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Volumn 5, Issue , 2010, Pages

Chk1 suppressed cell death

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EID: 77956472414     PISSN: None     EISSN: 17471028     Source Type: Journal    
DOI: 10.1186/1747-1028-5-21     Document Type: Review
Times cited : (31)

References (52)
  • 1
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: ten years after
    • 10.1016/j.molcel.2007.11.015, 18082599
    • Harper JW, Elledge SJ. The DNA damage response: ten years after. Mol Cell 2007, 28:739-745. 10.1016/j.molcel.2007.11.015, 18082599.
    • (2007) Mol Cell , vol.28 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 2
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • 10.1016/S1097-2765(01)00214-3, 11463392
    • Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001, 7:683-694. 10.1016/S1097-2765(01)00214-3, 11463392.
    • (2001) Mol Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 3
    • 0035265823 scopus 로고    scopus 로고
    • PUMA induces the rapid apoptosis of colorectal cancer cells
    • 10.1016/S1097-2765(01)00213-1, 11463391
    • Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001, 7:673-682. 10.1016/S1097-2765(01)00213-1, 11463391.
    • (2001) Mol Cell , vol.7 , pp. 673-682
    • Yu, J.1    Zhang, L.2    Hwang, P.M.3    Kinzler, K.W.4    Vogelstein, B.5
  • 4
    • 0033453226 scopus 로고    scopus 로고
    • Identification and classification of p53-regulated genes
    • 10.1073/pnas.96.25.14517, 24468, 10588737
    • Yu J, Zhang L, Hwang PM, Rago C, Kinzler KW, Vogelstein B. Identification and classification of p53-regulated genes. Proc Natl Acad Sci USA 1999, 96:14517-14522. 10.1073/pnas.96.25.14517, 24468, 10588737.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14517-14522
    • Yu, J.1    Zhang, L.2    Hwang, P.M.3    Rago, C.4    Kinzler, K.W.5    Vogelstein, B.6
  • 5
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • 10.1128/MCB.21.13.4129-4139.2001, 87074, 11390642
    • Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 2001, 21:4129-4139. 10.1128/MCB.21.13.4129-4139.2001, 87074, 11390642.
    • (2001) Mol Cell Biol , vol.21 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2
  • 6
    • 0037069326 scopus 로고    scopus 로고
    • Disruption of the checkpoint kinase1/cell division cycle 25A pathway abrogates ionizing radiation-inducd S and G2 checkpoints
    • 10.1073/pnas.182557299, 137498, 12399544
    • Zhao H, Watkins JL, Piwnica-Worms H. Disruption of the checkpoint kinase1/cell division cycle 25A pathway abrogates ionizing radiation-inducd S and G2 checkpoints. Proc Natl Acad Sci USA 2002, 99:14795-14800. 10.1073/pnas.182557299, 137498, 12399544.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14795-14800
    • Zhao, H.1    Watkins, J.L.2    Piwnica-Worms, H.3
  • 7
    • 34250010317 scopus 로고    scopus 로고
    • Chk1 regulates the density of active replication origins during the vertabrate S phase
    • 10.1038/sj.emboj.7601714, 1888675, 17491592
    • Maya-Mendoza A, Petermann E, Gillespie DA, Caldecott KW, Jackson DA. Chk1 regulates the density of active replication origins during the vertabrate S phase. EMBO J 2007, 26:2719-2731. 10.1038/sj.emboj.7601714, 1888675, 17491592.
    • (2007) EMBO J , vol.26 , pp. 2719-2731
    • Maya-Mendoza, A.1    Petermann, E.2    Gillespie, D.A.3    Caldecott, K.W.4    Jackson, D.A.5
  • 8
    • 11844300367 scopus 로고    scopus 로고
    • Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures
    • 10.1128/MCB.25.2.563-574.2005, 543419, 15632059
    • Zachos G, Rainey MD, Gillespie DA. Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures. Mol Cell Biol 2005, 25:563-574. 10.1128/MCB.25.2.563-574.2005, 543419, 15632059.
