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Volumn 1, Issue 2, 2010, Pages 257-264

The use of Cox-2 and PPARγ signaling in anti-cancer therapies (Review)

Author keywords

Cyclooxygenase 2; Nonsteroidal anti inflammatory drugs; Peroxisome proliferator activated receptor ; Prostaglandins

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 2 [1 CARBOXY 2 [4 [2 (5 METHYL 2 PHENYL 4 OXAZOLYL)ETHOXY]PHENYL]ETHYLAMINO]BENZOIC ACID METHYL ESTER; CELECOXIB; CIGLITAZONE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FLUFENAMIC ACID; FLURBIPROFEN; IBUPROFEN; INDOMETACIN; MEFENAMIC ACID; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIRINIXIC ACID; PROSTAGLANDIN F2 ALPHA; ROSIGLITAZONE; SULINDAC SULFIDE; TILMACOXIB; TROGLITAZONE;

EID: 77956208412     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm_00000040     Document Type: Review
Times cited : (23)

References (93)
  • 2
    • 34247179157 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2 and its inhibition in cancer: Is there a role?
    • Liao Z, Mason KA and Milas L: Cyclo-oxygenase-2 and its inhibition in cancer: is there a role? Drugs 67: 821-845, 2007.
    • (2007) Drugs , vol.67 , pp. 821-845
    • Liao, Z.1    Mason, K.A.2    Milas, L.3
  • 3
    • 3042788940 scopus 로고    scopus 로고
    • COX-2 inhibition and colorectal cancer
    • Koehne CH and Dubois RN: COX-2 inhibition and colorectal cancer. Semin Oncol 31: 12-21, 2004.
    • (2004) Semin Oncol , vol.31 , pp. 12-21
    • Koehne, C.H.1    Dubois, R.N.2
  • 4
    • 0035805054 scopus 로고    scopus 로고
    • Breast cancer and NSAID use: A meta-analysis
    • Khuder SA and Mutgi AB: Breast cancer and NSAID use: a meta-analysis. Br J Cancer 84: 1188-1192, 2001.
    • (2001) Br J Cancer , vol.84 , pp. 1188-1192
    • Khuder, S.A.1    Mutgi, A.B.2
  • 6
    • 33846947152 scopus 로고    scopus 로고
    • COX-2 inhibition: A possible role in the management of prostate cancer?
    • Sooriakumaran P, Langley SE, Laing RW and Coley HM: COX-2 inhibition: a possible role in the management of prostate cancer? J Chemother 19: 21-32, 2007.
    • (2007) J Chemother , vol.19 , pp. 21-32
    • Sooriakumaran, P.1    Langley, S.E.2    Laing, R.W.3    Coley, H.M.4
  • 8
    • 3042836326 scopus 로고    scopus 로고
    • COX-2 inhibition and lung cancer
    • Sandler AB and Dubinett SM: COX-2 inhibition and lung cancer. Semin Oncol 31: 45-52, 2004.
    • (2004) Semin Oncol , vol.31 , pp. 45-52
    • Sandler, A.B.1    Dubinett, S.M.2
  • 11
    • 0033572578 scopus 로고    scopus 로고
    • Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines
    • Soriano F, Helfrich B, Chan DC, Heasley LE, Bunn PA Jr and Chou TC: Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines. Cancer Res 59: 6178-6184, 1999.
    • (1999) Cancer Res , vol.59 , pp. 6178-6184
    • Soriano, F.1    Helfrich, B.2    Chan, D.C.3    Heasley, L.E.4    Bunn Jr., P.A.5    Chou, T.C.6
  • 12
    • 11244315274 scopus 로고    scopus 로고
    • Continuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme
    • Tuettenberg J, Grobholz R, Korn T, Wenz F, Erber R and Vajkoczy P: Continuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme. J Cancer Res Clin Oncol 131: 31-40, 2005.
