메뉴 건너뛰기




Volumn 52, Issue 2, 2010, Pages 111-124

Graft-versus-host disease

Author keywords

Allogeneic hematopoietic stem cell transplantation; Antigen presenting cells (APC); Cytokines; Minor histocompatibility (miHAs); T cells

Indexed keywords

AUTACOID; CYTOKINE;

EID: 77955433080     PISSN: 00310808     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (18)

References (185)
  • 1
    • 0035902174 scopus 로고    scopus 로고
    • Haematopoietic cell transplantation as immunotherapy
    • Appelbaum FR. Haematopoietic cell transplantation as immunotherapy. Nature. 2001;411:385-389
    • (2001) Nature , vol.411 , pp. 385-389
    • Appelbaum, F.R.1
  • 3
    • 30344461633 scopus 로고    scopus 로고
    • Pathophysiology of graft-versus-host disease
    • Ferrara JL, Reddy P. Pathophysiology of graft-versus-host disease. Semin Hematol. 2006;43:3-10.
    • (2006) Semin Hematol. , vol.43 , pp. 3-10
    • Ferrara, J.L.1    Reddy, P.2
  • 4
    • 34248356010 scopus 로고    scopus 로고
    • How i treat refractory acute GVHD
    • Deeg HJ. How I Treat Refractory Acute GVHD. Blood. 2007.
    • (2007) Blood
    • Deeg, H.J.1
  • 5
    • 0018764352 scopus 로고
    • Antileukemic effect of graft-verauj-host disease in human recipients of allogeneic-marrow grafts
    • Weiden PL, Floumoy N, Thomas ED, et al. Antileukemic effect of graft-verauj-host disease in human recipients of allogeneic-marrow grafts. N Engl J Med. 1979;300:1068-1073
    • (1979) N Engl J Med. , vol.300 , pp. 1068-1073
    • Weiden, P.L.1    Floumoy, N.2    Thomas, E.D.3
  • 6
    • 0019861205 scopus 로고
    • Antileukemic effect of chronic graft-verms-host disease: Contribution to improved survival after allogeneic marrow transplantation
    • Weiden PL, Sullivan KM, Flournoy N, Storb R, Thomas ED. Antileukemic effect of chronic graft-verms-host disease: Contribution to improved survival after allogeneic marrow transplantation. N Engl J Med. 1981;304:1529-1533
    • (1981) N Engl J Med. , vol.304 , pp. 1529-1533
    • Weiden, P.L.1    Sullivan, K.M.2    Flournoy, N.3    Storb, R.4    Thomas, E.D.5
  • 7
    • 19344363574 scopus 로고    scopus 로고
    • New approaches for preventing and treating chronic graft-versus-host disease
    • Lee SJ. New approaches for preventing and treating chronic graft-versus-host disease. Blood. 2005;105:4200-4206
    • (2005) Blood , vol.105 , pp. 4200-4206
    • Lee, S.J.1
  • 9
    • 0013989358 scopus 로고
    • The biology of graft-versus-host reactions
    • Billingham RE. The biology of graft-versus-host reactions. Harvey Lec. 1966;62:21-78.
    • (1966) Harvey Lec. , vol.62 , pp. 21-78
    • Billingham, R.E.1
  • 10
    • 8044242405 scopus 로고
    • Purified T cell subsets and lethal graft-versus-host disease in mice
    • Gale RP, Champlin R, eds. New York: Alan R. Liss, Inc.
    • Korngold R, Sprent J. Purified T cell subsets and lethal graft-versus-host disease in mice. In: Gale RP, Champlin R, eds. Progress in Bone Marrow Transplant. New York: Alan R. Liss, Inc.; 1987:213-218
    • (1987) Progress in Bone Marrow Transplant , pp. 213-218
    • Korngold, R.1    Sprent, J.2
  • 11
    • 0022521334 scopus 로고
    • Clonable T lymphocytes in T cell-depleted bone marrow transplants correlate with development of graft-v-host disease.
    • Kernan NA, Collins NH, Juliano L, Cartagena T, Dupont B, RJ OR. Clonable T lymphocytes in T cell-depleted bone marrow transplants correlate with development of graft- v-host disease. Blood. 1986;68:770-773
    • (1986) Blood , vol.68 , pp. 770-773
    • Kernan, N.A.1    Collins, N.H.2    Juliano, L.3    Cartagena, T.4    Dupont, B.5    O, R.R.J.6
  • 13
    • 0026055167 scopus 로고
    • Different types of allospecific CTL clones identified by their ability to recognize peptide loading-defective target cells
    • Aosai F, Ohlen C, Ljunggren HG, et al. Different types of allospecif-ic CTL clones identified by their ability to recognize peptide loading-defective target cells. Eur J Immunol. 1991;21:2767-2774
    • (1991) Eur J Immunol. , vol.21 , pp. 2767-2774
    • Aosai, F.1    Ohlen, C.2    Ljunggren, H.G.3
  • 14
    • 0031941346 scopus 로고    scopus 로고
    • Class I-restrict-ed alloreactive cytotoxic T lymphocytes recognize a complex array of specific MHC-associated peptides
    • Wang W, Man S, Gulden PH, Hunt DF, Engelhard VH. Class I-restrict-ed alloreactive cytotoxic T lymphocytes recognize a complex array of specific MHC-associated peptides. J Immunol. 1998; 160:1091-1097.
    • (1998) J Immunol. , vol.160 , pp. 1091-1097
    • Wang, W.1    Man, S.2    Gulden, P.H.3    Hunt, D.F.4    Engelhard, V.H.5
  • 15
    • 0026588532 scopus 로고
    • Role of endogenous peptide in human alloreactive cytotoxic T cell responses
    • Man S, Salter RD, Engelhard VH. Role of endogenous peptide in human alloreactive cytotoxic T cell responses. Int Immunol. 1992;4:367-375.
    • (1992) Int Immunol. , vol.4 , pp. 367-375
    • Man, S.1    Salter, R.D.2    Engelhard, V.H.3
  • 16
    • 30344457046 scopus 로고    scopus 로고
    • Genetics of risk factors for graft-verasus-host disease
    • Petersdorf EW, Malkki M. Genetics of risk factors for graft-verasus-host disease. Semin Hematol. 2006;43:11-23.
    • (2006) Semin Hematol. , vol.43 , pp. 11-23
    • Petersdorf, E.W.1    Malkki, M.2
  • 17
    • 0024537269 scopus 로고
    • Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma
    • Anasetti C, Amos D, Beatty PG, et al. Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma. N Engl J Med. 1989;320:197-204.
    • (1989) N Engl J Med. , vol.320 , pp. 197-204
    • Anasetti, C.1    Amos, D.2    Beatty, P.G.3
  • 18
    • 1842307418 scopus 로고
    • Donor-recipient disparities for HLA-C genes is a risk factor for graft failure following marrow transplantation from unrelated donors
    • Petersdorf EW, Longton G, Anasetti C, al. e. Donor-recipient disparities for HLA-C genes is a risk factor for graft failure following marrow transplantation from unrelated donors. Blood. 1995;86, Suppl. 1:291a.
    • (1995) Blood , vol.86 , Issue.SUPPL 1
    • Petersdorf, E.W.1    Longton, G.2    Anasetti, C.3
  • 19
    • 0031018433 scopus 로고    scopus 로고
    • Association of HLA-C disparity with great failure after marrow transplantation from unrelated donors.
    • Petersdorf EW, Longton GM, Anasetti C, Mickelson EM, McKinney SK. Association of HLA-C Disparity with Great Failure After Marrow Transplantation from Unrelated Donors. Blood. 1997;89:1818-1823
    • (1997) Blood , vol.89 , pp. 1818-1823
    • Petersdorf, E.W.1    Longton, G.M.2    Anasetti, C.3    Mickelson, E.M.4    McKinney, S.K.5
  • 20
    • 4644359708 scopus 로고    scopus 로고
    • Impact of HLA class i and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome
    • Flomenberg N, Baxter-Lowe LA, Confer D, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004;104:1923-1930
    • (2004) Blood , vol.104 , pp. 1923-1930
    • Flomenberg, N.1    Baxter-Lowe, L.A.2    Confer, D.3
  • 21
    • 0042738931 scopus 로고    scopus 로고
    • Umbilical-cord blood transplantation for the treatment of cancer
    • Barker JN, Wagner JE. Umbilical-cord blood transplantation for the treatment of cancer. Nat Rev Cancer. 2003;3:526-532
    • (2003) Nat Rev Cancer. , vol.3 , pp. 526-532
    • Barker, J.N.1    Wagner, J.E.2
  • 22
    • 9244256765 scopus 로고    scopus 로고
    • Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia
    • Laughlin MJ, Eapen M, Rubinstein P, et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med. 2004;351:2265-2275
    • (2004) N Engl J Med. , vol.351 , pp. 2265-2275
    • Laughlin, M.J.1    Eapen, M.2    Rubinstein, P.3
  • 23
    • 12844273651 scopus 로고    scopus 로고
    • Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy
    • Barker JN, Weisdorf DJ, DeFor TE, et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood. 2005;105:1343-1347.
    • (2005) Blood , vol.105 , pp. 1343-1347
    • Barker, J.N.1    Weisdorf, D.J.2    Defor, T.E.3
  • 24
    • 0029027351 scopus 로고
    • Identification of a graft versus host disease-associated human minor histocompatibility antigen
    • Den Haan JM, Sherman NE, Blokland E, et al. Identification of a graft versus host disease-associated human minor histocompatibility antigen. Science. 1995;268:1476-1480
    • (1995) Science. , vol.268 , pp. 1476-1480
    • Den Haan, J.M.1    Sherman, N.E.2    Blokland, E.3
  • 25
    • 0026728223 scopus 로고
    • Tissue distribution of human minor histocompatibility antigens. Ubiquitous versus restricted tissue distribution indicates heterogeneity among human cytotoxic T lymphocyte-defined non-MHC antigens
    • de Bueger M, Bakker A, Van Rood JJ, Van der Woude F, Goulmy E. Tissue distribution of human minor histocompatibility antigens. Ubiquitous versus restricted tissue distribution indicates heterogeneity among human cytotoxic T lymphocyte-defined non-MHC antigens. J Immunol. 1992;149:1788-1794.
