-
1
-
-
36749022214
-
The DNA damage response: ten years after
-
10.1016/j.molcel.2007.11.015, 18082599
-
Harper JW, Elledge SJ. The DNA damage response: ten years after. Mol Cell 2007, 28:739-745. 10.1016/j.molcel.2007.11.015, 18082599.
-
(2007)
Mol Cell
, vol.28
, pp. 739-745
-
-
Harper, J.W.1
Elledge, S.J.2
-
2
-
-
0035265686
-
PUMA, a novel proapoptotic gene, is induced by p53
-
10.1016/S1097-2765(01)00214-3, 11463392
-
Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001, 7:683-694. 10.1016/S1097-2765(01)00214-3, 11463392.
-
(2001)
Mol Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
3
-
-
0035265823
-
PUMA induces the rapid apoptosis of colorectal cancer cells
-
10.1016/S1097-2765(01)00213-1, 11463391
-
Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001, 7:673-682. 10.1016/S1097-2765(01)00213-1, 11463391.
-
(2001)
Mol Cell
, vol.7
, pp. 673-682
-
-
Yu, J.1
Zhang, L.2
Hwang, P.M.3
Kinzler, K.W.4
Vogelstein, B.5
-
4
-
-
0033453226
-
Identification and classification of p53-regulated genes
-
10.1073/pnas.96.25.14517, 24468, 10588737
-
Yu J, Zhang L, Hwang PM, Rago C, Kinzler KW, Vogelstein B. Identification and classification of p53-regulated genes. Proc Natl Acad Sci USA 1999, 96:14517-14522. 10.1073/pnas.96.25.14517, 24468, 10588737.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 14517-14522
-
-
Yu, J.1
Zhang, L.2
Hwang, P.M.3
Rago, C.4
Kinzler, K.W.5
Vogelstein, B.6
-
5
-
-
0034967556
-
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
-
10.1128/MCB.21.13.4129-4139.2001, 87074, 11390642
-
Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 2001, 21:4129-4139. 10.1128/MCB.21.13.4129-4139.2001, 87074, 11390642.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4129-4139
-
-
Zhao, H.1
Piwnica-Worms, H.2
-
6
-
-
0037069326
-
Disruption of the checkpoint kinase1/cell division cycle 25A pathway abrogates ionizing radiation-inducd S and G2 checkpoints
-
10.1073/pnas.182557299, 137498, 12399544
-
Zhao H, Watkins JL, Piwnica-Worms H. Disruption of the checkpoint kinase1/cell division cycle 25A pathway abrogates ionizing radiation-inducd S and G2 checkpoints. Proc Natl Acad Sci USA 2002, 99:14795-14800. 10.1073/pnas.182557299, 137498, 12399544.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14795-14800
-
-
Zhao, H.1
Watkins, J.L.2
Piwnica-Worms, H.3
-
7
-
-
34250010317
-
Chk1 regulates the density of active replication origins during the vertabrate S phase
-
10.1038/sj.emboj.7601714, 1888675, 17491592
-
Maya-Mendoza A, Petermann E, Gillespie DA, Caldecott KW, Jackson DA. Chk1 regulates the density of active replication origins during the vertabrate S phase. EMBO J 2007, 26:2719-2731. 10.1038/sj.emboj.7601714, 1888675, 17491592.
-
(2007)
EMBO J
, vol.26
, pp. 2719-2731
-
-
Maya-Mendoza, A.1
Petermann, E.2
Gillespie, D.A.3
Caldecott, K.W.4
Jackson, D.A.5
-
8
-
-
11844300367
-
Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures
-
10.1128/MCB.25.2.563-574.2005, 543419, 15632059
-
Zachos G, Rainey MD, Gillespie DA. Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures. Mol Cell Biol 2005, 25:563-574. 10.1128/MCB.25.2.563-574.2005, 543419, 15632059.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 563-574
-
-
Zachos, G.1
Rainey, M.D.2
Gillespie, D.A.3
-
9
-
-
13944266820
-
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
-
10.1038/ncb1212, 15665856
-
Sorensen CS, Hansen LT, Dziegielewski J, Syljuasen RG, Lundin C, Bartek J, Helleday T. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol 2005, 7:195-201. 10.1038/ncb1212, 15665856.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 195-201
-
-
Sorensen, C.S.1
Hansen, L.T.2
Dziegielewski, J.3
Syljuasen, R.G.4
Lundin, C.5
Bartek, J.6
Helleday, T.7
-
10
-
-
0035848819
-
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
-
10.1038/35071124, 11298456
-
Falck J, Malland N, Syljuasen RG, Bartek J, Lukas J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 2001, 410:842-847. 10.1038/35071124, 11298456.
