Amyloid peptide pores and the beta sheet conformation

Advances in Experimental Medicine and Biology

Volumn 677, Issue , 2010, Pages 150-167

  Kagan, Bruce L ^a   Thundimadathil, Jyothi ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA HEMOLYSIN; ALPHA LATROTOXIN; ALPHA SYNUCLEIN; AMYLIN; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ANDROGEN RECEPTOR; ANTHRAX TOXIN; APOLIPOPROTEIN A1; ATRIAL NATRIURETIC FACTOR; BACTERIAL TOXIN; BETA 2 MICROGLOBULIN; CALCITONIN; COPPER ZINC SUPEROXIDE DISMUTASE; FIBRINOGEN; GELSOLIN; HUNTINGTIN; LYSOZYME; MONELLIN; PERFRINGOLYSIN; POLYGLUTAMINE; PREALBUMIN; PRION PROTEIN; SERUM AMYLOID A; STEFIN B; TATA BINDING PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG; AMYLOID; MEMBRANE PROTEIN; PEPTIDE;

ALPHA HELIX; AMYLOIDOSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; BETA SHEET; CHANNEL GATING; CYTOTOXICITY; ION CONDUCTANCE; NONHUMAN; OLIGOMERIZATION; PHOSPHOLIPID MEMBRANE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; X RAY DIFFRACTION; ANIMAL; CELL MEMBRANE; CHEMISTRY; HUMAN; LIPID BILAYER; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; REVIEW;

AMYLOID; AMYLOIDOSIS; ANIMALS; BACTERIAL TOXINS; CELL MEMBRANE; HUMANS; LIPID BILAYERS; MEMBRANE PROTEINS; PEPTIDES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 77955862738     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-6327-7_13     Document Type: Article

References (97)

1. Sipe JD, Cohen AS. Review: history of the amyloid fibril. J Struct Biol 2000; 130:88-98.
2. Anguiano M, Nowak RJ, Lansbury PT. Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes. Biochemistry 2002; 41:11338-11343.
3. Hirakura Y, Kagan BL. Pore formation by beta-2-microglobulin: a mechanism for the pathogenesis of dialysis associated amyloidosis. Amyloid 2001; 8:94-100. (Pubitemid 32522152)
4. Sipe JD. Serum amyloid A: from fibril to function. Current status. Amyloid 2000; 7:10-12. (Pubitemid 30317619)
5. Kourie JI, Hanna EA, Henry CL. Properties and modulation of alpha human atrial natriuretic peptide (alpha-hANP)-formed ion channels. Can J Physiol Pharmacol 2001; 79:654-64. (Pubitemid 32745032)
6. Hirakura Y, Azimov R, Azimova R et al. Polyglutamine-induced ion channels: a possible mechanism for the neurotoxicity of huntington and other CAG repeat diseases. J Neurosci Res, 2000; 60:490-494. (Pubitemid 30252911)
7. Hirakura Y, Azimov R, Azimova R et al. Ion channels with different selectivity formed by transthyretin. Biophys J 2001; 80:120a.
8. Azimova RK, Kagan BL. Ion channels formed by a fragment of alpha-synucleain (NAC) in lipid membranes. Biophs J 2003; 84:53a.
9. Hirakura Y, Carreras I, Sipe JD et al. Channel formation by serum amyloid A: a potential mechanism for amyloid pathogenesis and host defense. Amyloid 2002; 9:13-23. (Pubitemid 34242332)
10. Stipani V, Galluci E, Micelli S et al. Channel formation by salmon and human calcitonin in black lipid membranes. Biophys J 2001; 81:3332-3338. (Pubitemid 33111480)
11. Malisauskas M, Zamotin V, Jass J et al. Amyloid protofilaments from the calcium-binding protein equine lysozyme: formation of ring and linear structures depends on pH and metal ion concentration. J Mol Biol 2003; 330:879-890.
