Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA

EMBO Journal

Volumn 21, Issue 22, 2002, Pages 6216-6224

  Calado, Angelo ^a,c   Treichel, Nathalie ^a   Müller, Eva Christina ^b   Otto, Albrecht ^b   Kutay, Ulrike ^a  

^a ETH ZURICH   (Switzerland)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY OF LISBON   (Portugal)

Author keywords

eEF1A; Export receptor; Exportin 5; Nucleo cytoplasmic transport; tRNA

Indexed keywords

BINDING PROTEIN; ELONGATION FACTOR 1ALPHA; EXPORTIN 5; EXPORTIN T; PROTEIN DERIVATIVE; TRANSFER RNA; UNCLASSIFIED DRUG;

AMINOACYLATION; ANIMAL CELL; ARTICLE; CELL NUCLEUS; COMPLEX FORMATION; CONTROLLED STUDY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; XENOPUS LAEVIS;

ANIMALIA; EUKARYOTA; XENOPUS LAEVIS;

EID: 0037112842     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf620     Document Type: Article

References (42)

1. Arts, G.J., Fomerod, M. and Mattaj, I.W. (1998a) Identification of a nuclear export receptor for tRNA. Curr. Biol., 8, 305-314.
2. Arts, G.J., Kuersten, S., Romby, P., Ehresmann, B. and Mattaj, I.W. (1998b) The role of exportin-t in selective nuclear export of mature tRNAs. EMBO J., 17, 7430-7441.
3. Azad, A.K., Stanford, D.R., Sarkar, S. and Hopper, A.K. (2001) Role of nuclear pools of aminoacyl-tRNA synthetases in tRNA nuclear export. Mol. Biol. Cell, 12, 1381-1392.
4. Billaut-Mulot, O., Fernandez-Gomez, R., Loyens, M. and Ouaissi, A. (1996) Trypanosoma cruzi elongation factor 1-α: Nuclear localization in parasites undergoing apoptosis. Gene, 174, 19-26.
5. Blondel, M., Alepuz, P.M., Huang, L.S., Shaham, S., Ammerer, G. and Peter, M. (1999) Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p. Genes Dev., 13, 2284-2300.
6. Brownawell, A.M. and Macara, I.G. (2002) Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins. J. Cell Biol., 156, 53-64.
7. Cullen, B.R. (1998) Retroviruses as model systems for the study of nuclear RNA export pathways. Virology, 249, 203-210.
8. DeVit, M.J. and Johnston, M. (1999) The nuclear exportin Msn5 is required for nuclear export of the Mig1 glucose repressor of Saccharomyces cerevisiae. Curr. Biol., 9, 1231-1241.
9. Ejiri, S. (2002) Moonlighting functions of polypeptide elongation factor 1: From actin bundling to zinc finger protein R1-associated nuclear localization. Biosci. Biotechnol. Biochem., 66, 1-21.
10. Feng, W. and Hopper, A.K. (2002) A Los1p-independent pathway for nuclear export of intronless tRNAs in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA, 99, 5412-5417.
11. Fischer, U., Huber, J., Boelens, W.C., Mattaj, I.W. and Lührmann, R. (1995) The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell, 82, 475-83.
12. Fornerod, M., Ohno, M., Yoshida, M. and Mattaj, I.W. (1997) Crm1 is an export receptor for leucine rich nuclear export signals. Cell, 90, 1051-1060.
13. Fukuda, M., Asano, S., Nakamura, T., Adachi, M., Yoshida, M., Yanagida, M. and Nishida, E. (1997) CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature, 390, 308-311.
14. Gadal, O., Strauss, D., Kessl, J., Trumpower, B., Tollervey, D. and Hurt, E. (2001) Nuclear export of 60S ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rp110p. Mol. Cell. Biol., 21, 3405-3415.
15. Gangwani, L., Mikrut, M., Galcheva-Gargova, Z. and Davis, R.J. (1998) Interaction of ZPR1 with translation elongation factor-1α in proliferating cells. J. Cell Biol., 143, 1471-1484.
16. Görlich, D. and Kutay, U. (1999) Transport between the cell nucleus and the cytoplasm. Annu. Rev. Cell Dev. Biol., 15, 607-660.
17. Grosshans, H., Hurt, E. and Simos, G. (2000a) An aminoacylation- dependent nuclear tRNA export pathway in yeast. Genes Dev., 14, 830-840.
18. Grosshans, H., Simos, G. and Hurt, E. (2000b) Review: Transport of tRNA out of the nucleus - Direct channeling to the ribosome? J. Struct. Biol., 129, 288-294.
19. Grüter, P., Tabernero, C., von Kobbe, C., Schmitt, C., Saavedra, C., Bachi, A., Wilm, M., Felber, B.K. and Izaurralde, E. (1998) TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol. Cell, 1, 649-659.