-
(2001)
Nature
, vol.410
, pp. 842-847
-
-
Falck, J.1
Malland, N.2
Syljuasen, R.G.3
Bartek, J.4
Lukas, J.5
-
11
-
-
18244371925
-
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
-
10.1101/gad.1301205, PMC1091739, 15833913
-
Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev 2005, 19(9):1040-1052. 10.1101/gad.1301205, PMC1091739, 15833913.
-
(2005)
Genes Dev
, vol.19
, Issue.9
, pp. 1040-1052
-
-
Byun, T.S.1
Pacek, M.2
Yee, M.C.3
Walter, J.C.4
Cimprich, K.A.5
-
12
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
10.1126/science.1083430, 12791985
-
Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003, 300:1542-1548. 10.1126/science.1083430, 12791985.
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
13
-
-
0037452605
-
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp holder hRad17-replication factor C complex in vitro
-
10.1073/pnas.0437927100, 149884, 12578958
-
Bermudez VP, Lindesey-Boltz LA, Cesare AJ, Mainwa J, Griffith JD, Hurwitz J, Sancar A. Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp holder hRad17-replication factor C complex in vitro. Proc Natl Acad Sci USA 2003, 100:1633-1638. 10.1073/pnas.0437927100, 149884, 12578958.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 1633-1638
-
-
Bermudez, V.P.1
Lindesey-Boltz, L.A.2
Cesare, A.J.3
Mainwa, J.4
Griffith, J.D.5
Hurwitz, J.6
Sancar, A.7
-
14
-
-
0345564858
-
Replication protein A-mediated recruitment and activation of Rad17 cpmplexes
-
10.1073/pnas.2336100100, 283506, 14605214
-
Zou L, Liu D, Elledge SJ. Replication protein A-mediated recruitment and activation of Rad17 cpmplexes. Proc Natl Acad Sci USA 2003, 100:13827-13832. 10.1073/pnas.2336100100, 283506, 14605214.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 13827-13832
-
-
Zou, L.1
Liu, D.2
Elledge, S.J.3
-
15
-
-
34250705797
-
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
-
10.1101/gad.1547007, PMC1891424, 17575048
-
Delacroix S, Wagner JM, Kobayashi M, Yamamoto K, Karnitz LM. The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev 2007, 21(12):1472-1477. 10.1101/gad.1547007, PMC1891424, 17575048.
-
(2007)
Genes Dev
, vol.21
, Issue.12
, pp. 1472-1477
-
-
Delacroix, S.1
Wagner, J.M.2
Kobayashi, M.3
Yamamoto, K.4
Karnitz, L.M.5
-
16
-
-
34948889415
-
The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
-
10.1074/jbc.M704635200, 17636252
-
Lee J, Kumagi A, Dunphy WG. The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J Biol Chem 2007, 282:28036-28044. 10.1074/jbc.M704635200, 17636252.
-
(2007)
J Biol Chem
, vol.282
, pp. 28036-28044
-
-
Lee, J.1
Kumagi, A.2
Dunphy, W.G.3
-
17
-
-
0033634679
-
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
-
10.1016/S1097-2765(05)00092-4, 11090622
-
Kumagi WG, Dunphy WG. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell 2000, 6:839-849. 10.1016/S1097-2765(05)00092-4, 11090622.
