-
1
-
-
0035902174
-
Haematopoietic cell transplantation as immunotherapy
-
Appelbaum, F. R. Haematopoietic cell transplantation as immunotherapy. Nature 411, 385-389 (2001). Describes the 'paradigm shift' in haematopoietic stem-cell transplantation from a platform for high-dose chemotherapy/radiation therapy to immunotherapy.
-
(2001)
Nature
, vol.411
, pp. 385-389
-
-
Appelbaum, F.R.1
-
2
-
-
0032613565
-
Pathophysiologic mechanisms of acute graft-vs.-host disease
-
Ferrara, J. L. Levy, R. & Chao, N. J. Pathophysiologic mechanisms of acute graft-vs.-host disease. Biol. Blood Marrow Transplant 5, 347-356 (1999). Provides a comprehensive, well-written analysis of our current understanding of the complex pathophysiology of graft-versus-host disease.
-
(1999)
Biol. Blood Marrow Transplant.
, vol.5
, pp. 347-356
-
-
Ferrara, J.L.1
Levy, R.2
Chao, N.J.3
-
3
-
-
0027516895
-
Acute and chronic graft-versus-host disease
-
Vogelsang, G. B. Acute and chronic graft-versus-host disease. Curr. Opin. Oncol. 5, 276-281 (1993).
-
(1993)
Curr. Opin. Oncol.
, vol.5
, pp. 276-281
-
-
Vogelsang, G.B.1
-
5
-
-
0030754892
-
Human minor histocompatibility antigens: New concepts for marrow transplantation and adoptive immunotherapy
-
Goulmy, E. Human minor histocompatibility antigens: new concepts for marrow transplantation and adoptive immunotherapy. Immunol Rev. 157, 125-140 (1997)
-
(1997)
Immunol Rev.
, vol.157
, pp. 125-140
-
-
Goulmy, E.1
-
6
-
-
0035383762
-
Hematopoietic cell transplantation in older patients with hematologic malignancies: Replacing high-dose cytotoxic therapy with graft-versus-tumor effects
-
McSweeney, P. A. et al. Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects. Blood 97, 3390-3400 (2001).
-
(2001)
Blood
, vol.97
, pp. 3390-3400
-
-
McSweeney, P.A.1
-
7
-
-
0029100438
-
Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients
-
European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia
-
Kolb, H. J. et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia. Blood 86, 2041-2050 (1995).
-
(1995)
Blood
, vol.86
, pp. 2041-2050
-
-
Kolb, H.J.1
-
8
-
-
0004009693
-
-
(eds Forman, S. J., Blume, K. G. & Thomas, E. D.) (Blackwell Science, Malden, Massachusetts)
-
Kernan, N. A. in Hematopoietic Cell Transplantation (eds Forman, S. J., Blume, K. G. & Thomas, E. D.) 186-196 (Blackwell Science, Malden, Massachusetts, 1999).
-
(1999)
Hematopoietic Cell Transplantation
, pp. 186-196
-
-
Kernan, N.A.1
-
9
-
-
0018764352
-
Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts
-
Weiden, P. L. et al. Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts. N. Engl. J. Med. 300, 1068-1073 (1979).
-
(1979)
N. Engl. J. Med.
, vol.300
, pp. 1068-1073
-
-
Weiden, P.L.1
-
10
-
-
0028110928
-
Fas and perforin pathways as major mechanisms of T-cell-mediated cytotoxicity
-
Kagi, D. et al. Fas and perforin pathways as major mechanisms of T-cell-mediated cytotoxicity. Science 265, 528-530 (1994).
-
(1994)
Science
, vol.265
, pp. 528-530
-
-
Kagi, D.1
-
11
-
-
0027937745
-
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
-
Lowin, B., Hahne, M., Mattmann, C. & Tschopp, J. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 370, 650-652 (1994). References 10 and 11 used mice that are deficient for perforin or FasL to show that the perforin and FasL cytolytic pathways are responsible for most of the cytolytic activity of T cells.
-
(1994)
Nature
, vol.370
, pp. 650-652
-
-
Lowin, B.1
Hahne, M.2
Mattmann, C.3
Tschopp, J.4
-
12
-
-
0030892234
-
Apoptosis by death factor
-
Nagata, S. Apoptosis by death factor. Cell 88, 355-365 (1997).
