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Volumn 2, Issue 4, 2002, Pages 273-281

Cytolytic pathways in haematopoietic stem-cell transplantation

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; FAS ANTIGEN; FAS LIGAND; GRANZYME; PERFORIN; UNCLASSIFIED DRUG;

EID: 0036550199     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri775     Document Type: Review
Times cited : (147)

References (96)
  • 1
    • 0035902174 scopus 로고    scopus 로고
    • Haematopoietic cell transplantation as immunotherapy
    • Appelbaum, F. R. Haematopoietic cell transplantation as immunotherapy. Nature 411, 385-389 (2001). Describes the 'paradigm shift' in haematopoietic stem-cell transplantation from a platform for high-dose chemotherapy/radiation therapy to immunotherapy.
    • (2001) Nature , vol.411 , pp. 385-389
    • Appelbaum, F.R.1
  • 2
    • 0032613565 scopus 로고    scopus 로고
    • Pathophysiologic mechanisms of acute graft-vs.-host disease
    • Ferrara, J. L. Levy, R. & Chao, N. J. Pathophysiologic mechanisms of acute graft-vs.-host disease. Biol. Blood Marrow Transplant 5, 347-356 (1999). Provides a comprehensive, well-written analysis of our current understanding of the complex pathophysiology of graft-versus-host disease.
    • (1999) Biol. Blood Marrow Transplant. , vol.5 , pp. 347-356
    • Ferrara, J.L.1    Levy, R.2    Chao, N.J.3
  • 3
    • 0027516895 scopus 로고
    • Acute and chronic graft-versus-host disease
    • Vogelsang, G. B. Acute and chronic graft-versus-host disease. Curr. Opin. Oncol. 5, 276-281 (1993).
    • (1993) Curr. Opin. Oncol. , vol.5 , pp. 276-281
    • Vogelsang, G.B.1
  • 5
    • 0030754892 scopus 로고    scopus 로고
    • Human minor histocompatibility antigens: New concepts for marrow transplantation and adoptive immunotherapy
    • Goulmy, E. Human minor histocompatibility antigens: new concepts for marrow transplantation and adoptive immunotherapy. Immunol Rev. 157, 125-140 (1997)
    • (1997) Immunol Rev. , vol.157 , pp. 125-140
    • Goulmy, E.1
  • 6
    • 0035383762 scopus 로고    scopus 로고
    • Hematopoietic cell transplantation in older patients with hematologic malignancies: Replacing high-dose cytotoxic therapy with graft-versus-tumor effects
    • McSweeney, P. A. et al. Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects. Blood 97, 3390-3400 (2001).
    • (2001) Blood , vol.97 , pp. 3390-3400
    • McSweeney, P.A.1
  • 7
    • 0029100438 scopus 로고
    • Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients
    • European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia
    • Kolb, H. J. et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia. Blood 86, 2041-2050 (1995).
    • (1995) Blood , vol.86 , pp. 2041-2050
    • Kolb, H.J.1
  • 8
    • 0004009693 scopus 로고    scopus 로고
    • (eds Forman, S. J., Blume, K. G. & Thomas, E. D.) (Blackwell Science, Malden, Massachusetts)
    • Kernan, N. A. in Hematopoietic Cell Transplantation (eds Forman, S. J., Blume, K. G. & Thomas, E. D.) 186-196 (Blackwell Science, Malden, Massachusetts, 1999).
    • (1999) Hematopoietic Cell Transplantation , pp. 186-196
    • Kernan, N.A.1
  • 9
    • 0018764352 scopus 로고
    • Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts
    • Weiden, P. L. et al. Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts. N. Engl. J. Med. 300, 1068-1073 (1979).
    • (1979) N. Engl. J. Med. , vol.300 , pp. 1068-1073
    • Weiden, P.L.1
  • 10
    • 0028110928 scopus 로고
    • Fas and perforin pathways as major mechanisms of T-cell-mediated cytotoxicity
    • Kagi, D. et al. Fas and perforin pathways as major mechanisms of T-cell-mediated cytotoxicity. Science 265, 528-530 (1994).
    • (1994) Science , vol.265 , pp. 528-530
    • Kagi, D.1
  • 11
    • 0027937745 scopus 로고
    • Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
    • Lowin, B., Hahne, M., Mattmann, C. & Tschopp, J. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 370, 650-652 (1994). References 10 and 11 used mice that are deficient for perforin or FasL to show that the perforin and FasL cytolytic pathways are responsible for most of the cytolytic activity of T cells.
    • (1994) Nature , vol.370 , pp. 650-652
    • Lowin, B.1    Hahne, M.2    Mattmann, C.3    Tschopp, J.4
  • 12
    • 0030892234 scopus 로고    scopus 로고
    • Apoptosis by death factor
    • Nagata, S. Apoptosis by death factor. Cell 88, 355-365 (1997).
