Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets

Journal of Clinical Investigation

Volumn 105, Issue 9, 2000, Pages 1289-1298

  Nikolic, Boris ^a   Lee, Seika ^a   Bronson, Roderick T ^b   Grusby, Michael J ^c,d   Sykes, Megan ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b TUFTS UNIVERSITY   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STAT4 PROTEIN; STAT6 PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; DIARRHEA; FEMALE; GRAFT VERSUS HOST REACTION; HISTOPATHOLOGY; INTESTINE INJURY; KNOCKOUT MOUSE; LIVER INJURY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN INJURY; SPLEEN CELL; TH1 CELL; TH2 CELL; WEIGHT REDUCTION;

EID: 0034103630     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI7894     Document Type: Article

References (57)

1. Butturini, A., and Gale, R.P. 1988. T cell depletion in bone marrow transplantation for leukemia: current results and future directions. Bone Marrow Transplant. 3:185-192.
2. Abbas, A.K., Murphy, K.M., and Sher, A. 1996. Functional diversity of helper T lymphocytes. Nature. 383:787-793.
3. Antin, J.H., and Ferrara, J.L.M. 1992. Cytokine dysregulation in acute graft-versus-host disease. Blood. 80:2964-2068.
4. Blazar, B.R., Korngold, R., and Vallera, D.A. 1997. Recent advances in graft-versus-host disease (GVHD) prevention. Immunol. Rev. 157:79-109.
5. Fowler, D.H., Kurasawa, K., Smith, R., Eckhaus, M.A., Gress, R.E. 1994. Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice. Blood. 84:3540-3549.
6. Fowler, D.H., Kurasawa, K , Husebekk, A., Cohen, P.A., and Gress, R.E. 1994. Cells of the Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. Regulation of cytokines and CD8+ lymphoid engraftment. J. Immunol. 152:1004-1013.
7. Pan, L., Delmonte, J., Jalonen, C.K., and Ferrara, J.L.M. 1997. Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces seventy of experimental graft-versus-host disease. Blood. 86:4422-4429.
8. Krenger, W., et al. 1996. Transplantation of polarized type 2 donor T cells reduces mortality caused by experimental graft-versus-host disease. Transplantation. 62:1278-1285.
9. Blazar, B.K., Taylor, P.A., Smith, S. and Vallera, D.A. 1995. Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow cells. Blood. 85:842-851.
10. Krenger, W., Snyder, K., Smith, S., and Ferrara, J.L.M. 1994. Effects of exogenous interleukin-10 in a murine model of graft-versus-host disease to minor histocompatibility antigens. Transplantation. 58:1251-1257.
11. Yang, Y.-G., Dey, B., Sergio, J.J., Pearson, D.A., and Sykes, M. 1998. Donor-derived interferon γ is required for inhibition of acute graft-versus-host disease by interleukin 12. J. Clin. Invest. 102:2126-2135.
12. Murphy, W.J., et al. 1998. Differential effects of the absence of interferon-γ and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice. J. Clin. Invest. 102:1742-1748.
13. Kaplan, M.H., Sun, Y.-L., Hoey, T., and Grusby, M.J. 1997. Impaired IL-12 responses and enhanced development of Th2 cells in STAT4-deficient mice. Nature. 382:174-177.
14. Thierfelder, W.E., et al. 1996. Requirement for STAT4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 382:171-174.
15. Takeda, K., et al. 1996. Essential role of STAT6 in IL-4 signalling. Nature. 380:627-530.
16. Kaplan, M.H., Schindler, U., Smiley, S.T., and Grusby, M.J. 1996. STAT6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity. 4:313-319.
17. Shimoda, K., et al. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted STAT6 gene. Nature. 380:630-633.
18. Sykes, M., Romick, M.L., and Sachs, D.H. 1990. Interleukin 2 prevents graft-versus-host disease while preserving rhe graft-versus-leukemia effect of allogeneic T cells. Proc. Natl. Acad. Sci. USA. 87:5633-5637.
19. Dialynas, D.P., et al. 1983. Characterization of murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to human Leu3/T4 molecule J. Immunol. 131:2445-2451.
20. Sarmiento, M., Glasebrook, A.L., and Fitch, F.W. 1980. IgG or IgM monoclonal antibodies reacrive with different determinants on the molecular complex bearing Lyt2 antigen block T cell-mediated cytolysis in the absence of complement. J. Immunol. 125:2665-2672.
21. + T cell activity. J. Immunol. 150:197-205.
22. Sykes, M., Romick, M.L., Hoyles, K.A., and Sachs, D.H. 1990. In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftment. J. Exp. Med. 171:645-658.
23. Unkeless, J.C. 1979. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 150:580-596.
24. Ozato, K., Mayer, N.M., and Sachs, D.H. 1982. Monoclonal antibodies to mouse major histocompatibility complex antigens IV. A series of hybridoma clones producing anti-H-2d antibodies and an examination of expression of H-2d antigens on the surface of these cells. Transplantation. 34:113-120.
25. Wang, M.-G., Szebeni, J., Pearson, D.A., Szot, G.L., and Sykes, M. 1995. Inhibition of graft-versus-host disease (GVHD) by IL-2 trearment is associated with altered cytokine production by expanded GVH-reactive CD4+ helper cells. Transplantation. 60:481-490.
26. Ohdan, H., Yang, Y.-G., Shimizu, A., Swenson, K.G., and Sykes, M. 1999. Mixed chimerism induced without lethal conditioning prevents T cell-and anti-Galα1,3Gal-mediated graft rejection. J. Clin. Invest. 104:281-290.
