메뉴 건너뛰기




Volumn 54, Issue 4, 2010, Pages 352-359

South African mutations of the CCR5 coreceptor for HIV modify interaction with chemokines and HIV envelope protein

Author keywords

CCR5 coreceptor mutants; CCR5 expression; Envdirected fusion

Indexed keywords

CHEMOKINE RECEPTOR CCR5; ENVELOPE PROTEIN; MUTANT PROTEIN; CHEMOKINE; COMPLEMENTARY DNA; DNA; GAG PROTEIN; PRIMER DNA; VIRUS ENVELOPE PROTEIN;

EID: 77955491861     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181e0c7b2     Document Type: Article
Times cited : (11)

References (66)
  • 1
    • 0030018156 scopus 로고    scopus 로고
    • CC CKR5: A RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1
    • Alkhatib G, Combadiere C, Broder CC, et al. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science. 1996;272:1955-1958.
    • (1996) Science , vol.272 , pp. 1955-1958
    • Alkhatib, G.1    Combadiere, C.2    Broder, C.C.3
  • 2
    • 15844419153 scopus 로고    scopus 로고
    • Identification of a major co-receptor for primary isolates of HIV-1
    • Deng H, Liu R, Ellmeier W, et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature. 1996;381:661-666.
    • (1996) Nature , vol.381 , pp. 661-666
    • Deng, H.1    Liu, R.2    Ellmeier, W.3
  • 3
    • 0030604727 scopus 로고    scopus 로고
    • A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5 CKR-3 and CKR-2b as fusion cofactors
    • Doranz BJ, Rucker J, Yi Y, et al. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell. 1996;85:1149-1158.
    • (1996) Cell , vol.85 , pp. 1149-1158
    • Doranz, B.J.1    Rucker, J.2    Yi, Y.3
  • 4
    • 15844389650 scopus 로고    scopus 로고
    • HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
    • Dragic T, Litwin V, Allaway GP, et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature. 1996;381: 667-673.
    • (1996) Nature , vol.381 , pp. 667-673
    • Dragic, T.1    Litwin, V.2    Allaway, G.P.3
  • 5
    • 15844388931 scopus 로고    scopus 로고
    • Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
    • Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 1996;86:367-377.
    • (1996) Cell , vol.86 , pp. 367-377
    • Liu, R.1    Paxton, W.A.2    Choe, S.3
  • 6
    • 0033012398 scopus 로고    scopus 로고
    • Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
    • Berger EA, Murphy PM, Farber JM. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu Rev Immunol. 1999;17:657-700.
    • (1999) Annu Rev Immunol , vol.17 , pp. 657-700
    • Berger, E.A.1    Murphy, P.M.2    Farber, J.M.3
  • 8
    • 0035912248 scopus 로고    scopus 로고
    • Gulliver's travels in HIVland
    • Weiss RA. Gulliver's travels in HIVland. Nature. 2001;410:963-967.
    • (2001) Nature , vol.410 , pp. 963-967
    • Weiss, R.A.1
  • 9
    • 0030002637 scopus 로고    scopus 로고
    • HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane G protein-coupled receptor
    • Feng Y, Broder CC, Kennedy PE, et al. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science. 1996;272:872-877.
    • (1996) Science , vol.272 , pp. 872-877
    • Feng, Y.1    Broder, C.C.2    Kennedy, P.E.3
  • 10
    • 0030035550 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha
    • Raport CJ, Gosling J, Schweickart VL, et al. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha. J Biol Chem. 1996; 271:17161-17166.
    • (1996) J Biol Chem , vol.271 , pp. 17161-17166
    • Raport, C.J.1    Gosling, J.2    Schweickart, V.L.3
  • 11
    • 44649102135 scopus 로고    scopus 로고
    • Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
    • Keele BF, Giorgi EE, Salazar-Gonzalez JF, et al. Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proc Natl Acad Sci\USA. 2008;105: 7552-7557.