    • (1992) J Immunol. , vol.149 , pp. 1788-1794
    • De Bueger, M.1    Bakker, A.2    Van Rood, J.J.3    Van Der Woude, F.4    Goulmy, E.5
  • 26
    • 0027830468 scopus 로고
    • Human minor histocompatibility antigens
    • de Bueger M, Goulmy E. Human minor histocompatibility antigens. Transpl Immunol. 1993;1:28-38.
    • (1993) Transpl Immunol. , vol.1 , pp. 28-38
    • De Bueger, M.1    Goulmy, E.2
  • 27
    • 13344278000 scopus 로고    scopus 로고
    • Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation
    • Goulmy E, Schipper R, Pool J, Blokland E, Falkenburg F. Mismatches of Minor Histocompatibility Antigens Between HLA-Identical Donors and Recipients and the Development of Graft-Versus-Host Disease After Bone Marrow Transplantation. The New England Journal of Medicine. 1996;334:281-285
    • (1996) The New England Journal of Medicine. , vol.334 , pp. 281-285
    • Goulmy, E.1    Schipper, R.2    Pool, J.3    Blokland, E.4    Falkenburg, F.5
  • 28
    • 33646771379 scopus 로고    scopus 로고
    • Minor histocompatibility antigens: From transplantation problems to therapy of cancer
    • Goulmy E. Minor histocompatibility antigens: from transplantation problems to therapy of cancer. Hum Immunol. 2006;67:433-438
    • (2006) Hum Immunol. , vol.67 , pp. 433-438
    • Goulmy, E.1
  • 29
    • 0038190942 scopus 로고    scopus 로고
    • A human minor histocompatibility antigen resulting from differential expression due to a gene deletion
    • Murata M, Warren EH, Riddell SR. A human minor histocompatibility antigen resulting from differential expression due to a gene deletion. J Exp Med. 2003; 197:1279-1289
    • (2003) J Exp Med. , vol.197 , pp. 1279-1289
    • Murata, M.1    Warren, E.H.2    Riddell, S.R.3
  • 30
    • 0032193663 scopus 로고    scopus 로고
    • The molecular and functional characterization of a dominant minor H antigen, H60
    • Malarkannan S, Shih PP, Eden PA, et al. The molecular and functional characterization of a dominant minor H antigen, H60. J Immunol. 1998;161:3501-3509
    • (1998) J Immunol. , Issue.161 , pp. 3501-3509
    • Malarkannan, S.1    Shih, P.P.2    Eden, P.A.3
  • 31
    • 2342484524 scopus 로고    scopus 로고
    • Molecules and mechanisms of the graft-ver-jus-leukaemia effect
    • Bleakley M, Riddell SR. Molecules and mechanisms of the graft-ver-jus-leukaemia effect. Nat Rev Cancer. 2004;4:371-380
    • (2004) Nat Rev Cancer. , vol.4 , pp. 371-380
    • Bleakley, M.1    Riddell, S.R.2
  • 33
    • 0037114627 scopus 로고    scopus 로고
    • Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease
    • Choi EY, Christianson GJ, Yoshimura Y, etal. Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-vehost disease. Blood. 2002;100:4259-65.
    • (2002) Blood , vol.100 , pp. 4259-65
    • Choi, E.Y.1    Christianson, G.J.2    Yoshimura, Y.3
  • 34
    • 0036850785 scopus 로고    scopus 로고
    • Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptide
    • Choi EY, Christianson GJ, Yoshimura Y, et al. Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptide. Immunity. 2002;17:593-603.
    • (2002) Immunity. , vol.17 , pp. 593-603
    • Choi, E.Y.1    Christianson, G.J.2    Yoshimura, Y.3
  • 35
    • 0034928716 scopus 로고    scopus 로고
    • Adoptive transfer of minor histocompatibility antigen-specific T lymphocytes eradicates leukemia cells without causing graft-verjuj-host disease
    • Fontaine P, Roy-Proulx G, Knafo L, Baron C, Roy DC, Perreault C. Adoptive transfer of minor histocompatibility antigen-specific T lymphocytes eradicates leukemia cells without causing graft-verjuj-host disease. Nat Med. 2001 ;7:789-794
    • (2001) Nat Med. , vol.7 , pp. 789-794
    • Fontaine, P.1    Roy-Proulx, G.2    Knafo, L.3    Baron, C.4    Roy, D.C.5    Perreault, C.6
  • 36
    • 0036107517 scopus 로고    scopus 로고
    • In situ dissection of the graft-vmiw-host activities of cytotoxic T cells specific for minor histocompatibility antigens
    • Dickinson AM, Wang XN, Sviland L, et al. In situ dissection of the graft-vmiw-host activities of cytotoxic T cells specific for minor histocompatibility antigens. Nat Med. 2002;8:410-414
    • (2002) Nat Med. , vol.8 , pp. 410-414
    • Dickinson, A.M.1    Wang, X.N.2    Sviland, L.3
  • 37
    • 0027194040 scopus 로고
    • High frequencies of cytotoxic T cell precursors against minor histocompatibility antigens after HLA-identical BMT: Absence of correlation with GVHD
    • de Bueger M, Bakker A, Bontkes H, van Rood JJ, Goulmy E. High frequencies of cytotoxic T cell precursors against minor histocompatibility antigens after HLA-identical BMT: absence of correlation with GVHD. Bone Marrow Transpl. 1993; 11.
    • (1993) Bone Marrow Transpl. , vol.11
    • De Bueger, M.1    Bakker, A.2    Bontkes, H.3    Van Rood, J.J.4    Goulmy, E.5
  • 38
    • 20144388509 scopus 로고    scopus 로고
    • Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
    • Miller JS, SoignierY, Panoskaltsis-Mortari A, etal. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood. 2005; 105:3051-3057
    • (2005) Blood , vol.105 , pp. 3051-3057
    • Miller, J.S.1    Soigniery2    Panoskaltsis-Mortari, A.3
  • 39
    • 34247581578 scopus 로고    scopus 로고
    • Missing KIR-ligands is associated with less relapse and increased graft versus host disease (GVHD) following unrelated donor allogeneic HCT
    • Miller JS, Cooley S, Parham P, et al. Missing KIR-ligands is associated with less relapse and increased graft versus host disease (GVHD) following unrelated donor allogeneic HCT. Blood. 2007.
    • (2007) Blood.
    • Miller, J.S.1    Cooley, S.2    Parham, P.3
  • 40
    • 0036716947 scopus 로고    scopus 로고
    • NK cells: A lesson from mismatched hematopoietic transplantation
    • Velardi A, Ruggeri L, Alessandro, Moretta, Moretta L. NK cells: a lesson from mismatched hematopoietic transplantation. Trends Immunol. 2002;23:438-444
    • (2002) Trends Immunol. , vol.23 , pp. 438-444
    • Velardi, A.1    Ruggeri, L.2    Alessandro, M.3    Moretta, L.4
  • 41
    • 33748199972 scopus 로고    scopus 로고
    • Immunogenomics of unrelated hematopoietic cell transplantation
    • Petersdorf EW. Immunogenomics of unrelated hematopoietic cell transplantation. Curr Opin Immunol. 2006;18:559-564
    • (2006) Curr Opin Immunol. , vol.18 , pp. 559-564
    • Petersdorf, E.W.1
  • 42
    • 33746031836 scopus 로고    scopus 로고
    • KIR ligands and prediction of relapse after unrelated donor hematopoietic cell transplantation for hematologic malignancy
    • Hsu KC, Gooley T, Malkki M, et al. KIR Ligands and Prediction of Relapse after Unrelated Donor Hematopoietic Cell Transplantation for Hematologic Malignancy. Biol Blood Marrow Transpl. 2006;12:828-836
    • (2006) Biol Blood Marrow Transpl. , vol.12 , pp. 828-836
    • Hsu, K.C.1    Gooley, T.2    Malkki, M.3
  • 43
    • 0037086131 scopus 로고    scopus 로고
    • Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    • Ruggeri L, Capanni M, Urbani E, et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science. 2002;295:2097-2100.