12. Bahadi R, Farrelly PV, Kenna BL et al. Channels formed with a mutant prion protein PrP(82-146) homologous to a 7-kDa fragment in diseased brain of GSS patients. Am J Physiol Cell Physiol 2003; 285:C862-872. (Pubitemid 37158811)
13. Quist A, Doudevski J, Lin H et al. Amyloid ion channels: a common structural link for protein-misfolding disease. Proc Natl Acad Sci USA 2005; 102:10427-10432. (Pubitemid 41061570)
14. Pieri L, Bucciantini M, Guasti P et al. Synthetic lipid vesicles recruit native-like aggregates and affect the aggregation process of the prion Ure2p: Insights on vesicle permeabilization and charge selectivity. Biophys J 2009; 96:3319-3330.
15. Canale C, Torrassa S, Rispoli P et al. A. Natively folded HypF-N and its early amyloid aggregates interact with phospholipid monolayers and destabilize supported phospholipid bilayers. Biophys J 2006; 91:4575-4588. (Pubitemid 44904242)
16. Ceru S, Kokalj SJ, Rabzelj S et al. Size and morphology of toxic oligomers of amyloidogenic proteins: a case study of human stefin B. Amyloid 2008; 15:147-159.
17. Hawkins PN, Richardson S, MacSweeney JE et al. Scintigraphic quantification and serial monitoring of human visceral amyloid deposits provide evidence for turnover and regression. Q J Med 1993; 86:365-374. (Pubitemid 23197326)
18. Hardy J, Alsop D. Amyloid deposition as the central event in the etiology of Alzheimer's disease. Trends Pharmacol 1991; 12:383-388.
19. Samaia HB, Mari JJ, Vallada HP et al. A prion-linked psychiatric disorder. Nature 1997; 20; 390:241.
20. Forloni G, Angeretti N, Chiesa R et al. Neurotoxicity of a prion fragment. Nature 1993; 362:543-546.
21. Lorenzo A, Razzaboni B, Weir GC et al. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 1994; 368:756-760. (Pubitemid 24153418)
22. Pike CJ, Burdick D, Walencewicz AJ et al. Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci 1993; 13:1676-1687. (Pubitemid 23095409)
23. Harper JD, Lansbury PT. Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. Ann Rev of Biochem 1997; 66:385-407. (Pubitemid 27274662)
24. Hirakura Y, Satoh Y, Hirashima N et al. Membrane perturbation by the neurotoxic Alzheimer amyloid fragment beta 25-35 requires aggregation and beta-sheet formation. Biochem Mol Biol Int 1998; 46:787-794. (Pubitemid 28537697)
25. Lesne S, Koh MT, Kotilinek L et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006; 440:352-357.
26. Walsh DM, Klyubin I, Fadeeva JV et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002; 416:535-539. (Pubitemid 34288854)
27. Lin H, Bhatia R et al. Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology. Faseb J 2001; 15:2433-2444. (Pubitemid 33063171)
28. Janson J, Ashley RH, Harrison D et al The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. Diabetes 1999; 48:491-498. (Pubitemid 29106861)
29. Lashuel HA, Petre BM, Wall J et al. Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. J Mol Biol 2002; 322:1089-1102. (Pubitemid 35266514)
30. Kayed R, Head E, Thompson JL et al. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 2003; 300:486-489. (Pubitemid 36444329)
31. Kagan BL, Azimov R, Azimova R. Amyloid peptide channels. J Membr Biol 2004; 202:1-10. (Pubitemid 40298660)
32. Capone R, Garcia-Quinn F, Prangkio R et al. Amyloid beta ion channels in artificial lipid bilayer and neuronal cells. Neurotoxicity Res 2009 (in press).
33. Fernandez A, Berry RS. Proteins with H-bond packing defects are highly interactive with lipid bilayers: Implications for amyloidogenesis. Proc Natl Acad Sci USA 2003; 100:2391-2396. (Pubitemid 36297509)
34. Stefani M, Dobson CM. Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution. J Mol Med 2003; 81:678-699. (Pubitemid 37491594)
35. McLaurin J, Chakrabartty A. Characterization of the interactions of Alzheimer beta-amyloid peptides with phospholipid membranes. Eur J Biochem 1997; 245:355-363. (Pubitemid 27171258)
36. Wong PT, Schauerte JA, Wisser KC et al. Amyloid-beta membrane binding and permeabilization are distinct processes influenced separately by membrane charge and fluidity. J Mol Biol 2009; 386:81-96.
