Nonsteroidal anti-inflammatory drugs induce apoptosis in association with activation of peroxisome proliferator-activated receptor γ in rheumatoid synovial cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 1, 2002, Pages 18-25

  Yamazaki, Ryuta ^a   Kusunoki, Natsuko ^b   Matsuzaki, Takeshi ^b   Hashimoto, Shusuke ^a   Kawai, Shinichi ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; DNA FRAGMENT; INDOMETACIN; KETOPROFEN; MESSENGER RNA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; OXAPROZIN; PARACETAMOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TROGLITAZONE; ZALTOPROFEN;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; GENE EXPRESSION; HUMAN; HUMAN CELL; NICK END LABELING; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SYNOVIOCYTE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; ARTHRITIS, RHEUMATOID; BIOTRANSFORMATION; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DNA FRAGMENTATION; HUMANS; IN SITU NICK-END LABELING; ISOENZYMES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNOVIAL MEMBRANE; TRANSCRIPTION FACTORS;

EID: 0036082592     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.302.1.18     Document Type: Article

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