Attenuation of β-amyloid-induced neuroinflammation by KHG21834 in vivo

BMB Reports

Volumn 43, Issue 6, 2010, Pages 413-418

  Kim, Eun A ^a,b   Hahn, Hoh Gyu ^c   Kim, Tae Ue ^b   Choi, Soo Young ^d   Cho, Sung Woo ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Yonsei University Wonju   (South Korea)

^c Korea Institute of Science and Technology   (South Korea)

^d Hallym University   (South Korea)

Author keywords

Alzheimer's disease; Beta amyloid; KHG21834; Microglia; Neuroinflammation

Indexed keywords

AMYLOID BETA PROTEIN; BENZOTHIAZOLE DERIVATIVE; KHG21834;

ANIMAL; BRAIN CORTEX; C57BL MOUSE; DRUG EFFECTS; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; MESENCEPHALON; MOUSE; NERVE CELL; PATHOLOGY; PHYSIOLOGY;

AMYLOID BETA-PEPTIDES; ANIMALS; BENZOTHIAZOLES; CEREBRAL CORTEX; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN VITRO TECHNIQUES; INFLAMMATION; MESENCEPHALON; MICE; MICE, INBRED C57BL; NEURONS;

EID: 77955836320     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2010.43.6.413     Document Type: Article

References (41)