    • (2005) Mol Cell Biol , vol.25 , pp. 563-574
    • Zachos, G.1    Rainey, M.D.2    Gillespie, D.A.3
  • 9
    • 13944266820 scopus 로고    scopus 로고
    • The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
    • 10.1038/ncb1212, 15665856
    • Sorensen CS, Hansen LT, Dziegielewski J, Syljuasen RG, Lundin C, Bartek J, Helleday T. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol 2005, 7:195-201. 10.1038/ncb1212, 15665856.
    • (2005) Nat Cell Biol , vol.7 , pp. 195-201
    • Sorensen, C.S.1    Hansen, L.T.2    Dziegielewski, J.3    Syljuasen, R.G.4    Lundin, C.5    Bartek, J.6    Helleday, T.7
  • 10
    • 0035848819 scopus 로고    scopus 로고
    • The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
    • 10.1038/35071124, 11298456
    • Falck J, Malland N, Syljuasen RG, Bartek J, Lukas J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 2001, 410:842-847. 10.1038/35071124, 11298456.
    • (2001) Nature , vol.410 , pp. 842-847
    • Falck, J.1    Malland, N.2    Syljuasen, R.G.3    Bartek, J.4    Lukas, J.5
  • 11
    • 18244371925 scopus 로고    scopus 로고
    • Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
    • 10.1101/gad.1301205, PMC1091739, 15833913
    • Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev 2005, 19(9):1040-1052. 10.1101/gad.1301205, PMC1091739, 15833913.
    • (2005) Genes Dev , vol.19 , Issue.9 , pp. 1040-1052
    • Byun, T.S.1    Pacek, M.2    Yee, M.C.3    Walter, J.C.4    Cimprich, K.A.5
  • 12
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • 10.1126/science.1083430, 12791985
    • Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003, 300:1542-1548. 10.1126/science.1083430, 12791985.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 13
    • 0037452605 scopus 로고    scopus 로고
    • Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp holder hRad17-replication factor C complex in vitro
    • 10.1073/pnas.0437927100, 149884, 12578958
    • Bermudez VP, Lindesey-Boltz LA, Cesare AJ, Mainwa J, Griffith JD, Hurwitz J, Sancar A. Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp holder hRad17-replication factor C complex in vitro. Proc Natl Acad Sci USA 2003, 100:1633-1638. 10.1073/pnas.0437927100, 149884, 12578958.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1633-1638
    • Bermudez, V.P.1    Lindesey-Boltz, L.A.2    Cesare, A.J.3    Mainwa, J.4    Griffith, J.D.5    Hurwitz, J.6    Sancar, A.7
  • 14
    • 0345564858 scopus 로고    scopus 로고
    • Replication protein A-mediated recruitment and activation of Rad17 cpmplexes
    • 10.1073/pnas.2336100100, 283506, 14605214
    • Zou L, Liu D, Elledge SJ. Replication protein A-mediated recruitment and activation of Rad17 cpmplexes. Proc Natl Acad Sci USA 2003, 100:13827-13832. 10.1073/pnas.2336100100, 283506, 14605214.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 13827-13832
    • Zou, L.1    Liu, D.2    Elledge, S.J.3
  • 15
    • 34250705797 scopus 로고    scopus 로고
    • The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
    • 10.1101/gad.1547007, PMC1891424, 17575048
    • Delacroix S, Wagner JM, Kobayashi M, Yamamoto K, Karnitz LM. The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev 2007, 21(12):1472-1477. 10.1101/gad.1547007, PMC1891424, 17575048.
    • (2007) Genes Dev , vol.21 , Issue.12 , pp. 1472-1477
    • Delacroix, S.1    Wagner, J.M.2    Kobayashi, M.3    Yamamoto, K.4    Karnitz, L.M.5
  • 16
    • 34948889415 scopus 로고    scopus 로고
    • The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
    • 10.1074/jbc.M704635200, 17636252
    • Lee J, Kumagi A, Dunphy WG. The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J Biol Chem 2007, 282:28036-28044. 10.1074/jbc.M704635200, 17636252.
    • (2007) J Biol Chem , vol.282 , pp. 28036-28044
    • Lee, J.1    Kumagi, A.2    Dunphy, W.G.3
  • 17
    • 0033634679 scopus 로고    scopus 로고
    • Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
    • 10.1016/S1097-2765(05)00092-4, 11090622
    • Kumagi WG, Dunphy WG. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell 2000, 6:839-849. 10.1016/S1097-2765(05)00092-4, 11090622.
