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Volumn 29, Issue 16, 2010, Pages 2689-2699

Spatial cycles in G-protein crowd control

Author keywords

intracellular signalling; reaction diffusion; spatial organization

Indexed keywords

CALCIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; PHOSPHOTRANSFERASE;

EID: 77955838654     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2010.184     Document Type: Review
Times cited : (20)

References (125)
  • 1
    • 1242274449 scopus 로고    scopus 로고
    • Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems
    • Angeli D, Ferrell JE, Sontag ED (2004) Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems. Proc Natl Acad Sci USA 101: 1822-1827
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1822-1827
    • Angeli, D.1    Ferrell, J.E.2    Sontag, E.D.3
  • 2
    • 0031865393 scopus 로고    scopus 로고
    • Mind the GAP, Rho, Rab and GDI
    • Antonarakis S, Van Aelst L (1998) Mind the GAP, Rho, Rab and GDI. Nat Genet 19: 106-108
    • (1998) Nat Genet , vol.19 , pp. 106-108
    • Antonarakis, S.1    Van Aelst, L.2
  • 3
    • 0034062812 scopus 로고    scopus 로고
    • H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway
    • Apolloni A, Prior IA, Lindsay M, Parton RG, Hancock JF (2000) H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Mol Cell Biol 20: 2475-2487
    • (2000) Mol Cell Biol , vol.20 , pp. 2475-2487
    • Apolloni, A.1    Prior, I.A.2    Lindsay, M.3    Parton, R.G.4    Hancock, J.F.5
  • 4
    • 25444517781 scopus 로고    scopus 로고
    • Ran-GTP regulates kinetochore attachment in somatic cells
    • Arnaoutov A, Dasso M (2005) Ran-GTP regulates kinetochore attachment in somatic cells. Cell Cycle 4: 1161-1165
    • (2005) Cell Cycle , vol.4 , pp. 1161-1165
    • Arnaoutov, A.1    Dasso, M.2
  • 5
    • 0036911347 scopus 로고    scopus 로고
    • Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos
    • Askjaer P, Galy V, Hannak E, Mattaj IW (2002) Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Mol Biol Cell 13: 4355-4370
    • (2002) Mol Biol Cell , vol.13 , pp. 4355-4370
    • Askjaer, P.1    Galy, V.2    Hannak, E.3    Mattaj, I.W.4
  • 6
    • 0037017395 scopus 로고    scopus 로고
    • Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells
    • Barbero P, Bittova L, Pfeffer SR (2002) Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells. J Cell Biol 156: 511-518
    • (2002) J Cell Biol , vol.156 , pp. 511-518
    • Barbero, P.1    Bittova, L.2    Pfeffer, S.R.3
  • 7
    • 0032883098 scopus 로고    scopus 로고
    • Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae
    • Bartels DJ, Mitchell DA, Dong X, Deschenes RJ (1999) Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae. Mol Cell Biol 19: 6775-6787
    • (1999) Mol Cell Biol , vol.19 , pp. 6775-6787
    • Bartels, D.J.1    Mitchell, D.A.2    Dong, X.3    Deschenes, R.J.4
  • 8
    • 38249002914 scopus 로고
    • Analysis of pattern formation in reaction diffusion models with spatially inhomogen-ous diffusion coefficients
    • Benson DL, Maini PK, Sherratt JA (1993) Analysis of pattern formation in reaction diffusion models with spatially inhomogen-ous diffusion coefficients. Math Comput Modelling 17: 29-34
    • (1993) Math Comput Modelling , vol.17 , pp. 29-34
    • Benson, D.L.1    Maini, P.K.2    Sherratt, J.A.3
  • 9
    • 0000578162 scopus 로고    scopus 로고
    • Unravelling the Turing bifurcation using spatially varying diffusion coefficients
    • Benson DL, Maini PK, Sherratt JA (1998) Unravelling the Turing bifurcation using spatially varying diffusion coefficients. J Math Biol 37: 381-417
    • (1998) J Math Biol , vol.37 , pp. 381-417
    • Benson, D.L.1    Maini, P.K.2    Sherratt, J.A.3
  • 10
    • 4444288866 scopus 로고    scopus 로고
    • Active Solubilization and Refolding of Stable Protein Aggregates by Cooperative Unfolding Action of Individual Hsp70 Chaperones
    • Ben-Zvi A, De Los Rios P, Dietler G, Goloubinoff P (2004) Active Solubilization and Refolding of Stable Protein Aggregates By Cooperative Unfolding Action of Individual Hsp70 Chaperones. J Biol Chem 279: 37298-37303
    • (2004) J Biol Chem , vol.279 , pp. 37298-37303
    • Ben-Zvi, A.1    De Los Rios, P.2    Dietler, G.3    Goloubinoff, P.4
  • 11