    • (2008) Proc Natl Acad Sci\USA , vol.105 , pp. 7552-7557
    • Keele, B.F.1    Giorgi, E.E.2    Salazar-Gonzalez, J.F.3
  • 12
    • 16044373004 scopus 로고    scopus 로고
    • Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
    • Samson M, Libert F, Doranz BJ, et al. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature. 1996;382:722-725.
    • (1996) Nature , vol.382 , pp. 722-725
    • Samson, M.1    Libert, F.2    Doranz, B.J.3
  • 13
    • 0035951491 scopus 로고    scopus 로고
    • Novel mutations identified using a comprehensive CCR5-denaturing gradient gel electrophoresis assay
    • Petersen DC, Kotze MJ, Zeier MD, et al. Novel mutations identified using a comprehensive CCR5-denaturing gradient gel electrophoresis assay. AIDS. 2001;15:171-177.
    • (2001) AIDS , vol.15 , pp. 171-177
    • Petersen, D.C.1    Kotze, M.J.2    Zeier, M.D.3
  • 14
    • 38049029212 scopus 로고    scopus 로고
    • Identification of the CCR5-Delta32 HIV resistance allele and new mutations of the CCR5 gene in different Tunisian populations
    • Jlizi A, Edouard J, Fadhlaoui-Zid K, et al. Identification of the CCR5-Delta32 HIV resistance allele and new mutations of the CCR5 gene in different Tunisian populations. Hum Immunol. 2007;68:993-1000.
    • (2007) Hum Immunol , vol.68 , pp. 993-1000
    • Jlizi, A.1    Edouard, J.2    Fadhlaoui-Zid, K.3
  • 15
    • 0031455968 scopus 로고    scopus 로고
    • Novel alleles of the chemokine-receptor gene CCR5
    • Carrington M, Kissner T, Gerrard B, et al. Novel alleles of the chemokine-receptor gene CCR5. Am J Hum Genet. 1997;61:1261-1267.
    • (1997) Am J Hum Genet , vol.61 , pp. 1261-1267
    • Carrington, M.1    Kissner, T.2    Gerrard, B.3
  • 16
    • 0033046559 scopus 로고    scopus 로고
    • Alleles that may influence HIV-1 pathogenesis in Chinese subjects
    • Shieh B, Liau YE, Yan YP, et al. Alleles that may influence HIV-1 pathogenesis in Chinese subjects. AIDS. 1999;13:421-424.
    • (1999) AIDS , vol.13 , pp. 421-424
    • Shieh, B.1    Liau, Y.E.2    Yan, Y.P.3
  • 17
    • 17344372255 scopus 로고    scopus 로고
    • Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes
    • Stephens JC, Reich DE, Goldstein DB, et al. Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. Am J Hum Genet. 1998;62:1507-1515.
    • (1998) Am J Hum Genet , vol.62 , pp. 1507-1515
    • Stephens, J.C.1    Reich, D.E.2    Goldstein, D.B.3
  • 18
    • 0030951920 scopus 로고    scopus 로고
    • Global distribution of the CCR5 gene 32-basepair deletion
    • Martinson JJ, Chapman NH, Rees DC, et al. Global distribution of the CCR5 gene 32-basepair deletion. Nat Genet. 1997;16:100-103.
    • (1997) Nat Genet , vol.16 , pp. 100-103
    • Martinson, J.J.1    Chapman, N.H.2    Rees, D.C.3
  • 19
    • 20944435640 scopus 로고    scopus 로고
    • Biochemical and HIV-1 coreceptor properties of K26R, a new CCR5 Variant in China's Sichuan population
    • Ma L, Dudoit Y, Tran T, et al. Biochemical and HIV-1 coreceptor properties of K26R, a new CCR5 Variant in China's Sichuan population. J Acquir Immune Defic Syndr. 2005;39:38-43.