-
(1997)
Cell
, vol.88
, pp. 355-365
-
-
Nagata, S.1
-
13
-
-
0031973637
-
Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligand
-
Suzuki, I. & Fink, P. J. Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligand. J. Exp. Med. 187, 123-128 (1998).
-
(1998)
J. Exp. Med.
, vol.187
, pp. 123-128
-
-
Suzuki, I.1
Fink, P.J.2
-
14
-
-
0032482160
-
A role for Fas in negative selection of thymocytes in vivo
-
Kishimoto, H., Surh, C. D. & Sprent, J. A role for Fas in negative selection of thymocytes in vivo. J. Exp. Med 187, 1427-1438 (1998)
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1427-1438
-
-
Kishimoto, H.1
Surh, C.D.2
Sprent, J.3
-
15
-
-
0028219791
-
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
-
Kagi, D. et al. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice, Nature 369, 31-37 (1994).
-
(1994)
Nature
, vol.369
, pp. 31-37
-
-
Kagi, D.1
-
16
-
-
0032980707
-
A role for perforin in downregulating T-cell responses during chronic viral infection
-
Matloubian, M. et al. A role for perforin in downregulating T-cell responses during chronic viral infection. J Virol. 73, 2527-2536 (1999).
-
(1999)
J. Virol.
, vol.73
, pp. 2527-2536
-
-
Matloubian, M.1
-
17
-
-
0035320526
-
A fresh look at tumor immunosurveillance and immunotherapy
-
Smyth, M. J., Godfrey, D. I. & Trapani, J. A. A fresh look at tumor immunosurveillance and immunotherapy. Nature Immunol. 2, 293-299 (2001).
-
(2001)
Nature Immunol.
, vol.2
, pp. 293-299
-
-
Smyth, M.J.1
Godfrey, D.I.2
Trapani, J.A.3
-
18
-
-
0029804782
-
Decreased tumor surveillance in perforin-deficient mice
-
Van den Broek, M. E. et al. Decreased tumor surveillance in perforin-deficient mice. J. Exp. Med. 184, 1781-1790 (1996).
-
(1996)
J. Exp. Med.
, vol.184
, pp. 1781-1790
-
-
Van den Broek, M.E.1
-
19
-
-
0031307852
-
+ T cells clear influenza virus by perforin- or Fas-dependent processes
-
+ T cells clear influenza virus by perforin- or Fas-dependent processes. J. Immunol. 159, 5197-5200 (1997).
-
(1997)
J. Immunol.
, vol.159
, pp. 5197-5200
-
-
Topham, D.J.1
Tripp, P.A.2
Doherty, P.C.3
-
20
-
-
0035412359
-
The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis
-
Straus, S. E. et al. The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis. Blood 98, 194-200 (2001).
-
(2001)
Blood
, vol.98
, pp. 194-200
-
-
Straus, S.E.1
-
21
-
-
0032101118
-
Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas-ligand interactions
-
Davidson, W. F., Giese, T. & Fredrickson, T. N. Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas-ligand interactions. J. Exp. Med. 187, 1825-1838 (1998).
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1825-1838
-
-
Davidson, W.F.1
Giese, T.2
Fredrickson, T.N.3
-
22
-
-
0033555391
-
A role for perforin in activation-induced T-cell death in vivo: Increased expansion of allogeneic perforin-deficient T cells in SCID mice
-
Spaner, D., Raju, K., Rabinovich, B. & Miller, R. G. A role for perforin in activation-induced T-cell death in vivo: increased expansion of allogeneic perforin-deficient T cells in SCID mice. J. Immunol. 162, 1192-1199 (1999).
-
(1999)
J. Immunol.
, vol.162
, pp. 1192-1199
-
-
Spaner, D.1
Raju, K.2
Rabinovich, B.3
Miller, R.G.4
-
23
-
-
0032503979
-
Enhanced antibody and cytokine responses to influenza viral antigens in perforin-deficient mice
-
Sambhara, S. et al. Enhanced antibody and cytokine responses to influenza viral antigens in perforin-deficient mice. Cell. Immunol. 187, 13-18 (1998).
-
(1998)
Cell. Immunol.
, vol.187
, pp. 13-18
-
-
Sambhara, S.1
-
24
-
-
0031974934
-
Perforin protects against autoimmunity in lupus-prone mice
-
Peng, S. L., Moslehi, J., Robert, M. E. & Craft, J. Perforin protects against autoimmunity in lupus-prone mice. J. Immunol. 160, 652-660 (1998).
