메뉴 건너뛰기




Volumn 112, Issue 8, 2008, Pages 3508-3516

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD19 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; GAMMA INTERFERON; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 12; INTERLEUKIN 6; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR;

EID: 54049153247     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-09-113670     Document Type: Article
Times cited : (70)

References (52)
  • 1
    • 0033543947 scopus 로고    scopus 로고
    • Dendritic cell maturation and subsequent enhanced T-cell stimulation induced with the novel synthetic immune response modifier R-848
    • Ahonen CL, Gibson SJ, Smith RM, et al. Dendritic cell maturation and subsequent enhanced T-cell stimulation induced with the novel synthetic immune response modifier R-848. Cell Immunol. 1999;197:62-72.
    • (1999) Cell Immunol , vol.197 , pp. 62-72
    • Ahonen, C.L.1    Gibson, S.J.2    Smith, R.M.3
  • 2
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas ZK, Rasmussen WL Krieg AM. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol. 1996;157:1840-1845.
    • (1996) J Immunol , vol.157 , pp. 1840-1845
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 3
    • 0035979192 scopus 로고    scopus 로고
    • Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
    • Bauer S, Kirschning CJ, Hacker H, et al. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci U S A. 2001;98:9237-9242.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 9237-9242
    • Bauer, S.1    Kirschning, C.J.2    Hacker, H.3
  • 4
    • 2442592788 scopus 로고    scopus 로고
    • Toll-like receptor ligands directly promote activated CD4+ T cell survival
    • Gelman AE, Zhang J, Choi Y, Turka LA. Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol. 2004;172:6065-6073.
    • (2004) J Immunol , vol.172 , pp. 6065-6073
    • Gelman, A.E.1    Zhang, J.2    Choi, Y.3    Turka, L.A.4
  • 5
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V, Rothenfusser S, Britsch S, et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol. 2002;168: 4531-4537.
    • (2002) J Immunol , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3
  • 7
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens
    • Kadowaki N, Ho S, Antonenko S, et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med. 2001;194:863-869.
    • (2001) J Exp Med , vol.194 , pp. 863-869
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3
  • 8
    • 0033980073 scopus 로고    scopus 로고
    • The role of CpG motifs in innate immunity
    • Krieg AM. The role of CpG motifs in innate immunity. Curr Opin Immunol. 2000;12:35-43.
    • (2000) Curr Opin Immunol , vol.12 , pp. 35-43
    • Krieg, A.M.1
  • 9
    • 0038717560 scopus 로고    scopus 로고
    • CpG motifs: The active ingredient in bacterial extracts?
    • Krieg AM. CpG motifs: the active ingredient in bacterial extracts? Nat Med. 2003;9:831-835.
    • (2003) Nat Med , vol.9 , pp. 831-835
    • Krieg, A.M.1
  • 10
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA trigger direct B-cell activation
    • Krieg AM, Yi AK, Matson S, et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature. 1995;374:546-549.
    • (1995) Nature , vol.374 , pp. 546-549
    • Krieg, A.M.1    Yi, A.K.2    Matson, S.3
  • 11
    • 0034777579 scopus 로고    scopus 로고
    • Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
    • Krug A, Towarowski A, Britsch S, et al. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur J Immunol. 2001;31:3026-3037.
    • (2001) Eur J Immunol , vol.31 , pp. 3026-3037
    • Krug, A.1    Towarowski, A.2    Britsch, S.3
  • 12
    • 34247622766 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity in B-cell activation and antibody responses
    • Lanzavecchia A, Sallusto F. Toll-like receptors and innate immunity in B-cell activation and antibody responses. Curr Opin Immunol. 2007;19: 268-274.
    • (2007) Curr Opin Immunol , vol.19 , pp. 268-274
    • Lanzavecchia, A.1    Sallusto, F.2
  • 13
    • 0032533269 scopus 로고    scopus 로고
    • Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor
    • Liu HM. Newbrough SE, Bhatia SK, Dahle CE, Krieg AM, Weiner GJ. Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor. Blood. 1998;92:3730-3736.