    • (2005) J Acquir Immune Defic Syndr , vol.39 , pp. 38-43
    • Ma, L.1    Dudoit, Y.2    Tran, T.3
  • 20
    • 0037045059 scopus 로고    scopus 로고
    • African-based CCR5 single-nucleotide polymorphism associated with HIV-1 disease progression
    • Hayes VM, Petersen DC, Scriba TJ, et al. African-based CCR5 single-nucleotide polymorphism associated with HIV-1 disease progression. AIDS. 2002;16:2229-2231.
    • (2002) AIDS , vol.16 , pp. 2229-2231
    • Hayes, V.M.1    Petersen, D.C.2    Scriba, T.J.3
  • 21
    • 0029986131 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of a new human CC-chemokine receptor gene
    • Samson M, Labbe O, Mollereau C, et al. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry. 1996;35:3362-3367.
    • (1996) Biochemistry , vol.35 , pp. 3362-3367
    • Samson, M.1    Labbe, O.2    Mollereau, C.3
  • 22
    • 0029890173 scopus 로고    scopus 로고
    • Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES
    • Combadiere C, Ahuja SK, Tiffany HL, et al. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES. J Leukoc Biol. 1996;60:147-152.
    • (1996) J Leukoc Biol , vol.60 , pp. 147-152
    • Combadiere, C.1    Ahuja, S.K.2    Tiffany, H.L.3
  • 23
    • 0033567969 scopus 로고    scopus 로고
    • CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist
    • Blanpain C, Migeotte I, Lee B, et al. CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999;94: 1899-1905.
    • (1999) Blood , vol.94 , pp. 1899-1905
    • Blanpain, C.1    Migeotte, I.2    Lee, B.3
  • 24
    • 0033580695 scopus 로고    scopus 로고
    • LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity
    • Nibbs RJ, Yang J, Landau NR, et al. LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity. J Biol Chem. 1999;274:17478-17483.
    • (1999) J Biol Chem , vol.274 , pp. 17478-17483
    • Nibbs, R.J.1    Yang, J.2    Landau, N.R.3
  • 25
    • 0032745543 scopus 로고    scopus 로고
    • The LD78beta isoform of MIP-1alpha is the most potent CCR5 agonist and HIV-1-inhibiting chemokine
    • Menten P, Struyf S, Schutyser E, et al. The LD78beta isoform of MIP-1alpha is the most potent CCR5 agonist and HIV-1-inhibiting chemokine. J Clin Invest. 1999;104:R1-R5.
    • (1999) J Clin Invest , vol.104
    • Menten, P.1    Struyf, S.2    Schutyser, E.3
  • 26
    • 0032143524 scopus 로고    scopus 로고
    • Chemokines: Understanding their role in T-lymphocyte biology
    • Ward SG, Westwick J. Chemokines: understanding their role in T-lymphocyte biology. Biochem J. 1998;333:457-470.
    • (1998) Biochem J , vol.333 , pp. 457-470
    • Ward, S.G.1    Westwick, J.2
  • 27
    • 0030861238 scopus 로고    scopus 로고
    • Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1
    • Doranz BJ, Lu ZH, Rucker J, et al. Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1. J Virol. 1997;71:6305-6314.
    • (1997) J Virol , vol.71 , pp. 6305-6314
    • Doranz, B.J.1    Zh, L.2    Rucker, J.3
  • 28
    • 0031984539 scopus 로고    scopus 로고
    • Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry
    • Dragic T, Trkola A, Lin SW, et al. Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry. J Virol. 1998;72:279-285.
    • (1998) J Virol , vol.72 , pp. 279-285
    • Dragic, T.1    Trkola, A.2    Lin, S.W.3
  • 29
    • 0031883554 scopus 로고    scopus 로고
    • A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5
    • Farzan M, Choe H, Vaca L, et al. A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5. J Virol. 1998;72: 1160-1164.