37. Hirakura Y, Lin MC, Kagan BL. Alzheimer amyloid abeta1-42 channels: effects of solvent, pH and Congo Red. J Neurosci Res 1999; 57:458-466. (Pubitemid 29372920)
38. Terzi E, Holzamann G, Seelig J. Interaction of Alzheimer beta-amyloid peptide (1-40) with lipid membranes. J Mol Biochem 1997; 36:14845-14852. (Pubitemid 27524407)
39. Boqvist M, Lindstrom F, Watts A et al. Two types of Alzheimer's beta-amyloid (1-40) peptide membrane interaction aggregation preventing transmembrane anchoring versus accelerated fibril formation. J Mol Biol 2004; 335:1039-1049. (Pubitemid 38091609)
40. Alarcon JM, Brito JA, Hermosilla T et al. Ion channel formation by Alzheimer's disease amyloid beta-peptide (Abeta40) in unilameilar liposomes is determined by amionic phospholipds. Peptides 2006; 27:365-363.
41. Hertel C, Terzi E et al. Inhibition of the electrostatic interaction between beta-amyloid peptide and membranes prevents beta-amyloid-induced toxicity. Proc Natl Acad Sci USA 1997; 94:9412-9416. (Pubitemid 27357843)
42. Lau TL, Ambroggio EE et al. Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions. J Mol Biol 2006; 356:759-770. (Pubitemid 43139335)
43. Durell SR, Guy HR, Arispe N et al. Theoretical models of the ion channel structure of amyloid beta-protein. Biophy J 1994; 67:2137-2145. (Pubitemid 24369639)
44. Jang H, Ma B, Lal R et al. Models of toxic beta-sheet channels of protegrin-1 suggest a common subunit organization motif shared with toxic Alzheimer beta-amyloid ion channels. Biophys J 2008; 95:4631-4642.
45. Lee G, Pollard HB, Arispe N. Annexin 5 and apolipoprotein against Alzheimer's amyloid beta-peptide cytoxicity by competitive inhibition of a common phosphatadylserine receptor site. Peptides 2002; 23:1249-1263. (Pubitemid 34786704)
46. Kakio A, Nishimoto S, Yanagisawa K et al. Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid. Biochemistry 2002; 41:7385-7390. (Pubitemid 34602456)
47. Yanagisawa K. Role of gangliosides in Alzheimer's disease. Biochim Biophys Acta 2007; 1768:1943-1951. (Pubitemid 47125848)
48. Yanagisawa K, Odaka A, Suzuki N et al. GM1 ganglioside-bound amyloid beta-protein (A-beta): a possible form of preamyloid in Alzheimer's disease. Nat Med 1995; 1:1062-1066.
49. Arispe N, Doh M. Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AbetaP (1-40) and (1-42) peptides. FASEB J 2002; 16:1526-1536. (Pubitemid 35154635)
50. Westermark P, Wilander E. The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus. Diabetologia 1978; 15:417-421. (Pubitemid 9046993)
51. Mirzabekov TA, Lin MC, Kagan BL. Pore formation by the cytotoxic islet amyloid peptide amylin. J Biol Chem 1996; 271:1988-1992. (Pubitemid 26047780)
52. Sakagashira S, Hiddinga HJ, Tateishi K et al. S20G mutant amylin exhibits increased in vitro amyloidogenicity and increased intracellular cytotoxicity compared to wild-type-amylin. Am J Pathol 2000; 157:2101-2109.