    • 0037213362 scopus 로고    scopus 로고
    • The on-off story of protein palmi-toylation
    • Bijlmakers M, Marsh M (2003) The on-off story of protein palmi-toylation. Trends Cell Biol 13: 32-42
    • (2003) Trends Cell Biol , vol.13 , pp. 32-42
    • Bijlmakers, M.1    Marsh, M.2
  • 13
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos JL (1989) Ras oncogenes in human cancer: a review. Cancer Res 49: 4682-4689
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 14
    • 0026026818 scopus 로고
    • The GTPase super-family: Conserved structure and molecular mechanism
    • Bourne HR, Sanders DA, McCormick F (1991) The GTPase super-family: conserved structure and molecular mechanism. Nature 349: 117-127
    • (1991) Nature , vol.349 , pp. 117-127
    • Bourne, H.R.1    Sanders, D.A.2    McCormick, F.3
  • 15
    • 33749023589 scopus 로고    scopus 로고
    • Stochastic model of protein receptor trafficking prior to synaptogenesis
    • Bressloff PC (2006) Stochastic model of protein receptor trafficking prior to synaptogenesis. Phys Rev E Stat Nonlin Soft Matter Phys 74: 031910
    • (2006) Phys Rev e Stat Nonlin Soft Matter Phys , vol.74 , pp. 031910
    • Bressloff, P.C.1
  • 16
    • 0037033792 scopus 로고    scopus 로고
    • Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins
    • Brownawell AM, Macara IG (2002) Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins. J Cell Biol 156: 53-64
    • (2002) J Cell Biol , vol.156 , pp. 53-64
    • Brownawell, A.M.1    MacAra, I.G.2
  • 17
    • 0037291219 scopus 로고    scopus 로고
    • The hormetic dose-response model is more common than the threshold model in toxicology
    • Calabrese EJ, Baldwin LA (2003) The hormetic dose-response model is more common than the threshold model in toxicology. Toxicol Sci 71: 246-250
    • (2003) Toxicol Sci , vol.71 , pp. 246-250
    • Calabrese, E.J.1    Baldwin, L.A.2
  • 18
    • 0037112842 scopus 로고    scopus 로고
    • Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA
    • Calado A, Treichel N, Müller E, Otto A, Kutay U (2002) Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA. EMBO J 21: 6216-6224
    • (2002) EMBO J , vol.21 , pp. 6216-6224
    • Calado, A.1    Treichel, N.2    Müller, E.3    Otto, A.4    Kutay, U.5
  • 20
    • 23944436962 scopus 로고    scopus 로고
    • Spatial coordination of spindle assembly by chromosome-mediated signaling gradients
    • Caudron M, Bunt G, Bastiaens P, Karsenti E (2005) Spatial coordination of spindle assembly by chromosome-mediated signaling gradients. Science 309: 1373-1376
    • (2005) Science , vol.309 , pp. 1373-1376
    • Caudron, M.1    Bunt, G.2    Bastiaens, P.3    Karsenti, E.4
  • 21
    • 0020315258 scopus 로고
    • Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses
    • Chang EH, Gonda MA, Ellis RW, Scolnick EM, Lowy DR (1982) Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses. Proc Natl Acad Sci USA 79: 4848-4852
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 4848-4852
    • Chang, E.H.1    Gonda, M.A.2    Ellis, R.W.3    Scolnick, E.M.4    Lowy, D.R.5
  • 23
    • 0029939164 scopus 로고    scopus 로고
    • SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways
    • Chen D, Waters SB, Holt KH, Pessin JE (1996) SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways. J Biol Chem 271: 6328-6332
    • (1996) J Biol Chem , vol.271 , pp. 6328-6332
    • Chen, D.1    Waters, S.B.2    Holt, K.H.3    Pessin, J.E.4
  • 24
    • 74049125665 scopus 로고    scopus 로고
    • Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics
    • Cheng H, Force T (2010) Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics. Circ Res 106: 21-34
    • (2010) Circ Res , vol.106 , pp. 21-34
    • Cheng, H.1    Force, T.2
  • 26
    • 0032554840 scopus 로고    scopus 로고
    • Nucleocytoplasmic transport: Driving and directing transport
    • Cole CN, Hammell CM (1998) Nucleocytoplasmic transport: driving and directing transport. Curr Biol 8: R368-R372
    • (1998) Curr Biol , vol.8
    • Cole, C.N.1    Hammell, C.M.2
  • 27
    • 0026532884 scopus 로고
    • 2-Bromopalmitoyl-CoA and 2-bromopalmitate: Promiscuous inhibitors of membrane-bound enzymes
    • Coleman RA, Rao P, Fogelsong RJ, Bardes ES (1992) 2-Bromopalmitoyl-CoA and 2-bromopalmitate: promiscuous inhibitors of membrane-bound enzymes. Biochim Biophys Acta 1125: 203-209