    • (1998) Blood , vol.92 , pp. 3730-3736
    • Liu, H.M.1    Newbrough, S.E.2    Bhatia, S.K.3    Dahle, C.E.4    Krieg, A.M.5    Weiner, G.J.6
  • 14
    • 0036493558 scopus 로고    scopus 로고
    • Invivo manipulation of dendritic cells to induce therapeutic immunity
    • Merad M, Sugie T, Engleman EG, Fong L. Invivo manipulation of dendritic cells to induce therapeutic immunity. Blood. 2002;99:1676-1682.
    • (2002) Blood , vol.99 , pp. 1676-1682
    • Merad, M.1    Sugie, T.2    Engleman, E.G.3    Fong, L.4
  • 15
    • 2442473115 scopus 로고    scopus 로고
    • Dendritic cells (DC) activated by CpG DNA ex vivo are potent inducers of host resistance to an intracellular pathogen that is independent of IL-12 derived from the immunizing DC
    • Ramirez-Pineda JR, Frohlich A, Berberich C, Moll H. Dendritic cells (DC) activated by CpG DNA ex vivo are potent inducers of host resistance to an intracellular pathogen that is independent of IL-12 derived from the immunizing DC. J Immunol. 2004;172:6281-6289.
    • (2004) J Immunol , vol.172 , pp. 6281-6289
    • Ramirez-Pineda, J.R.1    Frohlich, A.2    Berberich, C.3    Moll, H.4
  • 16
    • 22544458161 scopus 로고    scopus 로고
    • CpG-containing oligodeoxynucleotides act through TLR9 to enhance the NK cell cytokine response to antibody-coated tumor cells
    • Roda JM, Parihar R, Carson WE III. CpG-containing oligodeoxynucleotides act through TLR9 to enhance the NK cell cytokine response to antibody-coated tumor cells. J Immunol. 2005; 175:1619-1627.
    • (2005) J Immunol , vol.175 , pp. 1619-1627
    • Roda, J.M.1    Parihar, R.2    Carson III, W.E.3
  • 17
    • 0034532681 scopus 로고    scopus 로고
    • Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins
    • Sparwasser T, Vabulas RM, Villmow B, Lipford GB, Wagner H. Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins. Eur J Immunol. 2000;30:3591-3597.
    • (2000) Eur J Immunol , vol.30 , pp. 3591-3597
    • Sparwasser, T.1    Vabulas, R.M.2    Villmow, B.3    Lipford, G.B.4    Wagner, H.5
  • 18
    • 0032995849 scopus 로고    scopus 로고
    • Bacterial CpG DNA activates immune cells to signal infectious danger
    • Wagner H. Bacterial CpG DNA activates immune cells to signal infectious danger. Adv Immunol. 1999;73:329-368.
    • (1999) Adv Immunol , vol.73 , pp. 329-368
    • Wagner, H.1
  • 19
    • 0030613651 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
    • Chu RS, Targoni OS, Krieg AM, Lehmann PV, Harding CV. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med. 1997;186:1623-1631.
    • (1997) J Exp Med , vol.186 , pp. 1623-1631
    • Chu, R.S.1    Targoni, O.S.2    Krieg, A.M.3    Lehmann, P.V.4    Harding, C.V.5
  • 20
    • 33749490571 scopus 로고    scopus 로고
    • Innate immune recognition of, and regulation by, DNA
    • Ishii KJ, Akira S. Innate immune recognition of, and regulation by, DNA. Trends Immunol. 2006: 27:525-532.
    • (2006) Trends Immunol , vol.27 , pp. 525-532
    • Ishii, K.J.1    Akira, S.2
  • 21
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol. 2002;20: 709-760.
    • (2002) Annu Rev Immunol , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 22
    • 0034933019 scopus 로고    scopus 로고
    • Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells
    • Krug A, Rothenfusser S, Hornung V, et al. Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur J Immunol. 2001;31:2154-2163.
