Effector cells derived from host CD8 memory T cells mediate rapid resistance against minor histocompatibility antigen-mismatched allogeneic marrow grafts without participation of perforin, fas ligand, and the simultaneous inhibition of 3 tumor necrosis factor family effector pathways

Biology of Blood and Marrow Transplantation

Volumn 11, Issue 8, 2005, Pages 576-586

  Zimmerman, Zachary ^a   Shatry, Alwi ^a   Deyev, Vadim ^a   Podack, Eckhard ^a   Mammolenti, Michele ^b   Blazar, Bruce R ^c   Yagita, Hideo ^d   Levy, Robert B ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Allogeneic bone marrow transplantation; Effector cells; Host CD8 memory T cells; Minor histocompatibility antigen mismatch

Indexed keywords

CD8 ANTIGEN; MINOR HISTOCOMPATIBILITY ANTIGEN; PERFORIN; TUMOR NECROSIS FACTOR;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CELL MEDIATED CYTOTOXICITY; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; HLA MATCHING; IMMUNE RESPONSE; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMORY CELL; MOUSE; NONHUMAN; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BONE MARROW TRANSPLANTATION; CARRIER PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; FAS LIGAND PROTEIN; GRAFT SURVIVAL; IMMUNOLOGIC MEMORY; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MINOR HISTOCOMPATIBILITY ANTIGENS; PORE FORMING CYTOTOXIC PROTEINS; SIGNAL TRANSDUCTION; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION, HOMOLOGOUS; TUMOR NECROSIS FACTORS;

EID: 22344458115     PISSN: 10838791     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbmt.2005.05.006     Document Type: Article

References (49)