    • (2000) Mol Cell , vol.6 , pp. 839-849
    • Kumagi, W.G.1    Dunphy, W.G.2
  • 18
    • 3242878502 scopus 로고    scopus 로고
    • Claspin, a regulator of Chk1 in DNA replication stress pathway
    • 10.1016/j.dnarep.2004.03.001, 15279790
    • Chini CCS, Chen J. Claspin, a regulator of Chk1 in DNA replication stress pathway. DNA Repair 2004, 3:1033-1037. 10.1016/j.dnarep.2004.03.001, 15279790.
    • (2004) DNA Repair , vol.3 , pp. 1033-1037
    • Chini, C.C.S.1    Chen, J.2
  • 20
    • 55049111236 scopus 로고    scopus 로고
    • FANCM and FAAP24 function in ATR-mediated Checkpoint signaling independently of the Fanconi anemia core complex
    • 10.1016/j.molcel.2008.10.014, 18995830
    • Collis SJ, Ciccia A, Deans AJ, Horejsi Z, Martin JS, Maslen SL, Skehel M, Elledge SJ, West SC, Boulton SJ. FANCM and FAAP24 function in ATR-mediated Checkpoint signaling independently of the Fanconi anemia core complex. Mol CEll 2008, 32:313-324. 10.1016/j.molcel.2008.10.014, 18995830.
    • (2008) Mol CEll , vol.32 , pp. 313-324
    • Collis, S.J.1    Ciccia, A.2    Deans, A.J.3    Horejsi, Z.4    Martin, J.S.5    Maslen, S.L.6    Skehel, M.7    Elledge, S.J.8    West, S.C.9    Boulton, S.J.10
  • 21
    • 75949092280 scopus 로고    scopus 로고
    • Bach1/FancJ acts with TopBP1 and participates early in DNA replication checkpoint control
    • 10.1016/j.molcel.2010.01.002, 20159562
    • Gong Z, Kim J-E, Leung CCY, Glover JNM, Chen J. Bach1/FancJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell 2010, 37:438-446. 10.1016/j.molcel.2010.01.002, 20159562.
    • (2010) Mol Cell , vol.37 , pp. 438-446
    • Gong, Z.1    Kim, J.-.E.2    Leung, C.C.Y.3    Glover, J.N.M.4    Chen, J.5
  • 22
    • 70449707748 scopus 로고    scopus 로고
    • Tim-Tipin dysfunction creates an undispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis
    • 10.1083/jcb.200905006, 2762102, 19805627
    • Smith KD, Fu MA, Brown EJ. Tim-Tipin dysfunction creates an undispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. J Cell Biol 2009, 187:15-23. 10.1083/jcb.200905006, 2762102, 19805627.
    • (2009) J Cell Biol , vol.187 , pp. 15-23
    • Smith, K.D.1    Fu, M.A.2    Brown, E.J.3
  • 23
    • 34247257202 scopus 로고    scopus 로고
    • The structural determinants of checkpoint activation
    • 10.1101/gad.1522607, PMC1847708, 17437996
    • MacDougall CA, Byun TS, Van C, Yee MC, Cimprich KA. The structural determinants of checkpoint activation. Genes Dev 2007, 21(8):898-903. 10.1101/gad.1522607, PMC1847708, 17437996.
    • (2007) Genes Dev , vol.21 , Issue.8 , pp. 898-903
    • MacDougall, C.A.1    Byun, T.S.2    Van, C.3    Yee, M.C.4    Cimprich, K.A.5
  • 24
    • 77951193923 scopus 로고    scopus 로고
    • Continued primer synthesis at stalled replication forks contributes to checkpoint activation
    • 10.1083/jcb.200909105, 20385778
    • Van C, Yan S, Michael WM, Waga S, Cimprich KA. Continued primer synthesis at stalled replication forks contributes to checkpoint activation. J Cell Biol 2010, 189:233-246. 10.1083/jcb.200909105, 20385778.