53. Jayasinghe SA, Langen R. Membrane interaction of islet amyloid polypeptide. Biochim Biophys Acta 2007; 1768:2002-2009. (Pubitemid 47125849)
54. Knight JD, Miranker AD. Phospholipid catalysis of diabetic amyloid assembly. J Mol Biol 2004; 341:1175-1187. (Pubitemid 39099208)
55. Knight JD, Hebda JA, Miranker AD. Conserved and cooperative assembly of membrane-bound alpha-helical states of islet amyloid polypeptide. Biochem 2006; 45:9496-9508. (Pubitemid 44223253)
56. Jayasinghe SA, Langen R. Lipid membranes modulate the structure of islet amyloid polypeptide. Biochemistry 2005; 45:12113-12119. (Pubitemid 41285709)
57. Sparr F, Engel MF, Sakharov DV et al. Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers. FEBS Lett 2004; 577:117-120. (Pubitemid 39452370)
58. Kayed J, Bernhagen N, Greenfield K et al. Conformational transmissions of islet amyloid polypeptide. (IAPP) in amyloid formation in vitro. J Mol Biol 1999; 287:781-796.
59. DeArmond SJ, Prusiner SB. Perspectives on prion biology, prion disease pathogenesis and pharmacologic approaches to treatment. Clin Lab Med 2003; 23:1-41. (Pubitemid 36514038)
60. Lin MC, Mirzebekov T, Kagan BL. Channel formation by a neurotoxic prion protein fragment. J Biol Chem 1997; 272:44-47. (Pubitemid 27021122)
61. Pan KM, Baldwin M, Nguyen J et al. Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc Natl Acad Sci USA 1993; 90:10962-10966.
62. Kazlauskaite J, Sanghera N, Sylvester I et al. Structural changes of the prion protein in lipid membranes leading to aggregation and fibrillization. Biochemistry 2003; 42:3295-3304. (Pubitemid 36348638)
63. Bahadi R, Farrelly PV, Kenna BL et al. Channels formed with a mutant prion protein PrP(82-146) homologous to a 7-kDa fragment in diseased brain of GSS patients. Am J Physiol Cell Physiol 2003b; 285:C862-872. (Pubitemid 37158811)
64. Volles MJ, Lansbury PT. Vesicle permeabilization by protofibrillar AS is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism. Biochemistry 2002; 41:4595-4602. (Pubitemid 34275660)
65. Zakharov SD, Hulleman JD, Dutseva EA et al. Helical alpha-synuclein forms highly conductive ion channels. Biochemistry 2007; 46:14369-14379. (Pubitemid 350276345)
66. Arispe N. Architecture of the Alzheimers AβP ion channel pore. J Membrane Biol 2004; 197:33-48. (Pubitemid 38221961)
67. Schutz GE. The structure of bacteria: outer membrane proteins. Biochim Biophys Acta 2002; 1565:308-317.
68. Benz R, Schmid A, Hancock RW. Ion selectivity of gram-negative bacterial porins. J Bacteriol 1983; 153:241-252.
69. Hill K, Model K, Ryan MT et al. Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins. Nature 1998; 395:516-521. (Pubitemid 28462448)
70. Schleiff E, Soll J, Kuchler M et al. Characterization of the translocon of the outer envelope of choloroplasts. J Cell Biol 2003; 160:541-551. (Pubitemid 36254392)
71. Wimley WC. The versatile β-barrel membrane protein. Curr Opin Struct Biol 2003; 13:404-411.
72. Song L, Hobaugh MR, Shustak C et al. Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore. Science 1996; 274:1859-1866. (Pubitemid 26424757)
73. Sekiya K, Satoh R, Danbara H et al. A ring-shaped structure with a crown formed by streptolysin O on the erythrocyte membrane. J Bacteriol 1993; 175:5953-5961. (Pubitemid 23277444)
74. Olofsson A, Hebert, Thiestam M. The projection structure of perfringolysin O (Clostridium perfringens theta-toxin). FEBS Lett 1993; 319:125-127. (Pubitemid 23074283)
75. Sharpe JC, London E. Diptheria toxin forms pores of different sizes depending on its concentration in membranes: probable relationionship to oligomerization. J Membr Biol 1999; 171:209-221. (Pubitemid 29468332)
76. Tadjibaeva G, Sabirov R, Tomita T. Flammutoxin, a cytolysin from the edible mushroom Flammulina velutipes, forms two different types of voltage-gated channels in lipid bilayer membranes. Biochem Biophys Acta 2000; 1467:431-443. (Pubitemid 30665595)
77. CabiauxV, Wolff C, Ruysschaert JM. Interaction with a lipid membrane: a key step in bacterial toxins virulence. Int J Biol Macromol 1997; 21:285-298.