    • (1998) J Virol , vol.72 , pp. 1160-1164
    • Farzan, M.1    Choe, H.2    Vaca, L.3
  • 30
    • 0031900659 scopus 로고    scopus 로고
    • Alanine substitutions of polar and nonpolar residues in the amino-terminal domain of CCR5 differently impair entry of macrophage-and dualtropic isolates of human immunodeficiency virus type 1
    • Rabut GE, Konner JA, Kajumo F, et al. Alanine substitutions of polar and nonpolar residues in the amino-terminal domain of CCR5 differently impair entry of macrophage-and dualtropic isolates of human immunodeficiency virus type 1. J Virol. 1998;72:3464-3468.
    • (1998) J Virol , vol.72 , pp. 3464-3468
    • Rabut, G.E.1    Konner, J.A.2    Kajumo, F.3
  • 31
    • 0031937625 scopus 로고    scopus 로고
    • Multiple residues contribute to the inability of murine CCR-5 to function as a coreceptor for macrophage-tropic human immunodeficiency virus type 1 isolates
    • Ross TM, Bieniasz PD, Cullen BR. Multiple residues contribute to the inability of murine CCR-5 to function as a coreceptor for macrophage-tropic human immunodeficiency virus type 1 isolates. J Virol. 1998;72: 1918-1924.
    • (1998) J Virol , vol.72 , pp. 1918-1924
    • Ross, T.M.1    Bieniasz, P.D.2    Cullen, B.R.3
  • 32
    • 0033520930 scopus 로고    scopus 로고
    • Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein
    • Blanpain C, Doranz BJ, Vakili J, et al. Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein. J Biol Chem. 1999; 274:34719-34727.
    • (1999) J Biol Chem , vol.274 , pp. 34719-34727
    • Blanpain, C.1    Doranz, B.J.2    Vakili, J.3
  • 33
    • 0033523018 scopus 로고    scopus 로고
    • Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function
    • Howard OM, Shirakawa AK, Turpin JA, et al. Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function. J Biol Chem. 1999;274: 16228-16234.
    • (1999) J Biol Chem , vol.274 , pp. 16228-16234
    • Howard, O.M.1    Shirakawa, A.K.2    Turpin, J.A.3
  • 34
    • 0037872129 scopus 로고    scopus 로고
    • Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors
    • Kazmierski W, Bifulco N, Yang H, et al. Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors. Bioorg Med Chem. 2003;11:2663-2676.
    • (2003) Bioorg Med Chem , vol.11 , pp. 2663-2676
    • Kazmierski, W.1    Bifulco, N.2    Yang, H.3
  • 35
    • 0037811018 scopus 로고    scopus 로고
    • HIV coreceptors: Role of structure, posttranslational modifications, and internalization in viral-cell fusion and as targets for entry inhibitors
    • Zaitseva M, Peden K, Golding H. HIV coreceptors: role of structure, posttranslational modifications, and internalization in viral-cell fusion and as targets for entry inhibitors. Biochim Biophys Acta. 2003;1614:51-61.
    • (2003) Biochim Biophys Acta , vol.1614 , pp. 51-61
    • Zaitseva, M.1    Peden, K.2    Golding, H.3
  • 36
    • 4444246007 scopus 로고    scopus 로고
    • Chemokine receptor CCR5: Insights into structure, function, and regulation
    • Oppermann M. Chemokine receptor CCR5: insights into structure, function, and regulation. Cell Signal. 2004;16:1201-1210.
    • (2004) Cell Signal , vol.16 , pp. 1201-1210
    • Oppermann, M.1
  • 37
    • 3042595910 scopus 로고    scopus 로고
    • Small-molecule antagonists of CCR5 and CXCR4: A promising new class of anti-HIV-1 drugs
    • Seibert C, Sakmar TP. Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs. Curr Pharm Des. 2004;10: 2041-2062.
    • (2004) Curr Pharm des , vol.10 , pp. 2041-2062
    • Seibert, C.1    Sakmar, T.P.2
  • 38
    • 0034625144 scopus 로고    scopus 로고
    • A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5
    • Dragic T, Trkola A, Thompson DA, et al. A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5. Proc Natl Acad Sci\USA. 2000;97:5639-5644.
