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Volumn 21, Issue 5, 2010, Pages 739-752

Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CHECKPOINT KINASE 1; HISTONE H2AX; SMALL INTERFERING RNA; THYMIDINE;

EID: 77649083117     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E09-07-0618     Document Type: Article
Times cited : (110)

References (44)
  • 1
    • 65549156128 scopus 로고    scopus 로고
    • The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication
    • Aparicio, T., Guillou, E., Coloma, J., Montoya, G., and Mendez, J. (2009). The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication. Nucleic Acids Res. 37, 2087-2095.
    • (2009) Nucleic Acids Res , vol.37 , pp. 2087-2095
    • Aparicio, T.1    Guillou, E.2    Coloma, J.3    Montoya, G.4    Mendez, J.5
  • 2
    • 18244385718 scopus 로고    scopus 로고
    • ATRIP binding to Replication Protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
    • Ball, H. L., Myers, J. S., and Cortez, D. (2005). ATRIP binding to Replication Protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol. Biol. Cell 16, 2372-2381.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 2372-2381
    • Ball, H.L.1    Myers, J.S.2    Cortez, D.3
  • 3
    • 34250707267 scopus 로고    scopus 로고
    • Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases δ and ε during S phase
    • Bauerschmidt, C., Pollok, S., Kremmer, E., Nasheuer, H.-P., and Grosse, F. (2007). Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases δ and ε during S phase. Genes Cell. 12, 745-758.
    • (2007) Genes Cell , vol.12 , pp. 745-758
    • Bauerschmidt, C.1    Pollok, S.2    Kremmer, E.3    Nasheuer, H.-P.4    Grosse, F.5
  • 4
    • 66149162000 scopus 로고    scopus 로고
    • A role for Chk1 in blocking transcriptional elongation of p21 during the S-phase checkpoint
    • Beckerman, R., Donner, A. J., Mattia, M., Peart, M. J., Manley, J. L., Espinosa, J. M., and Prives, C. (2009). A role for Chk1 in blocking transcriptional elongation of p21 during the S-phase checkpoint. Genes Dev. 23, 1364-1377.
    • (2009) Genes Dev , vol.23 , pp. 1364-1377
    • Beckerman, R.1    Donner, A.J.2    Mattia, M.3    Peart, M.J.4    Manley, J.L.5    Espinosa, J.M.6    Prives, C.7
  • 5
    • 9744284973 scopus 로고    scopus 로고
    • ATM is required for the cellular response to thymidine induced replication fork stress
    • Bolderson, E., Scorah, J., Helleday, T., Smythe, C., and Meuth, M. (2004). ATM is required for the cellular response to thymidine induced replication fork stress. Hum. Mol. Genet. 13, 2937-2945.
    • (2004) Hum. Mol. Genet , vol.13 , pp. 2937-2945
    • Bolderson, E.1    Scorah, J.2    Helleday, T.3    Smythe, C.4    Meuth, M.5
  • 7
    • 18244371925 scopus 로고    scopus 로고
    • Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
    • Byun, T. S., Pacek, M., Yee, M. C., Walter, J. C., and Cimprich, K. A. (2005). Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev. 19, 1040-1052.
    • (2005) Genes Dev , vol.19 , pp. 1040-1052
    • Byun, T.S.1    Pacek, M.2    Yee, M.C.3    Walter, J.C.4    Cimprich, K.A.5
  • 8
    • 0037012845 scopus 로고    scopus 로고
    • Genetic instability in mice lacking histone H2AX
    • Celeste, A., et al. (2002). Genetic instability in mice lacking histone H2AX. Science 296, 922-927.
    • (2002) Science , vol.296 , pp. 922-927
    • Celeste, A.1
  • 9
    • 22844436238 scopus 로고    scopus 로고
    • Chk1 is essential for tumor cell viability following activation of the replication checkpoint
    • Cho, S. H., Toouli, C. D., Fujii, G. H., Crain, C., and Parry, D. (2005). Chk1 is essential for tumor cell viability following activation of the replication checkpoint. Cell Cycle 4, 131-139.
    • (2005) Cell Cycle , vol.4 , pp. 131-139
    • Cho, S.H.1    Toouli, C.D.2    Fujii, G.H.3    Crain, C.4    Parry, D.5
  • 10
    • 47749141560 scopus 로고    scopus 로고
    • ATR: an essential regulator of genome integrity
    • Cimprich, K. A., and Cortez, D. (2008). ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 9, 616-627.
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 13
    • 34248184571 scopus 로고    scopus 로고
    • H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon checkpoint abrogation
    • Ewald, B., Sampath, D., and Plunkett, W. (2007). H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon checkpoint abrogation. Mol. Cancer Ther. 6, 1239-1248.
    • (2007) Mol. Cancer Ther , vol.6 , pp. 1239-1248
    • Ewald, B.1    Sampath, D.2    Plunkett, W.3
  • 14
    • 0035802112 scopus 로고    scopus 로고
    • Activation of mammalian Chk1 during DNA replication arrest: A role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing
    • Feijoo, C., Hall-Jackson, C., Wu, R., Jenkins, D., Leitch, J., Gilbert, D. M., and Smythe, C. (2001). Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. J. Cell Biol. 154, 913-923.