-
(1998)
J. Immunol.
, vol.160
, pp. 652-660
-
-
Peng, S.L.1
Moslehi, J.2
Robert, M.E.3
Craft, J.4
-
25
-
-
0030859663
-
Difference in the expression of Fas/Fas-ligand and the lymphocyte subset reconstitution according to the occurrence of acute GVHD
-
Lee, S. et al. Difference in the expression of Fas/Fas-ligand and the lymphocyte subset reconstitution according to the occurrence of acute GVHD. Bone Marrow Transplant. 20, 883-888 (1997)
-
(1997)
Bone Marrow Transplant.
, vol.20
, pp. 883-888
-
-
Lee, S.1
-
27
-
-
0035451692
-
Accumulation and activation-induced release of preformed Fas (CD95) ligand during the pathogenesis of experimental graft-versus-host disease
-
Wasem, C. et al. Accumulation and activation-induced release of preformed Fas (CD95) ligand during the pathogenesis of experimental graft-versus-host disease. J. Immunol. 167, 2936-2941 (2001).
-
(2001)
J. Immunol.
, vol.167
, pp. 2936-2941
-
-
Wasem, C.1
-
28
-
-
0033038135
-
Levels of soluble FasL and FasL gene expression during the development of graft-versus-host disease in DLT-treated patients
-
Das, H. et al. Levels of soluble FasL and FasL gene expression during the development of graft-versus-host disease in DLT-treated patients. Br. J. Haematol. 104, 795-800 (1999).
-
(1999)
Br. J. Haematol.
, vol.104
, pp. 795-800
-
-
Das, H.1
-
29
-
-
0031736130
-
Increased soluble Fas-ligand in sera of bone-marrow transplant recipients with acute graft-versus-host disease
-
Kanda, Y. et al. Increased soluble Fas-ligand in sera of bone-marrow transplant recipients with acute graft-versus-host disease. Bone Marrow Transplant. 22, 751-754 (1998)
-
(1998)
Bone Marrow Transplant.
, vol.22
, pp. 751-754
-
-
Kanda, Y.1
-
30
-
-
0032519811
-
Soluble Fas levels in sera of bone marrow transplantation recipients are increased during acute graft-versus-host disease but not during infections
-
Liem, L. M. et al. Soluble Fas levels in sera of bone marrow transplantation recipients are increased during acute graft-versus-host disease but not during infections. Blood 91, 1464-1468 (1998).
-
(1998)
Blood
, vol.91
, pp. 1464-1468
-
-
Liem, L.M.1
-
31
-
-
0030050453
-
Cytotoxic T cells deficient in both functional Fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease
-
Braun, M. Y., Lowin, B., French, L., Acha-Orbea, H. & Tsohopp, J. Cytotoxic T cells deficient in both functional Fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease. J. Exp. Med. 183, 657-661 (1996).
-
(1996)
J. Exp. Med.
, vol.183
, pp. 657-661
-
-
Braun, M.Y.1
Lowin, B.2
French, L.3
Acha-Orbea, H.4
Tsohopp, J.5
-
32
-
-
0030589301
-
A major role for the Fas pathway in acute graft-versus-host disease
-
Via, C. S., Nguyen, P., Shustov, A., Drappa, J. & Elkon, K. B. A major role for the Fas pathway in acute graft-versus-host disease. J. Immunol. 157, 5387-5393 (1996).
-
(1996)
J. Immunol.
, vol.157
, pp. 5387-5393
-
-
Via, C.S.1
Nguyen, P.2
Shustov, A.3
Drappa, J.4
Elkon, K.B.5
-
33
-
-
0029953810
-
The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice
-
Baker, M. B., Altman, N. H., Podack, E. R. & Levy, R. B. The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice. J. Exp. Med 183, 2645-2656 (1996). References 31-33 (and reference 37) used mouse models of HSCT and mice that were deficient for FasL, perforin or granzyme B; they were the first to show the importance of the FasL and perforin-granzyme cytolytic pathways in the development of GVHD.