27. Krenger, W., Snyder, K.M., Byon, J.C.H., Falzarano, G., and Ferrara, J.L.M. 1995. Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease. J. Immunol. 155:585-593.
28. Heyd, J., Doonenberg, A.D., Burns, W.H., Saral, R., and Santos, G.W. 1988. Immunoglobulin E levels following allogeneic, autologous and syngeneic bone marrow transplantation: an indirect association between hyperproduction and acute GVHD in allogeneic bone marrow transplantation. Blood. 72:442-446.
29. Claman, H.N., and Spiegelberg, H. 1990. Immunoglobulin dysregulation in marine GVHD: a hyper IgE syndrome. Clin. Immunol. Immunopathol. 56:46-53.
30. Kelso, A. 1995. Th1 and Th2 subsets: paradigms lost? Immunol. Today 16:374-379.
31. Ushiyama, C., et al. 1995. Anti-IL-4 antibody prevents graft-versus-host disease in mice after allogeneic bone marrow transplantation. The IgE allotype is an important marker of graft-versus-host disease. J. Immunol. 154:2687-2696.
32. Sykes, M., Szot, G.L., Nguyen, P.L., and Pearson, D.A. 1995. Interleukin-12 inhibits murine graft-versus-host disease. Blood. 86:2429-2438.
33. Brok, H.P.M., Heidt, P.J., Van der Meide, P.H., Zurcher, C., and Vossen, J.M. 1993. Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice. J. Immunol. 151:6451-6459.
34. Williamson, E., Garside, P., Bradley, JA, More, I.A.R., and Mowat, A.M. 1997. Neutralizing IL-12 during induction of murine acute graft-versus-host disease polarises the cytokine profile toward a Th2-type alloimmune response and confers long term protection from disease. J. Immunol. 159:1208-1215.
35. Dey, B., Yang, Y.-G., Szot, G.L., Pearson, D.A., and Sykes, M. 1998. IL-12 inhibits GVHD through a Fas-mediated mechanism associated with alterations in donor T cell activation and expansion. Blood. 91:3315-3322.
36. Sykes, M., Abraham, V.S., Harty, M.W., and Pearson, D.A. 1992. Selective inhibition of CD4 graft-versus-host activity in IL-2-treated mice. Transplant. Proc. 25:1225-1226.
37. Sykes, M., and Abraham, V.S. 1992. Mechanism of IL-2-mediated protection against GVHD in mice. II. Protection occurs independently of NK/LAK cells. Transplantation. 53:1063-1070.
38. Sykes, M., Harty, M.W., Szot, G.L., and Pearson, D.A. 1994. Interleukin-2 inhibits graft-versus-host disease-promoting activity of CD4+ cells while preserving CD4- and CD8-mediated graft-versus-leukemia effects. Blood. 83:2560-2569.
39. Huang, H., and Paul, W.E. 1998. Impaired interleukin 4 signaling in T helper type 1 cells. J. Exp. Med. 187:1305-1313.
40. Akimoto, T., et al. 1998. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J. Exp. Med. 187:1537-1542.
41. Kaplan, M.H., Wurster, A.L., and Grusby, M.J. 1998. A signal transducer and activator of transcription (STAT)4-independent pathway for the development of T helper type 1 cells. J. Exp. Med. 6:1191-1196.
42. Simpson, J.S., et al. 1998. T cell-mediated pathology in two models of experimental colitis depends on the interleukin 12/signal transducer and activator of transcription (STAT)-4 pathway, but is not conditional on interferon γ expression by T cells J. Exp. Med. 187:1225-1234.
43. Xian, L.C., Zand, M.S., Li, Y., Zheng, X.X., and Strom, T.B. 1998. On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses. J. Immunol. 161:2241-2247.
44. Takai, S., et al. 1993. Increased IgE level as a marker of host-versus-graft disease: inhibition of this HVGD with a monoclonal antibody to IL-4. Cell. Immunol. 149:1-10.
45. Carter, L. L., and Dutton, R.W. 1995. Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations. J. Immunol. 153:1026-1031.
46. Baker, M.B., Altman, N.H., Podack, E.R., and Levy, R.B. 1996. The role of cell-mediated cytotoxictty in acute GVHD after MHC-matched allogeneic bone marrow transplantation. J. Exp. Med. 183:2645-2654.
47. Tsukada, N., Kobata, T., Aizawa, Y., Yagita, H., and Okumura, K. 1999. Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation. Blood. 93:2738-2747.
48. Miwa, K., et al. 1999. Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus-host disease. Int. Immunol. 11:925-931.
49. Sallusto, F., Mackey, C.R., and Lanzavecchia, A. 1997. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Nature. 227:2005-2007.
50. Ward, S.G., Bacon, K.B., and Westwick, J. 1998. Chemokines and T lymphocytes: more than an attraction. Immunity. 9:1-11.
51. Xu, D., et al. 1998. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J. Exp. Med. 187:787-794.
52. Bonecchi, R., et al. 1998. Differential expression of chemokine receptors and chemotactic responsiveness of type I T helper cells (Th1s) and Th2s. J. Exp. Med. 187:129-134.
53. Austrup, F., et al. 1997. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues. Nature. 385:81-83.
54. Lafaille, J.J., et al. 1997. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J. Exp. Med. 186:307-312.
55. Pakala, S.V., Kurrer, M.O., and Katz, J.D. 1997. T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice. J. Exp. Med. 186:299-306.
56. O'Garra, A., Steinman, L., and Gijbels, K. 1998. CD4+ T-cell subsets in autoimmunity. Curr. Opin. Immunol. 9:872-883.
57. Chilosi, M., et al. 1996. CD30 cell expression and abnormal soluble CD30 serum accumulation in Omenn's syndrome: evidence for a T helper2-mediated condition. Eur. J. Immunol. 26:329-334.