    • (2005) J Cancer Res Clin Oncol , vol.131 , pp. 31-40
    • Tuettenberg, J.1    Grobholz, R.2    Korn, T.3    Wenz, F.4    Erber, R.5    Vajkoczy, P.6
  • 13
    • 42549145438 scopus 로고    scopus 로고
    • Combination therapy of S-1 with selective cyclooxygenase-2 inhibitor for liver metastasis of colorectal carcinoma
    • Tachimori A, Yamada N, Amano R, Ohira M and Hirakawa K: Combination therapy of S-1 with selective cyclooxygenase-2 inhibitor for liver metastasis of colorectal carcinoma. Anticancer Res 28: 629-638, 2008.
    • (2008) Anticancer Res , vol.28 , pp. 629-638
    • Tachimori, A.1    Yamada, N.2    Amano, R.3    Ohira, M.4    Hirakawa, K.5
  • 14
    • 43449102479 scopus 로고    scopus 로고
    • Decisive role of cyclooxygenase-2 and lipocalin-type prostaglandin D synthase in chemotherapeutic-induced apoptosis of human cervical carcinoma cells
    • Eichele K, Ramer R and Hinz B: Decisive role of cyclooxygenase-2 and lipocalin-type prostaglandin D synthase in chemotherapeutic-induced apoptosis of human cervical carcinoma cells. Oncogene 27: 3032-3044, 2008.
    • (2008) Oncogene , vol.27 , pp. 3032-3044
    • Eichele, K.1    Ramer, R.2    Hinz, B.3
  • 16
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann I and Green S: Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347: 645-650, 1990.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 17
    • 0036010555 scopus 로고    scopus 로고
    • Natural ligands of PPARγ: Are prostaglandin J2 derivatives really playing the part?
    • Nosjean O and Boutin JA: Natural ligands of PPARγ: Are prostaglandin J2 derivatives really playing the part? Cell Signal 14: 573-583, 2002.
    • (2002) Cell Signal , vol.14 , pp. 573-583
    • Nosjean, O.1    Boutin, J.A.2
  • 18
    • 0242661076 scopus 로고    scopus 로고
    • Activation of PPAR gamma in colon tumor cell lines by oxidized metabolites of linoleic acid, endogenous ligands for PPAR gamma
    • Bull AW, Steffensen KR, Leers J and Rafter JJ: Activation of PPAR gamma in colon tumor cell lines by oxidized metabolites of linoleic acid, endogenous ligands for PPAR gamma. Carcinogenesis 24: 1717-1722, 2003.
    • (2003) Carcinogenesis , vol.24 , pp. 1717-1722
    • Bull, A.W.1    Steffensen, K.R.2    Leers, J.3    Rafter, J.J.4
  • 19
    • 33646255424 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma: Novel therapeutic target linking adiposity, insulin resistance and atherosclerosis
    • Kepez A, Oto A and Dagdelen S: Peroxisome proliferator-activated receptor-gamma: novel therapeutic target linking adiposity, insulin resistance and atherosclerosis. BioDrugs 20: 121-135, 2006.
    • (2006) BioDrugs , vol.20 , pp. 121-135
    • Kepez, A.1    Oto, A.2    Dagdelen, S.3
  • 20
    • 44049108337 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonists and diabetes: Current evidence and future perspectives
    • Chiarelli F and Di Marzio D: Peroxisome proliferator-activated receptor-gamma agonists and diabetes: current evidence and future perspectives. Vasc Health Risk Manag 4: 297-304, 2008.
    • (2008) Vasc Health Risk Manag , vol.4 , pp. 297-304
    • Chiarelli, F.1    Di Marzio, D.2
  • 21
    • 39449114610 scopus 로고    scopus 로고
    • Thiazolidinediones: Effects on insulin resistance and the cardiovascular system
    • Quinn CE, Hamilton PK, Lockhart CJ and McVeigh GE: Thiazolidinediones: effects on insulin resistance and the cardiovascular system. Br J Pharmacol 153: 636-645, 2008.