-
(2000)
Mol Cell
, vol.6
, pp. 839-849
-
-
Kumagi, W.G.1
Dunphy, W.G.2
-
18
-
-
3242878502
-
Claspin, a regulator of Chk1 in DNA replication stress pathway
-
10.1016/j.dnarep.2004.03.001, 15279790
-
Chini CCS, Chen J. Claspin, a regulator of Chk1 in DNA replication stress pathway. DNA Repair 2004, 3:1033-1037. 10.1016/j.dnarep.2004.03.001, 15279790.
-
(2004)
DNA Repair
, vol.3
, pp. 1033-1037
-
-
Chini, C.C.S.1
Chen, J.2
-
19
-
-
33746857684
-
BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer
-
10.1016/j.ccr.2006.07.002, 1557410, 16872911
-
Rai R, Dai H, Multani AS, Li K, Chin K, Gray J, Lahad JP, Liang J, Mills GB, Meric-Bernstam F, et al. BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell 2006, 10:145-157. 10.1016/j.ccr.2006.07.002, 1557410, 16872911.
-
(2006)
Cancer Cell
, vol.10
, pp. 145-157
-
-
Rai, R.1
Dai, H.2
Multani, A.S.3
Li, K.4
Chin, K.5
Gray, J.6
Lahad, J.P.7
Liang, J.8
Mills, G.B.9
Meric-Bernstam, F.10
-
20
-
-
55049111236
-
FANCM and FAAP24 function in ATR-mediated Checkpoint signaling independently of the Fanconi anemia core complex
-
10.1016/j.molcel.2008.10.014, 18995830
-
Collis SJ, Ciccia A, Deans AJ, Horejsi Z, Martin JS, Maslen SL, Skehel M, Elledge SJ, West SC, Boulton SJ. FANCM and FAAP24 function in ATR-mediated Checkpoint signaling independently of the Fanconi anemia core complex. Mol CEll 2008, 32:313-324. 10.1016/j.molcel.2008.10.014, 18995830.
-
(2008)
Mol CEll
, vol.32
, pp. 313-324
-
-
Collis, S.J.1
Ciccia, A.2
Deans, A.J.3
Horejsi, Z.4
Martin, J.S.5
Maslen, S.L.6
Skehel, M.7
Elledge, S.J.8
West, S.C.9
Boulton, S.J.10
-
21
-
-
75949092280
-
Bach1/FancJ acts with TopBP1 and participates early in DNA replication checkpoint control
-
10.1016/j.molcel.2010.01.002, 20159562
-
Gong Z, Kim J-E, Leung CCY, Glover JNM, Chen J. Bach1/FancJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell 2010, 37:438-446. 10.1016/j.molcel.2010.01.002, 20159562.
-
(2010)
Mol Cell
, vol.37
, pp. 438-446
-
-
Gong, Z.1
Kim, J.-.E.2
Leung, C.C.Y.3
Glover, J.N.M.4
Chen, J.5
-
22
-
-
70449707748
-
Tim-Tipin dysfunction creates an undispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis
-
10.1083/jcb.200905006, 2762102, 19805627
-
Smith KD, Fu MA, Brown EJ. Tim-Tipin dysfunction creates an undispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. J Cell Biol 2009, 187:15-23. 10.1083/jcb.200905006, 2762102, 19805627.
-
(2009)
J Cell Biol
, vol.187
, pp. 15-23
-
-
Smith, K.D.1
Fu, M.A.2
Brown, E.J.3
-
23
-
-
34247257202
-
The structural determinants of checkpoint activation
-
10.1101/gad.1522607, PMC1847708, 17437996
-
MacDougall CA, Byun TS, Van C, Yee MC, Cimprich KA. The structural determinants of checkpoint activation. Genes Dev 2007, 21(8):898-903. 10.1101/gad.1522607, PMC1847708, 17437996.