    • (2001) J. Cell Biol , vol.154 , pp. 913-923
    • Feijoo, C.1    Hall-Jackson, C.2    Wu, R.3    Jenkins, D.4    Leitch, J.5    Gilbert, D.M.6    Smythe, C.7
  • 15
    • 33646691757 scopus 로고    scopus 로고
    • p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine
    • Furuta, T., Hayward, R. L., Meng, L. H., Takemura, H., Aune, G. J., Bonner, W. M., Aladjem, M. I., Kohn, K. W., and Pommier, Y. (2006). p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine. Oncogene 25, 2839-2849.
    • (2006) Oncogene , vol.25 , pp. 2839-2849
    • Furuta, T.1    Hayward, R.L.2    Meng, L.H.3    Takemura, H.4    Aune, G.J.5    Bonner, W.M.6    Aladjem, M.I.7    Kohn, K.W.8    Pommier, Y.9
  • 16
    • 0038820065 scopus 로고    scopus 로고
    • Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA doublestrand breaks induced by mammalian DNA topoisomerase I cleavage complexes
    • Furuta, T., et al. (2003). Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA doublestrand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J. Biol. Chem. 278, 20303-20312.
    • (2003) J. Biol. Chem , vol.278 , pp. 20303-20312
    • Furuta, T.1
  • 18
    • 0037228519 scopus 로고    scopus 로고
    • The protein kinase C inhibitor Go6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints
    • Kohn, E. A., Yoo, C. J., and Eastman, A. (2003). The protein kinase C inhibitor Go6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints. Cancer Res. 63, 31-35.
    • (2003) Cancer Res , vol.63 , pp. 31-35
    • Kohn, E.A.1    Yoo, C.J.2    Eastman, A.3
  • 19
    • 33745487368 scopus 로고    scopus 로고
    • Cell apoptosis: Requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3
    • Lu, C., Zhu, F., Cho, Y.-Y., Tang, F., Zykove, T., Ma, W.-y., Bode, A. M., and Dong, Z. (2006). Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol. Cell 23, 121-132.
    • (2006) Mol. Cell , vol.23 , pp. 121-132
    • Lu, C.1    Zhu, F.2    Cho, Y.-Y.3    Tang, F.4    Zykove, T.5    Ma, W.-Y.6    Bode, A.M.7    Dong, Z.8
  • 20
    • 33745607326 scopus 로고    scopus 로고
    • H2AX phosphorylation within the G1 phase after UV irradiation depends upon nucleotide excision repair and not double-strand breaks
    • Marti, T. M., Hefner, E., Feeney, L., Natale, V., and Cleaver, J. E. (2006). H2AX phosphorylation within the G1 phase after UV irradiation depends upon nucleotide excision repair and not double-strand breaks. Proc. Natl. Acad. Sci USA 103, 9891-9896.
    • (2006) Proc. Natl. Acad. Sci USA , vol.103 , pp. 9891-9896
    • Marti, T.M.1    Hefner, E.2    Feeney, L.3    Natale, V.4    Cleaver, J.E.5
  • 21
    • 34250010317 scopus 로고    scopus 로고
    • Chk1 regulates the density of active replication origins during the vertebrate S phase
    • Maya-Mendoza, A., Petermann, E., Gillespie, D. A., Caldecott, K. W., and Jackson, D. A. (2007). Chk1 regulates the density of active replication origins during the vertebrate S phase. EMBO J. 26, 2719-2731.
    • (2007) EMBO J , vol.26 , pp. 2719-2731
    • Maya-Mendoza, A.1    Petermann, E.2    Gillespie, D.A.3    Caldecott, K.W.4    Jackson, D.A.5
  • 22
    • 58949092221 scopus 로고    scopus 로고
    • Myers, K., Gagou, M. E., Zuazua-Villar, P., Rodriguez, R., and Meuth, M. (2009). ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress. PLoS Genet. 5, e1000324.
    • Myers, K., Gagou, M. E., Zuazua-Villar, P., Rodriguez, R., and Meuth, M. (2009). ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress. PLoS Genet. 5, e1000324.
  • 23
    • 0035979213 scopus 로고    scopus 로고
    • ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation
    • Nghiem, P., Park, P. K., Kim, Y., Vaziri, C., and Schreiber, S. L. (2001). ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc. Natl. Acad. Sci. USA 98, 9092-9097.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9092-9097
    • Nghiem, P.1    Park, P.K.2    Kim, Y.3    Vaziri, C.4    Schreiber, S.L.5
  • 24
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., and Bonner, W. M. (2000). A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10, 886-895.
    • (2000) Curr. Biol , vol.10 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 25
    • 42149152648 scopus 로고    scopus 로고
    • Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45
    • Rodriguez, R., Gagou, M. E., and Meuth, M. (2008). Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45. Cell Death Differ. 15, 889-898.