    • (2008) Br J Pharmacol , vol.153 , pp. 636-645
    • Quinn, C.E.1    Hamilton, P.K.2    Lockhart, C.J.3    McVeigh, G.E.4
  • 22
    • 33750987072 scopus 로고    scopus 로고
    • NF-κB/PPARγ and/or AP-1/PPAR PPAR γ 'on/off' switches and induction of CBP in colon adenocarcinomas: Correlation with COX-2 expression
    • Konstantinopoulos PA, Vandoros GP, Sotiropoulou-Bonikou G, Kominea A and Papavassiliou AG: NF-κB/PPARγ and/or AP-1/PPAR PPAR γ 'on/off' switches and induction of CBP in colon adenocarcinomas: correlation with COX-2 expression. Int J Colorectal Dis 22: 57-68, 2007.
    • (2007) Int J Colorectal Dis , vol.22 , pp. 57-68
    • Konstantinopoulos, P.A.1    Vandoros, G.P.2    Sotiropoulou-Bonikou, G.3    Kominea, A.4    Papavassiliou, A.G.5
  • 23
    • 0037211366 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis
    • Badawi AF and Badr MZ: Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis. Int J Cancer 103: 84-90, 2003.
    • (2003) Int J Cancer , vol.103 , pp. 84-90
    • Badawi, A.F.1    Badr, M.Z.2
  • 25
    • 41149141789 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma is a potent target for prevention and treatment in human prostate and testicular cancer
    • Matsuyama M and Yoshimura R: Peroxisome proliferator-activated receptor-gamma is a potent target for prevention and treatment in human prostate and testicular cancer. PPAR Res 2008: 249849, 2008.
    • (2008) PPAR Res 2008 , pp. 249849
    • Matsuyama, M.1    Yoshimura, R.2
  • 32
    • 3042815666 scopus 로고    scopus 로고
    • Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists
    • Grommes C, Landreth GE and Heneka MT: Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists. Lancet Oncol 5: 419-429, 2004.
    • (2004) Lancet Oncol , vol.5 , pp. 419-429
    • Grommes, C.1    Landreth, G.E.2    Heneka, M.T.3
  • 34
    • 44249122635 scopus 로고    scopus 로고
    • PPAR ligands for cancer chemoprevention
    • Yasui Y, Kim M and Tanaka T: PPAR ligands for cancer chemoprevention. PPAR Res 2008: 548919, 2008.
    • (2008) PPAR Res 2008 , pp. 548919
    • Yasui, Y.1    Kim, M.2    Tanaka, T.3
  • 37
    • 0031694577 scopus 로고    scopus 로고
    • Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
    • Lefebvre AM, Chen I, Desreumaux P, Najib J, Fruchart JC, Geboes K, Briggs M, Heyman R and Auwerx J: Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat Med 4: 1053-1057, 1998.
    • (1998) Nat Med , vol.4 , pp. 1053-1057
    • Lefebvre, A.M.1    Chen, I.2    Desreumaux, P.3    Najib, J.4    Fruchart, J.C.5    Geboes, K.6    Briggs, M.7    Heyman, R.8    Auwerx, J.9
  • 40
    • 47349128912 scopus 로고    scopus 로고
    • The role of PPAR-gamma and its interaction with COX-2 in pancreatic cancer
    • Eibl G: The role of PPAR-gamma and its interaction with COX-2 in pancreatic cancer. PPAR Res 2008: 326915, 2008.
    • (2008) PPAR Res 2008 , pp. 326915
    • Eibl, G.1
  • 41
    • 51449085113 scopus 로고    scopus 로고
    • Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1beta-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma
    • Kawashima A, Harada T, Imada K, Yano T and Mizuguchi K: Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1beta-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma. Prostaglandins Leukot Essent Fatty Acids 79: 59-65, 2008.
    • (2008) Prostaglandins Leukot Essent Fatty Acids , vol.79 , pp. 59-65
    • Kawashima, A.1    Harada, T.2    Imada, K.3    Yano, T.4    Mizuguchi, K.5
  • 42
    • 38949108301 scopus 로고    scopus 로고
    • PPARgamma1 as a molecular target of eicosapentaenoic acid in human colon cancer (HT-29) cells
    • Allred CD, Talbert DR, Southard RC, Wang X and Kilgore MW: PPARgamma1 as a molecular target of eicosapentaenoic acid in human colon cancer (HT-29) cells. J Nutr 138: 250-256, 2008.