    • (1997) Cell , vol.88 , pp. 355-365
    • Nagata, S.1
  • 13
    • 0031973637 scopus 로고    scopus 로고
    • Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligand
    • Suzuki, I. & Fink, P. J. Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligand. J. Exp. Med. 187, 123-128 (1998).
    • (1998) J. Exp. Med. , vol.187 , pp. 123-128
    • Suzuki, I.1    Fink, P.J.2
  • 14
    • 0032482160 scopus 로고    scopus 로고
    • A role for Fas in negative selection of thymocytes in vivo
    • Kishimoto, H., Surh, C. D. & Sprent, J. A role for Fas in negative selection of thymocytes in vivo. J. Exp. Med 187, 1427-1438 (1998)
    • (1998) J. Exp. Med. , vol.187 , pp. 1427-1438
    • Kishimoto, H.1    Surh, C.D.2    Sprent, J.3
  • 15
    • 0028219791 scopus 로고
    • Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
    • Kagi, D. et al. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice, Nature 369, 31-37 (1994).
    • (1994) Nature , vol.369 , pp. 31-37
    • Kagi, D.1
  • 16
    • 0032980707 scopus 로고    scopus 로고
    • A role for perforin in downregulating T-cell responses during chronic viral infection
    • Matloubian, M. et al. A role for perforin in downregulating T-cell responses during chronic viral infection. J Virol. 73, 2527-2536 (1999).
    • (1999) J. Virol. , vol.73 , pp. 2527-2536
    • Matloubian, M.1
  • 17
    • 0035320526 scopus 로고    scopus 로고
    • A fresh look at tumor immunosurveillance and immunotherapy
    • Smyth, M. J., Godfrey, D. I. & Trapani, J. A. A fresh look at tumor immunosurveillance and immunotherapy. Nature Immunol. 2, 293-299 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 293-299
    • Smyth, M.J.1    Godfrey, D.I.2    Trapani, J.A.3
  • 18
    • 0029804782 scopus 로고    scopus 로고
    • Decreased tumor surveillance in perforin-deficient mice
    • Van den Broek, M. E. et al. Decreased tumor surveillance in perforin-deficient mice. J. Exp. Med. 184, 1781-1790 (1996).
    • (1996) J. Exp. Med. , vol.184 , pp. 1781-1790
    • Van den Broek, M.E.1
  • 19
    • 0031307852 scopus 로고    scopus 로고
    • + T cells clear influenza virus by perforin- or Fas-dependent processes
    • + T cells clear influenza virus by perforin- or Fas-dependent processes. J. Immunol. 159, 5197-5200 (1997).
    • (1997) J. Immunol. , vol.159 , pp. 5197-5200
    • Topham, D.J.1    Tripp, P.A.2    Doherty, P.C.3
  • 20
    • 0035412359 scopus 로고    scopus 로고
    • The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis
    • Straus, S. E. et al. The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis. Blood 98, 194-200 (2001).
    • (2001) Blood , vol.98 , pp. 194-200
    • Straus, S.E.1
  • 21
    • 0032101118 scopus 로고    scopus 로고
    • Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas-ligand interactions
    • Davidson, W. F., Giese, T. & Fredrickson, T. N. Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas-ligand interactions. J. Exp. Med. 187, 1825-1838 (1998).
    • (1998) J. Exp. Med. , vol.187 , pp. 1825-1838
    • Davidson, W.F.1    Giese, T.2    Fredrickson, T.N.3
  • 22
    • 0033555391 scopus 로고    scopus 로고
    • A role for perforin in activation-induced T-cell death in vivo: Increased expansion of allogeneic perforin-deficient T cells in SCID mice
    • Spaner, D., Raju, K., Rabinovich, B. & Miller, R. G. A role for perforin in activation-induced T-cell death in vivo: increased expansion of allogeneic perforin-deficient T cells in SCID mice. J. Immunol. 162, 1192-1199 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 1192-1199
    • Spaner, D.1    Raju, K.2    Rabinovich, B.3    Miller, R.G.4
  • 23
    • 0032503979 scopus 로고    scopus 로고
    • Enhanced antibody and cytokine responses to influenza viral antigens in perforin-deficient mice
    • Sambhara, S. et al. Enhanced antibody and cytokine responses to influenza viral antigens in perforin-deficient mice. Cell. Immunol. 187, 13-18 (1998).
