A biological-based model that links genomic instability, bystander effects, and adaptive response

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 568, Issue 1 SPEC. ISS., 2004, Pages 129-143

  Scott, B R ^a  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

Author keywords

Adaptive response; Bystander effect; Genomic instability; Hormesis; Low dose radiation

Indexed keywords

ADAPTIVE RADIATION; APOPTOSIS; BYSTANDER EFFECT; CELL MUTANT; CELL TYPE; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; GENE MUTATION; GENETIC DAMAGE; GENETIC STABILITY; HUMAN; IONIZING RADIATION; LINEAR ENERGY TRANSFER; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROGENY; RADIATION DOSE; REVIEW; STOCHASTIC MODEL;

MAMMALIA;

EID: 7644240371     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2004.06.051     Document Type: Review

References (72)

1. B.R. Scott, D.M. Walker, V. Walker, Low dose radiation and genotoxic chemicals can protect against stochastic biological effects, Nonlinearity Biol. Toxicol. Med., in press.
2. C. Mothersill, and C.B. Seymour Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells Int. J. Radiat. Biol. 71 1997 421 427
3. C. Mothersill, and C.B. Seymour Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: evidence for release during irradiation of a signal controlling survival into the medium Radiat. Res. 149 1998 256 262
4. T.K. Hei, L.-J. Wu, S.-X. Liu, D. Vannais, C.A. Waldren, and G. Randers-Pehrson Mutagenic effects of a single and an exact number of α particles in mammalian cells Proc. Natl. Acad. Sci. U.S.A. 94 1997 3765 3770
5. E.I. Azzam, S.M. de Toledo, T. Gooding, and J.B. Little Intercellular communication is involved in bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles Radiat. Res. 150 1998 497 504
6. O.V. Belyakov, M. Folkard, C. Mothersill, K.M. Prise, and B.D. Michael Bystander-induced urothelial explants after charged particle microbeam irradiation Radiat. Prot. Dosim. 99 1-4 2002 249 251
7. O.V. Belyakov, M. Folkard, C. Mothersill, K.M. Prise, and B.D. Michael A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation Br. J. Cancer 88 5 2003 767 774
8. R.B. Iyer, and B.E. Lehnert Low dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells Mutat. Res. 503 2002 1 9
9. R.B. Iyer, and B.E. Lehnert Low-dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells Mutat. Res. 503 2002 1 9
10. D.J. Brenner, J.B. Little, and R.K. Sachs The bystander effect in radiation oncogenesis. II. A quantitative model Radiat. Res. 155 2001 402 408
11. Z. Goldberg, and B.E. Lehnert Radiation-induced effects in unirradiated cells: a review and implications for cancer Int. J. Oncol. 21 2002 337 349
12. B.R. Scott, D.M. Walker, Y. Tesfaigzi, and H. Schöllnberger Mechanistic basis for nonlinear dose-response relationships for low-dose radiation-induced stochastic effects Nonlinearity Biol. Toxicol. Med. 1 1 2003 93 122
13. J.M. Jürgensmeier, P. Höfler, and G. Bauer TGF-β-induced elimination of transformed fibroblast by normal cells: independence of cell-to-cell contact and dependence on reactive oxygen species Int. J. Oncol. 5 1994 525 531
14. J.M. Jürgensmeier, C.P. Schmitt, E. Viesel, P. Höfler, and G. Bauer Transforming growth factor beta-treated normal fibroblasts eliminate transformed fibroblasts by induction of apoptosis Cancer Res. 54 2 1994 393 398