-
(2007)
Genes Dev
, vol.21
, Issue.8
, pp. 898-903
-
-
MacDougall, C.A.1
Byun, T.S.2
Van, C.3
Yee, M.C.4
Cimprich, K.A.5
-
24
-
-
77951193923
-
Continued primer synthesis at stalled replication forks contributes to checkpoint activation
-
10.1083/jcb.200909105, 20385778
-
Van C, Yan S, Michael WM, Waga S, Cimprich KA. Continued primer synthesis at stalled replication forks contributes to checkpoint activation. J Cell Biol 2010, 189:233-246. 10.1083/jcb.200909105, 20385778.
-
(2010)
J Cell Biol
, vol.189
, pp. 233-246
-
-
Van, C.1
Yan, S.2
Michael, W.M.3
Waga, S.4
Cimprich, K.A.5
-
25
-
-
30344463835
-
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
-
10.1038/ncb1337, 16327781
-
Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 2006, 8:37-45. 10.1038/ncb1337, 16327781.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
Falck, J.2
Lukas, C.3
Bartek, J.4
Smith, G.C.5
Lukas, J.6
Jackson, S.P.7
-
26
-
-
17644432403
-
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
-
10.1101/gad.14.12.1448, PMC316686, 10859164
-
Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000, 14(12):1448-1459. 10.1101/gad.14.12.1448, PMC316686, 10859164.
-
(2000)
Genes Dev
, vol.14
, Issue.12
, pp. 1448-1459
-
-
Liu, Q.1
Guntuku, S.2
Cui, X.S.3
Matsuoka, S.4
Cortez, D.5
Tamai, K.6
Luo, G.7
Carattini-Rivera, S.8
DeMayo, F.9
Bradley, A.10
-
27
-
-
0034659341
-
Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/- mice
-
10.1101/gad.14.12.1439, PMC316691, 10859163
-
Takai H, Tominaga K, Motoyama N, Minamishima YA, Nagahama H, Tsukiyama T, Ikeda K, Nakayama K, Nakanishi M, Nakayama K. Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/- mice. Genes Dev 2000, 14(12):1439-1447. 10.1101/gad.14.12.1439, PMC316691, 10859163.
-
(2000)
Genes Dev
, vol.14
, Issue.12
, pp. 1439-1447
-
-
Takai, H.1
Tominaga, K.2
Motoyama, N.3
Minamishima, Y.A.4
Nagahama, H.5
Tsukiyama, T.6
Ikeda, K.7
Nakayama, K.8
Nakanishi, M.9
Nakayama, K.10
-
28
-
-
0037415735
-
Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects
-
10.1093/emboj/cdg060, 140744, 12554671
-
Zachos G, Rainey MD, Gillespie DA. Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects. EMBO J 2003, 22:713-723. 10.1093/emboj/cdg060, 140744, 12554671.
-
(2003)
EMBO J
, vol.22
, pp. 713-723
-
-
Zachos, G.1
Rainey, M.D.2
Gillespie, D.A.3
-
29
-
-
22844436238
-
Chk1 is essential for tumor cell viability following activation of the replication checkpoint
-
Cho SH, Toouli CD, Fujii GH, Crain C, Parry D. Chk1 is essential for tumor cell viability following activation of the replication checkpoint. Cell Cycle 2005, 4:131-139.
-
(2005)
Cell Cycle
, vol.4
, pp. 131-139
-
-
Cho, S.H.1
Toouli, C.D.2
Fujii, G.H.3
Crain, C.4
Parry, D.5
-
30
-
-
30044440857
-
Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress
-
10.1091/mbc.E05-07-0594, 1345677, 16280359
-
Rodriguez R, Meuth M. Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol Biol Cell 2006, 17:402-412. 10.1091/mbc.E05-07-0594, 1345677, 16280359.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 402-412
-
-
Rodriguez, R.1
Meuth, M.2
-
31
-
-
44149090307
-
Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3
-
Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF, et al. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 2008, 133:2110-2118.