    • (1998) Cell. Immunol. , vol.187 , pp. 13-18
    • Sambhara, S.1
  • 24
    • 0031974934 scopus 로고    scopus 로고
    • Perforin protects against autoimmunity in lupus-prone mice
    • Peng, S. L., Moslehi, J., Robert, M. E. & Craft, J. Perforin protects against autoimmunity in lupus-prone mice. J. Immunol. 160, 652-660 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 652-660
    • Peng, S.L.1    Moslehi, J.2    Robert, M.E.3    Craft, J.4
  • 25
    • 0030859663 scopus 로고    scopus 로고
    • Difference in the expression of Fas/Fas-ligand and the lymphocyte subset reconstitution according to the occurrence of acute GVHD
    • Lee, S. et al. Difference in the expression of Fas/Fas-ligand and the lymphocyte subset reconstitution according to the occurrence of acute GVHD. Bone Marrow Transplant. 20, 883-888 (1997)
    • (1997) Bone Marrow Transplant. , vol.20 , pp. 883-888
    • Lee, S.1
  • 27
    • 0035451692 scopus 로고    scopus 로고
    • Accumulation and activation-induced release of preformed Fas (CD95) ligand during the pathogenesis of experimental graft-versus-host disease
    • Wasem, C. et al. Accumulation and activation-induced release of preformed Fas (CD95) ligand during the pathogenesis of experimental graft-versus-host disease. J. Immunol. 167, 2936-2941 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 2936-2941
    • Wasem, C.1
  • 28
    • 0033038135 scopus 로고    scopus 로고
    • Levels of soluble FasL and FasL gene expression during the development of graft-versus-host disease in DLT-treated patients
    • Das, H. et al. Levels of soluble FasL and FasL gene expression during the development of graft-versus-host disease in DLT-treated patients. Br. J. Haematol. 104, 795-800 (1999).
    • (1999) Br. J. Haematol. , vol.104 , pp. 795-800
    • Das, H.1
  • 29
    • 0031736130 scopus 로고    scopus 로고
    • Increased soluble Fas-ligand in sera of bone-marrow transplant recipients with acute graft-versus-host disease
    • Kanda, Y. et al. Increased soluble Fas-ligand in sera of bone-marrow transplant recipients with acute graft-versus-host disease. Bone Marrow Transplant. 22, 751-754 (1998)
    • (1998) Bone Marrow Transplant. , vol.22 , pp. 751-754
    • Kanda, Y.1
  • 30
    • 0032519811 scopus 로고    scopus 로고
    • Soluble Fas levels in sera of bone marrow transplantation recipients are increased during acute graft-versus-host disease but not during infections
    • Liem, L. M. et al. Soluble Fas levels in sera of bone marrow transplantation recipients are increased during acute graft-versus-host disease but not during infections. Blood 91, 1464-1468 (1998).
    • (1998) Blood , vol.91 , pp. 1464-1468
    • Liem, L.M.1
  • 31
    • 0030050453 scopus 로고    scopus 로고
    • Cytotoxic T cells deficient in both functional Fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease
    • Braun, M. Y., Lowin, B., French, L., Acha-Orbea, H. & Tsohopp, J. Cytotoxic T cells deficient in both functional Fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease. J. Exp. Med. 183, 657-661 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 657-661
    • Braun, M.Y.1    Lowin, B.2    French, L.3    Acha-Orbea, H.4    Tsohopp, J.5
  • 32
    • 0030589301 scopus 로고    scopus 로고
    • A major role for the Fas pathway in acute graft-versus-host disease
    • Via, C. S., Nguyen, P., Shustov, A., Drappa, J. & Elkon, K. B. A major role for the Fas pathway in acute graft-versus-host disease. J. Immunol. 157, 5387-5393 (1996).
    • (1996) J. Immunol. , vol.157 , pp. 5387-5393
    • Via, C.S.1    Nguyen, P.2    Shustov, A.3    Drappa, J.4    Elkon, K.B.5
  • 33
    • 0029953810 scopus 로고    scopus 로고
    • The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice
    • Baker, M. B., Altman, N. H., Podack, E. R. & Levy, R. B. The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice. J. Exp. Med 183, 2645-2656 (1996). References 31-33 (and reference 37) used mouse models of HSCT and mice that were deficient for FasL, perforin or granzyme B; they were the first to show the importance of the FasL and perforin-granzyme cytolytic pathways in the development of GVHD.
    • (1996) J. Exp. Med. , vol.183 , pp. 2465-2656
    • Baker, M.B.1    Altman, N.H.2    Podack, E.R.3    Levy, R.B.4
  • 34
    • 0031020849 scopus 로고    scopus 로고
    • Graft-versus-host-disease-associated lymphoid hypoplasia and B-cell dysfunction is dependent upon donor T-cell-mediated Fas-ligand function, but not perforin function
    • Baker, M. B., Riley, R. L., Podack, E. R. & Levy, R. B. Graft-versus-host-disease-associated lymphoid hypoplasia and B-cell dysfunction is dependent upon donor T-cell-mediated Fas-ligand function, but not perforin function. Proc. Natl Acad. Sci. USA 94, 1366-1371 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1366-1371
    • Baker, M.B.1    Riley, R.L.2    Podack, E.R.3    Levy, R.B.4
  • 35
    • 0030823702 scopus 로고    scopus 로고
    • Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation
    • Graubert, T. A., DiPersio, J. F., Russell, J. H. & Ley, T. J. Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J. Clin. Invest. 100, 904-911 (1997).
