I, Bird T. 2004. Intracellular accumulation of amyloidogenic fragments of amyloid-β precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. Am J Pathol 164:975-985. (Pubitemid 38235479)
-
(2004)
American Journal of Pathology
, vol.164
, Issue.3
, pp. 975-985
-
-
Jin, L.-W.1
Maezawa, I.2
Vincent, I.3
Bird, T.4
-
20
-
-
11344265672
-
Beta-amyloid peptide and central cholinergic neurons: Functional interrelationships and possible implications in Alzheimer's disease pathology
-
Kar S, Slowikowski SP, Westaway D, Mount HTJ. 2004. Beta-amyloid peptide and central cholinergic neurons: Functional interrelationships and possible implications in Alzheimer's disease pathology. J Psychiatry Neurosci 29:427-441.
-
(2004)
J Psychiatry Neurosci
, vol.29
, pp. 427-441
-
-
Kar, S.1
Slowikowski, S.P.2
Westaway, D.3
Mount, H.T.J.4
-
21
-
-
0037423184
-
Trafficking of cholesterol from cell bodies to distal axons in Niemann Pick C1 deficient neurons
-
Karten B, Vance DE, Campenot RB, Vance JE. 2003. Trafficking of cholesterol from cell bodies to distal axons in Niemann Pick C1 deficient neurons. J Biol Chem 278:4168-4175.
-
(2003)
J Biol Chem
, vol.278
, pp. 4168-4175
-
-
Karten, B.1
Vance, D.E.2
Campenot, R.B.3
Vance, J.E.4
-
22
-
-
40849098025
-
Cellular distribution of g-secretase subunit nicastrin in the developing and adult rat brains
-
DOI 10.1016/j.neurobiolaging.2006.12.005, PII S0197458006004581
-
Kodam A, Vetrivel KS, Thinakaran G, Kar S. 2008. Cellular distribution of g-secretase subunit nicastrin in the developing and adult rat brains. Neurobiol Aging 29:724-738. (Pubitemid 351400827)
-
(2008)
Neurobiology of Aging
, vol.29
, Issue.5
, pp. 724-738
-
-
Kodam, A.1
Vetrivel, K.S.2
Thinakaran, G.3
Kar, S.4
-
23
-
-
33749247584
-
Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: Bridging Niemann-Pick disease type C, Alzheimer's disease
-
Koh CH, Cheung NS. 2006. Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: Bridging Niemann-Pick disease type C, Alzheimer's disease. Cell Signal 18:1844-1853.
-
(2006)
Cell Signal
, vol.18
, pp. 1844-1853
-
-
Koh, C.H.1
Cheung, N.S.2
-
24
-
-
53349129897
-
Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of β-amyloid generation
-
Lee JW, Lee YK, Yuk DY, Choi DY, Ban SB, Oh KW, Hong JT. 2008. Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of β-amyloid generation. J Neuroinflammation 5:1-14.
-
(2008)
J Neuroinflammation
, vol.5
, pp. 1-14
-
-
Lee, J.W.1
Lee, Y.K.2
Yuk, D.Y.3
Choi, D.Y.4
Ban, S.B.5
Oh, K.W.6
Hong, J.T.7
-
25
-
-
16844373434
-
Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease
-
Li H, Repa JJ, Valasek MA, Beltroy EP, Turley SD, German DC, Dietschy JM. 2005. Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease. J Neuropathol Exp Neurol 64:323-333.
-
(2005)
J Neuropathol Exp Neurol
, vol.64
, pp. 323-333
-
-
Li, H.1
Repa, J.J.2
Valasek, M.A.3
Beltroy, E.P.4
Turley, S.D.5
German, D.C.6
Dietschy, J.M.7
-
26
-
-
34548860918
-
-/- mouse brain
-
-/- mouse brain. Am J Pathol 171:962-975.