    • (2008) J Nutr , vol.138 , pp. 250-256
    • Allred, C.D.1    Talbert, D.R.2    Southard, R.C.3    Wang, X.4    Kilgore, M.W.5
  • 43
    • 0035053973 scopus 로고    scopus 로고
    • Cyclopentenone prostaglandins: New insights on biological activities and cellular targets
    • Straus DS and Glass CK: Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res Rev 21: 185-210, 2001.
    • (2001) Med Res Rev , vol.21 , pp. 185-210
    • Straus, D.S.1    Glass, C.K.2
  • 44
    • 34548766145 scopus 로고    scopus 로고
    • Prostaglandin receptor signaling in disease
    • Matsuoka T and Narumiya S: Prostaglandin receptor signaling in disease. ScientificWorldJournal 7: 1329-1347, 2007.
    • (2007) ScientificWorldJournal , vol.7 , pp. 1329-1347
    • Matsuoka, T.1    Narumiya, S.2
  • 45
    • 28544444039 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis
    • Castellone MD, Teramoto H, Williams BO, Druey KM and Gutkind JS: Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science 310: 1504-1510, 2005.
    • (2005) Science , vol.310 , pp. 1504-1510
    • Castellone, M.D.1    Teramoto, H.2    Williams, B.O.3    Druey, K.M.4    Gutkind, J.S.5
  • 46
    • 33744968176 scopus 로고    scopus 로고
    • Prostaglandins and the colon cancer connection
    • Chan TA: Prostaglandins and the colon cancer connection. Trends Mol Med 12: 240-244, 2006.
    • (2006) Trends Mol Med , vol.12 , pp. 240-244
    • Chan, T.A.1
  • 47
    • 11444261543 scopus 로고    scopus 로고
    • 15d-PGJ2: The anti-inflammatory prostaglandin?
    • Scher JU and Pillinger MH: 15d-PGJ2: the anti-inflammatory prostaglandin? Clin Immunol 114: 100-109, 2005.
    • (2005) Clin Immunol , vol.114 , pp. 100-109
    • Scher, J.U.1    Pillinger, M.H.2
  • 48
    • 0036117576 scopus 로고    scopus 로고
    • Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand-induced apoptosis in colon cancer cells
    • Shimada T, Kojima K, Yoshiura K, Hiraishi H and Terano A: Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand-induced apoptosis in colon cancer cells. Gut 50: 658-664, 2002.
    • (2002) Gut , vol.50 , pp. 658-664
    • Shimada, T.1    Kojima, K.2    Yoshiura, K.3    Hiraishi, H.4    Terano, A.5
  • 49
    • 31544451531 scopus 로고    scopus 로고
    • Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis
    • Millan O, Rico D, Peinado H, Zarich N, Stamatakis K, Pérez-Sala D, Rojas JM, Cano A and Boscá L: Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis. Carcinogenesis 27: 328-336, 2006.
    • (2006) Carcinogenesis , vol.27 , pp. 328-336
    • Millan, O.1    Rico, D.2    Peinado, H.3    Zarich, N.4    Stamatakis, K.5    Pérez-Sala, D.6    Rojas, J.M.7    Cano, A.8    Boscá, L.9
  • 50
  • 51
    • 0031939716 scopus 로고    scopus 로고
    • Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor gamma
    • Reginato MJ, Krakow SL, Bailey ST and Lazar MA: Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor gamma. J Biol Chem 273: 1855-1858, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 1855-1858
    • Reginato, M.J.1    Krakow, S.L.2    Bailey, S.T.3    Lazar, M.A.4
  • 52
    • 0034672055 scopus 로고    scopus 로고
    • Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells
    • Padilla J, Kaur K, Cao HJ, Smith TJ and Phipps RP: Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells. J Immunol 165: 6941-6948, 2000.