    • (2002) Science , vol.295 , pp. 2097-2100
    • Ruggeri, L.1    Capanni, M.2    Urbani, E.3
  • 44
    • 0037111776 scopus 로고    scopus 로고
    • Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor
    • Davies SM, Ruggieri L, DeFor T, et al. Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor. Blood. 2002; 100:3825-3827
    • (2002) Blood , vol.100 , pp. 3825-3827
    • Davies, S.M.1    Ruggieri, L.2    Defor, T.3
  • 45
    • 20444394742 scopus 로고    scopus 로고
    • Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes
    • Hsu KC, Keever-Taylor CA, Wilton A, et al. Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes. Blood. 2005;105:4878-4884
    • (2005) Blood , vol.105 , pp. 4878-4884
    • Hsu, K.C.1    Keever-Taylor, C.A.2    Wilton, A.3
  • 46
    • 0027048743 scopus 로고
    • Cytokine dysregulation and acute graft-versus-host disease
    • Antin JH, Ferrara JL. Cytokine dysregulation and acute graft-versus-host disease. Blood. 1992;80:2964-2968
    • (1992) Blood , vol.80 , pp. 2964-2968
    • Antin, J.H.1    Ferrara, J.L.2
  • 47
    • 0033485649 scopus 로고    scopus 로고
    • Recipient tumor necrosis factor-alpha and interleukin-10 gene polymorphisms associate with early mortality and acute graft-versus-host disease severity in HLA-matched sibling bone marrow transplants
    • Cavet J, Middleton PO, Segall M, Noreen H, Davies SM, Dickinson AM. Recipient tumor necrosis factor-alpha and interleukin-10 gene polymorphisms associate with early mortality and acute graft-versus-host disease severity in HLA-matched sibling bone marrow transplants. Blood. 1999;94:3941-3946
    • (1999) Blood , vol.94 , pp. 3941-3946
    • Cavet, J.1    Middleton, P.O.2    Segall, M.3    Noreen, H.4    Davies, S.M.5    Dickinson, A.M.6
  • 48
    • 23944460869 scopus 로고    scopus 로고
    • Non-HLA immunogenetics in hematopoietic stem cell transplantation
    • DOI 10.1016/j.coi.2005.07.017, PII S0952791505001214
    • Dickinson AM, Charron D. Non-HLA immunogenetics in hematopoietic stem cell transplantation. Curr Opin Immunol. 2005;17:517-525 (Pubitemid 41207956)
    • (2005) Current Opinion in Immunology , vol.17 , Issue.5 , pp. 517-525
    • Dickinson, A.M.1    Charron, D.2
  • 49
    • 84983719872 scopus 로고    scopus 로고
    • Relation of an interleukin-10 promoter polymorphism to graft-veraui-host disease and survival after hematopoietic-cell transplantation
    • Lin MT, Storer B, Martin PJ, et al. Relation of an interleukin-10 promoter polymorphism to graft-veraui-host disease and survival after hematopoietic-cell transplantation. N Engl J Med. 2003;349:2201-2210
    • (2003) N Engl J Med. , vol.349 , pp. 2201-2210
    • Lin, M.T.1    Storer, B.2    Martin, P.J.3
  • 50
    • 33846288929 scopus 로고    scopus 로고
    • New directions in the genomics of allogeneic hematopoietic stem cell transplantation
    • Mullighan CG, Bardy PG. New directions in the genomics of allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transpl. 2007;13:127-144
    • (2007) Biol Blood Marrow Transpl. , vol.13 , pp. 127-144
    • Mullighan, C.G.1    Bardy, P.G.2
  • 51
    • 0035438384 scopus 로고    scopus 로고
    • Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation
    • Cavet J, Dickinson AM, Norden J, Taylor PR, Jackson GH, Middleton PG. Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation. Blood. 2001;98:1594-1600.
    • (2001) Blood , vol.98 , pp. 1594-1600
    • Cavet, J.1    Dickinson, A.M.2    Norden, J.3    Taylor, P.R.4    Jackson, G.H.5    Middleton, P.G.6
  • 52
    • 33646591889 scopus 로고    scopus 로고
    • Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: Effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination
    • Holler E, Rogler G, Brenmoehl J, et al. Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood. 2006;107:4189-4193
    • (2006) Blood , vol.107 , pp. 4189-4193
    • Holler, E.1    Rogler, G.2    Brenmoehl, J.3
  • 53
    • 35349016235 scopus 로고    scopus 로고
    • Recognition of microorganisms and activation of the immune response
    • Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature. 2007;449:819-826
    • (2007) Nature , vol.449 , pp. 819-826
    • Medzhitov, R.1
  • 54
    • 0032533897 scopus 로고    scopus 로고
    • Tumor necrosis factor- alpha production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host disease
    • Cooke KR, Hill GR, Crawford JM, et al. Tumor necrosis factor- alpha production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host disease. J Clin Invest. 1998;102:1882-1891
    • (1998) J Clin Invest. , vol.102 , pp. 1882-1891
    • Cooke, K.R.1    Hill, G.R.2    Crawford, J.M.3
  • 55
    • 0034193057 scopus 로고    scopus 로고
    • The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: Rationale for the use of cytokine shields in allogeneic bone marrow transplantation
    • Hill GR, Ferrara JL. The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: Rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood. 2000;95:2754-2759
    • (2000) Blood , vol.95 , pp. 2754-2759
    • Hill, G.R.1    Ferrara, J.L.2
  • 56
    • 0030861750 scopus 로고    scopus 로고
    • Total body irradiation and acute graft-versus-host disease: The role of gastrointestinal damage and inflammatory cytokines
    • Hill GR, Crawford JM, Cooke KR, Brinson YS, Pan L, Ferrara JL. Total body irradiation and acute graft-versus-host disease: The role of gastrointestinal damage and inflammatory cytokines. Blood. 1997;90:3204-3213
    • (1997) Blood , vol.90 , pp. 3204-3213
    • Hill, G.R.1    Crawford, J.M.2    Cooke, K.R.3    Brinson, Y.S.4    Pan, L.5    Ferrara, J.L.6
  • 57
    • 0028208934 scopus 로고
    • Effect of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graft-versus-host disease in H-2-incom-patible transplanted SCID mice
    • Xun CQ, Thompson JS, Jennings CD, Brown SA, Widmer MB. Effect of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graft-versus-host disease in H-2-incom-patible transplanted SCID mice. Blood. 1994;83:2360-2367
    • (1994) Blood , vol.83 , pp. 2360-2367
    • Xun, C.Q.1    Thompson, J.S.2    Jennings, C.D.3    Brown, S.A.4    Widmer, M.B.5
  • 58
    • 68249160054 scopus 로고    scopus 로고
    • Blockade of interleukin-6 signaling augments regulatory T cell reconstitution and attenuates the severity of graft versus host disease
    • Chen X, Das R, Komorowski R, et al. Blockade of interleukin-6 signaling augments regulatory T cell reconstitution and attenuates the severity of graft versus host disease. Blood. 2009.
    • (2009) Blood
    • Chen, X.1    Das, R.2    Komorowski, R.3
  • 59
    • 54049153247 scopus 로고    scopus 로고
    • TLR agonists regulate allore-sponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection
    • Taylor PA, Ehrhardt MJ, Lees CJ, et al. TLR agonists regulate allore-sponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection. Blood. 2008; 112:3508-3516
    • (2008) Blood , vol.112 , pp. 3508-3516
    • Taylor, P.A.1    Ehrhardt, M.J.2    Lees, C.J.3
  • 60
    • 58149191879 scopus 로고    scopus 로고
    • The host environment regulates the function of CD8+ graft-versus-host- reactive effector cells
    • Chakraverty R, Flutter B, Fallah-Arani F, et al. The host environment regulates the function of CD8+ graft-versus-host-reactive effector cells. J Immunol. 2008;181:6820-6828
    • (2008) J Immunol. , vol.181 , pp. 6820-6828
    • Chakraverty, R.1    Flutter, B.2    Fallah-Arani, F.3
  • 61
    • 0038624558 scopus 로고    scopus 로고
    • NODs: Intracellular proteins involved in inflammation and apoptosis
    • Inohara N, Nunez G. NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol. 2003;3:371-382
    • (2003) Nat Rev Immunol. , vol.3 , pp. 371-382
    • Inohara, N.1    Nunez, G.2
  • 62
    • 3242771408 scopus 로고    scopus 로고
    • Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation
    • Holler E, Rogler G, Herfarth H, et al. Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood. 2004;104:889-894
    • (2004) Blood , vol.104 , pp. 889-894
    • Holler, E.1    Rogler, G.2    Herfarth, H.3
  • 63
    • 63149171602 scopus 로고    scopus 로고
    • CD24 and Siglec-10 selectively repress tissue damage-induced immune responses
    • Chen GY, Tang J, Zheng P, Liu Y. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science. 2009;323:1722-1725
    • (2009) Science , vol.323 , pp. 1722-1725
    • Chen, G.Y.1    Tang, J.2    Zheng, P.3    Liu, Y.4
  • 64
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998;392:245-252
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 65
    • 0033575383 scopus 로고    scopus 로고
    • Prevention of graft versus host disease by inactivation of host antigen-presenting cells
    • Shlomchik WD, Couzens MS, Tang CB, et al. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science. 1999;285:412-415
    • (1999) Science , vol.285 , pp. 412-415
    • Shlomchik, W.D.1    Couzens, M.S.2    Tang, C.B.3
  • 66
    • 30744443483 scopus 로고    scopus 로고
    • A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses
    • Reddy P, Maeda Y, Liu C, Krijanovski OI, Korngold R, Ferrara JL. A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses. Nat Med. 2005; 11:1244-9.
    • (2005) Nat Med. , vol.11 , pp. 1244-1249
    • Reddy, P.1    Maeda, Y.2    Liu, C.3    Krijanovski, O.I.4    Korngold, R.5    Ferrara, J.L.6
  • 67
    • 4644269742 scopus 로고    scopus 로고
    • Donor APCs are required for maximal GVHD but not for GVL
    • Matte CC, Liu J, Cormier J, et al. Donor APCs are required for maximal GVHD but not for GVL. Nat Med. 2004;10:987-992
    • (2004) Nat Med. , vol.10 , pp. 987-992
    • Matte, C.C.1    Liu, J.2    Cormier, J.3
  • 68
    • 2442658900 scopus 로고    scopus 로고
    • Depletion of host Langerhans cells before transplantation of donor alloreacti ve T cells prevents skin graft-versus-host disease
    • Merad M, Hoffmann P, Ranheim E, et al. Depletion of host Langerhans cells before transplantation of donor alloreacti ve T cells prevents skin graft-versus-host disease. Nat Med. 2004; 10:510-517
    • (2004) Nat Med. , vol.10 , pp. 510-517
    • Merad, M.1    Hoffmann, P.2    Ranheim, E.3
  • 69
    • 34247573902 scopus 로고    scopus 로고
    • Graft-versus-host disease
    • Shlomchik WD. Graft-versus-host disease. Nat Rev Immunol. 2007;7:340-352
    • (2007) Nat Rev Immunol. , vol.7 , pp. 340-352
    • Shlomchik, W.D.1
  • 70
    • 65249187333 scopus 로고    scopus 로고
    • Enhancing immunity through autophagy
    • Munz C. Enhancing immunity through autophagy. Annu Rev Immunol. 2009;27:423-449
    • (2009) Annu Rev Immunol. , vol.27 , pp. 423-449
    • Munz, C.1
  • 71
    • 54549096767 scopus 로고    scopus 로고
    • CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease
    • Hadeiba H, Sato T, Habtezion A, Oderup C, Pan J, Butcher EC. CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat Immunol. 2008;9:1253-1260
    • (2008) Nat Immunol. , vol.9 , pp. 1253-1260
    • Hadeiba, H.1    Sato, T.2    Habtezion, A.3    Oderup, C.4    Pan, J.5    Butcher, E.C.6
  • 72
    • 61849153910 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells prime alloreactive T cells to mediate graii-versus-host disease as antigen-presenting cells
    • Koyama M, Hashimoto D, Aoyama K, et al. Plasmacytoid dendritic cells prime alloreactive T cells to mediate graii-versus-host disease as antigen-presenting cells. Blood. 2009; 113:2088-2095
    • (2009) Blood. , vol.113 , pp. 2088-2095
    • Koyama, M.1    Hashimoto, D.2    Aoyama, K.3
  • 73
    • 60549085836 scopus 로고    scopus 로고
    • Graft-versus-host disease prevents the maturation of plasmacytoid dendritic cells
    • Banovic T, Markey KA, Kuns RD, et al. Graft-versus-host disease prevents the maturation of plasmacytoid dendritic cells. J Immunol. 2009;182:912-920
    • (2009) J Immunol. , vol.182 , pp. 912-920
    • Banovic, T.1    Markey, K.A.2    Kuns, R.D.3
  • 74
    • 63049112195 scopus 로고    scopus 로고
    • Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation
    • Haniffa M, Ginhoux F, Wang XN, et al. Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation. J Exp Med. 2009;206:371-385.