    • (2010) J Cell Biol , vol.189 , pp. 233-246
    • Van, C.1    Yan, S.2    Michael, W.M.3    Waga, S.4    Cimprich, K.A.5
  • 25
    • 30344463835 scopus 로고    scopus 로고
    • ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
    • 10.1038/ncb1337, 16327781
    • Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 2006, 8:37-45. 10.1038/ncb1337, 16327781.
    • (2006) Nat Cell Biol , vol.8 , pp. 37-45
    • Jazayeri, A.1    Falck, J.2    Lukas, C.3    Bartek, J.4    Smith, G.C.5    Lukas, J.6    Jackson, S.P.7
  • 26
    • 17644432403 scopus 로고    scopus 로고
    • Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
    • 10.1101/gad.14.12.1448, PMC316686, 10859164
    • Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000, 14(12):1448-1459. 10.1101/gad.14.12.1448, PMC316686, 10859164.
    • (2000) Genes Dev , vol.14 , Issue.12 , pp. 1448-1459
    • Liu, Q.1    Guntuku, S.2    Cui, X.S.3    Matsuoka, S.4    Cortez, D.5    Tamai, K.6    Luo, G.7    Carattini-Rivera, S.8    DeMayo, F.9    Bradley, A.10
  • 28
    • 0037415735 scopus 로고    scopus 로고
    • Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects
    • 10.1093/emboj/cdg060, 140744, 12554671
    • Zachos G, Rainey MD, Gillespie DA. Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects. EMBO J 2003, 22:713-723. 10.1093/emboj/cdg060, 140744, 12554671.
    • (2003) EMBO J , vol.22 , pp. 713-723
    • Zachos, G.1    Rainey, M.D.2    Gillespie, D.A.3
  • 29
    • 22844436238 scopus 로고    scopus 로고
    • Chk1 is essential for tumor cell viability following activation of the replication checkpoint
    • Cho SH, Toouli CD, Fujii GH, Crain C, Parry D. Chk1 is essential for tumor cell viability following activation of the replication checkpoint. Cell Cycle 2005, 4:131-139.
    • (2005) Cell Cycle , vol.4 , pp. 131-139
    • Cho, S.H.1    Toouli, C.D.2    Fujii, G.H.3    Crain, C.4    Parry, D.5
  • 30
    • 30044440857 scopus 로고    scopus 로고
    • Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress
    • 10.1091/mbc.E05-07-0594, 1345677, 16280359
    • Rodriguez R, Meuth M. Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol Biol Cell 2006, 17:402-412. 10.1091/mbc.E05-07-0594, 1345677, 16280359.
    • (2006) Mol Biol Cell , vol.17 , pp. 402-412
    • Rodriguez, R.1    Meuth, M.2
  • 32
    • 77649083117 scopus 로고    scopus 로고
    • Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1
    • 10.1091/mbc.E09-07-0618, 2828961, 20053681
    • Gagou ME, Zuazua-Villar P, Meuth M. Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1. Mol Biol Cell 2010, 21:739-752. 10.1091/mbc.E09-07-0618, 2828961, 20053681.
    • (2010) Mol Biol Cell , vol.21 , pp. 739-752
    • Gagou, M.E.1    Zuazua-Villar, P.2    Meuth, M.3
  • 33
    • 58949092221 scopus 로고    scopus 로고
    • ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress
    • 10.1371/journal.pgen.1000324, 2607051, 19119425
    • Myers K, Gagou ME, Zuazua-Villar P, Rodriguez R, Meuth M. ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress. PLoS Genet 2009, 5:e1000324. 10.1371/journal.pgen.1000324, 2607051, 19119425.
    • (2009) PLoS Genet , vol.5
    • Myers, K.1    Gagou, M.E.2    Zuazua-Villar, P.3    Rodriguez, R.4    Meuth, M.5
  • 34
    • 34248579748 scopus 로고    scopus 로고
    • The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
    • 10.1038/nature05740, 17429352
    • Stracker TH, Morales M, Couto SS, Hussein H, Petrini JH. The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature 2007, 447:218-221. 10.1038/nature05740, 17429352.
    • (2007) Nature , vol.447 , pp. 218-221
    • Stracker, T.H.1    Morales, M.2    Couto, S.S.3    Hussein, H.4    Petrini, J.H.5
  • 35
    • 0030879563 scopus 로고    scopus 로고
    • Atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity
    • 10.1038/ng0897-397, 9241281
    • Westphal CH, Rowan S, Schmaltz C, Elson A, Fisher DE, Leder P. Atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nat Genet 1997, 16:397-401. 10.1038/ng0897-397, 9241281.
