Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 23, 2010, Pages 10620-10625

  Jang, Ihn Kyung ^a,e   Zhang, Jinping ^a   Chiang, Yungping J ^b   Kole, Hemanta K ^c   Cronshaw, Darran G ^d   Zou, Yongrui ^d   Gu, Hua ^a  

^a College of Physicians and Surgeons ^*  (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Grb2; Signal transduction; T cell development; Tyrosine phosphorylation

Indexed keywords

CALCIUM; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MUTANT PROTEIN; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THYMOCYTE;

ANIMALS; CELL DIFFERENTIATION; MICE; MICE, KNOCKOUT; PHOSPHOPROTEINS; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; THYMUS GLAND;

EID: 77953800164     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0905039107     Document Type: Article

References (33)

1. Benoist C, Mathis D (1997) Positive selection of T cells: Fastidious or promiscuous? Curr Opin Immunol 9:245-249.
2. Jameson SC, Hogquist KA, Bevan MJ (1995) Positive selection of thymocytes. Annu Rev Immunol 13:93-126.
3. Kisielow P, von Boehmer H (1995) Development and selection of T cells: Facts and puzzles. Adv Immunol 58:87-209.
4. Robey E, Fowlkes BJ (1994) Selective events in T cell development. Annu Rev Immunol 12:675-705.
5. Ashton-Rickardt PG, Van Kaer L, Schumacher TN, Ploegh HL, Tonegawa S (1993) Repertoire-determining role of peptide in the positive selection of CD8+ T cells. Immunol Rev 135:157-182. (Pubitemid 2002513)
6. Ashton-Rickardt PG, Tonegawa S (1994) A differential-avidity model for T-cell selection. Immunol Today 15:362-366.
7. Hogquist KA, et al. (1994) T cell receptor antagonist peptides induce positive selection. Cell 76:17-27. (Pubitemid 24035278)
8. Sebzda E, et al. (1994) Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263:1615-1618. (Pubitemid 24128366)
9. Weiss A, Littman DR (1994) Signal transduction by lymphocyte antigen receptors. Cell 76:263-274. (Pubitemid 24046689)
10. Samelson LE, Donovan JA, Isakov N, Ota Y, Wange RL (1995) Signal transduction mediated by the T-cell antigen receptor. Ann N Y Acad Sci 766:157-172. (Pubitemid 26169092)
11. Weil R, Veillette A (1996) Signal transduction by the lymphocyte-specific tyrosine protein kinase p56lck. Curr Top Microbiol Immunol 205:63-87.
12. Samelson LE (1999) Adaptor proteins and T-cell antigen receptor signaling. Prog Biophys Mol Biol 71:393-403. (Pubitemid 29156309)
13. Schaeffer EM, Schwartzberg PL (2000) Tec family kinases in lymphocyte signaling and function. Curr Opin Immunol 12:282-288. (Pubitemid 30240537)
14. Myung PS, Boerthe NJ, Koretzky GA (2000) Adapter proteins in lymphocyte antigen-receptor signaling. Curr Opin Immunol 12:256-266.
15. Rozakis-Adcock M, Fernley R, Wade J, Pawson T, Bowtell D (1993) The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature 363:83-85. (Pubitemid 23144967)
16. Cheng AM, et al. (1998) Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell 95:793-803.
17. Gong Q, et al. (2001) Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. Nat Immunol 2:29-36. (Pubitemid 33704950)
18. Dower NA, et al. (2000) RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat Immunol 1:317-321.
19. Takahama Y, et al. (1998) Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene. Eur J Immunol 28:2159-2166.
20. Murphy KM, Heimberger AB, Loh DY (1990) Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250:1720-1723.
21. Kisielow P, Blüthmann H, Staerz UD, Steinmetz M, von Boehmer H (1988) Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature 333:742-746.
22. White J, et al. (1989) The V beta-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56:27-35.
23. Jenkinson EJ, Kingston R, Owen JJ (1990) Newly generated thymocytes are not refractory to deletion when the alpha/beta component of the T cell receptor is engaged by the superantigen staphylococcal enterotoxin B. Eur J Immunol 20:2517-2520.
24. Das J, et al. (2009) Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell 136:337-351.
25. Houtman JC, et al. (2006) Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1. Nat Struct Mol Biol 13:798-805.
26. Stork B, et al. (2004) Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes. Immunity 21:681-691.
27. Chow LM, Veillette A (1995) The Src and Csk families of tyrosine protein kinases in hemopoietic cells. Semin Immunol 7:207-226.
28. Latour S, Veillette A (2001) Proximal protein tyrosine kinases in immunoreceptor signaling. Curr Opin Immunol 13:299-306.
29. Leo A, Schraven B (2001) Adapters in lymphocyte signalling. Curr Opin Immunol 13:307-316.
30. Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K (1994) Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265:103-106.
31. Naramura M, et al. (2002) c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation. Nat Immunol 3:1192-1199.
32. Ashe JM, Wiest DL, Abe R, Singer A (1999) ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck). J Exp Med 189:1163-1168.
33. Zou YR, et al. (2001) Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage. Nat Genet 29:332-336.