-
(1996)
J. Exp. Med.
, vol.183
, pp. 2465-2656
-
-
Baker, M.B.1
Altman, N.H.2
Podack, E.R.3
Levy, R.B.4
-
34
-
-
0031020849
-
Graft-versus-host-disease-associated lymphoid hypoplasia and B-cell dysfunction is dependent upon donor T-cell-mediated Fas-ligand function, but not perforin function
-
Baker, M. B., Riley, R. L., Podack, E. R. & Levy, R. B. Graft-versus-host-disease-associated lymphoid hypoplasia and B-cell dysfunction is dependent upon donor T-cell-mediated Fas-ligand function, but not perforin function. Proc. Natl Acad. Sci. USA 94, 1366-1371 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 1366-1371
-
-
Baker, M.B.1
Riley, R.L.2
Podack, E.R.3
Levy, R.B.4
-
35
-
-
0030823702
-
Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation
-
Graubert, T. A., DiPersio, J. F., Russell, J. H. & Ley, T. J. Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J. Clin. Invest. 100, 904-911 (1997).
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 904-911
-
-
Graubert, T.A.1
DiPersio, J.F.2
Russell, J.H.3
Ley, T.J.4
-
36
-
-
0032701975
-
IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation
-
Teshima, T. et al. IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation. J. Clin. Invest. 104, 317-325 (1999).
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 317-325
-
-
Teshima, T.1
-
37
-
-
0030027957
-
The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection
-
Graubert, T. A., Russell, J. H. & Ley, T. J. The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection. Blood 87, 1232-1237 (1996)
-
(1996)
Blood
, vol.87
, pp. 1232-1237
-
-
Graubert, T.A.1
Russell, J.H.2
Ley, T.J.3
-
38
-
-
0035353187
-
Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect
-
Schmaltz, C. et al. Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect. Blood 97, 2886-2895 (2001).
-
(2001)
Blood
, vol.97
, pp. 2886-2895
-
-
Schmaltz, C.1
-
39
-
-
0033561434
-
Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation
-
Tsukada, N., Kobata, T., Aizawa, Y., Yagita, H. & Okumura, K. Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation. Blood 93, 2738-2747 (1999). References 37-39 (and reference 52) showed, in mouse HSCT models, the differential use of the FasL and perforin cytolytic pathways by donor T cells in GVHD and GVT activity.
-
(1999)
Blood
, vol.93
, pp. 2738-2747
-
-
Tsukada, N.1
Kobata, T.2
Aizawa, Y.3
Yagita, H.4
Okumura, K.5
-
40
-
-
0030984020
-
+ T cells each can utilize a perforin-dependent pathway to mediate lethal graft-versus-host disease in major histocompatibility complex-disparate recipients
-
+ T cells each can utilize a perforin-dependent pathway to mediate lethal graft-versus-host disease in major histocompatibility complex-disparate recipients. Transplantation 64, 571-576 (1997).
-
(1997)
Transplantation
, vol.64
, pp. 571-576
-
-
Blazar, B.R.1
Taylor, P.A.2
Vallera, D.A.3
-
41
-
-
0033805162
-
Role of perforin in controlling B-cell hyperactivity and humoral autoimmunity
-
Shustov, A. et al. Role of perforin in controlling B-cell hyperactivity and humoral autoimmunity. J. Clin. Invest. 106, R39-R47 (2000).
-
(2000)
J. Clin. Invest.
, vol.106
-
-
Shustov, A.1
-
42
-
-
0033061656
-
Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus-host disease
-
Miwa, K. et al. Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus-host disease. Int. J. Immunol. 11, 925-931 (1999).
-
(1999)
Int. J. Immunol.
, vol.11
, pp. 925-931
-
-
Miwa, K.1
-
43
-
-
0032127448
-
Involvement of Fas-mediated apoptosis in the hematopoietic progenitor cells of graft-versus-host-reaction-associated myelosuppression
-
Mori, T. et al. Involvement of Fas-mediated apoptosis in the hematopoietic progenitor cells of graft-versus-host-reaction-associated myelosuppression. Blood 92, 101-107 (1998).
-
(1998)
Blood
, vol.92
, pp. 101-107
-
-
Mori, T.1
-
44
-
-
0032100478
-
Differential effects of anti-Fas ligand and anti-tumor necrosis factor-α antibodies on acute graft-versus-host disease pathologies
-
Hattori, K. et al. Differential effects of anti-Fas ligand and anti-tumor necrosis factor-α antibodies on acute graft-versus-host disease pathologies. Blood 91, 4051-4055 (1998). This study showed, by the administration of neutralizing antibodies in mouse HSCT models, the specific role of the FasL and TNF pathways in the development of target-organ GVHD.