    • (2000) J Immunol , vol.165 , pp. 6941-6948
    • Padilla, J.1    Kaur, K.2    Cao, H.J.3    Smith, T.J.4    Phipps, R.P.5
  • 54
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann JM, Lenhard JM, Oliver BB, Ringold GM and Kliewer SA: Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272: 3406-3410, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 56
    • 33847749541 scopus 로고    scopus 로고
    • Modulation of the expression of peroxisome proliferator-activated receptors in human fibroblasts
    • Diamond MP and Saed G: Modulation of the expression of peroxisome proliferator-activated receptors in human fibroblasts. Fertil Steril 87: 706-709, 2007.
    • (2007) Fertil Steril , vol.87 , pp. 706-709
    • Diamond, M.P.1    Saed, G.2
  • 57
    • 1642369791 scopus 로고    scopus 로고
    • Effect of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of lung tumors and their expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma
    • Shaik MS, Chatterjee A and Singh M: Effect of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of lung tumors and their expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma. Clin Cancer Res 10: 1521-1529, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 1521-1529
    • Shaik, M.S.1    Chatterjee, A.2    Singh, M.3
  • 58
    • 0036082592 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs induce apoptosis in association with activation of peroxisome proliferator-activated receptor gamma in rheumatoid synovial cells
    • Yamazaki R, Kusunoki N, Matsuzaki T, Hashimoto S and Kawai S: Nonsteroidal anti-inflammatory drugs induce apoptosis in association with activation of peroxisome proliferator-activated receptor gamma in rheumatoid synovial cells. J Pharmacol Exp Ther 302: 18-25, 2002.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 18-25
    • Yamazaki, R.1    Kusunoki, N.2    Matsuzaki, T.3    Hashimoto, S.4    Kawai, S.5
  • 59
    • 28144445331 scopus 로고    scopus 로고
    • In vitro and in vivo effects and mechanisms of celecoxib-induced growth inhibition of human hepatocellular carcinoma cells
    • Cui W, Yu CH and Hu KQ: In vitro and in vivo effects and mechanisms of celecoxib-induced growth inhibition of human hepatocellular carcinoma cells. Clin Cancer Res 11: 8213-8221, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 8213-8221
    • Cui, W.1    Yu, C.H.2    Hu, K.Q.3
  • 60
    • 38449107339 scopus 로고    scopus 로고
    • Mechanisms of anti-proliferative effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on human liver cancer cells
    • Nagahara T, Okano J and Murawaki Y: Mechanisms of anti-proliferative effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on human liver cancer cells. Oncol Rep 18: 1281-1290, 2007.
    • (2007) Oncol Rep , vol.18 , pp. 1281-1290
    • Nagahara, T.1    Okano, J.2    Murawaki, Y.3
  • 61
    • 0033583029 scopus 로고    scopus 로고
    • Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells
    • Meade EA, McIntyre TM, Zimmerman GA and Prescott SM: Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells. J Biol Chem 274: 8328-8334, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 8328-8334
    • Meade, E.A.1    McIntyre, T.M.2    Zimmerman, G.A.3    Prescott, S.M.4
  • 62
    • 0037066768 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is induced in monocytes by peroxisome proliferator activated receptor gamma and oxidized alkyl phospholipids from oxidized low density lipoprotein
    • Pontsler AV, St Hilaire A, Marathe GK, Zimmerman GA and McIntyre TM: Cyclooxygenase-2 is induced in monocytes by peroxisome proliferator activated receptor gamma and oxidized alkyl phospholipids from oxidized low density lipoprotein. J Biol Chem 277: 13029-13036, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 13029-13036
    • Pontsler, A.V.1    St Hilaire, A.2    Marathe, G.K.3    Zimmerman, G.A.4    McIntyre, T.M.5
  • 63
    • 13644257646 scopus 로고    scopus 로고
    • PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: Indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist
    • Bishop-Bailey D and Warner TD: PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist. FASEB J 17: 1925-1927, 2003.
