The spread of Ras activity triggered by activation of a single dendritic spine

Science

Volumn 321, Issue 5885, 2008, Pages 136-140

  Harvey, Christopher D ^a,b   Yasuda, Ryohei ^b,c   Zhong, Haining ^a,b   Svoboda, Karel ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b Watson School of Biological Sciences   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; GUANOSINE TRIPHOSPHATASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RAS PROTEIN;

CALCIUM; FLUORESCENCE; IMAGE; SIGNALING;

ARTICLE; BRAIN FUNCTION; DENDRITIC SPINE; FLUORESCENCE RESONANCE ENERGY TRANSFER; LONG TERM POTENTIATION; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CALCIUM; CELL MEMBRANE; DENDRITIC SPINES; DIFFUSION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GLUTAMIC ACID; GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HIPPOCAMPUS; LONG-TERM POTENTIATION; PYRAMIDAL CELLS; RAS PROTEINS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SYNAPSES; TRANSFECTION;

EID: 46849102728     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1159675     Document Type: Article

References (31)

1. E. A. Nimchinsky, B. L. Sabatini, K. Svoboda, Annu. Rev. Physiol. 64, 313 (2002).
2. K. Svoboda, D. W. Tank, W. Denk, Science 272, 716 (1996).
3. B. L. Bloodgood, B. L. Sabatini, Science 310, 866 (2005).
4. W. Muller, J. A. Connor, Nature 354, 73 (1991).
5. R. Yuste, W. Denk, Nature 375, 682 (1995).
6. B. L. Sabatini, T. G. Oertner, K. Svoboda, Neuron 33, 439 (2002).
7. M. B. Kennedy, H. C. Beale, H. J. Carlisle, L. R. Washburn, Nat. Rev. Neurosci. 6, 423 (2005).
8. M. J. Kim, A. W. Dunah, Y. T. Wang, M. Sheng, Neuron 46, 745 (2005).
9. X. Tian et al., EMBO J. 23, 1567 (2004).
10. H. Y. Yun, M. Gonzalez-Zulueta, V. L. Dawson, T. M. Dawson, Proc. Natl. Acad. Sci. U.S.A. 95, 5773 (1998).
11. J. J. Zhu, Y. Qin, M. Zhao, L. Van Aelst, R. Malinow, Cell 110, 443 (2002).
12. R. C. Malenka, M. F. Bear, Neuron 44, 5 (2004).
13. M. Matsuzaki, N. Honkura, G. C. Ellis-Davies, H. Kasai, Nature 429, 761 (2004).
14. S. Tsuriel et al., PLoS Biol. 4, e271 (2006).
15. N. W. Gray, R. M. Weimer, I. Bureau, K. Svoboda, PLoS Biol. 4, e370 (2006).
16. C. D. Harvey, K. Svoboda, Nature 450, 1195 (2007).
17. R. Yasuda et al., Nat. Neurosci. 9, 283 (2006).
18. N. Mochizuki et al., Nature 411, 1065 (2001).
19. O. Rocks et al., Science 307, 1746 (2005).
20. D. W. Piston, D. R. Sandison, W. W. Webb, in Time-Resolved Laser Spectroscopy in Biochemistry III, J. R. Lakowicz, Ed. (SPIE, Bellingham, WA, 1992), pp. 379-389.
21. E. Gratton, S. Breusegem, J. Sutin, Q. Ruan, N. Barry, J. Biomed. Opt. 8, 381 (2003).
22. Supporting online material is available on Science Online.
23. E. A. Nimchinsky, R. Yasuda, T. G. Oertner, K. Svoboda, J. Neurosci. 24, 2054 (2004).
24. C. D. Kopec, B. Li, W. Wei, J. Boehm, R. Malinow, J. Neurosci. 26, 2000 (2006).
25. M. Fivaz, S. Bandara, T. Inoue, T. Meyer, Curr. Biol. 18, 44 (2008).
26. G. H. Patterson, J. Lippincott-Schwartz, Science 297, 1873 (2002).
27. E. A. Reits, J. J. Neefjes, Nat. Cell Biol. 3, E145 (2001).
28. H. Niv, O. Gutman, Y. Kloog, Y. I. Henis, J. Cell Biol. 157, 865 (2002).
29. P. H. Lommerse et al., Biophys. J. 86, 609 (2004).
30. A. Losonczy, J. K. Makara, J. C. Magee, Nature 452, 436 (2008).
31. We thank N. Ghitani, B. Burbach, C. Zhang, B. Shields, and H. White for technical assistance; N. Gray for help with immunostaining; L. van Aelst for helpful discussions; and J. Dudman for comments on the manuscript. This work was supported by the Howard Hughes Medical Institute, NIH, a David and Fanny Luke Fellowship (C.D.H.), Burroughs Wellcome Fund (R.Y.), Dana Foundation (R.Y.), National Alliance for Autism Research (R.Y.), National Institute of Mental Health (R.Y.), and National Alliance for Research on Schizophrenia and Depression (H.Z.).