20. Hellmuth, K., Lau, D.M., Bischoff, F.R., Kunzler, M., Hurt, E. and Simos, G. (1998) Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA. Mol. Cell. Biol., 18, 6374-6386.
21. Ho, J.H., Kallstrom, G. and Johnson, A.W. (2000) Nmd3p is a crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit. J. Cell Biol., 151, 1057-1066.
22. Hurt, D.J., Wang, S.S., Lin, Y.H. and Hopper, A.K. (1987) Cloning and characterization of LOS1, a Saccharomyces cerevisiae gene that affects tRNA splicing. Mol. Cell. Biol., 7, 1208-1216.
23. Iborra, F.J., Jackson, D.A. and Cook, P.R. (2001) Coupled transcription and translation within nuclei of mammalian cells. Science, 293, 1139-1142.
24. Izaurralde, E., Kutay, U., von Kobbe, C., Mattaj, I.W. and Görlich, D. (1997) The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. EMBO J., 16, 6535-6547.
25. Jarmolowski, A., Boelens, W.C., Izaurralde, E. and Mattaj, I.W. (1994) Nuclear export of different classes of RNA is mediated by specific factors. J. Cell Biol., 124, 627-635.
26. Kaffman, A., Rank, N.M., O'Neill, E.M., Huang, L.S. and O'Shea, E.K. (1998) The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus. Nature, 396, 482-486.
27. Kjaer, S., Wind, T., Ravn, P., Ostergaard, M., Clark, B.F. and Nissim, A. (2001) Generation and epitope mapping of high-affinity scFv to eukaryotic elongation factor 1A by dual application of phage display. Eur. J. Biochem., 268, 3407-3415.
28. Kuersten, S., Ohno, M. and Mattaj, I.W. (2001) Nucleocytoplasmic transport: Ran, β and beyond. Trends Cell Biol., 11, 497-503.
29. Kutay, U., Bischoff, F.R., Kostka, S., Kraft, R. and Görlich, D. (1997) Export of importin α from the nucleus is mediated by a specific nuclear transport factor. Cell, 90, 1061-1071.
30. Kutay, U., Lipowsky, G., Izaurralde, E., Bischoff, F.R., Schwarzmaier, P., Hartmann, E. and Görlich, D. (1998) Identification of a tRNA-specific nuclear export receptor. Mol. Cell, 1, 359-369.
31. Kutay, U., Hartmann, E., Treichel, N., Calado, A., Carmo-Fonseca, M., Prehn, S., Kraft, R., Görlich, D. and Bischoff, F.R. (2000) Identification of two novel RanGTP-binding proteins belonging to the importin β superfamily. J. Biol. Chem., 275, 40163-40168.
32. Lipowsky, G., Bischoff, F.R., Izaurralde, E., Kutay, U., Schäfer, S., Gross, H.J., Beier, H. and Görlich,D. (1999) Coordination of tRNA nuclear export with processing of tRNA. RNA, 5, 539-549.
33. Lund, E. and Dahlberg, J.E. (1998) Proofreading and aminoacylation of tRNAs before export from the nucleus. Science, 282, 2082-2085.
34. Macara, I.G. (2001) Transport into and out of the nucleus. Microbiol. Mol. Biol. Rev., 65, 570-594.
35. Mattaj, I.W. and Englmeier, L. (1998) Nucleocytoplasmic transport: The soluble phase. Annu. Rev. Biochem., 67, 265-306.
36. Mühlhäusser, P., Müller, E.C., Otto, A. and Kutay, U. (2001) Multiple pathways contribute to nuclear import of core histones. EMBO Rep., 2, 690-696.
37. Negrutskii, B.S. and El'skaya, A.V. (1998) Eukaryotic translation elongation factor 1α: Structure, expression, functions and possible role in aminoacyl-tRNA channeling. Prog. Nucleic Acid Res. Mol. Biol., 60, 47-78.
38. Ohno, M., Segref A., Bachi, A., Wilm, M. and Mattaj, I.W. (2000) PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Cell, 101, 187-198.
39. Roobol, K. and Moller, W. (1978) The role of guanine nucleotides in the interaction between aminoacyl-tRNA and elongation factor 1 of Artemia salina. Eur. J. Biochem., 90, 471-7.
40. Sanders, J., Brandsma, M., Janssen, G.M., Dijk, J. and Moller, W. (1996) Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 βγδ in the endoplasmic reticulum. J. Cell Sci., 109, 1113-1117.
41. Sarkar, S. and Hopper, A.K. (1998) tRNA nuclear export in Saccharomyces cerevisiae: In situ hybridization analysis. Mol. Biol. Cell, 9, 3041-3055.
42. Sarkar, S., Azad, A.K. and Hopper, A.K. (1999) Nuclear tRNA aminoacylation and its role in nuclear export of endogenous tRNAs in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA, 96, 14366-14371.