    • (2001) Eur J Immunol , vol.31 , pp. 2154-2163
    • Krug, A.1    Rothenfusser, S.2    Hornung, V.3
  • 23
    • 0030764558 scopus 로고    scopus 로고
    • Immunostimulatory DNA sequences function as Thelper-1-promoting adjuvants
    • Roman M, Martin-Orozco E, Goodman JS, et al. Immunostimulatory DNA sequences function as Thelper-1-promoting adjuvants. Nat Med. 1997; 3:849-854.
    • (1997) Nat Med , vol.3 , pp. 849-854
    • Roman, M.1    Martin-Orozco, E.2    Goodman, J.S.3
  • 25
    • 34248169629 scopus 로고    scopus 로고
    • Development of TLR9 agonists for cancer therapy
    • Krieg AM. Development of TLR9 agonists for cancer therapy. J Clin Invest. 2007;117:1184-1194.
    • (2007) J Clin Invest , vol.117 , pp. 1184-1194
    • Krieg, A.M.1
  • 26
    • 0035883093 scopus 로고    scopus 로고
    • Synthetic unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides are potent stimulators of antileukemia responses in naive and bone marrow transplant recipients
    • Blazar BR, Krieg AM, Taylor PA. Synthetic unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides are potent stimulators of antileukemia responses in naive and bone marrow transplant recipients. Blood. 2001;98:1217-1225.
    • (2001) Blood , vol.98 , pp. 1217-1225
    • Blazar, B.R.1    Krieg, A.M.2    Taylor, P.A.3
  • 27
    • 33846181945 scopus 로고    scopus 로고
    • Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats
    • Hammerbeck DM, Burleson GR, Schuller CJ, et al. Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats. Antiviral Res. 2007;73:1-11.
    • (2007) Antiviral Res , vol.73 , pp. 1-11
    • Hammerbeck, D.M.1    Burleson, G.R.2    Schuller, C.J.3
  • 28
    • 33846865333 scopus 로고    scopus 로고
    • Preformed antibody, not primed T cells, is the initial and major barrier to bone marrow engraftment in allosensitized recipients
    • Taylor PA, Ehrhardt MJ, Roforth MM, et al. Preformed antibody, not primed T cells, is the initial and major barrier to bone marrow engraftment in allosensitized recipients. Blood. 2007;109:1307-1315.
    • (2007) Blood , vol.109 , pp. 1307-1315
    • Taylor, P.A.1    Ehrhardt, M.J.2    Roforth, M.M.3
  • 29
    • 33746932816 scopus 로고    scopus 로고
    • An inflammatory checkpoint regulates recruitment of graftversus-host reactive T cells to peripheral tissues
    • Chakraverty R, Cote D, Buchli J, et al. An inflammatory checkpoint regulates recruitment of graftversus-host reactive T cells to peripheral tissues. J Exp Med. 2006;203:2021-2031.
    • (2006) J Exp Med , vol.203 , pp. 2021-2031
    • Chakraverty, R.1    Cote, D.2    Buchli, J.3
  • 30
    • 0037153130 scopus 로고    scopus 로고
    • The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
    • Horng T, Barton GM, Flavell RA, Medzhitov R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature. 2002; 420:329-333.
    • (2002) Nature , vol.420 , pp. 329-333
    • Horng, T.1    Barton, G.M.2    Flavell, R.A.3    Medzhitov, R.4
  • 31
    • 0037153191 scopus 로고    scopus 로고
    • Essential role forTIRAP in activation of the signalling cascade shared by TLR2 and TLR4
    • Yamamoto M, Sato S, Hemmi H, et al. Essential role forTIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature. 2002; 420:324-329.
    • (2002) Nature , vol.420 , pp. 324-329
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3
  • 32
    • 37749044421 scopus 로고    scopus 로고
    • Synthetic agonists of Toll-like receptors 7, 8 and 9
    • Agrawal S, Kandimalla ER. Synthetic agonists of Toll-like receptors 7, 8 and 9. Biochem Soc Trans. 2007;35:1461-1467.