    • (2003) FASEB J , vol.17 , pp. 1925-1927
    • Bishop-Bailey, D.1    Warner, T.D.2
  • 64
    • 0036166465 scopus 로고    scopus 로고
    • Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: Evidence for receptor antagonism
    • Kalajdzic T, Faour WH, He QW, Fahmi H, Martel-Pelletier J, Pelletier JP and Di Battista JA: Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism. Arthritis Rheum 46: 494-506, 2002.
    • (2002) Arthritis Rheum , vol.46 , pp. 494-506
    • Kalajdzic, T.1    Faour, W.H.2    He, Q.W.3    Fahmi, H.4    Martel-Pelletier, J.5    Pelletier, J.P.6    Di Battista, J.A.7
  • 65
    • 36148937876 scopus 로고    scopus 로고
    • 15-Deoxy-delta 12,14-prostaglandin J2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes
    • Lee JH, Yu SM, Yoon EK, Lee WK, Jung JC and Kim SJ: 15-Deoxy-delta 12,14-prostaglandin J2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes. J Korean Med Sci 22: 891-897, 2007.
    • (2007) J Korean Med Sci , vol.22 , pp. 891-897
    • Lee, J.H.1    Yu, S.M.2    Yoon, E.K.3    Lee, W.K.4    Jung, J.C.5    Kim, S.J.6
  • 66
    • 21644449708 scopus 로고    scopus 로고
    • Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: Evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma)
    • Patel KM, Wright KL, Whittaker P, Chakravarty P, Watson ML and Ward SG: Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma). Cell Signal 17: 1098-1110, 2005.
    • (2005) Cell Signal , vol.17 , pp. 1098-1110
    • Patel, K.M.1    Wright, K.L.2    Whittaker, P.3    Chakravarty, P.4    Watson, M.L.5    Ward, S.G.6
  • 68
    • 0037438456 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: Role of peroxisome proliferator-activated receptors
    • Pang L, Nie M, Corbett L and Knox AJ: Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors. J Immunol 170: 1043-1051, 2003.
    • (2003) J Immunol , vol.170 , pp. 1043-1051
    • Pang, L.1    Nie, M.2    Corbett, L.3    Knox, A.J.4
  • 69
    • 51449118364 scopus 로고    scopus 로고
    • 15-Deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation
    • Ulivi V, Cancedda R and Cancedda FD: 15-Deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: involvement of COX-2 in resolution of inflammation. J Cell Physiol 217: 433-441, 2008.
    • (2008) J Cell Physiol , vol.217 , pp. 433-441
    • Ulivi, V.1
  • 70
    • 10644230914 scopus 로고    scopus 로고
    • Neurotoxic prostaglandin J2 enhances cyclooxygenase-2 expression in neuronal cells through the p38MAPK pathway: A death wish?
    • Li Z, Jansen M, Ogburn K, Salvatierra L, Hunter L, Mathew S and Figueiredo-Pereira ME: Neurotoxic prostaglandin J2 enhances cyclooxygenase-2 expression in neuronal cells through the p38MAPK pathway: a death wish? J Neurosci Res 78: 824-836, 2004.
    • (2004) J Neurosci Res , vol.78 , pp. 824-836
    • Li, Z.1    Jansen, M.2    Ogburn, K.3    Salvatierra, L.4    Hunter, L.5    Mathew, S.6    Figueiredo-Pereira, M.E.7
  • 71
    • 46949093659 scopus 로고    scopus 로고
    • P38/NF -κB-dependent expression of COX-2 during differentiation and inflammatory response of chondrocytes
    • Ulivi V, Giannoni P, Gentili C, Cancedda R and Descalzi F: p38/NF -κB-dependent expression of COX-2 during differentiation and inflammatory response of chondrocytes. J Cell Biochem 104: 1393-1406, 2008.