    • (2009) J Exp Med. , vol.206 , pp. 371-385
    • Haniffa, M.1    Ginhoux, F.2    Wang, X.N.3
  • 75
    • 0037902480 scopus 로고    scopus 로고
    • T cell anergy and costimulation
    • Appleman U, Boussiotis VA. T cell anergy and costimulation. Immunol Rev. 2003;192:161-180
    • (2003) Immunol Rev. , vol.192 , pp. 161-180
    • Appleman, U.1    Boussiotis, V.A.2
  • 77
    • 65349189555 scopus 로고    scopus 로고
    • Costimulatory pathways in transplantation: Challenges and new developments
    • Li XC, Rothstein DM, Sayegh MH. Costimulatory pathways in transplantation: challenges and new developments. Immunol Rev. 2009;229:271-293
    • (2009) Immunol Rev. , vol.229 , pp. 271-293
    • Li, X.C.1    Rothstein, D.M.2    Sayegh, M.H.3
  • 78
    • 0035284861 scopus 로고    scopus 로고
    • Ligation of 4-1BB (CDw 137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients
    • Blazar BR, Kwon BS, Panoskaltsis-Mortari A, Kwak KB, Peschon JJ, Taylor PA. Ligation of 4-1BB (CDw 137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients. J Immunol. 2001;166:3174-3183
    • (2001) J Immunol. , vol.166 , pp. 3174-3183
    • Blazar, B.R.1    Kwon, B.S.2    Panoskaltsis-Mortari, A.3    Kwak, K.B.4    Peschon, J.J.5    Taylor, P.A.6
  • 79
    • 4344659974 scopus 로고    scopus 로고
    • CD30/CD30 ligand (CD 153) interaction regulates CD4+ T cell-mediated graft-versus-host disease
    • Blazar BR, Levy RB, Mak TW, et al. CD30/CD30 ligand (CD 153) interaction regulates CD4+ T cell-mediated graft-versus-host disease. J Immunol. 2004;173:2933-2941
    • (2004) J Immunol. , vol.173 , pp. 2933-2941
    • Blazar, B.R.1    Levy, R.B.2    Mak, T.W.3
  • 80
    • 0037528710 scopus 로고    scopus 로고
    • Ligation of OX40 (CD 134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients
    • Blazar BR, Sharpe AH, Chen Al, et al. Ligation of OX40 (CD 134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients. Blood. 2003;101:3741-3748
    • (2003) Blood , vol.101 , pp. 3741-3748
    • Blazar, B.R.1    Sharpe, A.H.2    Chen, A.I.3
  • 81
    • 0028234261 scopus 로고
    • In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-vesus-host disease across the major histocompatibility complex barrier in mice
    • Blazar BR, Taylor PA, Linsley PS, Vallera DA. in vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-vesus-host disease across the major histocompatibility complex barrier in mice. Blood. 1994;83:3815-3825
    • (1994) Blood , vol.83 , pp. 3815-3825
    • Blazar, B.R.1    Taylor, P.A.2    Linsley, P.S.3    Vallera, D.A.4
  • 82
    • 0030639082 scopus 로고    scopus 로고
    • Blockade of CD40 ligand-CD40 interaction impairs CD4+T cell-mediated allore-activity by inhibiting mature donor T cell expansion and function after bone marrow transplantation
    • Blazar BR, Taylor PA, Panoskaltsis-Mortari A, et al. Blockade of CD40 ligand-CD40 interaction impairs CD4+T cell-mediated allore-activity by inhibiting mature donor T cell expansion and function after bone marrow transplantation. J Immunol. 1997;158:29-39.
    • (1997) J Immunol. , vol.158 , pp. 29-39
    • Blazar, B.R.1    Taylor, P.A.2    Panoskaltsis-Mortari, A.3
  • 83
    • 27644527044 scopus 로고    scopus 로고
    • Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation
    • Hubbard VM, Eng JM, Ramirez-Montagut T, et al. Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation. Blood. 2005;106:3285-3292
    • (2005) Blood. , vol.106 , pp. 3285-3292
    • Hubbard, V.M.1    Eng, J.M.2    Ramirez-Montagut, T.3
  • 84
    • 0041845131 scopus 로고    scopus 로고
    • Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism
    • Blazar BR, Carreno BM, Panoskaltsis-Mortari A, et al. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol. 2003;171:1272-1277
    • (2003) J Immunol. , vol.171 , pp. 1272-1277
    • Blazar, B.R.1    Carreno, B.M.2    Panoskaltsis-Mortari, A.3
  • 85
    • 64149127331 scopus 로고    scopus 로고
    • Induction of natural killer T cell-dependent alloreactivity by administration of granulocyte colony-stimulating factor after bone marrow transplantation
    • Morris ES, MacDonald KP, Kuns RD, et al. Induction of natural killer T cell-dependent alloreactivity by administration of granulocyte colony-stimulating factor after bone marrow transplantation. Nat Med. 2009;15:436-441
    • (2009) Nat Med. , vol.15 , pp. 436-441
    • Morris, E.S.1    MacDonald, K.P.2    Kuns, R.D.3
  • 86
    • 1442265964 scopus 로고    scopus 로고
    • Treatment with granulocyte colony-stimulating factor after allogeneic bone marrow transplantation for acute leukemia increases the risk of graft-versus-host disease and death: A study from the acute leukmia working party of the European group for blood and marrow transplantation
    • Ringden O, Labopin M, Gorin NC, et al. Treatment with granulocyte colony-stimulating factor after allogeneic bone marrow transplantation for acute leukemia increases the risk of graft-versus-host disease and death: a study from the Acute Leukmia Working Party of the European Group for Blood and Marrow Transplantation. J Clin Oncol. 2004;22:416-423
    • (2004) J Clin Oncol. , vol.22 , pp. 416-423
    • Ringden, O.1    Labopin, M.2    Gorin, N.C.3
  • 87
    • 1642415712 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect
    • Reddy P, Maeda Y, Hotary K, et al. Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect. Proc Natl Acad Sci U S A. 2004;101:3921-3926
    • (2004) Proc Natl Acad Sci U S A. , vol.101 , pp. 3921-3926
    • Reddy, P.1    Maeda, Y.2    Hotary, K.3
  • 88
    • 46749144173 scopus 로고    scopus 로고
    • Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase- dependent DC functions and regulates experimental graft-versus-host disease in mice
    • Reddy P, Sun Y, Toubai T, et al. Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice. J Clin Invest. 2008;118:2562-2573
    • (2008) J Clin Invest. , vol.118 , pp. 2562-2573
    • Reddy, P.1    Sun, Y.2    Toubai, T.3
  • 89
    • 70349737858 scopus 로고    scopus 로고
    • Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3
    • Sun Y, Chin YE, Weisiger E, et al. Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3. J Immunol. 2009;182:5899-5903
    • (2009) J Immunol. , vol.182 , pp. 5899-5903
    • Sun, Y.1    Chin, Y.E.2    Weisiger, E.3
  • 90
    • 63049129393 scopus 로고    scopus 로고
    • Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease
    • Wilson J, Cullup H, Lourie R, et al. Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease. J Exp Med. 2009;206:387-398
    • (2009) J Exp Med. , vol.206 , pp. 387-398
    • Wilson, J.1    Cullup, H.2    Lourie, R.3
  • 91
    • 22144461789 scopus 로고    scopus 로고
    • Critical role of host gammadelta T cells in experimental acute graft-versus-host disease
    • Maeda Y, Reddy P, Lowler KP, Liu C, Bishop DK, Ferrara JL. Critical role of host gammadelta T cells in experimental acute graft-versus-host disease. Blood. 2005;106:749-755
    • (2005) Blood , vol.106 , pp. 749-755
    • Maeda, Y.1    Reddy, P.2    Lowler, K.P.3    Liu, C.4    Bishop, D.K.5    Ferrara, J.L.6
  • 92
    • 0032080398 scopus 로고    scopus 로고
    • Suppression of graft-versus-host disease and amplification of graft-versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation
    • Asai O, Longo DL, Tian Z, Hornung RL, Taub DD, Ruscetti FW. Suppression of graft-versus-host disease and amplification of graft-versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation. J Clin Invest. 1998;101:1835-1842
    • (1998) J Clin Invest. , vol.101 , pp. 1835-1842
    • Asai, O.1    Longo, D.L.2    Tian, Z.3    Hornung, R.L.4    Taub, D.D.5    Ruscetti, F.W.6
  • 93
    • 0035874525 scopus 로고    scopus 로고
    • Expansion of cytolytic CD8(+) natural killerT cells with limited capacity for graft-versus-host disease induction due to interferon gamma production
    • Baker J, Verneris MR, Ito M, Shizuru JA, Negrin RS. Expansion of cytolytic CD8(+) natural killerT cells with limited capacity for graft-versus-host disease induction due to interferon gamma production. Blood. 2001;97:2923-2931
    • (2001) Blood , vol.97 , pp. 2923-2931
    • Baker, J.1    Verneris, M.R.2    Ito, M.3    Shizuru, J.A.4    Negrin, R.S.5
  • 94
    • 55249095629 scopus 로고    scopus 로고
    • In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity
    • Nishimura R, Baker J, Beilhack A, et al. in vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity. Blood. 2008; 112:2563-2574
    • (2008) Blood. , vol.112 , pp. 2563-2574
    • Nishimura, R.1    Baker, J.2    Beilhack, A.3
  • 95
    • 66149101300 scopus 로고    scopus 로고
    • Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease
    • Pillai AB, George TI, Dutt S, Strober S. Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease. Blood. 2009; 113:4458-4467
    • (2009) Blood , vol.113 , pp. 4458-4467
    • Pillai, A.B.1    George, T.I.2    Dutt, S.3    Strober, S.4
  • 96
    • 34248172955 scopus 로고    scopus 로고
    • Host NKT cells can prevent graft-versus-host disease and permit graft antitumor activity after bone marrow transplantation
    • Pillai AB, George TI, Dun S, Teo P, Strober S. Host NKT cells can prevent graft-versus-host disease and permit graft antitumor activity after bone marrow transplantation. J Immunol. 2007;178:6242-6251
    • (2007) J Immunol. , vol.178 , pp. 6242-6251
    • Pillai, A.B.1    George, T.I.2    Dun, S.3    Teo, P.4    Strober, S.5
  • 97
    • 27644443729 scopus 로고    scopus 로고
    • NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs
    • Morris ES, MacDonald KP, Rowe V, et al. NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs. J Clin Invest. 2005; 115:3093-3103
    • (2005) J Clin Invest. , vol.115 , pp. 3093-3103
    • Morris, E.S.1    MacDonald, K.P.2    Rowe, V.3
  • 98
    • 67651115861 scopus 로고    scopus 로고
    • Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration
    • Kuns RD, Morris ES, Macdonald KP, et al. Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration. Blood. 2009; 113:5999-6010.