    • (1992) Biochim Biophys Acta , vol.1125 , pp. 203-209
    • Coleman, R.A.1    Rao, P.2    Fogelsong, R.J.3    Bardes, E.S.4
  • 28
    • 0030886261 scopus 로고    scopus 로고
    • The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole
    • Cowles C (1997) The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell 91: 109-118
    • (1997) Cell , vol.91 , pp. 109-118
    • Cowles, C.1
  • 29
    • 0002120835 scopus 로고
    • Sustained coherent spatial structures in a quasi-1D reaction-diffusion system
    • De Kepper P, Ouyang Q, Boissonade J, Roux JC (1990) Sustained coherent spatial structures in a quasi-1D reaction-diffusion system. React Kinet Catal Lett 42: 275-288
    • (1990) React Kinet Catal Lett , vol.42 , pp. 275-288
    • De Kepper, P.1    Ouyang, Q.2    Boissonade, J.3    Roux, J.C.4
  • 33
    • 33747373791 scopus 로고
    • Pattern formation in generalized Turing systems
    • Dillon R, Maini PK, Othmer HG (1994) Pattern formation in generalized Turing systems. J Math Biol 32: 345-393
    • (1994) J Math Biol , vol.32 , pp. 345-393
    • Dillon, R.1    Maini, P.K.2    Othmer, H.G.3
  • 34
    • 41949135105 scopus 로고    scopus 로고
    • P204 protein is a novel modulator of ras activity
    • Ding B, Lengyel P (2008) p204 protein is a novel modulator of ras activity. J Biol Chem 283: 5831-5848
    • (2008) J Biol Chem , vol.283 , pp. 5831-5848
    • Ding, B.1    Lengyel, P.2
  • 35
    • 15844381486 scopus 로고    scopus 로고
    • Palmitoylation of Ha-Ras facilitates membrane binding, activation of downstream effectors, and meiotic maturation in xenopus oocytes
    • Dudler T, Gelb MH (1996) Palmitoylation of Ha-Ras facilitates membrane binding, activation of downstream effectors, and meiotic maturation in xenopus oocytes. J Biol Chem 271: 11541-11547
    • (1996) J Biol Chem , vol.271 , pp. 11541-11547
    • Dudler, T.1    Gelb, M.H.2
  • 36
    • 77951884380 scopus 로고    scopus 로고
    • RCC1 uses a conformationally diverse loop region to interact with the nucleosome: A model for the RCC1-nucleosome complex
    • England JR, Huang J, Jennings MJ, Makde RD, Tan S (2010) RCC1 uses a conformationally diverse loop region to interact with the nucleosome: a model for the RCC1-nucleosome complex. J Mol Biol 398: 518-529
    • (2010) J Mol Biol , vol.398 , pp. 518-529
    • England, J.R.1    Huang, J.2    Jennings, M.J.3    Makde, R.D.4    Tan, S.5
  • 37
    • 71149086936 scopus 로고    scopus 로고
    • Signaling Motifs and Weber's Law
    • Ferrell Jr JE (2009) Signaling Motifs and Weber's Law. Molecular Cell 36: 724-727
    • (2009) Molecular Cell , vol.36 , pp. 724-727
    • Ferrell Jr., J.E.1
  • 38
    • 67349211783 scopus 로고    scopus 로고
    • Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5
    • Finegan KG, Wang X, Lee E, Robinson AC, Tournier C (2009) Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5. Cell Death Differ 16: 674-683
    • (2009) Cell Death Differ , vol.16 , pp. 674-683
    • Finegan, K.G.1    Wang, X.2    Lee, E.3    Robinson, A.C.4    Tournier, C.5
  • 41
    • 77953167957 scopus 로고    scopus 로고
    • Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor
    • Goh LK, Huang F, Kim W, Gygi S, Sorkin A (2010) Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor. J Cell Biol 189: 871-883
    • (2010) J Cell Biol , vol.189 , pp. 871-883
    • Goh, L.K.1    Huang, F.2    Kim, W.3    Gygi, S.4    Sorkin, A.5
  • 43
    • 37849004725 scopus 로고    scopus 로고
    • Operating regimes of signaling cycles: Statics, dynamics, and noise filtering
    • Gomez-Uribe C, Verghese GC, Mirny LA (2007) Operating regimes of signaling cycles: statics, dynamics, and noise filtering. PLoS Comput Biol 3: e246
    • (2007) PLoS Comput Biol , vol.3
    • Gomez-Uribe, C.1    Verghese, G.C.2    Mirny, L.A.3
  • 44
    • 0033056764 scopus 로고    scopus 로고
    • The molecular perspective: The ras oncogene
    • Goodsell DS (1999) The molecular perspective: the ras oncogene. Oncologist 4: 263-264
    • (1999) Oncologist , vol.4 , pp. 263-264
    • Goodsell, D.S.1
  • 45
    • 0027937653 scopus 로고
    • Isolation of a protein that is essential for the first step of nuclear protein import
