Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1β-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 79, Issue 1-2, 2008, Pages 59-65

  Kawashima, Akiko ^a   Harada, Tsuyoshi ^a   Imada, Kazunori ^a   Yano, Takashi ^a   Mizuguchi, Kiyoshi ^a  

^a MOCHIDA PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY 12,14 PROSTAGLANDIN J2; CIGLITAZONE; ICOSAPENTAENOIC ACID; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ANTAGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PROSTAGLANDIN J2; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CELL LINE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEGENERATIVE DISEASE; DOWN REGULATION; DRUG INHIBITION; DRUG MECHANISM; GLIOMA CELL; NONHUMAN; PRIORITY JOURNAL;

ANILIDES; ANIMALS; BENZAMIDES; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSAPENTAENOIC ACID; ENZYME-LINKED IMMUNOSORBENT ASSAY; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FATTY ACIDS, UNSATURATED; GLIOMA; INDOLES; INTERLEUKIN-1BETA; INTERLEUKIN-6; MICE; PPAR GAMMA; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES; TUMOR CELLS, CULTURED;

EID: 51449085113     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plefa.2008.07.002     Document Type: Article

References (35)

1. James M.J., Gibson R.A., and Cleland L.G. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am. J. Clin. Nutr. 71 (2000) 343S-348S
2. Meydani S.N., Endres S., Woods M.M., et al. Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women. J. Nutr. 121 (1991) 547-555
3. Kremer J.M., Lawrence D.A., Jubiz W., et al. Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects. Arthritis Rheum. 33 (1990) 810-820
4. Simopoulos A.P. Omega-3 fatty acids in inflammation and autoimmune diseases. J. Am. Coll. Nutr. 21 (2002) 495-505
5. Donadio J.V., and Grande J.P. The role of fish oil/omega-3 fatty acids in the treatment of IgA nephropathy. Semin. Nephrol. 24 (2004) 225-243
6. Simi A., Tsakiri N., Wang P., and Rothwell N.J. Interleukin-1 and inflammatory neurodegeneration. Biochem. Soc. Trans. 35 (2007) 1122-1126
7. Huell M., Strauss S., Volk B., Berger M., and Bauer J. Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients. Acta Neuropathol. 89 (1995) 544-551
8. Gadient R.A., and Otten U.H. Interleukin-6 (IL-6)-a molecule with both beneficial and destructive potentials. Prog. Neurobiol. 52 (1997) 379-390
9. Van Wagoner N.J., and Benveniste E.N. Interleukin-6 expression and regulation in astrocytes. J. Neuroimmunol. 100 (1999) 124-139
10. Lynch A.M., Loane D.J., Minogue A.M., et al. Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus. Neurobiol. Aging 28 (2007) 845-855
11. Willson T.M., Brown P.J., Sternbach D.D., and Henke B.R. The PPARs: from orphan receptors to drug discovery. J. Med. Chem. 43 (2000) 527-550
12. Kapadia R., Yi J.H., and Vemuganti R. Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists. Front. Biosci. 13 (2008) 1813-1826
13. Perez-Ortiz J.M., Tranque P., Vaquero C.F., et al. Glitazones differentially regulate primary astrocyte and glioma cell survival. Involvement of reactive oxygen species and peroxisome proliferator-activated receptor-gamma. J. Biol. Chem. 279 (2004) 8976-8985
14. Zumwalt J.W., Thunstrom B.J., and Spangelo B.L. Interleukin-1beta and catecholamines synergistically stimulate interleukin-6 release from rat C6 glioma cells in vitro: a potential role for lysophosphatidylcholine. Endocrinology 140 (1999) 888-896
15. Shirota T., Haji S., Yamasaki M., et al. Apoptosis in human pancreatic cancer cells induced by eicosapentaenoic acid. Nutrition 21 (2005) 1010-1017
16. Krey G., Braissant O., L'Horset F., et al. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol. 11 (1997) 779-791
17. Combs C.K., Johnson D.E., Karlo J.C., Cannady S.B., and Landreth G.E. Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J. Neurosci. 20 (2000) 558-567
18. Zhao G., Etherton T.D., Martin K.R., et al. Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. Biochem. Biophys. Res. Commun. 336 (2005) 909-917
19. Staels B., Koenig W., Habib A., et al. Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators. Nature 393 (1998) 790-793
20. Zhao Y., Joshi-Barve S., Barve S., and Chen L.H. Eicosapentaenoic acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation. J. Am. Coll. Nutr. 23 (2004) 71-78
21. De Smedt-Peyrusse V., Sargueil F., Moranis A., Harizi H., Mongrand S., and Laye S. Docosahexaenoic acid prevents LPS-induced cytokine production in microglial cells by inhibiting LPS receptor presentation but not its membrane subdomain localization. J. Neurochem. (2008)
22. Kavanagh T., Lonergan P.E., and Lynch M.A. Eicosapentaenoic acid and gamma-linolenic acid increase hippocampal concentrations of IL-4 and IL-10 and abrogate lipopolysaccharide-induced inhibition of long-term potentiation. Prostaglandins Leukot. Essent. Fatty Acids 70 (2004) 391-397
23. Minogue A.M., Lynch A.M., Loane D.J., Herron C.E., and Lynch M.A. Modulation of amyloid-beta-induced and age-associated changes in rat hippocampus by eicosapentaenoic acid. J. Neurochem. 103 (2007) 914-926
24. Xu H.E., Lambert M.H., Montana V.G., et al. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol. Cell 3 (1999) 397-403
25. Finnen M.J., and Lovell C.R. Purification and characterisation of phospholipase A2 from human epidermis. Biochem. Soc. Trans. 19 (1991) 91S
26. Song C., Li X., Kang Z., and Kadotomi Y. Omega-3 fatty acid ethyl-eicosapentaenoate attenuates IL-1beta-induced changes in dopamine and metabolites in the shell of the nucleus accumbens: involved with PLA2 activity and corticosterone secretion. Neuropsychopharmacology 32 (2007) 736-744
27. Bernardo A., and Minghetti L. PPAR-gamma agonists as regulators of microglial activation and brain inflammation. Curr. Pharm. Des. 12 (2006) 93-109
28. Feige J.N., Gelman L., Michalik L., Desvergne B., and Wahli W. From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog. Lipid Res. 45 (2006) 120-159
29. Vanden Berghe W., De Bosscher K., Boone E., Plaisance S., and Haegeman G. The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter. J. Biol. Chem. 274 (1999) 32091-32098
30. Takata Y., Kitami Y., Yang Z.H., Nakamura M., Okura T., and Hiwada K. Vascular inflammation is negatively autoregulated by interaction between CCAAT/enhancer-binding protein-delta and peroxisome proliferator-activated receptor-gamma. Circ. Res. 91 (2002) 427-433
31. Wang L.H., Yang X.Y., Zhang X., et al. Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells. Immunity 20 (2004) 205-218
32. Kelly D., Campbell J.I., King T.P., et al. Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat. Immunol. 5 (2004) 104-112
33. Li M., Pascual G., and Glass C.K. Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene. Mol. Cell Biol. 20 (2000) 4699-4707
34. Pascual G., Fong A.L., Ogawa S., et al. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature 437 (2005) 759-763
35. Wu Y., Chin W.W., Wang Y., and Burris T.P. Ligand and coactivator identity determines the requirement of the charge clamp for coactivation of the peroxisome proliferator-activated receptor gamma. J. Biol. Chem. 278 (2003) 8637-8644