mTOR-mediated regulation of translation factors by amino acids

Biochemical and Biophysical Research Communications

Volumn 313, Issue 2, 2004, Pages 429-436

  Proud, Christopher G ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Amino acids; Calmodulin; Cycloheximide; eEF2 kinase; Elongation factor; Initiation factor; Leucine; mRNA translation; mTOR; Rapamycin

Indexed keywords

AMINO ACID; ELONGATION FACTOR 2; MAMMALIAN TARGET OF RAPAMYCIN; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; IN VIVO STUDY; INTRACELLULAR SPACE; MAMMAL CELL; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; RNA TRANSLATION; SIGNAL TRANSDUCTION;

EUKARYOTA; MAMMALIA; RAPTORES; TOSCANA VIRUS;

EID: 0347627139     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.07.015     Document Type: Conference Paper

References (48)

1. Kimball S.R., Jefferson L.S. Control of protein synthesis by amino acid availability. Curr. Opin. Clin. Nutr. Metab. Care. 5:2002;63-67.
2. Proud C.G. Regulation of mammalian translation factors by nutrients. Eur. J. Biochem. 269:2002;5338-5349.
3. Kimball S.R. Regulation of translation initiation by amino acids in eukaryotic cells. Prog. Mol. Subcell. Biol. 26:2001;155-184.
4. Hara K., Yonezawa K., Weng Q.P., Kozlowski M.T., Belham C., Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF4E BP1 through a common effector mechanism. J. Biol. Chem. 273:1998;14484-14494.
5. Gingras A.-C., Raught B., Sonenberg N. Control of translation by the target of rapamycin proteins. Prog. Mol. Subcell. Biol. 27:2001;143-174.
6. Avruch J., Belham C., Weng Q.P., Hara K., Yonezawa K. The p70 S6 kinase integrates nutrient and growth signals to control translational capacity. Prog. Mol. Subcell. Biol. 26:2001;115-154.
7. Gingras A.-C., Raught B., Sonenberg N. eIF4 translation factors: effectors of recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68:1999;913-963.
8. Carlberg U., Nilsson A., Nygård O. Functional properties of phosphorylated elongation factor 2. Eur. J. Biochem. 191:1990;639-645.
9. Browne G.J., Proud C.G. Regulation of peptide-elongation in mammalian cells. Eur. J. Biochem. 269:2002;5360-5368.
10. Redpath N.T., Foulstone E.J., Proud C.G. Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway. EMBO J. 15:1996;2291-2297.
11. Ryazanov A.G., Ward M.D., Mendola C.E., Pavur K.S., Dorovkov M.V., Wiedmann M., Erdjument-Bromage H., Tempst P., Parmer T.G., Prostko C.R., Germino F.J., Hait W.N. Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase. Proc. Natl. Acad. Sci. USA. 94:1997;4884-4889.
12. Cardenas M.E., Cutler N.S., Lorenz M.C., Di Como C.J., Heitman J. The TOR signalling cascade regulates gene expression in response to nutrients. Genes Dev. 13:1999;3271-3279.
13. Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell. 103:2000;193-200.
14. Rohde J., Heitman J., Cardenas M.E. The TOR kinases link nutrient sensing to cell growth. J. Biol. Chem. 276:2001;9583-9586.
15. Neshat M.S., Mellinghoff I.K., Tran C., Stiles B., Thomas G., Petersen P., Frost P., Gibbons J.J., Wu H., Sawyers C.L. Enhanced sensitivity of PTEN-deficient tumours to inhibition of FRAP/mTOR. Proc. Natl. Acad. Sci. USA. 98:2001;10314-10319.
16. +/-mice. Proc. Natl. Acad. Sci. USA. 98:2001;10320-10325.
17. Thomas G., Hall M.N. TOR signalling and the control of cell growth. Curr. Opin. Cell Biol. 9:1998;782-787.
18. Montagne J., Stewart M.J., Stocker H., Hafen E., Kozma S.C., Thomas G. Drosophila S6 kinase: a regulator of cell size. Science. 285:1999;2126-2129.
19. Fingar D.C., Salama S., Tsou C., Harlow E., Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16:2002;1472-1487.
20. Iraqui I., Vissers S., Bernard F., de Craene J.-O., Boles E., Urrestarazu A., Andre B. Amino acid signalling in Saccharomyces cerevisiae: a permease-like sensor of external amino acids and F-box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease. Mol. Cell. Biol. 19:1999;989-1001.
21. Mortimore G.E., Wert J.J., Miotto G., Venerando R., Kadowaki M. Leucine-specific binding of photoreactive Leu7-MAP to a high molecular weight protein on the plasma membrane of the isolated rat hepatocyte. Biochem. Biophys. Res. Commun. 203:1994;200-208.
22. Christie G.R., Hajduch E., Hundal H.S., Proud C.G., Taylor P.M. Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a TOR-dependent manner. J. Biol. Chem. 277:2002;9952-9957.