-
(2007)
Am J Pathol
, vol.171
, pp. 962-975
-
-
Liao, G.1
Yao, Y.2
Liu, J.3
Yu, Z.4
Cheung, S.5
Xie, A.6
Liang, X.7
Bi, X.8
-
27
-
-
0030768084
-
Murine model of Niemann-Pick C disease: Mutation in a cholesterol homeostasis gene
-
DOI 10.1126/science.277.5323.232
-
Loftus SK, Morris JA, Carstea ED, Gu JZ, Cummings C, Brown A, Ellison J, Ohno K, Rosenfeld MA, Tagle DA, Pentchev PG, Pavan WJ. 1997. Murine model of Niemann-Pick C disease: Mutation in a cholesterol homeostasis gene. Science 277:232-235. (Pubitemid 27446077)
-
(1997)
Science
, vol.277
, Issue.5323
, pp. 232-235
-
-
Loftus, S.K.1
Morris, J.A.2
Carstea, E.D.3
Gu, J.Z.4
Cummings, C.5
Brown, A.6
Ellison, J.7
Ohno, K.8
Rosenfeld, M.A.9
Tagle, D.A.10
Pentchev, P.G.11
Pavan, W.J.12
-
29
-
-
44949138575
-
Increased expression of the γ-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury
-
Nadler Y, Alexandrovich A, Grigoriadis N, Hartmann T, Rao KS, Shohami, Stein R. 2008. Increased expression of the γ-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury. Glia 56:552-567.
-
(2008)
Glia
, vol.56
, pp. 552-567
-
-
Nadler, Y.1
Alexandrovich, A.2
Grigoriadis, N.3
Hartmann, T.4
Rao, K.S.5
Shohami6
Stein, R.7
-
30
-
-
1242316279
-
Niemann-Pick type C disease and Alzheimer's disease: The APP-endosome connection fattens up
-
Nixon RA. 2004. Niemann-Pick type C disease and Alzheimer's disease: The APP-endosome connection fattens up. Am J Pathol 164:757-761.
-
(2004)
Am J Pathol
, vol.164
, pp. 757-761
-
-
Nixon, R.A.1
-
31
-
-
51849116835
-
The pathogenesis of Niemann-Pick type C disease: A role for autophagy?
-
Pacheco CD, Lieberman AP. 2008. The pathogenesis of Niemann-Pick type C disease: A role for autophagy? Expert Rev Mol Med 10:1-14.
-
(2008)
Expert Rev Mol Med
, vol.10
, pp. 1-14
-
-
Pacheco, C.D.1
Lieberman, A.P.2
-
32
-
-
0032485016
-
The neuroprotective effects of the recombinant interleukin-1 receptor antagonist rhIL-1ra after excitotoxic stimulation with kainic acid and its relationship to the amyloid precursor protein gene
-
DOI 10.1016/S0022-510X(97)00214-1, PII S0022510X97002141
-
Panegyres PK, Hughes J. 1998. The neuroprotective effects of the recombinant interleukin-1 receptor antagonist rhIL-1ra after excitotoxic stimulation with kainic acid and its relationship to the amyloid precursor protein gene. J Neurol Sci 154:123-132. (Pubitemid 28156927)
-
(1998)
Journal of the Neurological Sciences
, vol.154
, Issue.2
, pp. 123-132
-
-
Panegyres, P.K.1
Hughes, J.2
-
33
-
-
4744356190
-
Before the loss: Neuronal dysfunction in Niemann-Pick Type C disease
-
Paul CA, Boegle AK, Maue RA. 2004. Before the loss: Neuronal dysfunction in Niemann-Pick Type C disease. Biochim Biophys Acta 1685:63-76.
-
(2004)
Biochim Biophys Acta
, vol.1685
, pp. 63-76
-
-
Paul, C.A.1
Boegle, A.K.2
Maue, R.A.3
-
34
-
-
0000815355
-
Niemann-Pick disease type C: A cellular cholesterol lipidosis
-
Scriver CR, Beaudet AL, Sly WS, Valle D, editors. New York: McGraw-Hill
-
Pentchev PV, Vanier MT, Suzuki K, Patterson MC. 1995. Niemann-Pick disease type C: A cellular cholesterol lipidosis. In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The metabolic and molecular basis of inherited disease, Vol. II. New York: McGraw-Hill. pp2625-2639.
