Mechanism of the guanine nucleotide exchange reaction of ras GTPase-evidence for a GTP/GDP displacement model

Biochemistry

Volumn 44, Issue 7, 2005, Pages 2566-2576

  Zhang, Baolin ^a   Zhang, Yaqin ^a   Shacter, Emily ^a   Zheng, Yi ^b  

^a Center for Drug Evaluation and Research   (United States)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIOCHEMISTRY; CATALYSIS; COMPLEXATION; CONCENTRATION (PROCESS); DISSOCIATION; ENERGY TRANSFER; FLUORESCENCE; HYDROPHOBICITY; PHOSPHATES; REACTION KINETICS; RESONANCE;

BINARY SWITCHES; CELL GROWTH; FLUORESCENCE RESONANCE ENERGY TRANSFER; GUANINE NUCLEOTIDE EXCHANGE FACTORS (GEFS);

CELL CULTURE;

2',3' O (2,4,6 TRINITROCYCLOHEXADIENYLIDENE) GUANOSINE TRIPHOSPHATE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE DIPHOSPHATE; GUANOSINE PHOSPHATE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; N METHYLANTHRANILOYL GUANOSINE DIPHOSPHATE; PYROPHOSPHATE; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; COMPLEX FORMATION; DISSOCIATION CONSTANT; ENZYME ACTIVATION; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; FLUORESCENCE RESONANCE ENERGY TRANSFER; MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION;

ANTHRANILIC ACIDS; BINDING SITES; CATALYSIS; DIPHOSPHATES; FLUORESCENCE RESONANCE ENERGY TRANSFER; GTP PHOSPHOHYDROLASES; GUANINE NUCLEOTIDES; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MODELS, BIOLOGICAL; PROTEIN BINDING; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; RAS PROTEINS; RAS-GRF1;

EID: 14044276363     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048755w     Document Type: Article

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