    • (2009) Blood , vol.113 , pp. 5999-6010
    • Kuns, R.D.1    Morris, E.S.2    MacDonald, K.P.3
  • 99
    • 33749358615 scopus 로고    scopus 로고
    • Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation
    • Rowe V, Banovic T, MacDonald KP, et al. Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation. Blood. 2006;108:2485-2492
    • (2006) Blood , vol.108 , pp. 2485-2492
    • Rowe, V.1    Banovic, T.2    MacDonald, K.P.3
  • 100
    • 61849178767 scopus 로고    scopus 로고
    • Influence of bone marrow graft B lymphocyte subsets on outcome after HLA-identical sibling transplants
    • Michonneau D, Peffault de Latour R, Porcher R, et al. Influence of bone marrow graft B lymphocyte subsets on outcome after HLA-identical sibling transplants. Br J Haematol. 2009;145:107-114
    • (2009) Br J Haematol. , vol.145 , pp. 107-114
    • Michonneau, D.1    Peffault De Latour, R.2    Porcher, R.3
  • 101
    • 41949129742 scopus 로고    scopus 로고
    • Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs
    • Beilhack A, Schulz S, Baker J, et al. Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs. Blood. 2008;111:2919-2928
    • (2008) Blood , vol.111 , pp. 2919-2928
    • Beilhack, A.1    Schulz, S.2    Baker, J.3
  • 102
    • 46749083929 scopus 로고    scopus 로고
    • Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells
    • Anderson BE, Taylor PA, McNiff JM, etal. Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood. 2008; 111:5242-5251
    • (2008) Blood , vol.111 , pp. 5242-5251
    • Anderson, B.E.1    Taylor, P.A.2    McNiff, J.M.3
  • 103
    • 33646758868 scopus 로고    scopus 로고
    • Induction of tumor immunity following allogeneic stem cell transplantation
    • Wu CJ, Ritz J. Induction of tumor immunity following allogeneic stem cell transplantation. Adv Immunol. 2006;90:133-173
    • (2006) Adv Immunol. , vol.90 , pp. 133-173
    • Wu, C.J.1    Ritz, J.2
  • 104
    • 34347206256 scopus 로고    scopus 로고
    • A uniform genomic minor histocompatibility antigen typing methodology and database designed to facilitate clinical applications
    • Spierings E, Drabbels J, Hendriks M, et al. A uniform genomic minor histocompatibility antigen typing methodology and database designed to facilitate clinical applications. PLoS ONE. 2006; 1 :e42.
    • (2006) PLoS ONE , vol.1
    • Spierings, E.1    Drabbels, J.2    Hendriks, M.3
  • 105
    • 54049083468 scopus 로고    scopus 로고
    • Overlap between in vitro donor antihost and in vivo posttransplantation TCR Vbeta use: A new paradigm for designer allogeneic blood and marrow transplantation
    • Friedman TM, Goldgirsh K, Berger SA, et al. Overlap between in vitro donor antihost and in vivo posttransplantation TCR Vbeta use: a new paradigm for designer allogeneic blood and marrow transplantation. Blood. 2008;112:3517-3525
    • (2008) Blood , vol.112 , pp. 3517-3525
    • Friedman, T.M.1    Goldgirsh, K.2    Berger, S.A.3
  • 106
    • 85047691367 scopus 로고    scopus 로고
    • Memory CD4+ T cells do not induce graft-versus-host disease
    • Anderson BE, McNiff J, Yan J, et al. Memory CD4+ T cells do not induce graft-versus-host disease. J Clin Invest. 2003;112:101-108.
    • (2003) J Clin Invest , vol.112 , pp. 101-108
    • Anderson, B.E.1    McNiff, J.2    Yan, J.3
  • 107
    • 0842263996 scopus 로고    scopus 로고
    • Transfer of allogeneic CD62L-memory T cells without graft-versus-host disease
    • Chen BJ, Cui X, Sempowski GD, Liu C, Chao NJ. Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease. Blood. 2004;103:1534-1541
    • (2004) Blood , vol.103 , pp. 1534-1541
    • Chen, B.J.1    Cui, X.2    Sempowski, G.D.3    Liu, C.4    Chao, N.J.5
  • 108
    • 14944346738 scopus 로고    scopus 로고
    • Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD
    • Ermann J, Hoffmann P, Edinger M, et al. Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood. 2005;105:2220-2226
    • (2005) Blood , vol.105 , pp. 2220-2226
    • Ermann, J.1    Hoffmann, P.2    Edinger, M.3
  • 109
    • 9444280125 scopus 로고    scopus 로고
    • L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection
    • Taylor PA, Panoskaltsis-Mortari A, Swedin JM, et al. L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood. 2004;104:3804-3812
    • (2004) Blood , vol.104 , pp. 3804-3812
    • Taylor, P.A.1    Panoskaltsis-Mortari, A.2    Swedin, J.M.3
  • 110
    • 41349101545 scopus 로고    scopus 로고
    • Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease
    • Zheng H, Matte-Martone C, Li H, et al. Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease. Blood. 2008; 111:2476-2484
    • (2008) Blood , vol.111 , pp. 2476-2484
    • Zheng, H.1    Matte-Martone, C.2    Li, H.3
  • 111
    • 34948824400 scopus 로고    scopus 로고
    • Lymphodepletion followed by donor lymphocyte infusion (DLI) causes significantly more acute graft-versus-host disease than DLI alone
    • Miller JS, Weisdorf DJ, Burns LJ, et al. Lymphodepletion followed by donor lymphocyte infusion (DLI) causes significantly more acute graft-versus-host disease than DLI alone. Blood. 2007;110:2761-2763
    • (2007) Blood , vol.110 , pp. 2761-2763
    • Miller, J.S.1    Weisdorf, D.J.2    Burns, L.J.3
  • 112
    • 14044274267 scopus 로고    scopus 로고
    • Alloreactive memory T cells are responsible for the persistence of graft-versus-host disease
    • Zhang Y, Joe G, Hexner E, Zhu J, Emerson SG. Alloreactive memory T cells are responsible for the persistence of graft-versus-host disease. J Immunol. 2005;174:3051-3058 (Pubitemid 40279726)
    • (2005) Journal of Immunology , vol.174 , Issue.5 , pp. 3051-3058
    • Zhang, Y.1    Joe, G.2    Hexner, E.3    Zhu, J.4    Emerson, S.G.5
  • 113
    • 28644437672 scopus 로고    scopus 로고
    • Host-reactive CD8+ memory stem cells in graft-versus-host disease
    • Zhang Y, Joe G, Hexner E, Zhu J, Emerson SG. Host-reactive CD8+ memory stem cells in graft-versus-host disease. Nature medicine. 2005;11:1299.
    • (2005) Nature Medicine. , vol.11 , pp. 1299
    • Zhang, Y.1    Joe, G.2    Hexner, E.3    Zhu, J.4    Emerson, S.G.5
  • 114
    • 38449089930 scopus 로고    scopus 로고
    • Naive and memory T cells induce different types of graft-versus-host disease
    • Dutt S, Tseng D, Ermann J, et al. Naive and Memory T Cells Induce Different Types of Graft-versus-Host Disease. J Immunol. 2007;179:6547-6554
    • (2007) J Immunol. , vol.179 , pp. 6547-6554
    • Dutt, S.1    Tseng, D.2    Ermann, J.3
  • 116
    • 33748297521 scopus 로고    scopus 로고
    • The role of CD4+CD25hi regulatory T cells in the physiopathogeny of graft-versus-host disease
    • Cohen JL, Boyer O. The role of CD4+CD25hi regulatory T cells in the physiopathogeny of graft-versus-host disease. Qirr Opin Immunol. 2006;18:580-585
    • (2006) Qirr Opin Immunol. , vol.18 , pp. 580-585
    • Cohen, J.L.1    Boyer, O.2
  • 117
    • 0001899960 scopus 로고    scopus 로고
    • The role of interleukin-10 in transplantation and GVHD
    • Ferrara JLM, Deeg HJ, Burakoff SJ, eds. (ed 2nd). New York: Marcel Dekker, Inc.;
    • Roncarolo MG. The Role of Interleukin-10 in Transplantation and GVHD. In: Ferrara JLM, Deeg HJ, Burakoff SJ, eds. Graft-versus-Host Disease (ed 2nd). New York: Marcel Dekker, Inc.; 1997:693-715.
