RCC1 in the Ran pathway

Journal of Biochemistry

Volumn 120, Issue 2, 1996, Pages 207-214

  Seki, Takashi ^a   Hayashi, Naoyuki ^a   Nishimoto, Takeharu ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Ran; RanBP1; RanBP2; RCC1; RNA1

Indexed keywords

CHROMOSOME PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; MESSENGER RNA; REGULATOR PROTEIN;

BINDING SITE; CELL CYCLE; CHROMATIN; CHROMATIN STRUCTURE; ENZYME ACTIVITY; MITOSIS; MITOSIS INHIBITION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REVIEW;

MAMMALIA;

EID: 0029791464     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a021400     Document Type: Review

References (50)

1. Nishitani, H., Ohtsubo, M., Yamashita, K., Iida, H., Pines, J., Yasuda, H., Shibata, Y., Hunter, T., and Nishimoto, T. (1991) Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis. EMBO J. 10, 1555-1564
2. Clark, K.L. and Sprague, G.F., Jr. (1989) Yeast pheromone response pathway: Characterization of a suppressor that restores mating to receptorless mutants. Mol. Cell. Biol. 9, 2682-2694
3. Aebi, M., Clark, M.W., Vijayraghavan, U., and Abelson, J. (1990) A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation. Mol. Gen. Genet. 224, 72-80
4. Kadowaki, T., Goldfarb, D., Spitz, L.M., Tartakoff, A.M., and Ohno, M. (1993) Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily. EMBO J. 12, 2929-2937
5. Bischoff, F.R. and Ponstingl, H. (1991) Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Nature 354, 80-82
6. Moore, M.S. and Blobel, G. (1993) The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature 365, 661-663
7. Ohtsubo, M., Kai, R., Furuno, N., Sekiguchi, T., Sekiguchi, M., Hayashida, H., Kuma, K., Miyata, T., Fukushige, S., Murotsu, T., Matsubara, K., and Nishimoto, T. (1987) Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation. Genes Dev. 1, 585-593
8. Miyabashira, J., Sekiguchi, T., and Nishimoto, T. (1994) Mammalian cells have two functional RCC1 proteins produced by alternative splicing. J. Cell Sci. 107, 2203-2208
9. Nishimoto, T., Seino, H., Seki, N., and Hori, T. (1994) The Human CHC1 gene encoding RCC1 (regulator of chromosome condensation) (CHC1) is localized to human chromosome 1p36.1. Gemonics 23, 719-721
10. Frasch, M. (1991) The maternally expressed Drosophila gene encoding the chromatin-binding protein BJ1 is a homologue of the vertebrate gene regulator of chromosome condensation, RCC1. EMBO J. 10 1225-1236
11. Matsumoto, T. and Beach, D. (1991) Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase. Cell 66, 347-360
12. Sazer, S. and Nurse, P. (1994) A fission yeast RCC1-related protein is required for the mitosis to interphase transition. EMBO J. 13, 606-615
13. Ohtsubo, M., Ozaki, H., and Nishimoto, T. (1989) The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and bind to DNA. J. Cell Biol. 109, 1389-1397
14. Bischoff, F.R., Maier, G., Tilz, G., and Ponstingl, H. (1990) A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation. Proc. Natl. Acad. Sci. USA 87, 8617-8621
15. Lee, A., Tam, R., Belhumeur, P., DiPaolo, T., and Clark, M.W. (1993) Prp20, the Saccharomyces cerevisiae homolog of the regulator of chromosome condensation, RCC1, interacts with double-stranded DNA through a multi-component complex containing GTP-binding proteins. J. Cell Sci. 106, 287-298
16. Seino, H., Hisamoto, N., Uzawa, S., Sekiguchi, T., and Nishimoto, T. (1992) DNA-binding domain of RCC1 protein is not essential for coupling mitosis with DNA replication. J. Cell Sci. 102, 393-400
17. Drivas, G.T., Shih, A., Coutavas, E., Rush, M.G., and D'Eustachio, P. (1990) Characterization of four novel RAS-related genes expressed in a human teratocarcinoma cell line. Mol. Cell. Biol. 10, 1793-1798
18. Belhumeur, P., Lee, A., Tam, R., DiPaolo, T., Fortin, N., and Clark, M.W. (1993) GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization. Mol. Cell. Biol. 13, 2152-2161
19. Scheffzek, K., Klebe, C., Fritz-Wolf, K., Kabsch, W., and Wittinghofer, A. (1995) Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form. Nature 374, 378-381
20. Kornbluth, S., Dasso, M., and Newport, J. (1994) Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression. J. Cell Biol. 125, 705-719
21. Coutavas, E., Ren, M., Oppenhelm, J.D., D'Eustachio, P., and Rush, M.G. (1993) Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4. Nature 366, 585-587
22. Richards, S.A., Lounsbury, K.M., and Macara, I.G. (1995) The C terminus of the nuclear Ran/Tc4 GTPase stabilize the GDP-bound state and mediates interactions with RCC1, Ran-GAP and HTF9A/RanBP1. J. Biol. Chem. 270, 14405-14411
23. Bischoff, F.R., Krebber, H., Kempf, T., Hermes, I., and Ponstingl, H. (1995) Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. Proc. Natl. Acad. Sci. USA 92, 1749-1753