15. J.M. Jürgensmeier, P. Höfler, and G. Bauer TGF-β induced elimination of transformed fibroblast by normal cells: independence of cell-to-cell contact and dependence on ROS Int. J. Oncol. 5 1994 525 531
16. G. Bauer Resistance to TGF-β-induced elimination of transformed cells is required during tumor progression Int. J. Oncol. 6 1995 1227 1229
17. G. Bauer Elimination of transformed cells by normal cells: novel concept for the control of carcinogenesis Histol. Histopathol. 11 1996 237 255
18. G. Bauer Reactive oxygen, nitrogen species: efficient, selective, and interactive signals during intercellular induction of apoptosis Anticancer Res. 20 6B 2000 4115 4139
19. C. Langer, J.M. Jürgensmeier, and G. Bauer Reactive oxygen species act at both TGF-beta-dependent and -independent steps during induction of apoptosis of transformed cells by normal cells Exp. Cell Res. 222 1 1996 117 124
20. M.L. Hipp, and G. Bauer Intercellular induction of apoptosis in transformed cells does not depend on p53 Oncogene 17 7 1997 791 797
21. J.M. Jürgensmeier, and G. Bauer Interference of bcl-2 with intercellular control of carcinogenesis Int. J. Cancer 71 4 1997 698 704
22. I. Engelmann, and G. Bauer How can tumor cells escape intercellular induction of apoptosis? Anticancer Res. 20 4 2000 2297 2306
23. M.M. Ahmed Regulation of radiation-induced apoptosis by early growth response-1 gene in solid tumors Curr. Cancer Drug Targets 4 1 2004 43 52
24. J.E. Chipuk, T. Kuwana, L. Bouchier-Hayes, N.M. Dorin, D.D. Newmeyer, M. Schuler, and D.R. Green Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis Science 303 5660 2004 1010 1014
25. S.G. Kim, H.S. Jong, T.Y. Kim, J.W. Lee, N.K. Lim, S.H. Hong, and Y.J. Bang Transforming growth factor-beta 1 induces apoptosis through Fas ligand-independent activation of the Fas death pathway in human gastric SNU-620 carcinoma cells Mol. Biol. Cell 15 2 2004 420 434 (Epub 31 October 2003)
26. E. Mori, M.J. Thomas, K. Motoki, K. Nakazawa, T. Tahara, K. Tomizuka, I. Ishida, and S. Kataoka Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2 Cell Death Differ. 11 2 2004 203 207
27. J. Lu, M.S. Caplan, A.P. Saraqf, D. Li, L. Adler, X. Liu, and T. Jilling Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells Am. J. Physiol. Gastrointest. Liver Physiol. 286 2 2003 G340 G350 (Epub 25 September 2003)
28. V. Panduri, S.A. Weitzman, N.S. Chandel, D.A. Kamp, Mitochondrial-derived free radicals mediate asbestos-induced alveolar epithelial cell apoptosis, Am. J. Physiol. Lung Cell Mol. Phsiol. 286 (6) (2004) L1220-L1227.
29. H. Schulze-Bergkamen, and P.H. Krammer Apoptosis in cancer - implications for therapy Semin. Oncol. 31 1 2004 90 119
30. P.A. Townsend, T.M. Scaravelli, S.M. Davidson, R.A. Knight, D.S. Latchman, and A. Stephanou STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis J. Biol. Chem. 279 7 2004 5811 5820 (Epub 5 November 2003)
31. W. Watjen, and D. Beyersmann Cadmium-induced apoptosis in C6 glioma cells: influence of oxidative stress Biometals 17 1 2004 65 78
32. P.J. Sykes, T.K. Day, S. Swinburne, M. Bhat, J. Cormack, J. Lane, A.A. Morley, A.M. Hooker, Effect of low dose radiation on somatic intrachromosomal recombination in vivo and in vitro, Office of Biological and Environmental Research DOE Lowdose Radiation Program Workshop IV, 2003 (abstract). Available via the web at http://lowdose.tricity.wsu.edu/.