    • (1997) Graft-versus-Host Disease , pp. 693-715
    • Roncarolo, M.G.1
  • 118
    • 0038545422 scopus 로고    scopus 로고
    • Inhibition of graft-versus-host disease by double-negative regulatory T cells
    • Young KJ, DuTemple B, Phillips MJ, Zhang L. Inhibition of graft-versus-host disease by double-negative regulatory T cells. J Immunol. 2003;171:134-141 (Pubitemid 36745281)
    • (2003) Journal of Immunology , vol.171 , Issue.1 , pp. 134-141
    • Young, K.J.1    DuTemple, B.2    Phillips, M.J.3    Zhang, L.4
  • 119
    • 0033526011 scopus 로고    scopus 로고
    • Bone marrow NKl.l(-) and NK 1.1 (+) T cells reciprocally regulate acute graft versus host disease
    • Zeng D, Lewis D, Dejbakhsh-Jones S, etal. Bone marrow NKl.l(-) and NK 1.1 (+) T cells reciprocally regulate acute graft versus host disease. J Exp Med. 1999;189:1073-1081
    • (1999) J Exp Med. , vol.189 , pp. 1073-1081
    • Zeng, D.1    Lewis, D.2    Dejbakhsh-Jones, S.3
  • 120
    • 34247277666 scopus 로고    scopus 로고
    • Foxp3 in control of the regulatory T cell lineage
    • Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nat Immunol. 2007;8:457-462
    • (2007) Nat Immunol. , vol.8 , pp. 457-462
    • Zheng, Y.1    Rudensky, A.Y.2
  • 121
    • 0037026001 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T Cells: New therapeutics for graft-versus-host disease
    • Cohen JL, Trenado A, Vasey D, Klatzmann D, Salomon BL. CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease. J Exp Med. 2002;196:401-406
    • (2002) J Exp Med. , vol.196 , pp. 401-406
    • Cohen, J.L.1    Trenado, A.2    Vasey, D.3    Klatzmann, D.4    Salomon, B.L.5
  • 122
    • 0141461418 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    • Edinger M, Hoffmann P, Ermann J, et al. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med. 2003;9:1144-1150
    • (2003) Nat Med. , vol.9 , pp. 1144-1150
    • Edinger, M.1    Hoffmann, P.2    Ermann, J.3
  • 123
    • 0037025943 scopus 로고    scopus 로고
    • Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    • Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med. 2002;196:389-399
    • (2002) J Exp Med. , vol.196 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Fathman, C.G.4    Strober, S.5
  • 124
    • 0242557055 scopus 로고    scopus 로고
    • Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response
    • Jones SC, Murphy GF, Korngold R. Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response. Biol Blood Marrow Transpl. 2003;9:243-256
    • (2003) Biol Blood Marrow Transpl. , vol.9 , pp. 243-256
    • Jones, S.C.1    Murphy, G.F.2    Korngold, R.3
  • 125
    • 0037093217 scopus 로고    scopus 로고
    • The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality
    • Taylor PA, Lees CJ, Blazar BR. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood. 2002;99:3493-3539
    • (2002) Blood , vol.99 , pp. 3493-3539
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 126
    • 55049124957 scopus 로고    scopus 로고
    • The biology and therapeutic potential of natural regulatory T-cells in the bone marrow transplant setting
    • Coghill JM, Carlson MJ, Moran TP, Serody JS. The biology and therapeutic potential of natural regulatory T-cells in the bone marrow transplant setting. Leuk Lymphoma. 2008;49:1860-1919
    • (2008) Leuk Lymphoma. , vol.49 , pp. 1860-1919
    • Coghill, J.M.1    Carlson, M.J.2    Moran, T.P.3    Serody, J.S.4
  • 127
    • 38349146500 scopus 로고    scopus 로고
    • The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation
    • Nguyen VH, Shashidhar S, Chang DS, et al. The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation. Blood. 2008; 111:945-953
    • (2008) Blood , vol.111 , pp. 945-953
    • Nguyen, V.H.1    Shashidhar, S.2    Chang, D.S.3
  • 128
    • 0035806244 scopus 로고    scopus 로고
    • Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood
    • Dieckmann D, Plottner H, Berchtold S, BergerT, Schuler G. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med. 2001; 193:1303-1310.
    • (2001) J Exp Med. , vol.193 , pp. 1303-1310
    • Dieckmann, D.1    Plottner, H.2    Berchtold, S.3    Berger, T.4    Schuler, G.5
  • 129
    • 0035806290 scopus 로고    scopus 로고
    • Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    • Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med. 2001;193:1285-1294
    • (2001) J Exp Med. , vol.193 , pp. 1285-1294
    • Jonuleit, H.1    Schmitt, E.2    Stassen, M.3    Tuettenberg, A.4    Knop, J.5    Enk, A.H.6
  • 130
    • 33244455884 scopus 로고    scopus 로고
    • Isolation of CD4+CD25+ regulatory T cells for clinical trials
    • Hoffmann P, Boeld TJ, Eder R, et al. Isolation of CD4+CD25+ regulatory T cells for clinical trials. Biol Blood Marrow Transpl. 2006;12:267-274
    • (2006) Biol Blood Marrow Transpl. , vol.12 , pp. 267-274
    • Hoffmann, P.1    Boeld, T.J.2    Eder, R.3
  • 131
    • 59349091835 scopus 로고    scopus 로고
    • Combined CD4+ donor lymphocyte infusion and low-dose recombinant IL-2 expand FOXP3+ regulatory T cells following allogeneic hematopoietic stem cell transplantation
    • Zom E, Mohseni M, Kim H, et al. Combined CD4+ donor lymphocyte infusion and low-dose recombinant IL-2 expand FOXP3+ regulatory T cells following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2009;15:382-388
    • (2009) Biol Blood Marrow Transplant. , vol.15 , pp. 382-388
    • Zom, E.1    Mohseni, M.2    Kim, H.3
  • 132
    • 13544256627 scopus 로고    scopus 로고
    • Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cells
    • MacDonald KP, Rowe V, Clouston AD, et al. Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cells. J Immunol. 2005;174:1841-1850
    • (2005) J Immunol. , vol.174 , pp. 1841-1850
    • MacDonald, K.P.1    Rowe, V.2    Clouston, A.D.3
  • 133
    • 0031984276 scopus 로고    scopus 로고
    • Graft-versus-host disease: The influence of type 1 and type 2 T cell cytokines
    • Ferrara JL, Krenger W. Graft-versus-host disease: the influence of type 1 and type 2 T cell cytokines. Transf Med Rev. 1998; 12:1-17.
    • (1998) Transf Med Rev. , vol.12 , pp. 1-17
    • Ferrara, J.L.1    Krenger, W.2
  • 134
    • 0028285059 scopus 로고
    • The cytokine storm of acute graft-versus host disease
    • Ferrara JLM. The cytokine storm of acute graft-versus host disease. Haematol Rev. 1994;8:27.
    • (1994) Haematol Rev. , vol.8 , pp. 27
    • Ferrara, J.L.M.1
  • 135
    • 0742270811 scopus 로고    scopus 로고
    • Pathophysiology of acute graft-versus-host disease
    • Reddy P. Pathophysiology of acute graft-versus-host disease. Hematol Oncol. 2003;21:149-161
    • (2003) Hematol Oncol. , vol.21 , pp. 149-161
    • Reddy, P.1
  • 136
    • 0032188990 scopus 로고    scopus 로고
    • Phase HI study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation
    • Ratanatharathorn V, Nash RA, Przepiorka D, et al. Phase HI study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation. Blood. 1998;92:2303-2314
    • (1998) Blood , vol.92 , pp. 2303-2314
    • Ratanatharathorn, V.1    Nash, R.A.2    Przepiorka, D.3
  • 137
    • 33846948640 scopus 로고    scopus 로고
    • T cell-directed therapies: Lessons learned and future prospects
    • Liu EH, Siegel RM, Harlan DM, O'Shea JJ. T cell-directed therapies: lessons learned and future prospects. Nat Immunol. 2007;8:25-30.
    • (2007) Nat Immunol. , vol.8 , pp. 25-30
    • Liu, E.H.1    Siegel, R.M.2    Harlan, D.M.3    O'shea, J.J.4
  • 138
    • 33745633856 scopus 로고    scopus 로고
    • Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production
    • Zeiser R, Nguyen VH, Beilhack A, et al. Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood. 2006;108:390-399.
    • (2006) Blood , vol.108 , pp. 390-399
    • Zeiser, R.1    Nguyen, V.H.2    Beilhack, A.3
  • 139
    • 30744458573 scopus 로고    scopus 로고
    • Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells
    • Zhang H, Chua KS, Guimond M, et al. Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells. Nat Med. 2005;11:1238-1243
    • (2005) Nat Med. , vol.11 , pp. 1238-1243
    • Zhang, H.1    Chua, K.S.2    Guimond, M.3
  • 140
    • 33847651713 scopus 로고    scopus 로고
    • Thymic development and peripheral homeostasis of regulatory T cells
    • Liston A, Rudensky AY. Thymic development and peripheral homeostasis of regulatory T cells. Curr Opin Immunol. 2007; 19:176-185
    • (2007) Curr Opin Immunol. , vol.19 , pp. 176-185
    • Liston, A.1    Rudensky, A.Y.2
  • 141
    • 33847153417 scopus 로고    scopus 로고
    • Foxp3-dependent programme of regulatory T-cell differentiation
    • Gavin MA, Rasmussen JP, Fontenot JD, et al. Foxp3-dependent programme of regulatory T-cell differentiation. Nature. 2007;445:771-775
    • (2007) Nature , vol.445 , pp. 771-775
    • Gavin, M.A.1    Rasmussen, J.P.2    Fontenot, J.D.3
  • 142
    • 0032535087 scopus 로고    scopus 로고
    • Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12
    • Yang YG, Dey BR, Sergio JJ, Pearson DA, Sykes M. Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12. J Clin Invest. 1998;102:2126-2135.