    • (2000) Proc Natl Acad Sci\USA , vol.97 , pp. 5639-5644
    • Dragic, T.1    Trkola, A.2    Thompson, D.A.3
  • 39
    • 0037404511 scopus 로고    scopus 로고
    • Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry
    • Tsamis F, Gavrilov S, Kajumo F, et al. Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry. J Virol. 2003; 77:5201-5208.
    • (2003) J Virol , vol.77 , pp. 5201-5208
    • Tsamis, F.1    Gavrilov, S.2    Kajumo, F.3
  • 40
    • 40849098660 scopus 로고    scopus 로고
    • Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists
    • Kondru R, Zhang J, Ji C, et al. Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists. Mol Pharmacol. 2008;73:789-800.
    • (2008) Mol Pharmacol , vol.73 , pp. 789-800
    • Kondru, R.1    Zhang, J.2    Ji, C.3
  • 41
    • 33744954776 scopus 로고    scopus 로고
    • Structural and molecular interactions of CCR5 inhibitors with CCR5
    • Maeda K, Das D, Ogata-Aoki H, et al. Structural and molecular interactions of CCR5 inhibitors with CCR5. J Biol Chem. 2006;281: 12688-12698.
    • (2006) J Biol Chem , vol.281 , pp. 12688-12698
    • Maeda, K.1    Das, D.2    Ogata-Aoki, H.3
  • 42
    • 33646514864 scopus 로고    scopus 로고
    • Interaction of small molecule inhibitors of HIV-1 entry with CCR5
    • Seibert C, Ying W, Gavrilov S, et al. Interaction of small molecule inhibitors of HIV-1 entry with CCR5. Virology. 2006;349:41-54.
    • (2006) Virology , vol.349 , pp. 41-54
    • Seibert, C.1    Ying, W.2    Gavrilov, S.3
  • 43
    • 0035497743 scopus 로고    scopus 로고
    • Is Galpha16 the optimal tool for fishing ligands of orphan G-protein-coupled receptors?
    • Kostenis E. Is Galpha16 the optimal tool for fishing ligands of orphan G-protein-coupled receptors? Trends Pharmacol Sci. 2001;22:560-564.
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 560-564
    • Kostenis, E.1
  • 44
    • 0035204258 scopus 로고    scopus 로고
    • Characterization of full-length HIV type 1 subtype C sequences from South Africa
    • van Harmelen J, Williamson C, Kim B, et al. Characterization of full-length HIV type 1 subtype C sequences from South Africa. AIDS Res Hum Retroviruses. 2001;17:1527-1531.
    • (2001) AIDS Res Hum Retroviruses , vol.17 , pp. 1527-1531
    • Van Harmelen, J.1    Williamson, C.2    Kim, B.3
  • 45
    • 0344406242 scopus 로고    scopus 로고
    • Characterization and selection of HIV-1 subtype C isolates for use in vaccine development
    • Williamson C, Morris L, Maughan MF, et al. Characterization and selection of HIV-1 subtype C isolates for use in vaccine development. AIDS Res Human Retroviruses. 2003;19:133-144.
    • (2003) AIDS Res Human Retroviruses , vol.19 , pp. 133-144
    • Williamson, C.1    Morris, L.2    Maughan, M.F.3
  • 46
    • 0038744307 scopus 로고    scopus 로고
    • Development of a high-throughput viral-free assay for the measurement of CCR5-mediated HIV/cell fusion
    • Jenkinson S, McCoy D, Kerner S, et al. Development of a high-throughput viral-free assay for the measurement of CCR5-mediated HIV/cell fusion. Receptors Channels. 2003;9:117-123.
    • (2003) Receptors Channels , vol.9 , pp. 117-123
    • Jenkinson, S.1    McCoy, D.2    Kerner, S.3
  • 47
    • 0033515588 scopus 로고    scopus 로고
    • Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function
    • Lee B, Sharron M, Blanpain C, et al. Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function. J Biol Chem. 1999;274: 9617-9626.