    • Görlich D, Prehn S, Laskey RA, Hartmann E (1994) Isolation of a protein that is essential for the first step of nuclear protein import. Cell 79: 767-778
    • (1994) Cell , vol.79 , pp. 767-778
    • Görlich, D.1    Prehn, S.2    Laskey, R.A.3    Hartmann, E.4
  • 46
    • 57749098786 scopus 로고    scopus 로고
    • Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport
    • Goytain A, Hines RM, Quamme GA (2008) Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport. J Biol Chem 283: 33365-33374
    • (2008) J Biol Chem , vol.283 , pp. 33365-33374
    • Goytain, A.1    Hines, R.M.2    Quamme, G.A.3
  • 48
    • 46849102728 scopus 로고    scopus 로고
    • The spread of Ras activity triggered by activation of a single dendritic spine
    • Harvey CD, Yasuda R, Zhong H, Svoboda K (2008) The spread of Ras activity triggered by activation of a single dendritic spine. Science 321: 136-140
    • (2008) Science , vol.321 , pp. 136-140
    • Harvey, C.D.1    Yasuda, R.2    Zhong, H.3    Svoboda, K.4
  • 50
  • 51
    • 58149279827 scopus 로고    scopus 로고
    • Activation of the MAPK module from different spatial locations generates distinct system outputs
    • Inder K, Harding A, Plowman SJ, Philips MR, Parton RG, Hancock JF (2008) Activation of the MAPK module from different spatial locations generates distinct system outputs. Mol Biol Cell 19: 4776-4784
    • (2008) Mol Biol Cell , vol.19 , pp. 4776-4784
    • Inder, K.1    Harding, A.2    Plowman, S.J.3    Philips, M.R.4    Parton, R.G.5    Hancock, J.F.6
  • 54
    • 77953800164 scopus 로고    scopus 로고
    • Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection
    • Jang IK, Zhang J, Chiang YJ, Kole HK, Cronshaw DG, Zou Y, Gu H (2010) Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection. Proc Natl Acad Sci USA 107: 10620-10625
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 10620-10625
    • Jang, I.K.1    Zhang, J.2    Chiang, Y.J.3    Kole, H.K.4    Cronshaw, D.G.5    Zou, Y.6    Gu, H.7
  • 55
    • 46249113438 scopus 로고    scopus 로고
    • The RanGTP gradient\a GPS for the mitotic spindle
    • Kalab P, Heald R (2008) The RanGTP gradient\a GPS for the mitotic spindle. J Cell Sci 121: 1577-1586
    • (2008) J Cell Sci , vol.121 , pp. 1577-1586
    • Kalab, P.1    Heald, R.2
  • 56
    • 0037192461 scopus 로고    scopus 로고
    • Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts
    • Kalab P, Weis K, Heald R (2002) Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts. Science 295: 2452-2456
    • (2002) Science , vol.295 , pp. 2452-2456
    • Kalab, P.1    Weis, K.2    Heald, R.3
  • 57
    • 0021716406 scopus 로고
    • A short amino acid sequence able to specify nuclear location
    • Kalderon D, Roberts BL, Richardson WD, Smith AE (1984) A short amino acid sequence able to specify nuclear location. Cell 39: 499-509
    • (1984) Cell , vol.39 , pp. 499-509
    • Kalderon, D.1    Roberts, B.L.2    Richardson, W.D.3    Smith, A.E.4
  • 62
    • 22144452865 scopus 로고    scopus 로고
    • Hysteresis in a synthetic mammalian gene network
    • Kramer BP, Fussenegger M (2005) Hysteresis in a synthetic mammalian gene network. Proc Natl Acad Sci USA 102: 9517-9522
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9517-9522
    • Kramer, B.P.1    Fussenegger, M.2
  • 64
    • 0032546549 scopus 로고    scopus 로고
    • Lipid-binding characteristics of the polybasic carboxy-terminal sequence of K-ras4B
    • Leventis R, Silvius JR (1998) Lipid-binding characteristics of the polybasic carboxy-terminal sequence of K-ras4B. Biochemistry 37: 7640-7648
    • (1998) Biochemistry , vol.37 , pp. 7640-7648
    • Leventis, R.1    Silvius, J.R.2
  • 66
    • 69249157304 scopus 로고    scopus 로고
    • Importin-beta is a GDP-to-GTP exchange factor of Ran: Implications for the mechanism of nuclear import
    • Lonhienne TG, Forwood JK, Marfori M, Robin G, Kobe B, Carroll BJ (2009) Importin-beta is a GDP-to-GTP exchange factor of Ran: implications for the mechanism of nuclear import. J Biol Chem 284: 22549-22558
    • (2009) J Biol Chem , vol.284 , pp. 22549-22558
    • Lonhienne, T.G.1    Forwood, J.K.2    Marfori, M.3    Robin, G.4    Kobe, B.5    Carroll, B.J.6
  • 69
    • 0000933807 scopus 로고
    • Pattern formation in reaction-diffusion models with spatially inhomogeneous diffusion coefficients