78. Thundimadathil J, Roeske RW, Guo L. A synthetic peptide forms voltage-gated porin-like ion channels in lipid bilayer membranes. Biochem Biophys Res Commun 2005; 330:585-590. (Pubitemid 40417685)
79. Conlan S, Zhang Y et al. Biochemical and biophysical characterization of OmpG: A monomeric porin Biochemistry 2000; 39:11845-11854.
80. Bainbridge G, Gokce I, Lakey JH. Voltage gating is a fundamental feature of porin and toxin β-barrel membrane channels. FEBS Lett 1998; 431:305-308. (Pubitemid 28352379)
81. Berrier C, Coulombe A et al. Fast and slow kinetics of porin channels from Escherichia coli reconstituted into giant liposomes and studied by patch-clamp. FEBS Lett 1992; 306:251-256.
82. Valeva A, Weisser A, Walker B et al. Molecular architecture of a toxin pore: a 15-residue sequence lines the transmembrane channel of staphylococcal alpha-toxin. EMBO J 1996; 15:1857-1864. (Pubitemid 26119691)
83. Thundimadathil J, Roeske RW et al. Aggregation and porin-like channel activity of a β-sheet peptide. Biochemistry 2005; 44:10259-10270. (Pubitemid 41076821)
84. Thundimadathil J, Roeske RW et al. Effect of membrane mimicking environment on the conformation of a pore forming (xSxG)6 peptide, Biopolymers. Peptide Science 2006; 84:317-328.
85. Mirzabekov T, Lin MC, Yuan WL et al. Channel formation in planar lipid bilayers by a neurotoxic fragment of the beta-amyloid peptide. Biochem Biophys Research Commun 1994; 202:1142-1148.
86. Lin MC, Kagan, BL. Electrophysiologic properties of channels induced by Abeta 25-26 in planar lipid bilayers. Peptides 2002; 23:1215-1228. (Pubitemid 34786701)
87. Arispe N, Rojas E, Pollard HB. Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum. Proc Natl Acad Sci USA 1993; 90:567-571. (Pubitemid 23028904)
88. Arispe N, Pollard HB, Rojas E. Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein (Abeta P(1-40)) in bilayer membraines. Proc Natl Acad Sci USA 1993; 90:10573-10577. (Pubitemid 23347084)
89. Lashuel HA, Hartley DM, Petre BM et al. Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores. J Mol Biol 2003; 332:795-808. (Pubitemid 37101368)
90. Kim HJ, Suh YH, Lee MH et al. Cation selective channels formed by a C-terminal fragment of beta-amyloid precursor protein. Neuroreport 1999; 10:1427-1431. (Pubitemid 29354324)
91. Kourie JI, Culverson A. Prion peptide fragment PrP(106-126) forms distinct cation channel types. Neurosci Res 2000; 62:120-133.
92. Wang L, Lashuel HA, Walz T et al. Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel. Proc Natl Acad Sci USA 2002; 99:15947-15952. (Pubitemid 35462729)
93. Kourie JI. Characterization of a C-type natriuretic peptide (CNP-39)-formed cation-selective channel from platypus (Omithorhynchus anatinus) venom. J Physiol 1999; 518:359-369. (Pubitemid 29366735)
94. Kourie JI. Synthetic mammalian C-type natriuretic peptide forms large cation channels. FEBS Lett 1999; 445:57-62. (Pubitemid 29101535)
95. Monoi H, Futaki S, Kugimiya S et al. Poly-L-glutamine forms cation channels: relevance to the pathogenesis of the polyglutamine diseases. Biophys J 2000; 78:2892-2894.
96. Ibrahim HR, Thomas U, Pellegrini A. A helix-loop-helix peptide at the upper lip of the active site cleft of lysozyme confers potent antimicrobial activity with membrane permeabilization action. J Biol Chem 2002; 276:43767-43774.
97. Chung J, Yang H, de Beus MD et al. Cu/Zn superoxide dismutase can form pore-like structures. Biochem Biophys Res Commun 2003; 312:873-876. (Pubitemid 37490898)