33. E.I. Azzam, S.M. de Toledo, G.P. Raaphorst, and R.E. Mitchel Low-dose ionizing radiation decreases the frequency of neoplastic transformation to a level below the spontaneous rate in C3H 10T1/2 cells Radiat. Res. 146 1996 369 373
34. J.L. Redpath, D. Liang, T.H. Taylor, C. James, E. Christie, and E. Elmore The shape of the dose-response curve for radiation-induced neoplastic transformation in vitro: evidence for an adaptive response against neoplastic transformation at low doses of low-LET radiation Radiat. Res. 156 2001 700 707
35. M.C. Pant, X-Y. Liao, Q. Lu, S. Molloi, E. Elmore, and J.L. Redpath Mechanisms of suppression of neoplastic transformation in vitro by low doses of low LET radiation Carcinogenesis 24 12 2003 1961 1965
36. S. Wolff The adaptive response in radiobiology: evolving insights and implications Environ. Health Perspect. 106 1998 277 283
37. O. Rigaud, and E. Moustacchi Radioadaptation for gene mutation and the possible molecular mechanisms of the adaptive response Mutat. Res. 358 1996 127 134
38. P.K. Zhou, X.Q. Zhiang, W.Z. Sun, X.Y. Liu, Y.P. Zhang, and K. Wei Adaptive response to mutagenesis and its molecular basis in human T-cell leukemia line primed with a low dose of gamma rays Radiat. Environ. Biophys. 33 1994 211 217
39. T. Ikushima, H. Aritomi, and J. Morista Radioadaptive response: efficient repair of radiation-induced DNA damage in adapted cells Mutat. Res. 358 1996 193 198
40. D.Yu. Klokov, S.I. Zaichkina, G.F. Aptikaeva, A.Kh. Akhmadieva, O.M. Rozanova, and E.E. Ganassi Induction of cytogenetic damages by combined chronic and acute gamma radiation in rat bone-marrow cells Russ. J. Genet. 33 6 1997 723 725 (Translated from Genetika 33 (6) 855-857)
41. 137Cs γ rays, Office of Biological and Environmental Research DOE Low Dose Radiation Program Workshop IV, 2003 (abstract). Available via http://lowdose.tricity.wsu.edu/.
42. J.H. Albert Computational methods using a Bayesian hierarchical generalized linear model J. Am. Statist. Assoc. 83 1988 1037 1045
43. B.P. Carlin, and T. Lewis Bayes and Empirical Bayes Methods for Data Analysis 1996 Chapman & Hall London
44. A.E. Gelfand, and A.F.M. Smith Sampling based approaches to calculating marginal densities J. Am. Statist. Assoc. 85 1990 398 409
45. A. Gelman, J.B. Carlin, H.S. Stern, and D.B. Rubin Bayesian Data Analysis 1995 Chapman & Hall London
46. D.S. Siva Data Analysis: A Bayesian Tutorial 1998 Oxford University Press New York, USA
47. D.J. Spiegelhalter, A. Thomas, and N.G. Best WinBUGS Version 1.4, Users Manual 2003 MRC Biostatistics Unit Cambridge, UK
48. D. Gamerman Markov Chain Monte Carlo, Stochastic Simulation for Bayesian Inference 1997 Chapman & Hall London
49. J.B. Little, L. Gorgojo, and H. Vetros Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells Int. J. Radiat. Oncol. Biol. Phys. 19 1990 1425 1429
50. B.A. Marder, and W.F. Morgan Delayed chromosomal instability induced by DNA damage Mol. Cell Biol. 13 1993 6667 6677
51. M.B. Martins, L. Sabatier, M. Ricoul, A. Pinton, and B. Durtrillaux Specific chromosome instability induced by heavy ions: a step towards transformation of human fibroblasts Mutat. Res. 285 1993 229 237
52. M.A. Kadhim, C.A. Walker, M.A. Plumb, and E.G. Wright No association between p53 status and α-particle-induced chromosomal instability in human lymphoblastoid cells Int. J. Radiat. Biol. 69 2 1996 167 174
