Aging mechanism of butyrylcholinesterase inhibited by an N-methyl analogue of tabun: Implications of the trigonal-bipyramidal transition state rearrangement for the phosphylation or reactivation of cholinesterases

Chemico-Biological Interactions

Volumn 187, Issue 1-3, 2010, Pages 44-48

  Nachon, Florian ^a   Carletti, Eugenie ^a   Worek, Franz ^b   Masson, Patrick ^a  

^a CENTRE DE RECHERCHES   (France)

^b BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

Author keywords

Acetylcholinesterase; Aging; Butyrylcholinesterase; Nerve agents; Reactivation; Transition state

Indexed keywords

CHOLINESTERASE; N METHYLETHYLPHOSPHORAMIDOFLUORIDATE; OXIME; TABUN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONJUGATION; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REACTIVATION; HUMAN; REACTION ANALYSIS;

EID: 77955551992     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.03.053     Document Type: Article

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