    • (1997) J. Clin. Invest. , vol.100 , pp. 904-911
    • Graubert, T.A.1    DiPersio, J.F.2    Russell, J.H.3    Ley, T.J.4
  • 36
    • 0032701975 scopus 로고    scopus 로고
    • IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation
    • Teshima, T. et al. IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation. J. Clin. Invest. 104, 317-325 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 317-325
    • Teshima, T.1
  • 37
    • 0030027957 scopus 로고    scopus 로고
    • The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection
    • Graubert, T. A., Russell, J. H. & Ley, T. J. The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection. Blood 87, 1232-1237 (1996)
    • (1996) Blood , vol.87 , pp. 1232-1237
    • Graubert, T.A.1    Russell, J.H.2    Ley, T.J.3
  • 38
    • 0035353187 scopus 로고    scopus 로고
    • Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect
    • Schmaltz, C. et al. Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect. Blood 97, 2886-2895 (2001).
    • (2001) Blood , vol.97 , pp. 2886-2895
    • Schmaltz, C.1
  • 39
    • 0033561434 scopus 로고    scopus 로고
    • Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation
    • Tsukada, N., Kobata, T., Aizawa, Y., Yagita, H. & Okumura, K. Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation. Blood 93, 2738-2747 (1999). References 37-39 (and reference 52) showed, in mouse HSCT models, the differential use of the FasL and perforin cytolytic pathways by donor T cells in GVHD and GVT activity.
    • (1999) Blood , vol.93 , pp. 2738-2747
    • Tsukada, N.1    Kobata, T.2    Aizawa, Y.3    Yagita, H.4    Okumura, K.5
  • 40
    • 0030984020 scopus 로고    scopus 로고
    • + T cells each can utilize a perforin-dependent pathway to mediate lethal graft-versus-host disease in major histocompatibility complex-disparate recipients
    • + T cells each can utilize a perforin-dependent pathway to mediate lethal graft-versus-host disease in major histocompatibility complex-disparate recipients. Transplantation 64, 571-576 (1997).
    • (1997) Transplantation , vol.64 , pp. 571-576
    • Blazar, B.R.1    Taylor, P.A.2    Vallera, D.A.3
  • 41
    • 0033805162 scopus 로고    scopus 로고
    • Role of perforin in controlling B-cell hyperactivity and humoral autoimmunity
    • Shustov, A. et al. Role of perforin in controlling B-cell hyperactivity and humoral autoimmunity. J. Clin. Invest. 106, R39-R47 (2000).
    • (2000) J. Clin. Invest. , vol.106
    • Shustov, A.1
  • 42
    • 0033061656 scopus 로고    scopus 로고
    • Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus-host disease
    • Miwa, K. et al. Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus-host disease. Int. J. Immunol. 11, 925-931 (1999).
    • (1999) Int. J. Immunol. , vol.11 , pp. 925-931
    • Miwa, K.1
  • 43
    • 0032127448 scopus 로고    scopus 로고
    • Involvement of Fas-mediated apoptosis in the hematopoietic progenitor cells of graft-versus-host-reaction-associated myelosuppression
    • Mori, T. et al. Involvement of Fas-mediated apoptosis in the hematopoietic progenitor cells of graft-versus-host-reaction-associated myelosuppression. Blood 92, 101-107 (1998).
    • (1998) Blood , vol.92 , pp. 101-107
    • Mori, T.1
  • 44
    • 0032100478 scopus 로고    scopus 로고
    • Differential effects of anti-Fas ligand and anti-tumor necrosis factor-α antibodies on acute graft-versus-host disease pathologies
    • Hattori, K. et al. Differential effects of anti-Fas ligand and anti-tumor necrosis factor-α antibodies on acute graft-versus-host disease pathologies. Blood 91, 4051-4055 (1998). This study showed, by the administration of neutralizing antibodies in mouse HSCT models, the specific role of the FasL and TNF pathways in the development of target-organ GVHD.
    • (1998) Blood , vol.91 , pp. 4051-4055
    • Hattori, K.1
  • 45
    • 0033980662 scopus 로고    scopus 로고
    • Fas-deficient lpr mice are more susceptible to graft-versus-host disease
    • Van den Brink, M. R. et al. Fas-deficient lpr mice are more susceptible to graft-versus-host disease. J. Immunol. 164, 469-480 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 469-480
    • Van den Brink, M.R.1
  • 46
    • 0031002790 scopus 로고    scopus 로고
    • Essential roles of the Fas ligand in the development of hepatitis
    • Kondo, T., Suda, T., Fukuyama, H., Adachi, M. & Nagata, S. Essential roles of the Fas ligand in the development of hepatitis. Nature Med. 3, 409-413 (1997).
    • (1997) Nature Med. , vol.3 , pp. 409-413
    • Kondo, T.1    Suda, T.2    Fukuyama, H.3    Adachi, M.4    Nagata, S.5
  • 47
    • 0023620524 scopus 로고
    • Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease
    • Piguet, P. F., Grau, G. E., Allet, B. & Vassalli, P. Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease. J. Exp. Med. 166, 1280-1289 (1987).