-
(1998)
Blood
, vol.91
, pp. 4051-4055
-
-
Hattori, K.1
-
45
-
-
0033980662
-
Fas-deficient lpr mice are more susceptible to graft-versus-host disease
-
Van den Brink, M. R. et al. Fas-deficient lpr mice are more susceptible to graft-versus-host disease. J. Immunol. 164, 469-480 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 469-480
-
-
Van den Brink, M.R.1
-
46
-
-
0031002790
-
Essential roles of the Fas ligand in the development of hepatitis
-
Kondo, T., Suda, T., Fukuyama, H., Adachi, M. & Nagata, S. Essential roles of the Fas ligand in the development of hepatitis. Nature Med. 3, 409-413 (1997).
-
(1997)
Nature Med.
, vol.3
, pp. 409-413
-
-
Kondo, T.1
Suda, T.2
Fukuyama, H.3
Adachi, M.4
Nagata, S.5
-
47
-
-
0023620524
-
Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease
-
Piguet, P. F., Grau, G. E., Allet, B. & Vassalli, P. Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease. J. Exp. Med. 166, 1280-1289 (1987).
-
(1987)
J. Exp. Med.
, vol.166
, pp. 1280-1289
-
-
Piguet, P.F.1
Grau, G.E.2
Allet, B.3
Vassalli, P.4
-
48
-
-
0026754027
-
Phase I-II trial of a monoclonal anti-tumor necrosis factor-α antibody for the treatment of refractory severe acute graft-versus-host disease
-
Herve, P. et al. Phase I-II trial of a monoclonal anti-tumor necrosis factor-α antibody for the treatment of refractory severe acute graft-versus-host disease. Blood 79, 3362-3368 (1992).
-
(1992)
Blood
, vol.79
, pp. 3362-3368
-
-
Herve, P.1
-
49
-
-
0032005020
-
Fas-ligand-mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease
-
Lin, T. et al. Fas-ligand-mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease. J. Clin. Invest. 101, 570-577 (1998).
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 570-577
-
-
Lin, T.1
-
50
-
-
0032864191
-
Intestinal crypt cell apoptosis in murine acute graft-versus-host disease is mediated by tumour necrosis factor-α and not by the FasL-Fas interaction: Effect of pentoxifylline on the development of mucosal atrophy
-
Stuber, E., Buschenfeld, A., von Freier, A., Arendt, T. & Folsch, U. R. Intestinal crypt cell apoptosis in murine acute graft-versus-host disease is mediated by tumour necrosis factor-α and not by the FasL-Fas interaction: effect of pentoxifylline on the development of mucosal atrophy. Gut 45, 229-235 (1999).
-
(1999)
Gut
, vol.45
, pp. 229-235
-
-
Stuber, E.1
Buschenfeld, A.2
Von Freier, A.3
Arendt, T.4
Folsch, U.R.5
-
51
-
-
0033564653
-
Granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation maintains graft-versus-leukemia effects through a perforin-dependent pathway while preventing graft-versus-host disease
-
Pan, L. et al. Granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation maintains graft-versus-leukemia effects through a perforin-dependent pathway while preventing graft-versus-host disease. Blood 93, 4071-4078 (1999).
-
(1999)
Blood
, vol.93
, pp. 4071-4078
-
-
Pan, L.1
-
52
-
-
0034254473
-
Differential use of FasL- and perforin-mediated cytolytic mechanisms by T-cell subsets involved in graft-versus-myeloid leukemia responses
-
Hsieh, M. H. & Korngold, R. Differential use of FasL- and perforin-mediated cytolytic mechanisms by T-cell subsets involved in graft-versus-myeloid leukemia responses. Blood 98, 1047-1055 (2000).
-
(2000)
Blood
, vol.98
, pp. 1047-1055
-
-
Hsieh, M.H.1
Korngold, R.2
-
53
-
-
0030854908
-
A metalloproteinase inhibitor prevents lethal acute graft-versus-host disease in mice
-
Hattori, K. et al. A metalloproteinase inhibitor prevents lethal acute graft-versus-host disease in mice. Blood 90, 542-548 (1997).