-
(1995)
The Metabolic and Molecular Basis of Inherited Disease
, vol.2
, pp. 2625-2639
-
-
Pentchev, P.V.1
Vanier, M.T.2
Suzuki, K.3
Patterson, M.C.4
-
35
-
-
0345669752
-
Alzheimer's disease: The cholesterol connection
-
Puglielli L, Tanzi RE, Kovacs DM. 2003. Alzheimer's disease: The cholesterol connection. Nat Neurosci 6:345-351.
-
(2003)
Nat Neurosci
, vol.6
, pp. 345-351
-
-
Puglielli, L.1
Tanzi, R.E.2
Kovacs, D.M.3
-
36
-
-
34547315810
-
Alzheimer's disease: Cholesterol, membrane rafts, isoprenoids and statins
-
DOI 10.1111/j.1582-4934.2007.00054.x
-
Reid PC, Urano Y, Kodama T, Hamakubo T. 2007. Alzheimer's disease: Cholesterol, membrane rafts, isoprenoids and statins. J Cell Mol Med 11:383-392. (Pubitemid 47153452)
-
(2007)
Journal of Cellular and Molecular Medicine
, vol.11
, Issue.3
, pp. 383-392
-
-
Reid, P.C.1
Urano, Y.2
Kodama, T.3
Hamakubo, T.4
-
37
-
-
0035370860
-
Neuronal and glial β-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology
-
Rossner S, Apelt J, Schliebs R, Perez-Polo JR, Bigl V. 2001. Neuronal and glial β-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology. J Neurosci Res 64:437-446.
-
(2001)
J Neurosci Res
, vol.64
, pp. 437-446
-
-
Rossner, S.1
Apelt, J.2
Schliebs, R.3
Perez-Polo, J.R.4
Bigl, V.5
-
39
-
-
0036523031
-
Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells
-
Runz H, Rietdorf J, Tomic I, de Bernard M, Beyreuther K, Pepperkok R, Hartmann T. 2002. Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells. J Neurosci 22:1679-1689. (Pubitemid 35386286)
-
(2002)
Journal of Neuroscience
, vol.22
, Issue.5
, pp. 1679-1689
-
-
Runz, H.1
Rietdorf, J.2
Tomic, I.3
De Bernard, M.4
Beyreuther, K.5
Pepperkok, R.6
Hartmann, T.7
-
40
-
-
0037428937
-
Patterned Purkinje cell degeneration in mouse models of Neimann-Pick type C disease
-
Sarna JR, Larouche M, Marzban H, Sillitoe RV, Rancourt DE, Hawkes R. 2003. Patterned Purkinje cell degeneration in mouse models of Neimann-Pick type C disease. J Comp Neurol 456:279-291.
-
(2003)
J Comp Neurol
, vol.456
, pp. 279-291
-
-
Sarna, J.R.1
Larouche, M.2
Marzban, H.3
Sillitoe, R.V.4
Rancourt, D.E.5
Hawkes, R.6
-
41
-
-
13844253258
-
Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons
-
DOI 10.1016/j.brainres.2004.11.054
-
Schmued LC, Stowers CC, Scallet AC, Xu L. 2005. Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons. Brain Res 1035:24-31. (Pubitemid 40248533)
-
(2005)
Brain Research
, vol.1035
, Issue.1
, pp. 24-31
-
-
Schmued, L.C.1
Stowers, C.C.2
Scallet, A.C.3
Xu, L.4
-
42
-
-
58149497521
-
Biochemistry and molecular biology of amyloid β-protein and mechanism of Alzheimer's disease
-
Selkoe DJ. 2008. Biochemistry and molecular biology of amyloid β-protein and mechanism of Alzheimer's disease. Handb Clin Neurol 89:245-260.
-
(2008)
Handb Clin Neurol
, vol.89
, pp. 245-260
-
-
Selkoe, D.J.1
-
43
-
-
8444247104
-
Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain
-
Siman R, Salidas S. 2004. Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain. Neuroscience 129:615-628.