    • (1997) Nat Genet , vol.16 , pp. 397-401
    • Westphal, C.H.1    Rowan, S.2    Schmaltz, C.3    Elson, A.4    Fisher, D.E.5    Leder, P.6
  • 36
    • 70549097114 scopus 로고    scopus 로고
    • Caspase-2 in apoptosis, the DNA damage response and tumour suppression: enigma no more
    • 10.1038/nrc2745, 19890334
    • Kumar S. Caspase-2 in apoptosis, the DNA damage response and tumour suppression: enigma no more. Nat Rev Cancer 2009, 9:897-903. 10.1038/nrc2745, 19890334.
    • (2009) Nat Rev Cancer , vol.9 , pp. 897-903
    • Kumar, S.1
  • 37
    • 42149152648 scopus 로고    scopus 로고
    • Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45
    • 10.1038/cdd.2008.4, 18239674
    • Rodriguez R, Gagou ME, Meuth M. Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45. Cell Death Differ 2008, 15:889-898. 10.1038/cdd.2008.4, 18239674.
    • (2008) Cell Death Differ , vol.15 , pp. 889-898
    • Rodriguez, R.1    Gagou, M.E.2    Meuth, M.3
  • 38
    • 65549156128 scopus 로고    scopus 로고
    • The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication
    • 10.1093/nar/gkp065, 2673421, 19223333
    • Aparicio T, Guillou E, Coloma J, Montoya G, Mendez J. The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication. Nucl Acids Res 2009, 37:2087-2095. 10.1093/nar/gkp065, 2673421, 19223333.
    • (2009) Nucl Acids Res , vol.37 , pp. 2087-2095
    • Aparicio, T.1    Guillou, E.2    Coloma, J.3    Montoya, G.4    Mendez, J.5
  • 39
    • 34250707267 scopus 로고    scopus 로고
    • Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases d and e during S phase
    • Bauerschmidt C, Pollok S, Kremmer E, Nasheuer H-P, Grosse F. Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases d and e during S phase. Genes Cells 2007, 12:745-758.
    • (2007) Genes Cells , vol.12 , pp. 745-758
    • Bauerschmidt, C.1    Pollok, S.2    Kremmer, E.3    Nasheuer, H.-.P.4    Grosse, F.5
  • 40
    • 33745607326 scopus 로고    scopus 로고
    • H2AX phosphorylation within the G1 phase after UV irradiation depends upon nucleotide excision repair and not double-strand breaks
    • 10.1073/pnas.0603779103, 1502549, 16788066
    • Marti TM, Hefner E, Feeney L, Natale V, Cleaver JE. H2AX phosphorylation within the G1 phase after UV irradiation depends upon nucleotide excision repair and not double-strand breaks. Proc Natl Acad Sci USA 2006, 103:9891-9896. 10.1073/pnas.0603779103, 1502549, 16788066.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9891-9896
    • Marti, T.M.1    Hefner, E.2    Feeney, L.3    Natale, V.4    Cleaver, J.E.5
  • 41
    • 33745487368 scopus 로고    scopus 로고
    • Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3
    • 10.1016/j.molcel.2006.05.023, 2227311, 16818236
    • Lu C, Zhu F, Cho Y-Y, Tang F, Zykove T, Ma W, Bode AM, Dong Z. Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol Cell 2006, 23:121-132. 10.1016/j.molcel.2006.05.023, 2227311, 16818236.
    • (2006) Mol Cell , vol.23 , pp. 121-132
    • Lu, C.1    Zhu, F.2    Cho, Y.-.Y.3    Tang, F.4    Zykove, T.5    Ma, W.6    Bode, A.M.7    Dong, Z.8
  • 42
    • 63849187827 scopus 로고    scopus 로고
    • Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
    • 10.1038/nature07849, 2692521, 19234442
    • Cook PJ, Ju BG, Telese F, Wang X, Glass CK, Rosenfeld MG. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature 2009, 458:591-596. 10.1038/nature07849, 2692521, 19234442.