1. N.A. Kernan C. Bordignon G. Heller et al. Graft failure after T-cell-depleted human leukocyte antigen identical marrow transplants for leukemia: I. Analysis of risk factors and results of secondary transplants Blood 74 1989 2227-2236
2. B.M. Sandmaier P. McSweeney C. Yu et al. Nonmyeloablative transplants preclinical and clinical results Semin Oncol 27 2000 78-81
3. J. Patterson H.G. Prentice M.K. Brenner et al. Graft rejection following HLA matched T-lymphocyte depleted bone marrow transplantation Br J Haematol 63 1986 221-230
4. W.J. Murphy V. Kumar M. Bennett Acute rejection of murine bone marrow allografts by natural killer cells and T cells differences in kinetics and target antigens recognized J Exp Med 166 1987 1499-1550
5. K. Takeda M.W. Moore G. Dennert Acute rejection of marrow grafts in mice. Dependence on and independence of functional TCR in the rejection process J Immunol 152 1994 4407-4416
6. V. Kumar T. George Y.Y. Yu et al. Role of murine NK cells and their receptors in hybrid resistance Curr Opin Immunol 9 1997 52-56
7. R.E. Champlin M.M. Horowitz D.W. van Bekkum et al. Graft failure following bone marrow transplantation for severe aplastic anemia risk factors and treatment results Blood 73 1989 606-613
8. G. Dennert C.G. Anderson J. Warner T-killer cells play a role in allogeneic bone-marrow graft-rejection but not in hybrid resistance J Immunol 135 1985 3729-3734
9. M. Jones M. Komatsu R.B. Levy Cytotoxically impaired transplant recipients can efficiently resist major histocompatibility complex-matched bone marrow allografts Biol Blood Marrow Transplant 6 2000 456-464
10. M. Komatsu M. Mammolenti M. Jones et al. Antigen-primed CD8+ T cells can mediate resistance, preventing allogeneic marrow engraftment in the simultaneous absence of perforin-, CD95L-, TNFR1-, and TRAIL-dependent killing Blood 101 2003 3991-3999
11. S. Malarkannan P.P. Shih P.A. Eden et al. The molecular and functional characterization of a dominant minor H antigen, H60 J Immunol 161 1998 3501-3509
12. M.J. Kaplan D. Ray R.L. Yung et al. Trail and tweak mediate antigen specific and autoreactive macrophage killing by D10 cells [abstract] FASEB J 14 2000 A554
13. G. Bamias C. Martin M. Marini et al. Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease J Immunol 171 2003 4868-4874
14. M. Nakayama K. Ishidoh Y. Kojima et al. Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death J Immunol 170 2003 341-348
15. J. Spielman R.K. Lee E.R. Podack Perforin/Fas-ligand double deficiency is associated with macrophage expansion and severe pancreatitis J Immunol 161 1998 7063-7070
16. D. Kagi F. Vignaux B. Ledermann et al. Fas and perforin pathways as major mechanisms of T-cell-mediated cytotoxicity Science 265 1994 528-530
17. N. Kayagaki N. Yamaguchi M. Nakayama et al. Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells J Immunol 163 1999 1906-1913
18. M. Nakayama N. Harada K. Okumura et al. Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies Biochem Biophys Res Commun 306 2003 819-825
19. D.A. Vallera P.A. Taylor A. Panoskaltsis-Mortari et al. Therapy for ongoing graft-versus-host disease induced across the major or minor histocompatibility barrier in mice with anti-CD3F(ab′)2-ricin toxin A chain immunotoxin Blood 86 1995 4367-4375
20. A.M. Hanash R.B. Levy Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation Blood 105 2005 1828-1836
21. P.J. Wettstein Immunodominance in the T cell response to multiple non-H-2 histocompatibility antigens. III. Single histocompatibility antigens dominate the male antigen J Immunol 137 1986 2073-2079
22. P.J. Wettstein Immunodominance in the T-cell response to multiple non-H-2 histocompatability antigens. 2. Observation of a hierarchy among dominant antigens Immunogenetics 24 1986 24-31
23. A. Cerwenka L.L. Carter J.B. Reome et al. In vivo persistence of CD8 polarized T cell subsets producing type 1 or type 2 cytokines J Immunol 161 1998 97-105
24. N. Seki Y. Hayakawa A.D. Brooks et al. Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer Cancer Res 63 2003 207-213
25. E.A. Marijt W.F. Veenhof E. Goulmy et al. Multiple minor histocompatibility antigen disparities between a recipient and four HLA-identical potential sibling donors for bone marrow transplantation Hum Immunol 37 1993 221-228
26. N.A. Kernan N. Flomenberg B. Dupont et al. Graft rejection in recipients of T-cell-depleted HLA-nonidentical marrow transplants for leukemia. Identification of host-derived antidonor allocytotoxic T lymphocytes Transplantation 43 1987 842-847
27. H. Nakamura R.E. Gress Graft-rejection by cytolytic T-cells-specificity of the effector mechanism in the rejection of allogeneic marrow Transplantation 49 1990 453-458
28. B. Lowin M. Hahne C. Mattmann et al. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways Nature 370 1994 650-652
29. T.S. Migone J. Zhang X. Luo et al. TL1A is a TNF-like ligand and functions as a T cell for DR3 and TR6/DcR3 costimulator Immunity 16 2002 479-492
30. J. Tanaka M. Imamura M. Kasai et al. Cytokine gene expression after allogeneic bone marrow transplantation Leuk Lymphoma 16 1995 413-418
31. J.L. Ferrara Cytokine dysregulation as a mechanism of graft versus host disease Curr Opin Immunol 5 1993 794-799
32. J.L. Prehn S. Mehdizadeh C.J. Landers et al. Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation Clin Immunol 112 2004 66-77
33. K.A. Papadakis J.L. Prehn C. Landers et al. TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells J Immunol 172 2004 7002-7007
34. E. Zorn D.B. Miklos B.H. Floyd et al. Minor histocompatibility antigen DBY elicits a coordinated B and T cell response after allogeneic stem cell transplantation J Exp Med 199 2004 1133-1142
35. D.B. Miklos H.T. Kim E. Zorn et al. Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donors Blood 103 2004 353-359
36. J. Maciejewski C. Selleri S. Anderson et al. Fas antigen expression on Cd34(+) human marrow-cells is induced by interferon-gamma and tumor-necrosis-factor-alpha and potentiates cytokine-mediated hematopoietic suppression in-vitro Blood 85 1995 3183-3190
37. T. Sato C. Selleri N.S. Young et al. Hematopoietic inhibition by interferon-gamma is partially mediated through interferon regulatory factor-I Blood 86 1995 3373-3380
38. V.M. Eng B.D. Car B. Schnyder et al. The stimulatory effects of interleukin (Il)-12 on hematopoiesis are antagonized by Il-12-induced interferon-gamma in-vivo J Exp Med 181 1995 1893-1898
39. H.W. Snoeck S. Weekx A. Moulijn et al. Tumor necrosis factor alpha is a potent synergistic factor for the proliferation of primitive human hematopoietic progenitor cells and induces resistance to transforming growth factor beta but not to interferon gamma J Exp Med 183 1996 705-710
40. Y. Kawano Y. Takaue A. Hirao et al. Synergy among erythropoietin, interleukin-3, stem-cell factor (c-kit ligand) and interferon-gamma on early human hematopoiesis Stem Cells 12 1994 514-520
41. P. Allavena G. Scala J.Y. Djeu et al. Production of multiple cytokines by clones of human large granular lymphocytes Cancer Immunol Immunother 19 1985 121-126
42. W.J. Murphy J.R. Keller C.L. Harrison et al. Interleukin-2-activated natural killer cells can support hematopoiesis in vitro and promote marrow engraftment in vivo Blood 80 1992 670-677
43. J.K. Booker E.A. Reap P.L. Cohen Expression and function of Fas on cells damaged by γ-irradiation in B6 and B6/lpr mice J Immunol 161 1998 4536-4541
44. C.Y. Koh L.A. Welniak W.J. Murphy Lack of correlation between an assay used to determine early marrow allograft rejection and long-term chimerism after murine allogeneic bone marrow transplantation effects of marrow dose Biol Blood Marrow Transplant 11 2005 252-259
45. E. James J.G. Chai H. Dewchand et al. Multiparity induces priming to male-specific minor histocompatibility antigen, HY, in mice and humans Blood 102 2003 388-393
46. R.M. Verdijk A. Kloosterman J. Pool et al. Pregnancy induces minor histocompatibility antigen-specific cytotoxic T cells implications for stem cell transplantation and immunotherapy Blood 103 2004 1961-1964
47. K. Atkinson C. Farrell G. Chapman et al. Female marrow donors increase the risk of acute graft-versus-host disease effect of donor age and parity and analysis of cell subpopulations in the donor marrow inoculum Br J Haematol 63 1986 231-239
48. A.B. Adams M.A. Williams T.R. Jones et al. Heterologous immunity provides a potent barrier to transplantation tolerance J Clin Invest 111 2003 1887-1895
49. R.P. Bourette P. DeSepulveda S. Arnaud et al. Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal J Biol Chem 276 2001 22133-22139