    • (1987) J. Exp. Med. , vol.166 , pp. 1280-1289
    • Piguet, P.F.1    Grau, G.E.2    Allet, B.3    Vassalli, P.4
  • 48
    • 0026754027 scopus 로고
    • Phase I-II trial of a monoclonal anti-tumor necrosis factor-α antibody for the treatment of refractory severe acute graft-versus-host disease
    • Herve, P. et al. Phase I-II trial of a monoclonal anti-tumor necrosis factor-α antibody for the treatment of refractory severe acute graft-versus-host disease. Blood 79, 3362-3368 (1992).
    • (1992) Blood , vol.79 , pp. 3362-3368
    • Herve, P.1
  • 49
    • 0032005020 scopus 로고    scopus 로고
    • Fas-ligand-mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease
    • Lin, T. et al. Fas-ligand-mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease. J. Clin. Invest. 101, 570-577 (1998).
    • (1998) J. Clin. Invest. , vol.101 , pp. 570-577
    • Lin, T.1
  • 50
    • 0032864191 scopus 로고    scopus 로고
    • Intestinal crypt cell apoptosis in murine acute graft-versus-host disease is mediated by tumour necrosis factor-α and not by the FasL-Fas interaction: Effect of pentoxifylline on the development of mucosal atrophy
    • Stuber, E., Buschenfeld, A., von Freier, A., Arendt, T. & Folsch, U. R. Intestinal crypt cell apoptosis in murine acute graft-versus-host disease is mediated by tumour necrosis factor-α and not by the FasL-Fas interaction: effect of pentoxifylline on the development of mucosal atrophy. Gut 45, 229-235 (1999).
    • (1999) Gut , vol.45 , pp. 229-235
    • Stuber, E.1    Buschenfeld, A.2    Von Freier, A.3    Arendt, T.4    Folsch, U.R.5
  • 51
    • 0033564653 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation maintains graft-versus-leukemia effects through a perforin-dependent pathway while preventing graft-versus-host disease
    • Pan, L. et al. Granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation maintains graft-versus-leukemia effects through a perforin-dependent pathway while preventing graft-versus-host disease. Blood 93, 4071-4078 (1999).
    • (1999) Blood , vol.93 , pp. 4071-4078
    • Pan, L.1
  • 52
    • 0034254473 scopus 로고    scopus 로고
    • Differential use of FasL- and perforin-mediated cytolytic mechanisms by T-cell subsets involved in graft-versus-myeloid leukemia responses
    • Hsieh, M. H. & Korngold, R. Differential use of FasL- and perforin-mediated cytolytic mechanisms by T-cell subsets involved in graft-versus-myeloid leukemia responses. Blood 98, 1047-1055 (2000).
    • (2000) Blood , vol.98 , pp. 1047-1055
    • Hsieh, M.H.1    Korngold, R.2
  • 53
    • 0030854908 scopus 로고    scopus 로고
    • A metalloproteinase inhibitor prevents lethal acute graft-versus-host disease in mice
    • Hattori, K. et al. A metalloproteinase inhibitor prevents lethal acute graft-versus-host disease in mice. Blood 90, 542-548 (1997).
    • (1997) Blood , vol.90 , pp. 542-548
    • Hattori, K.1
  • 54
    • 0032620961 scopus 로고    scopus 로고
    • Graft-vs.-lymphoma effect in an allogeneic hematopoietic stem cell transplantation model
    • Ito, M. & Shizuru, J. A. Graft-vs.-lymphoma effect in an allogeneic hematopoietic stem cell transplantation model. Biol. Blood Marrow Transplant. 5, 357-368 (1999).
    • (1999) Biol. Blood Marrow Transplant. , vol.5 , pp. 357-368
    • Ito, M.1    Shizuru, J.A.2
  • 55
    • 0032530890 scopus 로고    scopus 로고
    • Involvement of donor T-cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejection
    • + T-cell effectors that are responsible for causing bone-marrow graft rejection are sensitive to cytotoxicity that is mediated by both perforin- and FasL-dependent mechanisms, and also, that donor T cells must have at least one functional cytotoxic mechanism to prevent allogeneic marrow graft rejection.
    • (1998) Blood , vol.92 , pp. 2177-2181
    • Martin, P.J.1    Akatsuka, Y.2    Hahne, M.3    Sale, G.4
  • 56
    • 0029421460 scopus 로고
    • Perforin- and Fas-mediated cytotoxic pathways are not required for allogeneic resistance to bone marrow grafts in mice
    • Baker, M. B., Podack, E. R. & Levy, R. B. Perforin- and Fas-mediated cytotoxic pathways are not required for allogeneic resistance to bone marrow grafts in mice. Biol. Blood Marrow Transplant. 1, 69-73 (1995).