    • Maini PK, Benson DL, Sherratt JA (1992) Pattern formation in reaction-diffusion models with spatially inhomogeneous diffusion coefficients. Math Med Biol 9: 197-213
    • (1992) Math Med Biol , vol.9 , pp. 197-213
    • Maini, P.K.1    Benson, D.L.2    Sherratt, J.A.3
  • 70
    • 46649106145 scopus 로고    scopus 로고
    • Solubilization of protein aggregates by the acid stress chaperones HdeA and HdeB
    • Malki A, Le H, Milles S, Kern R, Caldas T, Abdallah J, Richarme G (2008) Solubilization of protein aggregates by the acid stress chaperones HdeA and HdeB. J Biol Chem 283: 13679-13687
    • (2008) J Biol Chem , vol.283 , pp. 13679-13687
    • Malki, A.1    Le Milles, H.S.2    Kern, R.3    Caldas, T.4    Abdallah, J.5    Richarme, G.6
  • 71
    • 0037805547 scopus 로고    scopus 로고
    • RAS oncogenes: The first 30 years
    • Malumbres M, Barbacid M (2003) RAS oncogenes: the first 30 years. Nat Rev Cancer 3: 459-465
    • (2003) Nat Rev Cancer , vol.3 , pp. 459-465
    • Malumbres, M.1    Barbacid, M.2
  • 72
    • 52049093202 scopus 로고    scopus 로고
    • The DHHC palmitoyltransferase approximated regulates fat signaling and Dachs localization and activity
    • Matakatsu H, Blair SS (2008) The DHHC palmitoyltransferase approximated regulates fat signaling and Dachs localization and activity. Curr Biol 18: 1390-1395
    • (2008) Curr Biol , vol.18 , pp. 1390-1395
    • Matakatsu, H.1    Blair, S.S.2
  • 73
    • 0037849951 scopus 로고    scopus 로고
    • Differences on the inhibitory specificities of H-Ras, K-Ras, and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization
    • Matallanas D, Arozarena I, Berciano MT, Aaronson DS, Pellicer A, Lafarga M, Crespo P (2003) Differences on the inhibitory specificities of H-Ras, K-Ras, and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization. J Biol Chem 278: 4572-4581
    • (2003) J Biol Chem , vol.278 , pp. 4572-4581
    • Matallanas, D.1    Arozarena, I.2    Berciano, M.T.3    Aaronson, D.S.4    Pellicer, A.5    Lafarga, M.6    Crespo, P.7
  • 74
    • 33644856168 scopus 로고    scopus 로고
    • Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation
    • Matallanas D, Sanz-Moreno V, Arozarena I, Calvo F, Agudo-Ibanez L, Santos E, Berciano MT, Crespo P (2006) Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation. Mol Cell Biol 26: 100-116
    • (2006) Mol Cell Biol , vol.26 , pp. 100-116
    • Matallanas, D.1    Sanz-Moreno, V.2    Arozarena, I.3    Calvo, F.4    Agudo-Ibanez, L.5    Santos, E.6    Berciano, M.T.7    Crespo, P.8
  • 75
    • 0031707505 scopus 로고    scopus 로고
    • Nucleocytoplasmic transport: The soluble phase
    • Mattaj IW, Englmeier L (1998) Nucleocytoplasmic transport: the soluble phase. Annu Rev Biochem 67: 265-306
    • (1998) Annu Rev Biochem , vol.67 , pp. 265-306
    • Mattaj, I.W.1    Englmeier, L.2
  • 76
    • 0032498541 scopus 로고    scopus 로고
    • SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex
    • Matunis MJ, Wu J, Blobel G (1998) SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex. J Cell Biol 140: 499-509
    • (1998) J Cell Biol , vol.140 , pp. 499-509
    • Matunis, M.J.1    Wu, J.2    Blobel, G.3
  • 77
    • 17044387386 scopus 로고    scopus 로고
    • Hsp70 chaperones: Cellular functions and molecular mechanism
    • Mayer M, Bukau B (2005) Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci 62: 670-684
    • (2005) Cell Mol Life Sci , vol.62 , pp. 670-684
    • Mayer, M.1    Bukau, B.2
  • 78
    • 33750619877 scopus 로고    scopus 로고
    • Potential for control of signaling pathways via cell size and shape
    • Meyers J, Craig J, Odde DJ (2006) Potential for control of signaling pathways via cell size and shape. Curr Biol 16: 1685-1693
    • (2006) Curr Biol , vol.16 , pp. 1685-1693
    • Meyers, J.1    Craig, J.2    Odde, D.J.3
  • 79
    • 75949103898 scopus 로고    scopus 로고
    • The Nup107-160 complex and gamma-TuRC regulate microtubule polymerization at kinetochores
    • Mishra RK, Chakraborty P, Arnaoutov A, Fontoura BMA, Dasso M (2010) The Nup107-160 complex and gamma-TuRC regulate microtubule polymerization at kinetochores. Nat Cell Biol 12: 164-169
    • (2010) Nat Cell Biol , vol.12 , pp. 164-169
    • Mishra, R.K.1    Chakraborty, P.2    Arnaoutov, A.3    Bma, F.4    Dasso, M.5