    • (1998) J Clin Invest. , vol.102 , pp. 2126-2135
    • Yang, Y.G.1    Dey, B.R.2    Sergio, J.J.3    Pearson, D.A.4    Sykes, M.5
  • 143
    • 0036624924 scopus 로고    scopus 로고
    • Donor-derived interferon gamma separates graft-versus-leukemia effects and graft-versus-host disease induced by donor CD8 T cells
    • Yang YG, Qi J, Wang MG, Sykes M. Donor-derived interferon gamma separates graft-versus-leukemia effects and graft-versus-host disease induced by donor CD8 T cells. Blood. 2002;99:4207-4215
    • (2002) Blood , vol.99 , pp. 4207-4215
    • Yang, Y.G.1    Qi, J.2    Wang, M.G.3    Sykes, M.4
  • 145
    • 34547933330 scopus 로고    scopus 로고
    • IFN(gamma) differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract
    • Burman AC, BanovicTD, Kuns RD, etal. IFN{gamma) differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract. Blood. 2007.
    • (2007) Blood
    • Burman, A.C.1    Banovic, T.D.2    Kuns, R.D.3
  • 146
    • 0028102952 scopus 로고
    • Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice
    • Fowler DH, Kurasawa K, Smith R, Eckhaus MA, Gress RE. Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice. Blood. 1994;84:3540-3549
    • (1994) Blood , vol.84 , pp. 3540-3549
    • Fowler, D.H.1    Kurasawa, K.2    Smith, R.3    Eckhaus, M.A.4    Gress, R.E.5
  • 147
    • 0029047940 scopus 로고
    • Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease
    • Krenger W, Snyder KM, Byon JC, Falzarano G, Ferrara JL. Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease. J Immunol. 1995; 155:585-593
    • (1995) J Immunol. , vol.155 , pp. 585-593
    • Krenger, W.1    Snyder, K.M.2    Byon, J.C.3    Falzarano, G.4    Ferrara, J.L.5
  • 148
    • 0028843985 scopus 로고
    • Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T-lym-phocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease
    • Pan L, Delmonte J, Jalonen C, Ferrara J. Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T-lym-phocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease. Blood. 1995;86:4422-4429
    • (1995) Blood , vol.86 , pp. 4422-4429
    • Pan, L.1    Delmonte, J.2    Jalonen, C.3    Ferrara, J.4
  • 149
    • 0032128206 scopus 로고    scopus 로고
    • Interleukin-11 promotes T cell polarization and prevents acute graft-verssus-host disease after allogeneic bone marrow transplantation
    • Hill GR, Cooke KR, Teshima T, et al. Interleukin-11 promotes T cell polarization and prevents acute graft-verssus-host disease after allogeneic bone marrow transplantation. J Clin Invest. 1998; 102:115-123
    • (1998) J Clin Invest. , vol.102 , pp. 115-123
    • Hill, G.R.1    Cooke, K.R.2    Teshima, T.3
  • 150
    • 0038784377 scopus 로고    scopus 로고
    • Pretreatment of donors with interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effects
    • Reddy P, Teshima T, Hildebrandt G, et al. Pretreatment of donors with interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effects. Blood. 2003;101:2877-2885
    • (2003) Blood , vol.101 , pp. 2877-2885
    • Reddy, P.1    Teshima, T.2    Hildebrandt, G.3
  • 151
    • 27144554518 scopus 로고    scopus 로고
    • Ex vivo rapamycin generates donor Th2 cells that potently inhibit graft-versus-host disease and graft-versus-tumor effects via an IL-4-dependent mechanism
    • Foley JE, Jung U, Miera A, et al. Ex vivo rapamycin generates donor Th2 cells that potently inhibit graft-versus-host disease and graft-versus-tumor effects via an IL-4-dependent mechanism. J Immunol. 2005;175:5732-5743
    • (2005) J Immunol. , vol.175 , pp. 5732-5743
    • Foley, J.E.1    Jung, U.2    Miera, A.3
  • 152
    • 33747332338 scopus 로고    scopus 로고
    • Ex vivo rapamycin generates Thl/Tcl orTh2/Tc2 effectorT cells with enhanced in vivo function and differential sensitivity to post-transplant rapamycin herapy
    • Jung U, Foley JE, Erdmann AA, et al. Ex vivo rapamycin generates Thl/Tcl orTh2/Tc2 effectorT cells with enhanced in vivo function and differential sensitivity to post-transplant rapamycin herapy. Biol Blood Marrow Transpl. 2006; 12:905-918
    • (2006) Biol Blood Marrow Transpl. , vol.12 , pp. 905-918
    • Jung, U.1    Foley, J.E.2    Erdmann, A.A.3
  • 153
    • 0034067656 scopus 로고    scopus 로고
    • Th2 and Tc2 cells in the regulation of GVHD GVL and graft rejection: Considerations for the allogeneic transplantation therapy of leukemia and lymphoma
    • Fowler DH, Gress RE. Th2 and Tc2 cells in the regulation of GVHD, GVL, and graft rejection: considerations for the allogeneic transplantation therapy of leukemia and lymphoma. Leuk Lymphoma. 2000;38:221-234
    • (2000) Leuk Lymphoma. , vol.38 , pp. 221-234
    • Fowler, D.H.1    Gress, R.E.2
  • 154
    • 47149106660 scopus 로고    scopus 로고
    • Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-versus-host disease
    • Tawara I, Maeda Y, Sun Y, et al. Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-versus-host disease. Exp Hematol. 2008;36:988-996
    • (2008) Exp Hematol. , vol.36 , pp. 988-996
    • Tawara, I.1    Maeda, Y.2    Sun, Y.3
  • 155
    • 0034103630 scopus 로고    scopus 로고
    • Thl andTh2mediate acute graft-versus-host disease, each with distinct end-organ targets
    • NikolicB,LeeS, BransonR.GrusbyM,SykesM.Thl andTh2mediate acute graft-versus-host disease, each with distinct end-organ targets. J Clin Invest. 2000;105:1289-1298
    • (2000) J Clin Invest. , vol.105 , pp. 1289-1298
    • Nikolic, B.1    Lee, S.2    Branson, R.3    Grusby, M.4    Sykes, M.5
  • 156
    • 52649136967 scopus 로고    scopus 로고
    • Absence of donor Thl7 leads to augmented Thl differentiation and exacerbated acute graft-versus-host disease
    • Yi T, Zhao D, Lin CL, et al. Absence of donor Thl7 leads to augmented Thl differentiation and exacerbated acute graft-versus-host disease. Blood. 2008; 112:2101-2110
    • (2008) Blood , vol.112 , pp. 2101-2110
    • Yi, T.1    Zhao, D.2    Lin, C.L.3
  • 157
    • 59649098784 scopus 로고    scopus 로고
    • IL-17 contributes to CD4-mediated graft-versus-host disease
    • Kappel LW, Goldberg GL, King CG, et al. IL-17 contributes to CD4-mediated graft-versus-host disease. Blood. 2009; 113:945-952
    • (2009) Blood , vol.113 , pp. 945-952
    • Kappel, L.W.1    Goldberg, G.L.2    King, C.G.3
  • 158
    • 60849118676 scopus 로고    scopus 로고
    • In vitro-differentiatedTH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations
    • Carlson MJ, West ML, Coghill JM, Panoskaltsis-Mortari A, Blazar BR, Serody JS. in vitro-differentiatedTH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations. Blood. 2009; 113:1365-1374
    • (2009) Blood , vol.113 , pp. 1365-1374
    • Carlson, M.J.1    West, M.L.2    Coghill, J.M.3    Panoskaltsis-Mortari, A.4    Blazar, B.R.5    Serody, J.S.6
  • 159
    • 17644365138 scopus 로고    scopus 로고
    • Chemokines, sphingosine-1 -phosphate, and cell migration in secondary lymphoid organs
    • Cyster JG. Chemokines, sphingosine-1 -phosphate, and cell migration in secondary lymphoid organs. Annu Rev Immunol. 2005;23:127-159.
    • (2005) Annu Rev Immunol. , vol.23 , pp. 127-159
    • Cyster, J.G.1
  • 161
    • 33947253233 scopus 로고    scopus 로고
    • Determining thymic output quantitatively: Using models to interpret experimental T-cell receptor excision circle (TREC) data
    • Ribeiro RM, Perelson AS. Determining thymic output quantitatively: using models to interpret experimental T-cell receptor excision circle (TREC) data. Immunol Rev. 2007;216:21-34.
    • (2007) Immunol Rev. , vol.216 , pp. 21-34
    • Ribeiro, R.M.1    Perelson, A.S.2
  • 162
    • 0035282934 scopus 로고    scopus 로고
    • Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation
    • Weinberg K, Blazar BR, Wagner JE, et al. Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation. Blood. 2001;97:1458-1466
    • (2001) Blood , vol.97 , pp. 1458-1466
    • Weinberg, K.1    Blazar, B.R.2    Wagner, J.E.3
  • 163
    • 67650607997 scopus 로고    scopus 로고
    • Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation
    • Clave E, Busson M, Douay C, et al. Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation. Blood. 2009;113:6477-6484
    • (2009) Blood , vol.113 , pp. 6477-6484
    • Clave, E.1    Busson, M.2    Douay, C.3
  • 164
    • 29844440286 scopus 로고    scopus 로고
    • A revision of Billingham's tenets: The central role of lymphocyte migration in acute graft-versus-host disease
    • Sackstein R. A revision of Billingham's tenets: The central role of lymphocyte migration in acute graft-versus-host disease. Biol Blood Marrow Transpl. 2006; 12:2-8.