-
(2008)
Cell
, vol.133
, pp. 2110-2118
-
-
Sidi, S.1
Sanda, T.2
Kennedy, R.D.3
Hagen, A.T.4
Jette, C.A.5
Hoffmans, R.6
Pascual, J.7
Imamura, S.8
Kishi, S.9
Amatruda, J.F.10
-
32
-
-
77649083117
-
Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1
-
10.1091/mbc.E09-07-0618, 2828961, 20053681
-
Gagou ME, Zuazua-Villar P, Meuth M. Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1. Mol Biol Cell 2010, 21:739-752. 10.1091/mbc.E09-07-0618, 2828961, 20053681.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 739-752
-
-
Gagou, M.E.1
Zuazua-Villar, P.2
Meuth, M.3
-
33
-
-
58949092221
-
ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress
-
10.1371/journal.pgen.1000324, 2607051, 19119425
-
Myers K, Gagou ME, Zuazua-Villar P, Rodriguez R, Meuth M. ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress. PLoS Genet 2009, 5:e1000324. 10.1371/journal.pgen.1000324, 2607051, 19119425.
-
(2009)
PLoS Genet
, vol.5
-
-
Myers, K.1
Gagou, M.E.2
Zuazua-Villar, P.3
Rodriguez, R.4
Meuth, M.5
-
34
-
-
34248579748
-
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
-
10.1038/nature05740, 17429352
-
Stracker TH, Morales M, Couto SS, Hussein H, Petrini JH. The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature 2007, 447:218-221. 10.1038/nature05740, 17429352.
-
(2007)
Nature
, vol.447
, pp. 218-221
-
-
Stracker, T.H.1
Morales, M.2
Couto, S.S.3
Hussein, H.4
Petrini, J.H.5
-
35
-
-
0030879563
-
Atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity
-
10.1038/ng0897-397, 9241281
-
Westphal CH, Rowan S, Schmaltz C, Elson A, Fisher DE, Leder P. Atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nat Genet 1997, 16:397-401. 10.1038/ng0897-397, 9241281.
-
(1997)
Nat Genet
, vol.16
, pp. 397-401
-
-
Westphal, C.H.1
Rowan, S.2
Schmaltz, C.3
Elson, A.4
Fisher, D.E.5
Leder, P.6
-
36
-
-
70549097114
-
Caspase-2 in apoptosis, the DNA damage response and tumour suppression: enigma no more
-
10.1038/nrc2745, 19890334
-
Kumar S. Caspase-2 in apoptosis, the DNA damage response and tumour suppression: enigma no more. Nat Rev Cancer 2009, 9:897-903. 10.1038/nrc2745, 19890334.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 897-903
-
-
Kumar, S.1
-
37
-
-
42149152648
-
Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45
-
10.1038/cdd.2008.4, 18239674
-
Rodriguez R, Gagou ME, Meuth M. Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45. Cell Death Differ 2008, 15:889-898. 10.1038/cdd.2008.4, 18239674.
-
(2008)
Cell Death Differ
, vol.15
, pp. 889-898
-
-
Rodriguez, R.1
Gagou, M.E.2
Meuth, M.3
-
38
-
-
65549156128
-
The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication
-
10.1093/nar/gkp065, 2673421, 19223333
-
Aparicio T, Guillou E, Coloma J, Montoya G, Mendez J. The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication. Nucl Acids Res 2009, 37:2087-2095. 10.1093/nar/gkp065, 2673421, 19223333.
-
(2009)
Nucl Acids Res
, vol.37
, pp. 2087-2095
-
-
Aparicio, T.1
Guillou, E.2
Coloma, J.3
Montoya, G.4
Mendez, J.5
-
39
-
-
34250707267
-
Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases d and e during S phase
-
Bauerschmidt C, Pollok S, Kremmer E, Nasheuer H-P, Grosse F. Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases d and e during S phase. Genes Cells 2007, 12:745-758.