    • (1995) Biol. Blood Marrow Transplant. , vol.1 , pp. 69-73
    • Baker, M.B.1    Podack, E.R.2    Levy, R.B.3
  • 57
    • 0033543962 scopus 로고    scopus 로고
    • Effect of graft-versus-host disease (GVHD) on host hematopoietic progenitor cells is mediated by Fas-Fas-ligand interactions but this does not explain the effect of GVHD on donor cells
    • Iwasaki, T. et al. Effect of graft-versus-host disease (GVHD) on host hematopoietic progenitor cells is mediated by Fas-Fas-ligand interactions but this does not explain the effect of GVHD on donor cells. Cell. Immunol. 197, 30-38 (1999).
    • (1999) Cell. Immunol. , vol.197 , pp. 30-38
    • Iwasaki, T.1
  • 58
    • 0034327197 scopus 로고    scopus 로고
    • Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions
    • Blazar, B. R. et al. Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions. J. Immunol. 165, 4901-4909 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 4901-4909
    • Blazar, B.R.1
  • 59
    • 0035383799 scopus 로고    scopus 로고
    • Allogeneic bone marrow cells that facilitate complete chimerism and eliminate tumor cells express both CD8 and T-cell antigen receptor-αβ
    • Lan, F., Zeng, D., Huie, P., Higgins, J. P. & Strober, S. Allogeneic bone marrow cells that facilitate complete chimerism and eliminate tumor cells express both CD8 and T-cell antigen receptor-αβ. Blood 97, 3458-3465 (2001).
    • (2001) Blood , vol.97 , pp. 3458-3465
    • Lan, F.1    Zeng, D.2    Huie, P.3    Higgins, J.P.4    Strober, S.5
  • 61
    • 0034661624 scopus 로고    scopus 로고
    • Fas-ligand-deficient gld mice are more susceptible to graft-versus-host disease
    • Van den Brink, M. R. et al. Fas-ligand-deficient gld mice are more susceptible to graft-versus-host disease. Transplantation 70, 184-191 (2000).
    • (2000) Transplantation , vol.70 , pp. 184-191
    • Van den Brink, M.R.1
  • 62
    • 0142233473 scopus 로고    scopus 로고
    • FasL and perforin cytotoxically impaired donor T cells induce GVHD in TNF receptor 1 (p55)-knockout MHC I/II mismatched recipients
    • Jiang, Z., Jones, M. & Levy, R. B. FasL and perforin cytotoxically impaired donor T cells induce GVHD in TNF receptor 1 (p55)-knockout MHC I/II mismatched recipients. Biol. Blood Marrow Transplant 7, 76 (2001).
    • (2001) Biol. Blood Marrow Transplant. , vol.7 , pp. 76
    • Jiang, Z.1    Jones, M.2    Levy, R.B.3
  • 63
    • 0035880242 scopus 로고    scopus 로고
    • Major-histocompatibility-complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4(+) donor T cells: Involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenesis
    • Jiang, Z., Podack, E. & Levy, P. B. Major-histocompatibility-complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4(+) donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenesis. Blood 98, 390-397 (2001).
    • (2001) Blood , vol.98 , pp. 390-397
    • Jiang, Z.1    Podack, E.2    Levy, P.B.3
  • 66
    • 0032169208 scopus 로고    scopus 로고
    • TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T-cell killing of target cells
    • Thomas, W. D. & Hersey, P. TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T-cell killing of target cells. J. Immunol. 161, 2195-2200 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 2195-2200
    • Thomas, W.D.1    Hersey, P.2
  • 67
    • 0033105638 scopus 로고    scopus 로고
    • + T-cell-mediated cytotoxicity
    • + T-cell-mediated cytotoxicity. J. Immunol. 162, 2639-2647 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 2639-2647
    • Kayagaki, N.1
  • 68
    • 0025100777 scopus 로고
    • Graft-versus-leukemia reactions after bone marrow transplantation
    • Horowitz, M. M. et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 75, 555-562 (1990).
    • (1990) Blood , vol.75 , pp. 555-562
    • Horowitz, M.M.1
  • 69
    • 0029868846 scopus 로고    scopus 로고
    • Allogeneic cell therapy with donor peripheral blood cells and recombinant human interleukin-2 to treat leukemia relapse after allogeneic bone marrow transplantation
    • Slavin, S. et al. Allogeneic cell therapy with donor peripheral blood cells and recombinant human interleukin-2 to treat leukemia relapse after allogeneic bone marrow transplantation. Blood 87, 2195-2204 (1996)
    • (1996) Blood , vol.87 , pp. 2195-2204
    • Slavin, S.1
  • 70
    • 0027537527 scopus 로고
    • Delayed infusion of normal donor cells after MHC-matched bone marrow transplantation provides an antileukemia reaction without graft-versus-host disease
    • Johnson, B D., Drobyski, W. R. & Truitt, R. L. Delayed infusion of normal donor cells after MHC-matched bone marrow transplantation provides an antileukemia reaction without graft-versus-host disease. Bone Marrow Transplant 11, 329-336 (1993).