    • (2006) Biol Blood Marrow Transpl. , vol.12 , pp. 2-8
    • Sackstein, R.1
  • 166
    • 0141707822 scopus 로고    scopus 로고
    • Role of CXCR3-induced donor T-cell migration in acute GVHD
    • Duffner U, Lu B, Hildebrandt GC, et al. Role of CXCR3-induced donor T-cell migration in acute GVHD. Exp Hematol. 2003;31:897-902.
    • (2003) Exp Hematol. , vol.31 , pp. 897-902
    • Duffner, U.1    Lu, B.2    Hildebrandt, G.C.3
  • 167
    • 0032740991 scopus 로고    scopus 로고
    • Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease
    • Murai M, Yoneyama H, Harada A, et al. Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease. J Clin Invest. 1999;104:49-57.
    • (1999) J Clin Invest. , vol.104 , pp. 49-57
    • Murai, M.1    Yoneyama, H.2    Harada, A.3
  • 168
    • 3142661927 scopus 로고    scopus 로고
    • Differential roles for CCR5 expression on donor T cells during graft-versus-host disease based on pretransplant conditioning
    • Wysocki CA, Burkett SB, Panoskaltsis-Mortari A, et al. Differential roles for CCR5 expression on donor T cells during graft-versus-host disease based on pretransplant conditioning. J Immunol. 2004; 173:845-854
    • (2004) J Immunol. , vol.173 , pp. 845-854
    • Wysocki, C.A.1    Burkett, S.B.2    Panoskaltsis-Mortari, A.3
  • 169
    • 27644497249 scopus 로고    scopus 로고
    • Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease
    • Wysocki CA, Jiang Q, Panoskaltsis-Mortari A, et al. Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease. Blood. 2005;106:3300-3307
    • (2005) Blood. , vol.106 , pp. 3300-3307
    • Wysocki, C.A.1    Jiang, Q.2    Panoskaltsis-Mortari, A.3
  • 170
    • 32644449066 scopus 로고    scopus 로고
    • Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine
    • Waldman E, Lu SX, Hubbard VM, et al. Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine. Blood. 2006; 107:1703-1711
    • (2006) Blood , vol.107 , pp. 1703-1711
    • Waldman, E.1    Lu, S.X.2    Hubbard, V.M.3
  • 171
    • 33646820021 scopus 로고    scopus 로고
    • Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR
    • Mapara MY, Leng C, Kim YM, et al. Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR. Biol Blood Marrow Transpl. 2006; 12:623-634
    • (2006) Biol Blood Marrow Transpl. , vol.12 , pp. 623-634
    • Mapara, M.Y.1    Leng, C.2    Kim, Y.M.3
  • 172
    • 0028110928 scopus 로고
    • Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity
    • Kagi D, Vignaux F, Ledermann B, et al. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science. 1994;265:528-530
    • (1994) Science , vol.265 , pp. 528-530
    • Kagi, D.1    Vignaux, F.2    Ledermann, B.3
  • 173
    • 0036550199 scopus 로고    scopus 로고
    • Cytolytic pathways in haematopoietic stem-cell transplantation
    • van den Brink MR, Burakoff SJ. Cytolytic pathways in haematopoietic stem-cell transplantation. Nat Rev Immunol. 2002;2:273-281
    • (2002) Nat Rev Immunol. , vol.2 , pp. 273-281
    • Van Den Brink, M.R.1    Burakoff, S.J.2
  • 174
    • 0037087341 scopus 로고    scopus 로고
    • TNF-TNFR2 interactions are critical for the development of intestinal graft-versus-host disease in MHC class II-disparate (C57BL/6J->C57BL/6J x bml2)Fl mice
    • Brown GR, Lee E, Thiele DL. TNF-TNFR2 interactions are critical for the development of intestinal graft-versus-host disease in MHC class II-disparate (C57BL/6J->C57BL/6J x bml2)Fl mice. J Immunol. 2002;168:3065-3071
    • (2002) J Immunol. , vol.168 , pp. 3065-3071
    • Brown, G.R.1    Lee, E.2    Thiele, D.L.3
  • 175
    • 17044411357 scopus 로고    scopus 로고
    • IL-12-indepen-dent LIGHT signaling enhances MHC class II disparate CD4+ T cell alloproliferation, IFN-gamma responses, and intestinal graft-versus-host disease
    • Brown GR, Lee EL, El-Hayek J, Kintner K, Luck C. IL-12-indepen-dent LIGHT signaling enhances MHC class II disparate CD4+ T cell alloproliferation, IFN-gamma responses, and intestinal graft-versus-host disease. J Immunol. 2005;174:4688-4695
    • (2005) J Immunol. , vol.174 , pp. 4688-4695
    • Brown, G.R.1    Lee, E.L.2    El-Hayek, J.3    Kintner, K.4    Luck, C.5
  • 176
    • 15444372266 scopus 로고    scopus 로고
    • TRAIL-transduced dendritic cells protect mice from acute graft-versus-host disease and leukemia relapse
    • Sato K, Nakaoka T, Yamashita N, et al. TRAIL-transduced dendritic cells protect mice from acute graft-versus-host disease and leukemia relapse. J Immunol. 2005;174:4025-4033
    • (2005) J Immunol. , vol.174 , pp. 4025-4033
    • Sato, K.1    Nakaoka, T.2    Yamashita, N.3
  • 177
    • 0036914180 scopus 로고    scopus 로고
    • T cells require TRAIL for optimal graft-versus-tumor activity
    • Schmaltz C, Alpdogan O, Kappel BJ, et al. T cells require TRAIL for optimal graft-versus-tumor activity. Nat Med. 2002;8:1433-1437
    • (2002) Nat Med. , vol.8 , pp. 1433-1437
    • Schmaltz, C.1    Alpdogan, O.2    Kappel, B.J.3
  • 178
    • 77955436329 scopus 로고    scopus 로고
    • Selective targeting of the LIGHT-HVEM co-stimulatory system for the treatment of graft-versus-host disease
    • Xu Y, Flies AS, Flies DB, et al. Selective targeting of the LIGHT-HVEM co-stimulatory system for the treatment of graft-versus-host disease. Blood. 2006.
    • (2006) Blood
    • Xu, Y.1    Flies, A.S.2    Flies, D.B.3
  • 179
    • 22344458115 scopus 로고    scopus 로고
    • Effector cells derived from host CD8 memory T cells mediate rapid resistance against minor histocompatibility antigen-mismatched allogeneic marrow grafts without participation of perforin Fas ligand and the simultaneous inhibition of 3 tumor necrosis factor family effector pathways
    • Zimmerman Z, Shatry A, Deyev V, et al. Effector cells derived from host CD8 memory T cells mediate rapid resistance against minor histocompatibility antigen-mismatched allogeneic marrow grafts without participation of perforin, Fas ligand, and the simultaneous inhibition of 3 tumor necrosis factor family effector pathways. Biol Blood Marrow Transpl. 2005;11:576-586
    • (2005) Biol Blood Marrow Transpl. , vol.11 , pp. 576-586
    • Zimmerman, Z.1    Shatry, A.2    Deyev, V.3
  • 180
    • 0023620524 scopus 로고
    • Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft versus host disease
    • Piguet PF, Grau GE, Allet B, Vassalli P. Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft versus host disease. J Exp Med. 1987;166:1280-1289
    • (1987) J Exp Med. , vol.166 , pp. 1280-1289
    • Piguet, P.F.1    Grau, G.E.2    Allet, B.3    Vassalli, P.4
  • 181
    • 0027716849 scopus 로고
    • Interleukin-1 is a critical effector molecule during cytokine dysregulation in graft versus host disease to minor histocompatibility antigens
    • Abhyankar S, Gilliland DG, Ferrara JL. Interleukin-1 is a critical effector molecule during cytokine dysregulation in graft versus host disease to minor histocompatibility antigens. Transplantation. 1993;56: 1518-1523
    • (1993) Transplantation. , vol.56 , pp. 1518-1523
    • Abhyankar, S.1    Gilliland, D.G.2    Ferrara, J.L.3
  • 182
    • 0029742960 scopus 로고    scopus 로고
    • Interferon-gamma suppresses T-cell proliferation to mitogen via the nitric oxide pathway during experimental acute graft-versus-host disease
    • Krenger W, Falzarano G, Delmonte J, Jr., Snyder KM, Byon JC, Ferrara JL. Interferon-gamma suppresses T-cell proliferation to mitogen via the nitric oxide pathway during experimental acute graft-versus-host disease. Blood. 1996;88:1113-1121
    • (1996) Blood , vol.88 , pp. 1113-1121
    • Krenger, W.1    Falzarano, G.2    Delmonte Jr., J.3    Snyder, K.M.4    Byon, J.C.5    Ferrara, J.L.6
  • 183
    • 0034284314 scopus 로고    scopus 로고
    • Activation of macrophage cytostatic effector mechanisms during acute graft-versus-host disease: Release of intracellular iron and nitric oxide-mediated cytostasis
    • Nestel FP, Greene RN, Kichian K, Ponka P, Lapp WS. Activation of macrophage cytostatic effector mechanisms during acute graft-versus-host disease: release of intracellular iron and nitric oxide-mediated cytostasis. Blood. 2000;96:1836-1843
    • (2000) Blood , vol.96 , pp. 1836-1843
    • Nestel, F.P.1    Greene, R.N.2    Kichian, K.3    Ponka, P.4    Lapp, W.S.5
  • 184
    • 0027048743 scopus 로고
    • Cytokine dysregulation and acute graft-versus-host disease
    • Antin JH, Ferrara JL. Cytokine dysregulation and acute graft-versus-host disease. Blood. 1992;80:2964-2968
    • (1992) Blood , vol.80 , pp. 2964-2968
    • Antin, J.H.1    Ferrara, J.L.2
  • 185
    • 34247867901 scopus 로고    scopus 로고
    • Immunobiology of allogeneic hematopoietic stem cell transplantation
    • Welniak LA, Blazar BR, Murphy WJ. Immunobiology of allogeneic hematopoietic stem cell transplantation. Annu Rev Immunol. 2007;25:139-170
    • (2007) Annu Rev Immunol. , vol.25 , pp. 139-170
    • Welniak, L.A.1    Blazar, B.R.2    Murphy, W.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.