24. Corbett, A.H., Koepp, D.M., Schlenstedt, G., Lee, M.S., Hopper, A.K., and Silver, P.A. (1995) Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import. J. Cell Biol. 130, 1017-1026
25. DeGregori, J., Russ, A., Melchner, H., Rayburn, H., Priyaranjan, P., Jenkins, N.A., Copeland, N.G., and Ruley, H.E. (1994) A murine homolog of the yeast RNA1 gene is required for postimplantation development. Genes Dev. 8, 265-276
26. Melchior, F., Weber, K., and Gerke, V. (1993) A functional homologue of the RNA1 gene product in Schizosaccharomyces pombe: Purification, biochemical characterization, and identification of a leucine-rich repeat motiff. Mol. Biol. Cell 4, 569-581
27. Klebe, C., Prinz, H., Wittinghofer, A., and Goody, R.S. (1995) The kinetics mechanism of Ran-nucleotide exchange catalyzed by RCC1. Biochemistry 34, 12543-12552
28. Hayashi, N., Yokoyama, N., Seki, T., Azuma, Y., Ohba, T., and Nishimoto, T. (1995) RanBP1, a Ras-like nuclear G-protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4. Mol. Gen. Genet. 247, 661-669
29. Ouspenski, I.L., Mueller, U.W., Matynia, A., Sazer, S., Elledge, S.J., and Brinkley, B.R. (1995) Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast. J. Biol. Chem. 270, 1975-1978
30. Schlenstedt, G., Wong, D.H., Koepp, D., and Silver, P.A. (1995) Mutants in a yeast Ran binding protein are defective in nuclear transport. EMBO J. 14, 5367-5378
31. Wu, J., Matunis, J., Kraemer, D., Blobel, G., and Coutavas, E. (1995) Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. J. Biol. Chem. 270, 14209-14213
32. Yokoyama, N., Hayashi, N., Seki, T., Pante, N., Ohba, T., Nishii, K., Kuma, K., Hayashida, T., Miyata, T., Aebi, U., Fukui, M., and Nishimoto, T. (1995) A giant nucleopore protein that binds Ran/TC4. Nature 376, 184-188
33. Sukegawa, J. and Blobel, G. (1993) A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm. Cell 72, 29-38
34. Melchior, F., Guan, T., Yokoyama, N., Nishimoto, T., and Gerace, L. (1995) GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of nuclear protein import. J. Cell Biol. 131, 571-581
35. Azuma, Y., Seino, H., Seki, T., Uzawa, S., Klebe, C., Ohba, T., Wittinghofer, A., Hayashi, N., and Nishimoto, T. (1996) Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran. J. Biochem. 120, 82-91
36. + RNA in the cytoplasm. Proc. Natl. Acad. Sci. USA 92, 225-229
37. Cheng, Y., Dahlberg, J.E., and Lund, E. (1995) Diverse effects of the guanine nucleotide exchange factor RCC1 on RNA transport. Science 267, 1807-1810
38. Tachibana, T., Imamoto, N., Seino, H., Nishimoto, T., and Yoneda, Y. (1994) Loss of RCC1 leads to suppression of nuclear protein import in living cells. J. Biol. Chem. 269, 24542-24545
39. Loeb, J.D.J., Schlenstedt, G., Pellman, D., Kornitzer, D., Silver, P.A., and Fink, G.R. (1995) The yeast nuclear import receptor is required for mitosis. Proc. Natl. Acad. Sci. USA 92, 7647-7651
40. Seki, T., Yamashita, K., Nishitani, H., Takagi, T., Russell, P., and Nishimoto, T. (1992) Chromosome condensation caused by loss of RCC1 function required the cdc25C protein that is located in the cytoplasm. Mol. Biol. Cell 3, 1373-1388
41. Ren, M., Coutavas, E., D'Eustachio, P.D., and Rush, M.G. (1994) Cell cycle arrest induced by mutant Ran/TC4 proteins. Mol. Cell. Biol. 14, 4216-4224
42. Ohba, T., Seki, T., Azuma, Y., and Nishimoto, T. (1996) Premature chromatin condensation induced by loss of RCC1 is inhibited by GTP- and GTPγS-Ran, but not GDP-Ran. J. Biol. Chem. 271, 14665-14667
43. Dasso, M., Seki, T., Azuma, Y., Ohba, T., and Nishimoto, T. (1994) A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation. EMBO J. 13, 5732-5744
44. Matsumoto, T. and Beach, D. (1993) Interaction of the pim1/spi1 mitotic checkpoint with a protein phosphatase. Mol. Biol. Cell 4, 337-345
45. Shimanuki, M., Kinoshita, N., Ohkura, H., Yoshida, T., Toda, T., and Yanagida, M. (1993) Isolation and characterization of the fission yeast protein phosphatase gene ppe1 - involved in cell shape control and mitosis. Mol. Biol. Cell 4, 303-313
46. + gene encodes a 110 kDa essential protein implicated in mitotic control. Mol. Cell. Biol. 11, 5839-5847
47. Bun-Ya, M., Harashima, S., and Oshima, Y. (1992) Putative GTP-binding protein, Gtr1, associated with the function of the Pho84 inorganic phosphate transporter in Saccharomyces cerevisiae. Mol. Cell. Biol. 12, 2958-2966
48. Compton, D.A. and Cleveland, D.W. (1993) NuMA is required for the proper completion of mitosis. J. Cell Biol. 120, 947-957
49. Kirkpatrick, D. and Solomon, F. (1994) Overexpression of yeast homologs of the mammalian checkpoint gene RCC1 suppresses the class of α-tubulin mutations that arrest with excess microtubules. Genetics 137, 381-392
50. Nishimoto, T., Ishida, R., Ajiro, K., Yamamoto, S., and Takahashi, T. (1981) The synthesis of protein(s) for chromosome condensation may be regulated by a post-transcriptional mechanism. J. Cell. Physiol. 109, 299-308