-
(2004)
Neuroscience
, vol.129
, pp. 615-628
-
-
Siman, R.1
Salidas, S.2
-
44
-
-
0032568552
-
Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons
-
Simons M, Keller P, De Strooper B, Beyreuther K, Dotti C, Simons K. 1998. Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons. Proc Natl Acad Sci USA 95:6460-6464.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6460-6464
-
-
Simons, M.1
Keller, P.2
De Strooper, B.3
Beyreuther, K.4
Dotti, C.5
Simons, K.6
-
45
-
-
13844255273
-
Molecular biology and genetics of Alzheimer's disease
-
DOI 10.1016/j.crvi.2004.10.013, PII S1631069104002604
-
St George-Hyslop PH, Petit A. 2005. Molecular biology and genetics of Alzheimer's disease. C R Biol 328:119-130. (Pubitemid 40247057)
-
(2005)
Comptes Rendus - Biologies
, vol.328
, Issue.2
, pp. 119-130
-
-
St George-Hyslop, P.H.1
Petit, A.2
-
46
-
-
57649174625
-
Intramembrane proteolysis by gamma-secretase
-
Steiner H, Fluhrer R, Haass C. 2008. Intramembrane proteolysis by gamma-secretase. J Biol Chem 283:29627-29631.
-
(2008)
J Biol Chem
, vol.283
, pp. 29627-29631
-
-
Steiner, H.1
Fluhrer, R.2
Haass, C.3
-
47
-
-
0036245342
-
Localization of beta-secretase memapsin 2 in the brain of Alzheimer's patients and normal aged controls
-
Sun A, Koelsch G, Tang J, Bing G. 2002. Localization of beta-secretase memapsin 2 in the brain of Alzheimer's patients and normal aged controls. Exp Neurol 175:10-22.
-
(2002)
Exp Neurol
, vol.175
, pp. 10-22
-
-
Sun, A.1
Koelsch, G.2
Tang, J.3
Bing, G.4
-
48
-
-
57649221135
-
Amyloid precursor protein trafficking, processing and function
-
Thinakaran G, Koo EH. 2008. Amyloid precursor protein trafficking, processing and function. J Biol Chem 283:29615-29619.
-
(2008)
J Biol Chem
, vol.283
, pp. 29615-29619
-
-
Thinakaran, G.1
Koo, E.H.2
-
49
-
-
0036674082
-
Lipid rafts play an important role in Aβ biogenesis by regulating the β-secretase pathway
-
Tun H, Marlow L, Pinnix I, Kinsey R, Samamurti K. 2002. Lipid rafts play an important role in Aβ biogenesis by regulating the β-secretase pathway. J Mol Neurosci 19:31-35.
-
(2002)
J Mol Neurosci
, vol.19
, pp. 31-35
-
-
Tun, H.1
Marlow, L.2
Pinnix, I.3
Kinsey, R.4
Samamurti, K.5
-
50
-
-
33749234799
-
Lipid imbalance in the neurological disorder, Niemann-Pick C disease
-
Vance JE. 2006. Lipid imbalance in the neurological disorder, Niemann-Pick C disease. FEBS Lett 580:5518-5524.
-
(2006)
FEBS Lett
, vol.580
, pp. 5518-5524
-
-
Vance, J.E.1
-
51
-
-
0031983861
-
Recent advances in elucidating Niemann-Pick C disease
-
Vanier MT, Suzuki K. 1998. Recent advances in elucidating Niemann-Pick C disease. Brain Pathol 8:163-174.
-
(1998)
Brain Pathol
, vol.8
, pp. 163-174
-
-
Vanier, M.T.1
Suzuki, K.2
-
52
-
-
7244258941
-
Association of γ-secretase with lipid rafts in post-Golgi and endosome membranes
-
Vetrivel KS, Cheng H, Lin W, Sakurai T, Li T, Nukina N, Wong PC, Xu H, Thinakaran G. 2004. Association of γ-secretase with lipid rafts in post-Golgi and endosome membranes. J Biol Chem 279:44945-44954.