53. C.H. Kennedy, C.E. Mitchell, N.H. Fukushima, R.E. Neft, and J.F. Lechner Induction of genomic instability in normal human bronchial epithelial cells by 238Pu alpha-particles Carcinogenesis 17 1996 1671 1676
54. W.F. Morgan, J.P. Day, M.L. Kaplan, E.M. McGhee, and C.L. Limolo Genomic instability induced by ionizing radiation Radiat. Res. 146 1996 247 258
55. J.B. Little Induction of genetic instability by ionizing radiation CR Acad. Sci. III 322 1999 127 134
56. C. Mothersill, and C.B. Seymour Review: mechanisms and implications of genomic instability and other delayed effects of ionizing radiation exposure Mutagenesis 13 5 1998 421 426
57. E.G. Wright Radiation-induced genomic instability in hemopoietic cells Int. J. Radiat. Biol. 74 1998 681 688
58. B.R. Scott A mechanistic model for neoplastic transformation of cells by high LET radiation and its implication for low dose, low dose rate risk assessment Radiat. Prot. Dosim. 72 1997 105 117
59. H. Schöllnberger, B.R. Scott, and T.E. Hanson Application of Bayesian inference to characterize risks associated with low doses of low-LET radiations Bull. Math. Biol. 63 2001 865 883
60. J.L. Redpath, and R.J. Antoniono Induction of an adaptive response against spontaneous neoplastic transformation in vitro by low-dose gamma radiation Radiat. Res. 149 1998 517 520
61. J.L. Redpath, S.C. Short, M. Woodcock, and P.J. Johnston Low-dose reduction in transformation frequency compared to unirradiated controls: the role of hyper-radiosensitivity to cell death Radiat. Res. 159 3 2003 433 436
62. E.I. Azzam, G.P. Raaphorst, and R.E. Mitchel Radiation-induced adaptive response for protection against micronucleus formation and neoplastic transformation in C3H 10T1/2 mouse embryo cells Radiat. Res. 138 1994 S28 S31
63. H. Nikjoo, P. O'Neil, M. Terrissol, and D.T. Goodhead Quantitative modeling of DNA damage using Monte Carlo tract structure method Radiat. Environ. Biophys. 28 1999 311 338
64. J.E. Ward Nature of lesions formed by ionizing radiation J.A. Nikoloff M.F. Hoekstra DNA Damage and Repair vol. 2 1998 Human Press Totowa, NJ 65 84
65. P.A. Jeggo The fidelity of repair of radiation damage Radiat. Prot. Dosim. 99 1-4 2002 117 122
66. K. Rothkamm, and M. Löbrich Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses PNAS 100 9 2003 5057 5062
67. S. Kojima, O. Matsuki, T. Nomura, A. Kubodera, Y. Honda, S. Honda, H. Tanooka, H. Wakasugi, and K. Yamaoka Induction of mRNAs for glutathione synthesis-related proteins in mouse liver by low doses of γ-rays Biochem. Biophys. Acta 1381 1998 312 318
68. H. Matsumoto, S. Hayashi, M. Hatashita, K. Ohnishi, H. Shioura, R. Ohtsubo, R. Kitai, T. Ohnishi, and E. Kano Induction of radioresistance by a nitric oxide-mediated bystander effect Radiat. Res. 155 2001 378 396
69. E.J. Broome, D.L. Brown, and R.E. Mitchel Dose responses for adaptation of low doses of 60Co γ rays and 3H β particles in normal human fibroblast Radiat. Res. 158 2002 181 186
70. V.P. Bond, L.E. Feinendegen, and J. Booz What is a 'low dose' of radiation? Int. J. Radiat. Biol. 53 1988 1 12
71. L.E. Feinendegen, M. Pollycove, C.A. Sondhaus, Responses to low doses of ionizing radiation in biological systems, Nonlinearity Biol. Toxicol. Med., in press.
72. D.T. Goodhead Track structure considerations in low dose, low dose rate effects of ionizing radiation Adv. Radiat. Biol. 16 1992 7 44