-
(2007)
Genes Cells
, vol.12
, pp. 745-758
-
-
Bauerschmidt, C.1
Pollok, S.2
Kremmer, E.3
Nasheuer, H.-.P.4
Grosse, F.5
-
40
-
-
33745607326
-
H2AX phosphorylation within the G1 phase after UV irradiation depends upon nucleotide excision repair and not double-strand breaks
-
10.1073/pnas.0603779103, 1502549, 16788066
-
Marti TM, Hefner E, Feeney L, Natale V, Cleaver JE. H2AX phosphorylation within the G1 phase after UV irradiation depends upon nucleotide excision repair and not double-strand breaks. Proc Natl Acad Sci USA 2006, 103:9891-9896. 10.1073/pnas.0603779103, 1502549, 16788066.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9891-9896
-
-
Marti, T.M.1
Hefner, E.2
Feeney, L.3
Natale, V.4
Cleaver, J.E.5
-
41
-
-
33745487368
-
Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3
-
10.1016/j.molcel.2006.05.023, 2227311, 16818236
-
Lu C, Zhu F, Cho Y-Y, Tang F, Zykove T, Ma W, Bode AM, Dong Z. Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol Cell 2006, 23:121-132. 10.1016/j.molcel.2006.05.023, 2227311, 16818236.
-
(2006)
Mol Cell
, vol.23
, pp. 121-132
-
-
Lu, C.1
Zhu, F.2
Cho, Y.-.Y.3
Tang, F.4
Zykove, T.5
Ma, W.6
Bode, A.M.7
Dong, Z.8
-
42
-
-
63849187827
-
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
-
10.1038/nature07849, 2692521, 19234442
-
Cook PJ, Ju BG, Telese F, Wang X, Glass CK, Rosenfeld MG. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature 2009, 458:591-596. 10.1038/nature07849, 2692521, 19234442.
-
(2009)
Nature
, vol.458
, pp. 591-596
-
-
Cook, P.J.1
Ju, B.G.2
Telese, F.3
Wang, X.4
Glass, C.K.5
Rosenfeld, M.G.6
-
43
-
-
0025365192
-
Cell-cycle regulated phosphorylation of DNA replication factor A from human and yeast cells
-
10.1101/gad.4.6.968, 2200738
-
Din S, Brill SJ, Fairman MP, Stillman B. Cell-cycle regulated phosphorylation of DNA replication factor A from human and yeast cells. Genes Dev 1990, 4(6):968-977. 10.1101/gad.4.6.968, 2200738.
-
(1990)
Genes Dev
, vol.4
, Issue.6
, pp. 968-977
-
-
Din, S.1
Brill, S.J.2
Fairman, M.P.3
Stillman, B.4
-
44
-
-
33745607897
-
Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses
-
10.1002/jcp.20622, 16523492
-
Zou Y, Liu Y, Wu X, Shell SM. Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses. J Cell Physiol 2006, 208:267-273. 10.1002/jcp.20622, 16523492.
-
(2006)
J Cell Physiol
, vol.208
, pp. 267-273
-
-
Zou, Y.1
Liu, Y.2
Wu, X.3
Shell, S.M.4
-
45
-
-
77953932126
-
The role of RPA2 phosphorylation in homologous recombination in response to replication arrest
-
10.1093/carcin/bgq035, 20130019
-
Shi W, Feng Z, Zhang J, Gonzalez-Suarez I, Vanderwaal RP, Wu X, Powell SN, Roti Roti JL, Gonzalo S, Zhang J. The role of RPA2 phosphorylation in homologous recombination in response to replication arrest. Carcinogenesis 2010, 31:994-1002. 10.1093/carcin/bgq035, 20130019.
-
(2010)
Carcinogenesis
, vol.31
, pp. 994-1002
-
-
Shi, W.1
Feng, Z.2
Zhang, J.3
Gonzalez-Suarez, I.4
Vanderwaal, R.P.5
Wu, X.6
Powell, S.N.7
Roti Roti, J.L.8
Gonzalo, S.9
Zhang, J.10
-
46
-
-
3142552523
-
Chk1 is haploinsufficient for multiple functions critical to tumor suppression
-
10.1016/j.ccr.2004.06.015, 15261141
-
Lam MH, Liu Q, Elledge SJ, Rosen JM. Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell 2004, 6:45-59. 10.1016/j.ccr.2004.06.015, 15261141.
