The Rab GTPase family

Genome Biology

Volumn 2, Issue 5, 2001, Pages

  Stenmark, Harald ^a   Olkkonen, Vesa M ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; MEMBRANE PROTEIN; RAB PROTEIN; RAS PROTEIN; TUBULIN;

ANIMAL CELL; CELL MOTION; CELL VACUOLE; CYTOSOL; ENZYME LOCALIZATION; ENZYME REGULATION; GENETIC CONSERVATION; GENOME; HUMAN; HUMAN CELL; INTRACELLULAR MEMBRANE; MEMBRANE FUSION; MEMBRANE TRANSPORT; NONHUMAN; PROTEIN FAMILY; REVIEW; YEAST;

AMINO ACID SEQUENCE; ANIMALS; EVOLUTION, MOLECULAR; HUMANS; INTRACELLULAR MEMBRANES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; PHYLOGENY; PROTEIN CONFORMATION; RAB GTP-BINDING PROTEINS;

ANIMALIA;

EID: 0034986111     PISSN: 14656906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (39)

1. Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: Molecular cloning of YPT-related cDNAs from a rat brain library
2. Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis
3. Rab proteins as membrane organizers
4. A genomic perspective on membrane compartment organization
5. The mammalian Ras family of small GTPases: Definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily
6. Subclass-specific sequence motifs identified in Rab GTPases
7. Hypervariable C-terminal domain of rab proteins acts as a targeting signal
8. Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms
9. Structural basis of activation and GTP hydrolysis in Rab proteins
10. Structural basis of Rab effector specificity: Crystal structure of the small C protein Rab3A complexed with the effector domain of Rabphilin-3A
11. Structure of the nucleotide-binding domain of Plasmodium falciparum Rab6 in the GDP-bound form
12. High-resolution crystal structure of S. cerevisiae Ypt51(ΔC15)-GppNHp, a small GTP-binding protein involved in the regulation of endocytosis
13. Molecular switch for signal transduction: Structural differences between active and inactive forms of protooncogenic ras proteins
14. Crystal structures of a Rab protein in its inactive and active conformations
15. Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis
16. Mechanism of Rab geranyl geranylation: Formation of the catalytic ternary complex
17. Rab escort protein-I is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes
18. Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI
19. Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins
20. Structure and mutational analysis of Rab GDP-dissociation inhibitor
21. Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange
22. Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion
23. EEAI links PI(3)K function to Rab5 regulation of endosome fusion
24. The Rab5 effector EEAI is a core component of endosome docking
25. rab5 controls early endosome fusion in vitro
26. A novel role for Rab5-GDI in ligand sequestration into clathrin-coated pits
27. Rab5 regulates motility of early endosomes on microtubules
28. Vesicular transport: How many Ypt/Rab-GTPases make a eukaryotic cell?
29. The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion
30. Genetic defects of intracellular membrane transport
31. Of yeast, mice and men: Rab proteins and organelle transport
32. Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome
33. Rab27a regulates the peripheral distribution of melanosomes in melanocytes
34. Rab27a is required for regulating secretion in cytotoxic T lymphocytes
35. Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene
36. Retinal degeneration in choroideremia: Deficiency of rab geranylgeranyl transferase
37. Deficient geranylgeranylation of Ram/Rab27 in choroideremia
38. Mutations in GDII are responsible for X-linked non-specific mental retardation
39. Role of rab GTPases in membrane traffic