  • 80
    • 77955502318 scopus 로고    scopus 로고
    • Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate
    • Narula J, Smith AM, Gottgens B, Igoshin OA (2010) Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate. PLoS Comput Biol 6: e1000771
    • (2010) PLoS Comput Biol , vol.6
    • Narula, J.1    Smith, A.M.2    Gottgens, B.3    Igoshin, O.A.4
  • 81
    • 0034658460 scopus 로고    scopus 로고
    • Nuclear import of the ran exchange factor, RCC1, is mediated by at least two distinct mechanisms
    • Nemergut ME, Macara IG (2000) Nuclear import of the ran exchange factor, RCC1, is mediated by at least two distinct mechanisms. J Cell Biol 149: 835-850
    • (2000) J Cell Biol , vol.149 , pp. 835-850
    • Nemergut, M.E.1    MacAra, I.G.2
  • 82
    • 0028357006 scopus 로고
    • Molecular cloning and characterization of two rab GDI species from rat brain: Brain-specific and ubiquitous types
    • Nishimura N, Nakamura H, Takai Y, Sano K (1994) Molecular cloning and characterization of two rab GDI species from rat brain: brain-specific and ubiquitous types. J Biol Chem 269: 14191-14198
    • (1994) J Biol Chem , vol.269 , pp. 14191-14198
    • Nishimura, N.1    Nakamura, H.2    Takai, Y.3    Sano, K.4
  • 84
    • 44449111555 scopus 로고    scopus 로고
    • Loss of E-Cadherin promotes metastasis via multiple downstream transcriptional pathways
    • Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA (2008) Loss of E-Cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 68: 3645-3654
    • (2008) Cancer Res , vol.68 , pp. 3645-3654
    • Onder, T.T.1    Gupta, P.B.2    Mani, S.A.3    Yang, J.4    Lander, E.S.5    Weinberg, R.A.6
  • 85
    • 0031026639 scopus 로고    scopus 로고
    • Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-Kinase
    • Panaretou C, Domin J, Cockcroft S, Waterfield MD (1997) Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-Kinase. J Biol Chem 272: 2477-2485
    • (1997) J Biol Chem , vol.272 , pp. 2477-2485
    • Panaretou, C.1    Domin, J.2    Cockcroft, S.3    Waterfield, M.D.4
  • 87
    • 14544299215 scopus 로고    scopus 로고
    • Mechanisms of receptor-mediated nuclear import and nuclear export
    • Pemberton LF, Paschal BM (2005) Mechanisms of receptor-mediated nuclear import and nuclear export. Traffic 6: 187-198
    • (2005) Traffic , vol.6 , pp. 187-198
    • Pemberton, L.F.1    Paschal, B.M.2
  • 88
    • 3242701513 scopus 로고    scopus 로고
    • Sef: A MEK/ERK catcher on the Golgi
    • Philips MR (2004) Sef: a MEK/ERK catcher on the Golgi. Mol Cell 15: 168-169
    • (2004) Mol Cell , vol.15 , pp. 168-169
    • Philips, M.R.1
  • 89
    • 77951918362 scopus 로고    scopus 로고
    • Identification of the switch in early-to-late endosome transition
    • Poteryaev D, Datta S, Ackema K, Zerial M, Spang A (2010) Identification of the switch in early-to-late endosome transition. Cell 141: 497-508
    • (2010) Cell , vol.141 , pp. 497-508
    • Poteryaev, D.1    Datta, S.2    Ackema, K.3    Zerial, M.4    Spang, A.5
  • 90
    • 24644434502 scopus 로고    scopus 로고
    • Bystander effects, genomic instability, adaptive response, and cancer risk assessment for radiation and chemical exposures
    • Preston RJ (2005) Bystander effects, genomic instability, adaptive response, and cancer risk assessment for radiation and chemical exposures. Toxicol Appl Pharmacol 207: 550-556
    • (2005) Toxicol Appl Pharmacol , vol.207 , pp. 550-556
    • Preston, R.J.1
  • 91
    • 0035067187 scopus 로고    scopus 로고
    • GTP-dependent segregation of H-ras from lipid rafts is required for biological activity
    • Prior IA, Harding A, Yan J, Sluimer J, Parton RG, Hancock JF (2001) GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat Cell Biol 3: 368-375
    • (2001) Nat Cell Biol , vol.3 , pp. 368-375
    • Prior, I.A.1    Harding, A.2    Yan, J.3    Sluimer, J.4    Parton, R.G.5    Hancock, J.F.6
  • 92
  • 93
    • 42149192000 scopus 로고    scopus 로고
    • Activated Kras, but Not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion
    • Quinlan MP, Quatela SE, Philips MR, Settleman J (2008) Activated Kras, but Not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion. Mol Cell Biol 28: 2659-2674
    • (2008) Mol Cell Biol , vol.28 , pp. 2659-2674