23. Wang X., Campbell L.E., Miller C.M., Proud C.G. Amino acid availability regulates p70 S6 kinase and multiple translation factors. Biochem. J. 334:1998;261-267.
24. Campbell L.E., Wang X., Proud C.G. Nutrients differentially modulate multiple translation factors and their control by insulin. Biochem. J. 344:1999;433-441.
25. Beugnet A., Tee A.R., Taylor P.M., Proud C.G. Regulation of targets of mTOR signalling by intracellular amino acid availability. Biochem. J. 372:2003;555-566.
26. Cano E., Hazzalin C.A., Mahadevan L.C. Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun. Mol. Cell. Biol. 14:1994;7352-7362.
27. Mothe-Satney I., Yang D., Fadden P., Haystead T.A.J., Lawrence J.C. Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression. Mol. Cell. Biol. 20:2000;3558-3567.
28. Gingras A.-C., Gygi S.P., Raught B., Polakiewicz R.D., Abraham R.T., Hoekstra M.F., Aebersold R., Sonenberg N. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev. 13:1999;1422-1437.
29. Wang X., Li W., Parra J.-L., Beugnet A., Proud C.G. The C-terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. Mol. Cell. Biol. 23:2003;1546-1557.
30. Tee A.R., Proud C.G. Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Mol. Cell. Biol. 22:2002;1674-1683.
31. Schalm S.S., Blenis J. Identification of a conserved motif required for mTOR signaling. Curr. Biol. 12:2002;632-639.
32. Schalm S.S., Fingar D.C., Sabatini D.M., Blenis J. TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr. Biol. 13:2003;797-806.
33. Hara K., Maruki Y., Long X., Yoshino K., Oshiro N., Hidayat S., Tokunaga C., Avruch J., Yonezawa K. Raptor, a binding partner of target of rapamycin, mTOR, mediates TOR action. Cell. 110:2002;177-189.
34. Kim D.H., Sarbassov D.D., Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H., Tempst P., Sabatini D.M. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell. 110:2002;163-175.
35. Loewith R., Jacinto E., Wullschleger S., Lorberg A., Crespo J.L., Bonenfant D., Oppliger W., Jeno P., Hall M.N. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell. 10:2002;457-468.
36. Nojima H., Tokunaga C., Eguchi S., Oshiro N., Hidayat S., Yoshino K., Hara K., Tanaka N., Avruch J., Yonezawa K. The mTOR partner, Raptor, binds the mTOR substrates, p70 S6 kinase and 4E-BP1, through their TOS (TOR signaling) motif. J. Biol. Chem. 278:2003;15461-15464.
37. Beugnet A., Wang X., Proud C.G. The TOR-signaling and RAIP motifs play distinct roles in the mTOR-dependent phosphorylation of initiation factor 4E-binding protein 1. J. Biol. Chem. 278:2003;40717-40722.
38. Choi K.M., McMahon L.P., Lawrence J.C. Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mTOR and for recognition by raptor. J. Biol. Chem. 278:2003;19667-19673.
39. Knebel A., Morrice N., Cohen P. A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. EMBO J. 20:2001;4360-4369.
40. RSK1 and p70 S6 kinase. EMBO J. 20:2001;4370-4379.
41. Knebel A., Haydon C.E., Morrice N., Cohen P. Stress-induced regulation of eEF2 kinase by SB203580-sensitive and -insensitive pathways. Biochem. J. 367:2002;525-532.
42. Saucedo L.J., Gao X., Chiarelli D.A., Li L., Pan D., Edgar B.A. Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat. Cell Biol. 5:2003;566-571.
43. Zhang Y., Gao X., Saucedo L.J., Ru B., Edgar B.A., Pan D. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat. Cell Biol. 5:2003;578-581.
44. Stocker H., Radimerski T., Schindelholz B., Wittwer F., Belawat P., Daram P., Breuer S., Thomas G., Hafen E. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat. Cell Biol. 5:2003;559-565.
45. Tee A.R., Manning B.D., Roux P.P., Cantley L.C., Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 13:2003;1259-1268.
46. McManus E.J., Alessi D.R. TSC1-TSC2: a complex tale of PKB-mediated S6K regulation. Nat. Cell Biol. 4:2002;E214-E216.
47. Tang H., Hornstein E., Stolovich M., Levy G., Livingstone M., Templeton D., Avruch J., Meyuhas J.O. Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signalling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation. Mol. Cell. Biol. 21:2001;8671-8683.
48. Blommaart E.F., Krause U., Schellens J.P., Vreeling-Sindelarova H., Meijer A.J. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur. J. Biochem. 243:1997;240-246.