    • (2008) J Cell Biochem , vol.104 , pp. 1393-1406
    • Ulivi, V.1    Giannoni, P.2    Gentili, C.3    Cancedda, R.4    Descalzi, F.5
  • 73
    • 0034623141 scopus 로고    scopus 로고
    • Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways
    • Paik JH, Ju JH, Lee JY, Boudreau MD and Hwang DH: Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. J Biol Chem 275: 28173-28179, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 28173-28179
    • Paik, J.H.1    Ju, J.H.2    Lee, J.Y.3    Boudreau, M.D.4    Hwang, D.H.5
  • 75
    • 33846651029 scopus 로고    scopus 로고
    • Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro
    • Liu JJ, Liu PQ, Lin DJ, Xiao RZ, Huang M, Li XD, He Y and Huang RW: Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. Ann Hematol 86: 173-183, 2007.
    • (2007) Ann Hematol , vol.86 , pp. 173-183
    • Liu, J.J.1    Liu, P.Q.2    Lin, D.J.3    Xiao, R.Z.4    Huang, M.5    Li, X.D.6    He, Y.7    Huang, R.W.8
  • 76
    • 34547843701 scopus 로고    scopus 로고
    • Ciglitazone mediates COX-2 dependent suppression of PGE2 in human non-small cell lung cancer cells
    • Hazra S and Dubinett SM: Ciglitazone mediates COX-2 dependent suppression of PGE2 in human non-small cell lung cancer cells. Prostaglandins Leukot Essent Fatty Acids 77: 51-58, 2007.
    • (2007) Prostaglandins Leukot Essent Fatty Acids , vol.77 , pp. 51-58
    • Hazra, S.1    Dubinett, S.M.2
  • 77
    • 40849140987 scopus 로고    scopus 로고
    • Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB
    • Bren-Mattison Y, Meyer AM, van Putten V, Li H, Kuhn K, Stearman R, Weiser-Evans M, Winn RA, Heasley LE and Nemenoff RA: Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB. Mol Pharmacol 73: 709-717, 2008.
    • (2008) Mol Pharmacol , vol.73 , pp. 709-717
    • Bren-Mattison, Y.1    Meyer, A.M.2    van Putten, V.3    Li, H.4    Kuhn, K.5    Stearman, R.6    Weiser-Evans, M.7    Winn, R.A.8    Heasley, L.E.9    Nemenoff, R.A.10
  • 78
    • 0034711185 scopus 로고    scopus 로고
    • Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators
    • Delerive P, Gervois P, Fruchart JC and Staels B: Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators. J Biol Chem 275: 36703-36707, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 36703-36707
    • Delerive, P.1    Gervois, P.2    Fruchart, J.C.3    Staels, B.4
  • 79
    • 33646524699 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and inflammation
    • Moraes LA, Piqueras L and Bishop-Bailey D: Peroxisome proliferator-activated receptors and inflammation. Pharmacol Ther 110: 371-385, 2006.
    • (2006) Pharmacol Ther , vol.110 , pp. 371-385
    • Moraes, L.A.1    Piqueras, L.2    Bishop-Bailey, D.3
  • 80
    • 43549100859 scopus 로고    scopus 로고
    • A gut feeling of the PXR, PPAR and NF-κB connection
    • Wahli W: A gut feeling of the PXR, PPAR and NF-κB connection. J Intern Med 263: 613-619, 2008.
    • (2008) J Intern Med , vol.263 , pp. 613-619
    • Wahli, W.1
  • 81
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
    • Ricote M, Li AC, Willson TM, Kelly CJ and Glass CK: The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391: 79-82, 1998.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 82
    • 0034610759 scopus 로고    scopus 로고
    • Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase
    • Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M and Santoro MG: Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature 403: 103-108, 2000.
    • (2000) Nature , vol.403 , pp. 103-108
    • Rossi, A.1    Kapahi, P.2    Natoli, G.3    Takahashi, T.4    Chen, Y.5    Karin, M.6    Santoro, M.G.7
  • 83
    • 23844555532 scopus 로고    scopus 로고
    • Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFκB signal disruption in human WISH and amnion cells
    • Ackerman WE, Zhang XL, Rovin BH and Kniss DA: Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFκB signal disruption in human WISH and amnion cells. Biol Reprod 73: 527-535, 2005.
