Antitumor benzothiazoles. 26.1 2-(3,4-dimethoxyphenyl)-5- fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines

Journal of Medicinal Chemistry

Volumn 49, Issue 1, 2006, Pages 179-185

  Mortimer, Catriona G ^a   Wells, Geoffrey ^a   Crochard, Jean Philippe ^a   Stone, Erica L ^a   Bradshaw, Tracey D ^a   Stevens, Malcolm F G ^a   Westwell, Andrew D ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3,4 DIMETHOXYPHENYL) 5 FLUOROBENZOTHIAZOLE; 2 AMINOTHIOPHENOL DISULFIDE DERIVATIVE; 2 PHENYLBENZOTHIAZOLE DERIVATIVE; 5 FLUORO 2 (3,4 DIMETHOXYPHENYL)BENZOTHIAZOLE; ANTINEOPLASTIC AGENT; BENZALDEHYDE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; CYTOCHROME P450 1A1; GW 610; NSC 721648; THIOPHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL PROLIFERATION; COLON CANCER; DRUG POTENCY; DRUG SELECTIVITY; DRUG SUBSTITUTION; DRUG SYNTHESIS; FLUORINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; PROTEIN EXPRESSION; REACTION ANALYSIS; REDUCTION KINETICS;

ANTINEOPLASTIC AGENTS; BENZOTHIAZOLES; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LUNG NEOPLASMS; MOLECULAR STRUCTURE; STEREOISOMERISM;

EID: 30444437324     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050942k     Document Type: Article

References (24)

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