    • (2007) Biochem Soc Trans , vol.35 , pp. 1461-1467
    • Agrawal, S.1    Kandimalla, E.R.2
  • 33
    • 37249041922 scopus 로고    scopus 로고
    • First in human phase I trial of 852A, a novel systemic tolllike receptor 7 agonist, to activate innate immune responses in patients with advanced cancer
    • Dudek AZ, Yunis C, Harrison LI, et al. First in human phase I trial of 852A, a novel systemic tolllike receptor 7 agonist, to activate innate immune responses in patients with advanced cancer. Clin Cancer Res. 2007;13:7119-7125.
    • (2007) Clin Cancer Res , vol.13 , pp. 7119-7125
    • Dudek, A.Z.1    Yunis, C.2    Harrison, L.I.3
  • 34
    • 0036008014 scopus 로고    scopus 로고
    • Small antiviral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Hemmi H, Kaisho T, Takeuchi O, et al. Small antiviral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol. 2002;3:196-200.
    • (2002) Nat Immunol , vol.3 , pp. 196-200
    • Hemmi, H.1    Kaisho, T.2    Takeuchi, O.3
  • 35
    • 34248582612 scopus 로고    scopus 로고
    • TLR7 imidazoquinoline ligand 3M-019 is a potent adjuvant for pure protein prototype vaccines
    • Johnston D, Zaidi B, Bystryn JC. TLR7 imidazoquinoline ligand 3M-019 is a potent adjuvant for pure protein prototype vaccines. Cancer Immunol Immunother. 2007;56:1133-1141.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 1133-1141
    • Johnston, D.1    Zaidi, B.2    Bystryn, J.C.3
  • 36
    • 34248672889 scopus 로고    scopus 로고
    • Antiviral signaling through pattern recognition receptors
    • Kawai T, Akira S. Antiviral signaling through pattern recognition receptors. J Biochem. 2007;141: 137-145.
    • (2007) J Biochem , vol.141 , pp. 137-145
    • Kawai, T.1    Akira, S.2
  • 37
    • 35748964708 scopus 로고    scopus 로고
    • Toll-like receptors 7, 8, and 9: Linking innate immunity to autoimmunity
    • Krieg AM, Vollmer J. Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity. Immunol Rev. 2007;220:251-269.
    • (2007) Immunol Rev , vol.220 , pp. 251-269
    • Krieg, A.M.1    Vollmer, J.2
  • 38
    • 43049102416 scopus 로고    scopus 로고
    • The antiviral activity of Toll-like receptor 7 and 7/8 agonists
    • Miller RL, Meng TC, Tomai MA. The antiviral activity of Toll-like receptor 7 and 7/8 agonists. Drug News Perspect. 2008;21:69-87.
    • (2008) Drug News Perspect , vol.21 , pp. 69-87
    • Miller, R.L.1    Meng, T.C.2    Tomai, M.A.3
  • 39
    • 33947574347 scopus 로고    scopus 로고
    • The antitumoral mode of action of imiquimod and other imidazoquinolines
    • Schon M, Schon MP. The antitumoral mode of action of imiquimod and other imidazoquinolines. Curr Med Chem. 2007;14:681-687.
    • (2007) Curr Med Chem , vol.14 , pp. 681-687
    • Schon, M.1    Schon, M.P.2
  • 40
    • 37848999304 scopus 로고    scopus 로고
    • TLR7 and TLR8 as targets in cancer therapy
    • Schon MP, Schon M. TLR7 and TLR8 as targets in cancer therapy. Oncogene. 2008;27:190-199.
    • (2008) Oncogene , vol.27 , pp. 190-199
    • Schon, M.P.1    Schon, M.2
  • 41
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol. 2005;17:1-14.
    • (2005) Int Immunol , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 42
    • 2942627451 scopus 로고    scopus 로고
    • Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease
    • Duffner UA, Maeda Y, Cooke KR, et al. Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease. J Immunol. 2004;172: 7393-7398.