    • (1993) Bone Marrow Transplant. , vol.11 , pp. 329-336
    • Johnson, B.D.1    Drobyski, W.R.2    Truitt, R.L.3
  • 71
    • 0029014567 scopus 로고
    • Adoptive immunotherapy using donor leukocytes following bone marrow transplantation for chronic myeloid leukemia: Is T-cell dose important in determining biological response?
    • Mackinnon, S. et al. Adoptive immunotherapy using donor leukocytes following bone marrow transplantation for chronic myeloid leukemia: is T-cell dose important in determining biological response? Bone Marrow Transplant. 15, 591-594 (1995).
    • (1995) Bone Marrow Transplant. , vol.15 , pp. 591-594
    • Mackinnon, S.1
  • 72
    • 0028871935 scopus 로고
    • CD8-depleted donor lymphocyte infusion as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation
    • Giralt, S. et al. CD8-depleted donor lymphocyte infusion as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation. Blood 86, 4337-4343 (1995).
    • (1995) Blood , vol.86 , pp. 4337-4343
    • Giralt, S.1
  • 73
    • 20244374668 scopus 로고    scopus 로고
    • Toxicity and efficacy of defined doses of CD4(+) donor lymphocytes for treatment of relapse after allogeneic bone marrow transplant
    • Alyea, E. P. et al. Toxicity and efficacy of defined doses of CD4(+) donor lymphocytes for treatment of relapse after allogeneic bone marrow transplant. Blood 91, 3671-3680 (1998).
    • (1998) Blood , vol.91 , pp. 3671-3680
    • Alyea, E.P.1
  • 74
    • 0029115281 scopus 로고
    • + T cells in graft-versus-leukemia activity and engraftment after allogeneic bone marrow transplantation
    • + T cells in graft-versus-leukemia activity and engraftment after allogeneic bone marrow transplantation. Transplantation 60, 355-361 (1995).
    • (1995) Transplantation , vol.60 , pp. 355-361
    • Palathumpat, V.1    Dejbakhsh-Jones, S.2    Strober, S.3
  • 75
    • 0033214650 scopus 로고    scopus 로고
    • A phase I-II clinical trial to evaluate removal of CD4 cells and partial depletion of CD8 cells from donor marrow for HLA-mismatched unrelated recipients
    • Martin, P. J. et al. A phase I-II clinical trial to evaluate removal of CD4 cells and partial depletion of CD8 cells from donor marrow for HLA-mismatched unrelated recipients. Blood 94, 2192-2199 (1999).
    • (1999) Blood , vol.94 , pp. 2192-2199
    • Martin, P.J.1
  • 76
    • 0032528017 scopus 로고    scopus 로고
    • + T-cell depletion does not prevent graft-versus-host disease
    • + T-cell depletion does not prevent graft-versus-host disease. Transplantation 66, 138-141 (1998).
    • (1998) Transplantation , vol.66 , pp. 138-141
    • Nagler, A.1
  • 77
    • 0032968981 scopus 로고    scopus 로고
    • Selective removal of alloreactive cells from haematopoietic stem cell grafts: Graft engineering for GVHD prophylaxis
    • Koh, M. B., Prentice, H. G. & Lowdell, M. W. Selective removal of alloreactive cells from haematopoietic stem cell grafts: graft engineering for GVHD prophylaxis. Bone Marrow Transplant 23, 1071-1079 (1999).
    • (1999) Bone Marrow Transplant. , vol.23 , pp. 1071-1079
    • Koh, M.B.1    Prentice, H.G.2    Lowdell, M.W.3
  • 78
    • 0033151956 scopus 로고    scopus 로고
    • Opposing roles of CD28-B7 and CTLA-4-B7 pathways in regulating in vivo alloresponses in murine recipients of MHC disparate T cells
    • Blazar, B. R., Taylor, P. A., Panoskaltsis-Mortari, A., Sharpe, A. H. & Vallera, D. A. Opposing roles of CD28-B7 and CTLA-4-B7 pathways in regulating in vivo alloresponses in murine recipients of MHC disparate T cells. J. Immunol. 162, 6368-6377 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 6368-6377
    • Blazar, B.R.1    Taylor, P.A.2    Panoskaltsis-Mortari, A.3    Sharpe, A.H.4    Vallera, D.A.5
  • 79
    • 0033519661 scopus 로고    scopus 로고
    • Transplantation of anergic histoincompatible bone marrow allografts
    • Guinan, E. C. et al. Transplantation of anergic histoincompatible bone marrow allografts N. Engl. J. Med. 340, 1704-1714 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1704-1714
    • Guinan, E.C.1
  • 82
    • 0033826799 scopus 로고    scopus 로고
    • Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia
    • Molldrem, J. J. et al. Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia. Nature Med. 6, 1018-1023 (2000).
    • (2000) Nature Med. , vol.6 , pp. 1018-1023
    • Molldrem, J.J.1
  • 83
    • 0030843493 scopus 로고    scopus 로고
    • HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia
    • Bonini, C. et al. HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 276, 1719-1724 (1997)
    • (1997) Science , vol.276 , pp. 1719-1724
    • Bonini, C.1
  • 84
    • 0034978248 scopus 로고    scopus 로고
    • LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation
    • Cooke, K. R. et al. LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation. J. Clin. Invest. 107, 1581-1589 (2001).
