Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain

NeuroToxicology

Volumn 30, Issue 6, 2009, Pages 1000-1007

  Fujimura, Masatake ^a   Usuki, Fusako ^a   Sawada, Masumi ^a   Takashima, Akihiko ^b  

^a NATIONAL INSTITUTE FOR MINAMATA DISEASE   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Cerebral cortex; JNK pathway; Methylmercury; Neuropathological changes; Tau hyperphosphorylation

Indexed keywords

METHYLMERCURY; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; SERINE; STRESS ACTIVATED PROTEIN KINASE; TAU PROTEIN; THREONINE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; FRONTOTEMPORAL DEMENTIA; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MERCURIALISM; MOUSE; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MERCURY POISONING, NERVOUS SYSTEM; METHYLMERCURY COMPOUNDS; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; TAU PROTEINS; TIME FACTORS;

MUS;

EID: 71049144033     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2009.08.001     Document Type: Article

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