-
(2004)
J Biol Chem
, vol.279
, pp. 44945-44954
-
-
Vetrivel, K.S.1
Cheng, H.2
Lin, W.3
Sakurai, T.4
Li, T.5
Nukina, N.6
Wong, P.C.7
Xu, H.8
Thinakaran, G.9
-
53
-
-
62149091579
-
Alzheimer disease Aβ production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts
-
Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G. 2009. Alzheimer disease Aβ production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem 284:3793-3803.
-
(2009)
J Biol Chem
, vol.284
, pp. 3793-3803
-
-
Vetrivel, K.S.1
Meckler, X.2
Chen, Y.3
Nguyen, P.D.4
Seidah, N.G.5
Vassar, R.6
Wong, P.C.7
Fukata, M.8
Kounnas, M.Z.9
Thinakaran, G.10
-
54
-
-
0036180950
-
Cholesterol-dependent γ-secretase activity in buoyant cholesterol-rich membrane microdomains
-
Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, Golde TE. 2002. Cholesterol-dependent γ-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol Dis 9:11-23.
-
(2002)
Neurobiol Dis
, vol.9
, pp. 11-23
-
-
Wahrle, S.1
Das, P.2
Nyborg, A.C.3
McLendon, C.4
Shoji, M.5
Kawarabayashi, T.6
Younkin, L.H.7
Younkin, S.G.8
Golde, T.E.9
-
56
-
-
7244236841
-
A modified beta-amyloid hypothesis: Intraneuronal accumulation of the beta-amyloid peptide - The first step of a fatal cascade
-
Wirths O, Multhaup G, Bayer TA. 2004. A modified beta-amyloid hypothesis: Intraneuronal accumulation of the beta-amyloid peptide - The first step of a fatal cascade. J Neurochem 91:513-520.
-
(2004)
J Neurochem
, vol.91
, pp. 513-520
-
-
Wirths, O.1
Multhaup, G.2
Bayer, T.A.3
-
57
-
-
11444254013
-
Apoptosis accompanied by up-regulation of TNF-a death pathway genes in the brain of Niemann-Pick type C disease
-
Wu YP, Mizukami H, Matsuda J, Saito Y, Proia R, Suzuki K. 2005. Apoptosis accompanied by up-regulation of TNF-a death pathway genes in the brain of Niemann-Pick type C disease. Mol Genet Metab 84:9-17.
-
(2005)
Mol Genet Metab
, vol.84
, pp. 9-17
-
-
Wu, Y.P.1
Mizukami, H.2
Matsuda, J.3
Saito, Y.4
Proia, R.5
Suzuki, K.6
-
58
-
-
33947512432
-
Interferon-γ and tumor necrosis factor-α regulate amyloid β plaque deposition and β-secretase expression in Swedish mutant APP transgenic mice
-
Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsch SM, Gendelman HE, Ikezu T. 2007. Interferon-γ and tumor necrosis factor-α regulate amyloid β plaque deposition and β-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol 170:680-692.
-
(2007)
Am J Pathol
, vol.170
, pp. 680-692
-
-
Yamamoto, M.1
Kiyota, T.2
Horiba, M.3
Buescher, J.L.4
Walsch, S.M.5
Gendelman, H.E.6
Ikezu, T.7
-
59
-
-
0035830844
-
Accumulation and aggregation of amyloid β-protein in late endosomes of Niemann-Pick type C cells
-
Yamazaki T, Chang T-Y, Haass C, Ihara Y. 2001. Accumulation and aggregation of amyloid β-protein in late endosomes of Niemann-Pick type C cells. J Biol Chem 276:4454-4460.
-
(2001)
J Biol Chem
, vol.276
, pp. 4454-4460
-
-
Yamazaki, T.1
Chang, T.-Y.2
Haass, C.3
Ihara, Y.4
-
60
-
-
0037017399
-
1-42 through p53 and Bax in cultured primary human neurons
-
DOI 10.1083/jcb.200110119
-
Zhang Y, McLaughlin R, Goodyer C, LeBlanc A. 2002. Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons. J Cell Biol 156:519-529. (Pubitemid 34839899)
-
(2002)
Journal of Cell Biology
, vol.156
, Issue.3
, pp. 519-529
-
-
Zhang, Y.1
McLaughlin, R.2
Goodyer, C.3
LeBlanc, A.4
|