Mechanisms of anti-proliferative effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on human liver cancer cells

Oncology Reports

Volumn 18, Issue 5, 2007, Pages 1281-1290

  Nagahara, Takakazu ^a   Okano, Jun Ichi ^a   Murawaki, Yoshikazu ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Hepatocellular carcinoma; JTE 522; PPAR ; Selective COX 2 inhibitor

Indexed keywords

4-(4-CYCLOHEXYL-2-METHYLOXAZOL-5-YL)-2-FLUOROBENZENESULFONAMIDE; BENZENESULFONIC ACID DERIVATIVE; CASPASE; CCNE1 PROTEIN, HUMAN; CYCLIN D; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; CYCLINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; OXAZOLE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN E2; PTGS2 PROTEIN, HUMAN; TILMACOXIB; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM;

APOPTOSIS; BENZENESULFONATES; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL PROLIFERATION; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLINS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; HUMANS; LIVER NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASES; ONCOGENE PROTEINS; OXAZOLES; PPAR GAMMA; TUMOR CELLS, CULTURED;

EID: 38449107339     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.18.5.1281     Document Type: Article

References (27)

1. Bosch FX, Ribes J and Borras J: Epidemiology of primary liver cancer. Semin Liver Dis 19: 271-285, 1999. (Pubitemid 29488770)
2. Okuda H: Hepatocellular carcinoma development in cirrhosis. Best Pract Res Clin Gastroenterol 21: 161-173, 2007.
3. Shiota G, Okubo M, Noumi T, et al: Cyclooxygenase-2 expression in hepatocellular carcinoma. Hepatogastroenterology 46: 407-412, 1999. (Pubitemid 29154786)
4. Leng J, Han C, Demetris AJ, Michalopoulos GK and Wu T: Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. Hepatology 38: 756-768, 2003. (Pubitemid 37052162)
5. Kern MA, Haugg AM, Koch AF, et al: Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. Cancer Res 66: 7059-7066, 2006. (Pubitemid 44197682)
6. Fodera D, D'Alessandro N, Cusimano A, et al: Induction of apoptosis and inhibition of cell growth in human hepatocellular carcinoma cells by COX-2 inhibitors. Ann NY Acad Sci 1028: 440-449, 2004. (Pubitemid 40361845)
7. Li J, Chen X, Dong X, Xu Z, Jiang H and Sun X: Specific COX-2 inhibitor, meloxicam, suppresses proliferation and induces apoptosis in human HepG2 hepatocellular carcinoma cells. J Gastroenterol Hepatol 21: 1814-1820, 2006. (Pubitemid 44657002)
8. Rahman MA, Dhar DK, Masunaga R, Yamanoi A, Kohno H and Nagasue N: Sulindac and exisulind exhibit a significant antiproliferative effect and induce apoptosis in human hepatocellular carcinoma cell lines. Cancer Res 60: 2085-2089, 2006.
9. Marquez-Rosado L, Trejo-Solis MC, Garcia-Cuellar CM and Villa-Trevino S: Celecoxib, a cyclooxygenase-2 inhibitor, prevents induction of liver preneoplastic lesions in rats. J Hepatol 43: 653-660, 2005. (Pubitemid 41253233)
10. Cervello M and Montalto G: Cyclooxygenases in hepatocellular carcinoma. World J Gastroenterol 12: 5113-5121, 2006. (Pubitemid 44355906)
11. Cheng J, Imanishi H, Amuro Y and Hada T: NS-398, a selective cyclooxygenase 2 inhibitor, inhibited cell growth and induced cell cycle arrest in human hepatocellular carcinoma cell lines. Int J Cancer 99: 755-761, 2002. (Pubitemid 34538759)
12. Matsumoto K, Okano J, Nagahara T and Murawaki Y: Apoptosis of liver cancer cells by vitamin K2 and enhancement by MEK inhibition. Int J Oncol 29: 1501-1518, 2006.
13. Tammali R, Ramana KV, Singhal SS, Awasthi S and Srivastava SK: Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells. Cancer Res 66: 9705-9713, 2006. (Pubitemid 44623671)
14. Chien PS, Mak OT and Huang HJ: Induction of COX-2 protein expression by vanadate in A549 human lung carcinoma cell line through EGF receptor and p38 MAPK-mediated pathway. Biochem Biophys Res Commun 339: 562-568, 2006.
15. Grosch S, Maier TJ, Schiffmann S and Geisslinger G: Cyclo-oxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors. J Natl Cancer Inst 98: 736-747, 2006. (Pubitemid 43983297)
16. Javelaud D and Mauviel A: Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis. Oncogene 24: 5742-5750, 2005. (Pubitemid 43086134)
17. Sun Y and Sinicrope FA: Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells. Mol Cancer Ther 4: 51-59, 2005. (Pubitemid 40268066)
18. Cui W, Yu CH and Hu KQ: In vitro and in vivo effects and mechanisms of celecoxib-induced growth inhibition of human hepatocellular carcinoma cells. Clin Cancer Res 11: 8213-8221, 2005. (Pubitemid 41698767)
19. Araki Y, Okamura S, Hussain SP, et al: Regulation of cyclo-oxygenase-2 expression by the Wnt and Ras pathways. Cancer Res 63: 728-734, 2003. (Pubitemid 36158154)
20. Thiel A, Heinonen M, Rintahaka J, et al: Expression of cyclo-oxygenase-2 is regulated by glycogen synthase kinase-3 beta in gastric cancer cells. J Biol Chem 281: 4564-4569, 2006. (Pubitemid 43847714)
21. Pang RP, Zhou JG, Zeng ZR, et al: Celecoxib induces apoptosis in COX-2 deficient human gastric cancer cells through Akt/GSK3beta/NAG-1 pathway. Cancer Lett 251: 268-277, 2007.
22. Koeffler HP: Peroxisome proliferator-activated receptor gamma and cancers. Clin Cancer Res 9: 1-9, 2003.
23. Yu J, Qiao L, Zimmermann L, et al: Troglitazone inhibits tumor growth in hepatocellular carcinoma in vitro and in vivo. Hepatology 43: 134-143, 2006. (Pubitemid 43733600)
24. Xu L, Han C, Lim K and Wu T: Cross-talk between peroxisome proliferator-activated receptor delta and cytosolic phospholipase A(2)alpha/cyclooxygenase-2/prostaglandin E(2) signaling pathways in human hepatocellular carcinoma cells. Cancer Res 66: 11859-11868, 2006. (Pubitemid 46094198)
25. McClure TD, Young ME, Taegtmeyer H, et al: Thyroid hormone interacts with PPARalpha and PGC-1 during mitochondrial maturation in sheep heart. Am J Physiol Heart Circ Physiol 289: H2258-H2264, 2005. (Pubitemid 41507381)
26. Sterchele PF, Sun H, Peterson RE and Vanden Heuvel JP: Regulation of peroxisome proliferator-activated receptor-alpha mRNA in rat liver. Arch Biochem Biophys 326: 281-289, 1996. (Pubitemid 26060145)
27. Chang HC and Weng CF: Cyclooxygenase-2 level and culture conditions influence NS398-induced apoptosis and caspase activation in lung cancer cells. Oncol Rep 8: 1321-1325, 2001.