    • Quinlan, M.P.1    Quatela, S.E.2    Philips, M.R.3    Settleman, J.4
  • 94
    • 33744548557 scopus 로고    scopus 로고
    • Temporally and spatially coordinated roles for Rho, Rac, Cdc42 and their effectors in growth cone guidance by a physiological electric field
    • Rajnicek AM, Foubister LE, McCaig CD (2006) Temporally and spatially coordinated roles for Rho, Rac, Cdc42 and their effectors in growth cone guidance by a physiological electric field. J Cell Sci 119: 1723-1735
    • (2006) J Cell Sci , vol.119 , pp. 1723-1735
    • Rajnicek, A.M.1    Foubister, L.E.2    McCaig, C.D.3
  • 100
    • 33847355217 scopus 로고    scopus 로고
    • Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
    • Santos SDM, Verveer PJ, Bastiaens PIH (2007) Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat Cell Biol 9: 324-330
    • (2007) Nat Cell Biol , vol.9 , pp. 324-330
    • Sdm, S.1    Verveer, P.J.2    Pih, B.3
  • 102
    • 0030696229 scopus 로고    scopus 로고
    • S-Acylation and plasma membrane targeting of the farnesylated carboxyl-terminal peptide of N-ras in mammalian fibroblasts
    • Schroeder H, Leventis R, Rex S, Schelhaas M, Nagele E, Waldmann H, Silvius JR (1997) S-Acylation and plasma membrane targeting of the farnesylated carboxyl-terminal peptide of N-ras in mammalian fibroblasts. Biochemistry 36: 13102-13109
    • (1997) Biochemistry , vol.36 , pp. 13102-13109
    • Schroeder, H.1    Leventis, R.2    Rex, S.3    Schelhaas, M.4    Nagele, E.5    Waldmann, H.6    Silvius, J.R.7
  • 103
    • 7644240371 scopus 로고    scopus 로고
    • A biological-based model that links genomic instability, bystander effects, and adaptive response
    • Scott B (2004) A biological-based model that links genomic instability, bystander effects, and adaptive response. Mutat Res/Fundam Mol Mech Mutagen 568: 129-143
    • (2004) Mutat Res/Fundam Mol Mech Mutagen , vol.568 , pp. 129-143
    • Scott, B.1
  • 105
    • 0242363237 scopus 로고    scopus 로고
    • Yip3 catalyses the dissociation of endosomal Rab-GDI complexes
    • Sivars U, Aivazian D, Pfeffer SR (2003) Yip3 catalyses the dissociation of endosomal Rab-GDI complexes. Nature 425: 856-859
    • (2003) Nature , vol.425 , pp. 856-859
    • Sivars, U.1    Aivazian, D.2    Pfeffer, S.R.3
  • 106
    • 34547116642 scopus 로고    scopus 로고
    • A novel negative regulatory function of the phosphopro-tein associated with glycosphingolipid-enriched microdomains: Blocking Ras activation
    • Smida M, Posevitz-Fejfar A, Horejsi V, Schraven B, Lindquist JA (2007) A novel negative regulatory function of the phosphopro-tein associated with glycosphingolipid-enriched microdomains: blocking Ras activation. Blood 11 0: 596-615
    • (2007) Blood , vol.11 , Issue.0 , pp. 596-615
    • Smida, M.1    Posevitz-Fejfar, A.2    Horejsi, V.3    Schraven, B.4    Lindquist, J.A.5
  • 107
    • 0027418539 scopus 로고
    • Rab GDI: A solubilizing and recycling factor for rab9 protein
    • Soldati T, Riederer M, Pfeffer S (1993) Rab GDI: a solubilizing and recycling factor for rab9 protein. Mol Biol Cell 4: 425-434
    • (1993) Mol Biol Cell , vol.4 , pp. 425-434
    • Soldati, T.1    Riederer, M.2    Pfeffer, S.3
  • 108
    • 67949093139 scopus 로고    scopus 로고
    • On the fate of early endosomes
    • Spang A (2009) On the fate of early endosomes. Biol Chem 390: 753-759
    • (2009) Biol Chem , vol.390 , pp. 753-759
    • Spang, A.1
  • 109
    • 0034986111 scopus 로고    scopus 로고
    • The Rab GTPase family
    • reviews3007.1-reviews3007.7
    • Stenmark H, Olkkonen V (2001) The Rab GTPase family. Genome Biol 2: reviews3007.1-reviews3007.7
    • (2001) Genome Biol , vol.2
    • Stenmark, H.1    Olkkonen, V.2
  • 110
    • 77249093066 scopus 로고    scopus 로고
    • Spatio-temporal correlations can drastically change the response of a MAPK pathway
    • Takahashi K, Ñase-Nicola S, ten Wolde PR (2010) Spatio-temporal correlations can drastically change the response of a MAPK pathway. Proc Natl Acad Sci 107: 2473-2478
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 2473-2478
    • Takahashi, K.1    Ñase-Nicola, S.2    Ten Wolde, P.R.3
  • 111
    • 0034616123 scopus 로고    scopus 로고
    • The nuclear import of RCC1 requires a specific nuclear localization sequence receptor, Karyopherin a3/Qip