1. Breitner, J. C. (1996) The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease. Annu. Rev. Med. 47, 401-411.
2. Eikelenboom, P. and Gool, W. A. (2004) Neuroinflammatory perspectives on the two faces of Alzheimer's disease. J. Neural. Transm. 111, 281-294.
3. Raine, C. S. (1994) Multiple sclerosis: immune system molecule expression in the central nervous system. J. Neuropathol. Exp. Neurol. 53, 328-337.
4. Matyszak, M. K. (1998) Inflammation in the CNS: balance between immunological privilege and immune responses. Prog. Neurobiol. 56, 19-35.
5. Giulian, D. (1999) Microglia and the immune pathology of Alzheimer disease. Am. J. Hum. Genet. 65, 13-18.
6. Gonzalez-Scarano, F. and Baltuch, G. (1999) Microglia as mediators of infammatory and degenerative diseases. Annu. Rev. Neurosci. 22, 219-240.
7. Qin, L., Liu, Y., Cooper, C., Liu, B., Wilson, B. and Hong, J. S. (2002) Microglia enhance β-amyloid peptide- induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species. J. Neurochem. 83, 973-983.
8. Combs, C. K., Karlo, J. C., Kao, S. C. and Landreth, G. E. (2001) β-amyloid stimulation of microglia and monocytes results in TNFα-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J. Neurosci. 21, 1179-1188.
9. Gao, H. M., Jiang, J., Wilson, B., Zhang, W. Q., Hong, J. S. and Liu, B. (2002) Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J. Neurochem. 81, 1285-1297.
10. Liu, Y., Qin, L., Wilson, B. C., An, L., Hong, J. S. and Liu, B. (2002) Inhibition by Naloxone stereoisomers of β-amyloid peptide (1-42) induced superoxide production in microglia and degeneration of cortical and mesencephalic neurons. J. Pharmacol. Exp. Ther. 302, 1212-1219.
11. Knethen, A., Brockhaus, F., Kleiter, I. and Brune, B. (1999) NO-evoked macrophage apoptosis is attenuated by cAMP-induced gene expression. Mol. Med. 5, 672-684.
12. Heneka, M. T., Loschmann, P. A., Gleichmann, M., Weller, M., Schulz, J. B., Wullner, U. and Klockgether, T. (1998) Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide. J. Neurochem. 71, 88-94.
13. Korhonen, R., Lahti, A., Kankaanranta, H. and Molanen, E. (2005) Nitric oxide production and signalling in inflammation. Curr. Drug Targets Inflamm. Allergy 4, 471-479.
14. Kleinert, H., Schwarz, P. M. and Forstermann, U. (2003) Regulation of the expression of inducible nitric oxide synthase. Biol. Chem. 384, 1343-1364.
15. Bhat, N. R., Zhang, P., Lee, J. C. and Hogan, E. L. (1998) Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 18, 1633-1641.
16. Ajizian, S. J., English, B. K. and Meals, E. A. (1999) Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma. J. Infect. Dis. 179, 939-944.
17. Carter, A. B., Monick, M. M. and Hunninghake, G. W. (1999) Both Erk and p38 Kinases are necessary for cytokine gene transcription. Am. J. Respir. Cell. Mol. Biol. 20, 751-758.
18. Moore, A. H. and O'Banion, M. K. (2002) Neuroinflammation and anti-inflammatory therapy for Alzheimer's disease. Adv. Drug Deliv. Rev. 54, 1627-1656.
19. Wang, M. J., Lin, W. W., Chen, H. L., Chang, Y. H., Ou, H. C., Kuo, J. S., Hong, J. S. and Jeng, K. C. (2002) Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation. Eur. J. Neurosci. 16, 2103-2112.
20. Allan, S. M., Tyrrell, P. J. and Rothwell, N. J. (2005) Interleukin-1β and neuronal injury. Nat. Rev. Immunol. 5, 629-640.
21. Emsley, H. C. A., Smith, C. J., Georgiou, R. F., Vail, A., Hopkins, S. J., Rothwell, N. J. and Tyrrell, P. J. (2005) A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients. J. Neurol. Neurosurg. Psychiatry 76, 1366-1372.
22. Heiser, V., Engemann, S., Brocker, W., Dunkel, I., Boeddrich, A., Waelter, S., Nordhoff, E., Lurz, R., Schugardt, N., Rautenberg, S., Herhaus, C., Barnickel, G., Bottcher, H., Lehrach, H. and Wanker, E. E. (2002) Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay. Proc. Natl. Acad. Sci. U.S.A. 99, 16400-16406.
23. Ishiyama, T., Okada, R., Nishibe, H., Mitsumoto, H. and Nakayama, C. (2004) Riluzole slows the progression of neuromuscular dysfunction in the wobbler mouse motor neuron disease. Brain Res. 1019, 226-236.
24. 1 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. J. Med. Chem. 49, 179-185.
25. Pietrancosta, N., Moumen, A., Dono, R., Lingor, P., Planchamp, V., Lamballe, F., Bahr, M., Kraus, J. L. and Maina, F. (2006) Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. J. Med. Chem. 49, 3645-3652.
26. Mathis, C. A., Bacskai, B. J., Kajdasz, S. T., Mclellan, M. E., Frosch, M. P., Hyman, B. T., Holt, D. P., Wang, Y., Huang, G. F., Debnath, M. L. and Klunk, W. E. (2002) A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorg. Med. Chem. Lett. 12, 295-298.
27. Klunk, W. E., Wang, Y., Huang, G., Debnath, M. L., Holt, D. P., Shao, L., Hamilton, R. L., Ikonomovic, M. D., DeKosky, S. T. and Mathis, C. A. (2003) The binding of 2-(4'-methylaminophenyl) benzothiazole to postmortem brain homogenates is dominated by the amyloid component. J. Neurosci. 23, 2086-2092.
28. Choi, M. M., Kim, E. A., Hahn, H. G., Nam, K. D., Yang, S. J., Choi, S. Y., Kim, T. U., Cho, S. W. and Huh, J. W. (2007) Protective effect of benzothiazole derivative KHG21834 on amyloid beta-induced neurotoxicity in PC12 cells and cortical and mesencephalic neurons. Toxicology 239, 156-166.
29. Kim, E. A., Kim, H., Ahn, J. Y., Hahn, H. G., Kim, K. S., Kim, T. U. and Cho, S. W. (2010) Suppression of lipopolysaccharide-induced microglial activation by a benzothiazole derivative. Mol. Cells (in press)
30. Small, D. H., Mok, S. S. and Bornstein, J. C. (2001) Alzheimer's disease and Aβ toxicity: from top to bottom. Nat. Rev. Neurosci. 2, 595-598.
31. Sebastiani, G., Morisette, C., Lagace, C., Boule, M., Quollette, M. J., McLaughin, R. W., Lacombe, D., Cervais, F. and Trembley, P. (2006) The cAMP-specific phosphodiesterase 4B mediates Aβ-induced microglial activation. Neurobiol. Aging 27, 691-701.
32. White, J. A., Manelli, A. M., Holmberg, K. H., Van Eldik, L. J. and Ladu, M. J. (2005) Differential effects of oligomeric and fibrillar amyloid-beta1-42 on astrocyte-mediated inflammation. Neurobiol. Dis. 18, 459-465.
33. Craft, J. M., Van Eldik, L. J., Zasadzki, M., Hu, W. and Watterson, D. M. (2004) Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human β-amyloid in a murine model of neuroinflammation. J. Mol. Neurosci. 24, 115-122.
34. Craft. J. M., Watterson, D. M., Frautschy, S. A. and Van Eldik, L. J. (2004) Aminopyridazines inhibit β-amyloid-induced glial activation and neuronal damage in vivo. Neurobiol. Aging 25, 1283-1292.
35. Craft, J. M., Watterson, D. M., Hirsch, E. and Van Eldik, L. J. (2005) Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid. J. Neuroinflammation 2, 15-23.
36. Craft, J. M., Watterson, D. M., Marks, A. and Van Eldik, L. J. (2005) Enhanced susceptibility of S100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human β-amyloid. Glia 51, 209-216.
37. Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J., Cole, G. M., Cooper, N. R., Eikelenboom, P., Emmerling, M., Fiebich, B. L., Finch, C. E., Frautschy, S., Griffin, W. S., Hampel, H., Hull, M., Landreth, G., Lue, L., Mrak, R., Mackenzie, I. R. and McGeer, P. L. (2000) Inflammation and Alzheimer's disease. Neurobiol. Aging 21, 383-421.
38. Ranaivo, H. R., Craft, J. M., Hu, W., Guo, L., Wing, L. K., Eldik, L. J. V. and Watterson, D. M. (2006) Glia as a therapeutic target: selective suppression of human amyloid-β-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration. J. Neurosci. 26, 662-670.
39. Cheramy, A., Barbeito, L., Godeheu, G. and Glowinski, J.(1992) Riluzole inhibits release of glutamate in the caudate nucleus of the cat in vitro. Neurosci. Lett. 147, 209-212.
40. Frautschy, S. A., Yang, F., Calderon, L. and Cole, G. M. (1996) Rodent models of Alzheimer's disease: rat Aβ infusion approaches to amyloid deposits. Neurobiol. Aging 17, 311-321.
41. Laursen, S. E. and Belknap, J. K. (1986) Intracerebroventricular injections in mice. Some methodological refinements. J. Pharmacol. Methods 16, 355-357.