    • (2004) J Immunol , vol.172 , pp. 7393-7398
    • Duffner, U.A.1    Maeda, Y.2    Cooke, K.R.3
  • 43
    • 2442658900 scopus 로고    scopus 로고
    • Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
    • Merad M, Hoffmann P, Ranheim E, et al. Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat Med. 2004;10:510-517.
    • (2004) Nat Med , vol.10 , pp. 510-517
    • Merad, M.1    Hoffmann, P.2    Ranheim, E.3
  • 44
    • 0033575383 scopus 로고    scopus 로고
    • Prevention of graft versus host disease by inactivation of host antigen-presenting cells
    • Shlomchik WD, Couzens MS, Tang CB, et al. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science. 1999;285:412-415.
    • (1999) Science , vol.285 , pp. 412-415
    • Shlomchik, W.D.1    Couzens, M.S.2    Tang, C.B.3
  • 45
    • 0036281797 scopus 로고    scopus 로고
    • Acute graft-versus-host disease does not require alloantigen expression on host epithelium
    • Teshima T, Ordemann R, Reddy P, et al. Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nat Med. 2002;8:575-581.
    • (2002) Nat Med , vol.8 , pp. 575-581
    • Teshima, T.1    Ordemann, R.2    Reddy, P.3
  • 46
    • 0036099858 scopus 로고    scopus 로고
    • Preterminal host dendritic cells in irradiated mice prime CD8+ T cell-mediated acute graft-versus-host disease
    • Zhang Y, Louboutin JP, Zhu J, Rivera AJ, Emerson SG. Preterminal host dendritic cells in irradiated mice prime CD8+ T cell-mediated acute graft-versus-host disease. J Clin Invest. 2002;109:1335-1344.
    • (2002) J Clin Invest , vol.109 , pp. 1335-1344
    • Zhang, Y.1    Louboutin, J.P.2    Zhu, J.3    Rivera, A.J.4    Emerson, S.G.5
  • 47
    • 0037114157 scopus 로고    scopus 로고
    • APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease
    • Zhang Y, Shlomchik WD, Joe G, et al. APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease. J Immunol. 2002;169:7111-7118.
    • (2002) J Immunol , vol.169 , pp. 7111-7118
    • Zhang, Y.1    Shlomchik, W.D.2    Joe, G.3
  • 49
    • 33947304311 scopus 로고    scopus 로고
    • TLR9 agonists as adjuvants for prophylactic and therapeutic vaccines
    • Daubenberger CA. TLR9 agonists as adjuvants for prophylactic and therapeutic vaccines. Curr Opin Mol Ther. 2007;9:45-52.
    • (2007) Curr Opin Mol Ther , vol.9 , pp. 45-52
    • Daubenberger, C.A.1
  • 50
    • 0033179892 scopus 로고    scopus 로고
    • Immune recognition of foreign DNA: A cure for bioterrorism?
    • Klinman DM, Verthelyi D, Takeshita F, Ishii KJ. Immune recognition of foreign DNA: a cure for bioterrorism? Immunity. 1999;11:123-129.
    • (1999) Immunity , vol.11 , pp. 123-129
    • Klinman, D.M.1    Verthelyi, D.2    Takeshita, F.3    Ishii, K.J.4
  • 51
    • 33750961667 scopus 로고    scopus 로고
    • Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA
    • McCluskie MJ, Krieg AM. Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA. Curr Top Microbiol Immunol. 2006;311:155-178.
    • (2006) Curr Top Microbiol Immunol , vol.311 , pp. 155-178
    • McCluskie, M.J.1    Krieg, A.M.2
  • 52
    • 0030955249 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization
    • Weiner GJ, Liu HM, Wooldridge JE, Dahle CE, Krieg AM. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc Natl Acad Sci U S A. 1997;94:10833-10837.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 10833-10837
    • Weiner, G.J.1    Liu, H.M.2    Wooldridge, J.E.3    Dahle, C.E.4    Krieg, A.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.