    • Talcott B, Moore MS (2000) The nuclear import of RCC1 requires a specific nuclear localization sequence receptor, Karyopherin a3/Qip. J Biol Chem 275: 10099-10104
    • (2000) J Biol Chem , vol.275 , pp. 10099-10104
    • Talcott, B.1    Moore, M.S.2
  • 113
    • 77649220197 scopus 로고    scopus 로고
    • Noise can induce bimodality in positive transcriptional feedback loops without bistability
    • To T, Maheshri N (2010) Noise can induce bimodality in positive transcriptional feedback loops without bistability. Science 327: 1142-1145
    • (2010) Science , vol.327 , pp. 1142-1145
    • To, T.1    Maheshri, N.2
  • 114
    • 33947247375 scopus 로고    scopus 로고
    • RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus
    • Tsai F, Shyu R, Jiang S (2007) RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus. Cell Signal 19: 989-999
    • (2007) Cell Signal , vol.19 , pp. 989-999
    • Tsai, F.1    Shyu, R.2    Jiang, S.3
  • 116
    • 77950872185 scopus 로고    scopus 로고
    • Two competing orientation patterns explain experimentally observed anomalies in growing actin networks
    • Weichsel J, Schwarz US (2010) Two competing orientation patterns explain experimentally observed anomalies in growing actin networks. Proc Natl Acad Sci USA 107: 6304-6309
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 6304-6309
    • Weichsel, J.1    Schwarz, U.S.2
  • 117
    • 0030738592 scopus 로고    scopus 로고
    • The interaction of Ras with GTPase-activating proteins
    • Wittinghofer A, Scheffzek K, Ahmadian MR (1997) The interaction of Ras with GTPase-activating proteins. FEBS Lett 410: 63-67
    • (1997) FEBS Lett , vol.410 , pp. 63-67
    • Wittinghofer, A.1    Scheffzek, K.2    Ahmadian, M.R.3
  • 118
    • 0030446448 scopus 로고    scopus 로고
    • Structural insights into the function of the Rab GDI superfamily
    • Wu SK, Zeng K, Wilson IA, Balch WE (1996) Structural insights into the function of the Rab GDI superfamily. Trends Biochem Sci 21: 472-476
    • (1996) Trends Biochem Sci , vol.21 , pp. 472-476
    • Wu, S.K.1    Zeng, K.2    Wilson, I.A.3    Balch, W.E.4
  • 119
    • 77953809435 scopus 로고    scopus 로고
    • Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes
    • Wu Y, Oesterlin LK, Tan K, Waldmann H, Alexandrov K, Goody RS (2010) Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes. Nat Chem Biol 6: 534-540
    • (2010) Nat Chem Biol , vol.6 , pp. 534-540
    • Wu, Y.1    Oesterlin, L.K.2    Tan, K.3    Waldmann, H.4    Alexandrov, K.5    Goody, R.S.6
  • 120
    • 0345359924 scopus 로고    scopus 로고
    • A positive-feedback-based bistable/'memory module/' that governs a cell fate decision
    • Xiong W, Ferrell JE (2003) A positive-feedback-based bistable/'memory module/' that governs a cell fate decision. Nature 426: 460-465
    • (2003) Nature , vol.426 , pp. 460-465
    • Xiong, W.1    Ferrell, J.E.2
  • 121
    • 38149094836 scopus 로고    scopus 로고
    • Membrane phosphatidylserine regulates surface charge and protein localization
    • Yeung T, Gilbert GE, Shi J, Silvius J, Kapus A, Grinstein S (2008) Membrane phosphatidylserine regulates surface charge and protein localization. Science 319: 210-213
    • (2008) Science , vol.319 , pp. 210-213
    • Yeung, T.1    Gilbert, G.E.2    Shi, J.3    Silvius, J.4    Kapus, A.5    Grinstein, S.6
  • 124
    • 14044276363 scopus 로고    scopus 로고
    • Mechanism of the guanine nucleotide exchange reaction of Ras GTPase\evidence for a GTP/GDP displacement model
    • Zhang B, Zhang Y, Shacter E, Zheng Y (2005) Mechanism of the guanine nucleotide exchange reaction of Ras GTPase\evidence for a GTP/GDP displacement model. Biochemistry 44: 2566-2576
    • (2005) Biochemistry , vol.44 , pp. 2566-2576
    • Zhang, B.1    Zhang, Y.2    Shacter, E.3    Zheng, Y.4
  • 125
    • 34447568476 scopus 로고    scopus 로고
    • Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos
    • Zhao C, Du G, Skowronek K, Frohman MA, Bar-Sagi D (2007) Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nat Cell Biol 9: 706-712
    • (2007) Nat Cell Biol , vol.9 , pp. 706-712
    • Zhao, C.1    Du, G.2    Skowronek, K.3    Frohman, M.A.4    Bar-Sagi, D.5


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