    • (2008) Cell Death Differ , vol.15 , pp. 889-898
    • Rodriguez, R.1    Gagou, M.E.2    Meuth, M.3
  • 26
    • 30044440857 scopus 로고    scopus 로고
    • Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress
    • Rodriguez, R., and Meuth, M. (2006). Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol. Biol. Cell 17, 402-412.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 402-412
    • Rodriguez, R.1    Meuth, M.2
  • 27
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou, E. P., Boon, C., Redon, C., and Bonner, W. M. (1999). Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 146, 905-916.
    • (1999) J. Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 28
    • 0034737439 scopus 로고    scopus 로고
    • Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139
    • Rogakou, E. P., Nieves-Neira, W., Boon, C., Pommier, Y., and Bonner, W. M. (2000). Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J. Biol. Chem. 275, 9390-9395.
    • (2000) J. Biol. Chem , vol.275 , pp. 9390-9395
    • Rogakou, E.P.1    Nieves-Neira, W.2    Boon, C.3    Pommier, Y.4    Bonner, W.M.5
  • 29
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., and Bonner, W. M. (1998). DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273, 5858-5868.
    • (1998) J. Biol. Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 30
    • 4544235194 scopus 로고    scopus 로고
    • Functional Interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest
    • Sengupta, S., et al. (2004). Functional Interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J. Cell Biol. 166, 801-813.
    • (2004) J. Cell Biol , vol.166 , pp. 801-813
    • Sengupta, S.1
  • 31
    • 44149090307 scopus 로고    scopus 로고
    • Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3
    • Sidi, S., et al. (2008). Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 133, 2110-2118.
    • (2008) Cell , vol.133 , pp. 2110-2118
    • Sidi, S.1
  • 33
    • 1942538492 scopus 로고    scopus 로고
    • ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
    • Stiff, T., O'Driscoll, M., Rief, N., Iwabuchi, K., Lobrich, M., and Jeggo, P. A. (2005). ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 64, 2390-2396.
    • (2005) Cancer Res , vol.64 , pp. 2390-2396
    • Stiff, T.1    O'Driscoll, M.2    Rief, N.3    Iwabuchi, K.4    Lobrich, M.5    Jeggo, P.A.6
  • 34
    • 29244434544 scopus 로고    scopus 로고
    • MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
    • Stucki, M., Clapperton, J. A., Mohammad, D., Yaffe, M. B., Smerdon, S. J., and Jackson, S. P. (2005). MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 123, 333-344.
    • (2005) Cell , vol.123 , pp. 333-344
    • Stucki, M.1    Clapperton, J.A.2    Mohammad, D.3    Yaffe, M.B.4    Smerdon, S.J.5    Jackson, S.P.6
  • 36
    • 33749028012 scopus 로고    scopus 로고
    • Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks
    • Takemura, H., Rao, V. A., Sordet, O., Furuta, T., Miao, Z. H., Meng, L., Zhang, H., and Pommier, Y. (2006). Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. J. Biol. Chem. 281, 30814-30823.
    • (2006) J. Biol. Chem , vol.281 , pp. 30814-30823
    • Takemura, H.1    Rao, V.A.2    Sordet, O.3    Furuta, T.4    Miao, Z.H.5    Meng, L.6    Zhang, H.7    Pommier, Y.8
  • 37
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
    • Ward, I. M., and Chen, J. (2001). Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 276, 47759-47762.
    • (2001) J. Biol. Chem , vol.276 , pp. 47759-47762
    • Ward, I.M.1    Chen, J.2
  • 38
    • 44949096478 scopus 로고    scopus 로고
    • A mutant allele of MRE11 found in mismatch repair deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner
    • Wen, Q., Scorah, J., Phear, G., Rodgers, G., Rodgers, S., and Meuth, M. (2008). A mutant allele of MRE11 found in mismatch repair deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner. Mol. Biol. Cell 19, 1693-1705.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 1693-1705
    • Wen, Q.1    Scorah, J.2    Phear, G.3    Rodgers, G.4    Rodgers, S.5    Meuth, M.6
  • 39
    • 14844315930 scopus 로고    scopus 로고
    • A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation
    • Xiao, Z., Xue, J., Sowin, T. J., Rosenberg, S. H., and Zhang, H. (2005). A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation. Oncogene 24, 1403-1411.
    • (2005) Oncogene , vol.24 , pp. 1403-1411
    • Xiao, Z.1    Xue, J.2    Sowin, T.J.3    Rosenberg, S.H.4    Zhang, H.5
  • 42
    • 0037415735 scopus 로고    scopus 로고
    • Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects
    • Zachos, G., Rainey, M. D., and Gillespie, D. A. (2003). Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects. EMBO J. 22, 713-723.
    • (2003) EMBO J , vol.22 , pp. 713-723
    • Zachos, G.1    Rainey, M.D.2    Gillespie, D.A.3
  • 43
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou, B.-B.S., and Elledge, S. J. (2000). The DNA damage response: putting checkpoints in perspective. Nature 408, 433-439.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.-B.S.1    Elledge, S.J.2
  • 44
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou, L., and Elledge, S. J. (2003). Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300, 1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2


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