    • (2001) J. Clin. Invest. , vol.107 , pp. 1581-1589
    • Cooke, K.R.1
  • 85
    • 0034641898 scopus 로고    scopus 로고
    • CD95's deadly mission in the immune system
    • Krammer, P. H. CD95's deadly mission in the immune system. Nature 407, 789-795 (2000).
    • (2000) Nature , vol.407 , pp. 789-795
    • Krammer, P.H.1
  • 86
    • 0026530828 scopus 로고
    • The cDNA structure, expression and chromosomal assignment of the mouse Fas antigen
    • Watanabe-Fukunaga, P. et al. The cDNA structure, expression and chromosomal assignment of the mouse Fas antigen. J. Immunol. 148, 1274-1279 (1992).
    • (1992) J. Immunol. , vol.148 , pp. 1274-1279
    • Watanabe-Fukunaga, P.1
  • 87
    • 13344268993 scopus 로고    scopus 로고
    • Fas ligand in human serum
    • Tanaka, M. et al. Fas ligand in human serum. Nature Med. 2, 317-322 (1996)
    • (1996) Nature Med. , vol.2 , pp. 317-322
    • Tanaka, M.1
  • 89
    • 0034733584 scopus 로고    scopus 로고
    • Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations
    • Siegel, R. M. et al. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science 288, 2354-2357 (2000).
    • (2000) Science , vol.288 , pp. 2354-2357
    • Siegel, R.M.1
  • 90
    • 0034733682 scopus 로고    scopus 로고
    • A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling
    • Chan, F. K. et al. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288, 2351-2354 (2000).
    • (2000) Science , vol.288 , pp. 2351-2354
    • Chan, F.K.1
  • 91
    • 0027946007 scopus 로고
    • A null mutation in the perforin gene impairs cytolytic T-lymphocyte and natural-killer-cell-mediated cytotoxicity
    • Lowin, B., Beermann, F., Schmidt, A. & Tschopp, J. A null mutation in the perforin gene impairs cytolytic T-lymphocyte and natural-killer-cell-mediated cytotoxicity. Proc Natl Acad. Sci. USA 91, 11571-11575 (1994).
    • (1994) Proc Natl Acad. Sci. USA , vol.91 , pp. 11571-11575
    • Lowin, B.1    Beermann, F.2    Schmidt, A.3    Tschopp, J.4
  • 92
    • 0028990676 scopus 로고
    • Perforin and lymphocyte-mediated cytolysis
    • Liu, C. C., Persechini, P. M. & Young, J. D. Perforin and lymphocyte-mediated cytolysis. Immunol. Rev. 146, 145-175 (1995).
    • (1995) Immunol. Rev. , vol.146 , pp. 145-175
    • Liu, C.C.1    Persechini, P.M.2    Young, J.D.3
  • 93
    • 0033523727 scopus 로고    scopus 로고
    • Inhibition of death receptor signaling by FLICE-inhibitory protein as a mechanism for immune escape of tumors
    • French, L. E. & Tschopp, J. Inhibition of death receptor signaling by FLICE-inhibitory protein as a mechanism for immune escape of tumors. J. Exp. Med. 190, 891-894 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 891-894
    • French, L.E.1    Tschopp, J.2
  • 94
    • 0033656875 scopus 로고    scopus 로고
    • T-cell subsets mediate graft-versus-myeloid leukemia responses via different cytotoxic mechanisms
    • Hsieh, M. H., Patterson, A. E. & Korngold, R. T-cell subsets mediate graft-versus-myeloid leukemia responses via different cytotoxic mechanisms. Biol. Blood Marrow Transplant. 6, 231-240 (2000).
    • (2000) Biol. Blood Marrow Transplant. , vol.6 , pp. 231-240
    • Hsieh, M.H.1    Patterson, A.E.2    Korngold, R.3
  • 95
    • 0034721646 scopus 로고    scopus 로고
    • Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T-cell-induced apoptosis
    • Motyka, B. et al. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T-cell-induced apoptosis. Cell 103, 491-500 (2000).
    • (2000) Cell , vol.103 , pp. 491-500
    • Motyka, B.1
  • 96
    • 0034564268 scopus 로고    scopus 로고
    • Cytotoxically impaired transplant recipients can efficiently resist major histocompatibility complex-matched bone marrow allografts
    • Jones, M., Komatsu, M. & Levy, R. B Cytotoxically impaired transplant recipients can efficiently resist major histocompatibility complex-matched bone marrow allografts. Biol. Blood Marrow Transplant 6, 456-464 (2000).
    • (2000) Biol. Blood Marrow Transplant. , vol.6 , pp. 456-464
    • Jones, M.1    Komatsu, M.2    Levy, R.B.3


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