    • (2009) Nature , vol.458 , pp. 591-596
    • Cook, P.J.1    Ju, B.G.2    Telese, F.3    Wang, X.4    Glass, C.K.5    Rosenfeld, M.G.6
  • 43
    • 0025365192 scopus 로고
    • Cell-cycle regulated phosphorylation of DNA replication factor A from human and yeast cells
    • 10.1101/gad.4.6.968, 2200738
    • Din S, Brill SJ, Fairman MP, Stillman B. Cell-cycle regulated phosphorylation of DNA replication factor A from human and yeast cells. Genes Dev 1990, 4(6):968-977. 10.1101/gad.4.6.968, 2200738.
    • (1990) Genes Dev , vol.4 , Issue.6 , pp. 968-977
    • Din, S.1    Brill, S.J.2    Fairman, M.P.3    Stillman, B.4
  • 44
    • 33745607897 scopus 로고    scopus 로고
    • Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses
    • 10.1002/jcp.20622, 16523492
    • Zou Y, Liu Y, Wu X, Shell SM. Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses. J Cell Physiol 2006, 208:267-273. 10.1002/jcp.20622, 16523492.
    • (2006) J Cell Physiol , vol.208 , pp. 267-273
    • Zou, Y.1    Liu, Y.2    Wu, X.3    Shell, S.M.4
  • 46
    • 3142552523 scopus 로고    scopus 로고
    • Chk1 is haploinsufficient for multiple functions critical to tumor suppression
    • 10.1016/j.ccr.2004.06.015, 15261141
    • Lam MH, Liu Q, Elledge SJ, Rosen JM. Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell 2004, 6:45-59. 10.1016/j.ccr.2004.06.015, 15261141.
    • (2004) Cancer Cell , vol.6 , pp. 45-59
    • Lam, M.H.1    Liu, Q.2    Elledge, S.J.3    Rosen, J.M.4
  • 48
    • 4644318239 scopus 로고    scopus 로고
    • Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation
    • 10.1158/0008-5472.CAN-04-1520, 15374968
    • Hammond EM, Dorie MJ, Giaccia AJ. Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Cancer Research 2004, 64:6556-6562. 10.1158/0008-5472.CAN-04-1520, 15374968.
    • (2004) Cancer Research , vol.64 , pp. 6556-6562
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 49
    • 33846856967 scopus 로고    scopus 로고
    • CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo
    • 10.1158/1078-0432.CCR-06-1424, 17255282
    • Tse AN, Rendahl KG, Sheikh T, Cheema H, Aardalen K, Embry M, Ma S, Moler EJ, Ni ZJ, Lopes de Menezes DE, et al. CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Clin Cancer Res 2007, 13:591-602. 10.1158/1078-0432.CCR-06-1424, 17255282.
    • (2007) Clin Cancer Res , vol.13 , pp. 591-602
    • Tse, A.N.1    Rendahl, K.G.2    Sheikh, T.3    Cheema, H.4    Aardalen, K.5    Embry, M.6    Ma, S.7    Moler, E.J.8    Ni, Z.J.9    Lopes de Menezes, D.E.10
  • 51
    • 67649390962 scopus 로고    scopus 로고
    • Checkpoint kinase inhibitors: a review of the patent literature
    • 10.1517/13543770802653622, 19441917
    • Janetka JW, Ashwell S. Checkpoint kinase inhibitors: a review of the patent literature. Expert Opin Ther Pat 2009, 19:165-197. 10.1517/13543770802653622, 19441917.
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 165-197
    • Janetka, J.W.1    Ashwell, S.2
  • 52
    • 65449142073 scopus 로고    scopus 로고
    • Chk1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair deficient tumors
    • 10.1186/1476-4598-8-24, 2672921, 19371427
    • Chen CC, Kennedy RD, Sidi S, Look AT, D'Andrea AA. Chk1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair deficient tumors. Mol Cancer 2009, 8:24. 10.1186/1476-4598-8-24, 2672921, 19371427.
    • (2009) Mol Cancer , vol.8 , pp. 24
    • Chen, C.C.1    Kennedy, R.D.2    Sidi, S.3    Look, A.T.4    D'Andrea, A.A.5


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