    • (1999) J Biol Chem , vol.274 , pp. 9617-9626
    • Lee, B.1    Sharron, M.2    Blanpain, C.3
  • 48
    • 77957052327 scopus 로고
    • Ligand binding and second-messenger assays for cloned Gq/G11-coupled neuropeptide receptors: The GnRH receptor
    • Millar RP, Davidson J, Flanagan C, et al. Ligand binding and second-messenger assays for cloned Gq/G11-coupled neuropeptide receptors: The GnRH receptor. Methods Neurosci. 1995;25:145-162.
    • (1995) Methods Neurosci , vol.25 , pp. 145-162
    • Millar, R.P.1    Davidson, J.2    Flanagan, C.3
  • 49
    • 0031764251 scopus 로고    scopus 로고
    • A high affinity gonadotropin-releasing hormone (GnRH) tracer, radioiodinated at position 6, facilitates analysis of mutant GnRH receptors
    • Flanagan CA, Fromme BJ, Davidson JS, et al. A high affinity gonadotropin-releasing hormone (GnRH) tracer, radioiodinated at position 6, facilitates analysis of mutant GnRH receptors. Endocrinology. 1998;139:4115-4119.
    • (1998) Endocrinology , vol.139 , pp. 4115-4119
    • Flanagan, C.A.1    Fromme, B.J.2    Davidson, J.S.3
  • 50
    • 0030961374 scopus 로고    scopus 로고
    • The extent of genetic variation in the CCR5 gene
    • Ansari-Lari MA, Liu XM, Metzker ML, et al. The extent of genetic variation in the CCR5 gene. Nat Genet. 1997;16:221-222.
    • (1997) Nat Genet , vol.16 , pp. 221-222
    • Ansari-Lari, M.A.1    Liu, X.M.2    Metzker, M.L.3
  • 51
    • 0027506471 scopus 로고
    • The probable arrangement of the helices in G protein-coupled receptors
    • Baldwin JM. The probable arrangement of the helices in G protein-coupled receptors. Embo J. 1993;12:1693-1703.
    • (1993) Embo J , vol.12 , pp. 1693-1703
    • Baldwin, J.M.1
  • 52
    • 0037452868 scopus 로고    scopus 로고
    • Sequence analyses of G-protein-coupled receptors: Similarities to rhodopsin
    • Mirzadegan T, Benko G, Filipek S, et al. Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry. 2003;42:2759-2767.
    • (2003) Biochemistry , vol.42 , pp. 2759-2767
    • Mirzadegan, T.1    Benko, G.2    Filipek, S.3
  • 53
    • 0035800850 scopus 로고    scopus 로고
    • Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
    • Ballesteros JA, Jensen AD, Liapakis G, et al. Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6. J Biol Chem. 2001; 276:29171-29177.
    • (2001) J Biol Chem , vol.276 , pp. 29171-29177
    • Ballesteros, J.A.1    Jensen, A.D.2    Liapakis, G.3
  • 54
    • 34249332756 scopus 로고    scopus 로고
    • The activation mechanism of chemokine receptor CCR5 involves common structural changes but a different network of interhelical interactions relative to rhodopsin
    • Springael JY, de Poorter C, Deupi X, et al. The activation mechanism of chemokine receptor CCR5 involves common structural changes but a different network of interhelical interactions relative to rhodopsin. Cell Signal. 2007;19:1446-1456.
    • (2007) Cell Signal , vol.19 , pp. 1446-1456
    • Springael, J.Y.1    De Poorter, C.2    Deupi, X.3
  • 55
    • 0030922697 scopus 로고    scopus 로고
    • Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity
    • Gosling J, Monteclaro FS, Atchison RE, et al. Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity. Proc Natl Acad Sci\USA. 1997;94:5061-5066.