    • (2005) Biol Reprod , vol.73 , pp. 527-535
    • Ackerman, W.E.1    Zhang, X.L.2    Rovin, B.H.3    Kniss, D.A.4
  • 85
    • 0036618210 scopus 로고    scopus 로고
    • Chemoprevention of breast cancer by targeting cyclooxygenase-2 and peroxisome proliferator-activated receptor-γ
    • Badawi AF and Badr MZ: Chemoprevention of breast cancer by targeting cyclooxygenase-2 and peroxisome proliferator-activated receptor-γ. Int J Oncol 20: 1109-1122, 2002.
    • (2002) Int J Oncol , vol.20 , pp. 1109-1122
    • Badawi, A.F.1    Badr, M.Z.2
  • 86
    • 0842301044 scopus 로고    scopus 로고
    • Inhibition of cyclo-oxygenase-2 and activation of peroxisome proliferator-activated receptor-γ synergistically induces apoptosis and inhibits growth of human breast cancer cells
    • Michael MS, Badr MZ and Badawi AF: Inhibition of cyclo-oxygenase-2 and activation of peroxisome proliferator-activated receptor-γ synergistically induces apoptosis and inhibits growth of human breast cancer cells. Int J Mol Med 11: 733-736, 2003.
    • (2003) Int J Mol Med , vol.11 , pp. 733-736
    • Michael, M.S.1    Badr, M.Z.2    Badawi, A.F.3
  • 87
    • 0842347429 scopus 로고    scopus 로고
    • Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma
    • Badawi AF, Eldeen MB, Liu Y, Ross EA and Badr MZ: Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma. Cancer Res 64: 1181-1189, 2004.
    • (2004) Cancer Res , vol.64 , pp. 1181-1189
    • Badawi, A.F.1    Eldeen, M.B.2    Liu, Y.3    Ross, E.A.4    Badr, M.Z.5
  • 88
    • 51049119421 scopus 로고    scopus 로고
    • Suppression of tumor formation by a cyclooxygenase-2 inhibitor and a peroxisome proliferator-activated receptor gamma agonist in an in vivo mouse model of spontaneous breast cancer
    • Mustafa A and Kruger WD: Suppression of tumor formation by a cyclooxygenase-2 inhibitor and a peroxisome proliferator-activated receptor gamma agonist in an in vivo mouse model of spontaneous breast cancer. Clin Cancer Res 14: 4935-4942, 2008.
    • (2008) Clin Cancer Res , vol.14 , pp. 4935-4942
    • Mustafa, A.1    Kruger, W.D.2
  • 89
    • 59349085139 scopus 로고    scopus 로고
    • Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells
    • Sun WH, Chen GS, Ou XL, Yang Y, Luo C, Zhang Y, Shao Y, Xu HC, Xiao B, Xue YP, Zhou SM, Zhao QS and Ding GX: Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells. Cancer Lett 275: 247-255, 2009.
    • (2009) Cancer Lett , vol.275 , pp. 247-255
    • Sun, W.H.1    Chen, G.S.2    Ou, X.L.3    Yang, Y.4    Luo, C.5    Zhang, Y.6    Shao, Y.7    Xu, H.C.8    Xiao, B.9    Xue, Y.P.10    Zhou, S.M.11    Zhao, Q.S.12    Ding, G.X.13
  • 90
    • 20344399923 scopus 로고    scopus 로고
    • A combination of docosahexaenoic acid and celecoxib prevents prostate cancer cell growth in vitro and is associated with modulation of nuclear factor-κB, and steroid hormone receptors
    • Narayanan NK, Narayanan BA and Reddy BS: A combination of docosahexaenoic acid and celecoxib prevents prostate cancer cell growth in vitro and is associated with modulation of nuclear factor-κB, and steroid hormone receptors. Int J Oncol 26: 785-792, 2005.
    • (2005) Int J Oncol , vol.26 , pp. 785-792
    • Narayanan, N.K.1    Narayanan, B.A.2    Reddy, B.S.3


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