-
(2004)
Cancer Cell
, vol.6
, pp. 45-59
-
-
Lam, M.H.1
Liu, Q.2
Elledge, S.J.3
Rosen, J.M.4
-
47
-
-
34547109117
-
The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor/progesterone receptor/HER-2 breast carcinomas
-
10.1158/0008-5472.CAN-06-3545, 17638866
-
Verlinden L, Vanden Bempt I, Eelen G, Drijkoningen M, Verlinden I, Marchal K, De Wolf-Peeters C, Christiaens MR, Michiels L, Bouillon R, et al. The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor/progesterone receptor/HER-2 breast carcinomas. Cancer Research 2007, 67:6574-6581. 10.1158/0008-5472.CAN-06-3545, 17638866.
-
(2007)
Cancer Research
, vol.67
, pp. 6574-6581
-
-
Verlinden, L.1
Vanden Bempt, I.2
Eelen, G.3
Drijkoningen, M.4
Verlinden, I.5
Marchal, K.6
De Wolf-Peeters, C.7
Christiaens, M.R.8
Michiels, L.9
Bouillon, R.10
-
48
-
-
4644318239
-
Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation
-
10.1158/0008-5472.CAN-04-1520, 15374968
-
Hammond EM, Dorie MJ, Giaccia AJ. Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Cancer Research 2004, 64:6556-6562. 10.1158/0008-5472.CAN-04-1520, 15374968.
-
(2004)
Cancer Research
, vol.64
, pp. 6556-6562
-
-
Hammond, E.M.1
Dorie, M.J.2
Giaccia, A.J.3
-
49
-
-
33846856967
-
CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo
-
10.1158/1078-0432.CCR-06-1424, 17255282
-
Tse AN, Rendahl KG, Sheikh T, Cheema H, Aardalen K, Embry M, Ma S, Moler EJ, Ni ZJ, Lopes de Menezes DE, et al. CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Clin Cancer Res 2007, 13:591-602. 10.1158/1078-0432.CCR-06-1424, 17255282.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 591-602
-
-
Tse, A.N.1
Rendahl, K.G.2
Sheikh, T.3
Cheema, H.4
Aardalen, K.5
Embry, M.6
Ma, S.7
Moler, E.J.8
Ni, Z.J.9
Lopes de Menezes, D.E.10
-
50
-
-
0032145499
-
Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein
-
Fuse E, Tanii H, Kurata N, Kobayashi H, Shimada Y, Tamura T, Sasaki Y, Y T, Lush RD, Headlee D, et al. Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein. Cancer Research 1998, 58:3248-3253.
-
(1998)
Cancer Research
, vol.58
, pp. 3248-3253
-
-
Fuse, E.1
Tanii, H.2
Kurata, N.3
Kobayashi, H.4
Shimada, Y.5
Tamura, T.6
Sasaki, Y.7
Y, T.8
Lush, R.D.9
Headlee, D.10
-
51
-
-
67649390962
-
Checkpoint kinase inhibitors: a review of the patent literature
-
10.1517/13543770802653622, 19441917
-
Janetka JW, Ashwell S. Checkpoint kinase inhibitors: a review of the patent literature. Expert Opin Ther Pat 2009, 19:165-197. 10.1517/13543770802653622, 19441917.
-
(2009)
Expert Opin Ther Pat
, vol.19
, pp. 165-197
-
-
Janetka, J.W.1
Ashwell, S.2
-
52
-
-
65449142073
-
Chk1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair deficient tumors
-
10.1186/1476-4598-8-24, 2672921, 19371427
-
Chen CC, Kennedy RD, Sidi S, Look AT, D'Andrea AA. Chk1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair deficient tumors. Mol Cancer 2009, 8:24. 10.1186/1476-4598-8-24, 2672921, 19371427.
-
(2009)
Mol Cancer
, vol.8
, pp. 24
-
-
Chen, C.C.1
Kennedy, R.D.2
Sidi, S.3
Look, A.T.4
D'Andrea, A.A.5
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