    • (1997) Proc Natl Acad Sci\USA , vol.94 , pp. 5061-5066
    • Gosling, J.1    Monteclaro, F.S.2    Atchison, R.E.3
  • 56
    • 0030946755 scopus 로고    scopus 로고
    • HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5
    • Farzan M, Choe H, Martin KA, et al. HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5. J Biol Chem. 1997;272:6854-6857.
    • (1997) J Biol Chem , vol.272 , pp. 6854-6857
    • Farzan, M.1    Choe, H.2    Martin, K.A.3
  • 57
    • 0030812438 scopus 로고    scopus 로고
    • Molecular mechanism of desensitization of the chemokine receptor CCR-5: Receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor
    • Aramori I, Ferguson SS, Bieniasz PD, et al. Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor. Embo J. 1997;16:4606-4616.
    • (1997) Embo J , vol.16 , pp. 4606-4616
    • Aramori, I.1    Ferguson, S.S.2    Bieniasz, P.D.3
  • 58
    • 0037320092 scopus 로고    scopus 로고
    • G protein-dependent CCR5 signaling is not required for efficient infection of primary T lymphocytes and macrophages by R5 human immunodeficiency virus type 1 isolates
    • Amara A, Vidy A, Boulla G, et al. G protein-dependent CCR5 signaling is not required for efficient infection of primary T lymphocytes and macrophages by R5 human immunodeficiency virus type 1 isolates. J Virol. 2003;77:2550-2558.
    • (2003) J Virol , vol.77 , pp. 2550-2558
    • Amara, A.1    Vidy, A.2    Boulla, G.3
  • 59
    • 0032902710 scopus 로고    scopus 로고
    • Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5
    • Olson WC, Rabut GE, Nagashima KA, et al. Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5. J Virol. 1999;73: 4145-4155.
    • (1999) J Virol , vol.73 , pp. 4145-4155
    • Olson, W.C.1    Rabut, G.E.2    Nagashima, K.A.3
  • 60
    • 0030779808 scopus 로고    scopus 로고
    • Interaction of chemokine receptor CCR5 with its ligands: Multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding
    • Wu L, LaRosa G, Kassam N, et al. Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding. J Exp Med. 1997;186:1373-1381.
    • (1997) J Exp Med , vol.186 , pp. 1373-1381
    • Wu, L.1    Larosa, G.2    Kassam, N.3
  • 61
    • 0030770546 scopus 로고    scopus 로고
    • Unwelcomed guests with master keys: How HIV uses chemokine receptors for cellular entry
    • Doms RW, Peiper SC. Unwelcomed guests with master keys: how HIV uses chemokine receptors for cellular entry. Virology. 1997;235:179-190.
    • (1997) Virology , vol.235 , pp. 179-190
    • Doms, R.W.1    Peiper, S.C.2
  • 63
    • 0033525590 scopus 로고    scopus 로고
    • Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry
    • Farzan M, Mirzabekov T, Kolchinsky P, et al. Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry. Cell. 1999;96:667-676.
    • (1999) Cell , vol.96 , pp. 667-676
    • Farzan, M.1    Mirzabekov, T.2    Kolchinsky, P.3
  • 65
    • 33745485344 scopus 로고    scopus 로고
    • CCR5: No longer a "good for nothing" gene\chemokine control of West Nile virus infection
    • Lim JK, Glass WG, McDermott DH, et al. CCR5: no longer a "good for nothing" gene\chemokine control of West Nile virus infection. Trends Immunol. 2006;27:308-312.
    • (2006) Trends Immunol , vol.27 , pp. 308-312
    • Lim, J.K.1    Glass, W.G.2    McDermott, D.H.3
  • 66
    • 39149133656 scopus 로고    scopus 로고
    • Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: A meta-analysis of 4 cohorts in the US epidemic
    • Lim JK, Louie CY, Glaser C, et al. Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic. J Infect Dis. 2008;197:262-265.
    • (2008) J Infect Dis , vol.197 , pp. 262-265
    • Lim, J.K.1    Louie, C.Y.2    Glaser, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.