Toxicity of methylmercury conjugated with L-cysteine on rat thymocytes and human leukemia K562 cells in comparison with that of methylmercury chloride

Environmental Toxicology and Pharmacology

Volumn 9, Issue 1-2, 2000, Pages 49-55

  Oyama, Yasuo ^a   Yamazaki, Yuko ^a   Okada, Yoshihiko ^a   Takahama, Kazuo ^b   Satoh, Masaya ^a   Hayashi, Hiromi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

L Cysteine; Methylmercury; Toxicity

Indexed keywords

CALCIUM; CYSTEINE; GLUTATHIONE; METHYLMERCURIC CHLORIDE; METHYLMERCURY; SUPEROXIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYPERPOLARIZATION; LEUKEMIA CELL; MEMBRANE DEPOLARIZATION; MERCURIALISM; NONHUMAN; PRIORITY JOURNAL; RAT; THYMOCYTE;

ANIMALIA;

EID: 0034530010     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1382-6689(00)00062-4     Document Type: Article

References (26)

1. Influence of dietary levels of protein and sulfur amino acids on the fate of methylmercury
2. Methyl mercury uptake across bovine brain capillary endothelial cells in vitro: The role of amino acids
3. Methylmercury uptake in rat primary astrocyte cultures: The role of the neutral amino acid transport system
4. 2+
5. 2-induced changes in cell viability and cellular nonprotein thiol level of dissociated rat thymocytes
6. Effects of triphenyltin on growth and viability of K562 cells
7. Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage
8. Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanism of xenobiotics
9. Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate β-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates
10. Methylmercury alters intrasynaptosomal concentrations of endogenous polyvalent cations
11. ++ and heavy metals in NG108-15 cells
12. Methylmercury transport across the blood-brain barrier by an amino acid carrier
13. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
14. Flow cytometric analysis on tri-n-butyltin-induced increase in annexin V binding to membranes of rat thymocytes
15. Fluorescent estimation on cytotoxicity of methylmercury in dissociated cerebellar neurons: Its comparison with ionomycin
16. Calcium ions and oxidative cell injury
17. 2+-dependent hyperpolarization of mouse thymocytes: A flow cytometric study using fluorescent dyes
18. Change in membrane permeability induced by amyloid β-protein fragment 25-35 in brain neurons dissociated from rats
19. Methylmercury toxicity in rat brain neurons: Modifications by L-cysteine and trimethylbenzylmercaptan and comparison with dimethylmercury, N-ethylmaleimide and ionomycin
20. Exposure of rat thymocytes to hydrogen peroxide increases annexin V binding to membranes: Inhibitory actions of deferoxamine and quercetin
21. 2+ and inositol phosphate levels in cultured cerebellar granule neurons
22. Oxidative mechanisms underlying methyl mercury neurotoxicity
23. Bcl-2 expression decreases methyl mercury-induced free-radical generation
24. Surface exposure of phosphatidylserine during apoptosis of rat thymocytes precedes nuclear changes
25. Mechanism of urinary excretion of methylmercury in mice