Endogenous thiols and MRP transporters contribute to Hg 2+ efflux in HgCl 2-treated tubular MDCK cells

Toxicology

Volumn 206, Issue 1, 2005, Pages 137-151

  Aleo, Maria Francesca ^a   Morandini, Fausta ^a   Bettoni, Francesca ^a   Giuliani, Roberta ^a   Rovetta, Francesca ^b   Steimberg, Nathalie ^b   Apostoli, Pietro ^b   Parrinello, Giovanni ^b   Mazzoleni, Giovanna ^b  

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

(3 3 (2 (7 chloro 2 quinionlinyl) ethenyl)phenyl) (3 di methylamino 3 oxopropyl)thio)methyl)thio) propanoic acid (MK 571); Glutathione conjugates substrates; MDCK cells; Mercuric ions (Hg 2+); Multidrug resistance proteins (MRPs); Nephrotoxicity

Indexed keywords

MERCURIC CHLORIDE; MERCURY; METAL; METAL ION; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; THIOL DERIVATIVE; VERLUKAST;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL DENSITY; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; EXPOSURE; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; KIDNEY CELL; KIDNEY DISTAL TUBULE; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SOLUBILITY; UPREGULATION;

ANIMALS; BLOTTING, NORTHERN; CATIONS, DIVALENT; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DOGS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; IMMUNOBLOTTING; KIDNEY TUBULES; MEMBRANE TRANSPORT MODULATORS; MEMBRANE TRANSPORT PROTEINS; MERCURIC CHLORIDE; MERCURY; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PROPIONATES; QUINOLINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SULFHYDRYL COMPOUNDS; UP-REGULATION;

EID: 10044268677     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.07.003     Document Type: Article

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