-
(1997)
Blood
, vol.90
, pp. 542-548
-
-
Hattori, K.1
-
54
-
-
0032620961
-
Graft-vs.-lymphoma effect in an allogeneic hematopoietic stem cell transplantation model
-
Ito, M. & Shizuru, J. A. Graft-vs.-lymphoma effect in an allogeneic hematopoietic stem cell transplantation model. Biol. Blood Marrow Transplant. 5, 357-368 (1999).
-
(1999)
Biol. Blood Marrow Transplant.
, vol.5
, pp. 357-368
-
-
Ito, M.1
Shizuru, J.A.2
-
55
-
-
0032530890
-
Involvement of donor T-cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejection
-
+ T-cell effectors that are responsible for causing bone-marrow graft rejection are sensitive to cytotoxicity that is mediated by both perforin- and FasL-dependent mechanisms, and also, that donor T cells must have at least one functional cytotoxic mechanism to prevent allogeneic marrow graft rejection.
-
(1998)
Blood
, vol.92
, pp. 2177-2181
-
-
Martin, P.J.1
Akatsuka, Y.2
Hahne, M.3
Sale, G.4
-
56
-
-
0029421460
-
Perforin- and Fas-mediated cytotoxic pathways are not required for allogeneic resistance to bone marrow grafts in mice
-
Baker, M. B., Podack, E. R. & Levy, R. B. Perforin- and Fas-mediated cytotoxic pathways are not required for allogeneic resistance to bone marrow grafts in mice. Biol. Blood Marrow Transplant. 1, 69-73 (1995).
-
(1995)
Biol. Blood Marrow Transplant.
, vol.1
, pp. 69-73
-
-
Baker, M.B.1
Podack, E.R.2
Levy, R.B.3
-
57
-
-
0033543962
-
Effect of graft-versus-host disease (GVHD) on host hematopoietic progenitor cells is mediated by Fas-Fas-ligand interactions but this does not explain the effect of GVHD on donor cells
-
Iwasaki, T. et al. Effect of graft-versus-host disease (GVHD) on host hematopoietic progenitor cells is mediated by Fas-Fas-ligand interactions but this does not explain the effect of GVHD on donor cells. Cell. Immunol. 197, 30-38 (1999).
-
(1999)
Cell. Immunol.
, vol.197
, pp. 30-38
-
-
Iwasaki, T.1
-
58
-
-
0034327197
-
Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions
-
Blazar, B. R. et al. Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions. J. Immunol. 165, 4901-4909 (2000).
-
(2000)
J. Immunol.
, vol.165
, pp. 4901-4909
-
-
Blazar, B.R.1
-
59
-
-
0035383799
-
Allogeneic bone marrow cells that facilitate complete chimerism and eliminate tumor cells express both CD8 and T-cell antigen receptor-αβ
-
Lan, F., Zeng, D., Huie, P., Higgins, J. P. & Strober, S. Allogeneic bone marrow cells that facilitate complete chimerism and eliminate tumor cells express both CD8 and T-cell antigen receptor-αβ. Blood 97, 3458-3465 (2001).
-
(2001)
Blood
, vol.97
, pp. 3458-3465
-
-
Lan, F.1
Zeng, D.2
Huie, P.3
Higgins, J.P.4
Strober, S.5
-
61
-
-
0034661624
-
Fas-ligand-deficient gld mice are more susceptible to graft-versus-host disease
-
Van den Brink, M. R. et al. Fas-ligand-deficient gld mice are more susceptible to graft-versus-host disease. Transplantation 70, 184-191 (2000).
-
(2000)
Transplantation
, vol.70
, pp. 184-191
-
-
Van den Brink, M.R.1
-
62
-
-
0142233473
-
FasL and perforin cytotoxically impaired donor T cells induce GVHD in TNF receptor 1 (p55)-knockout MHC I/II mismatched recipients
-
Jiang, Z., Jones, M. & Levy, R. B. FasL and perforin cytotoxically impaired donor T cells induce GVHD in TNF receptor 1 (p55)-knockout MHC I/II mismatched recipients. Biol. Blood Marrow Transplant 7, 76 (2001).
-
(2001)
Biol. Blood Marrow Transplant.
, vol.7
, pp. 76
-
-
Jiang, Z.1
Jones, M.2
Levy, R.B.3
-
63
-
-
0035880242
-
Major-histocompatibility-complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4(+) donor T cells: Involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenesis
-
Jiang, Z., Podack, E. & Levy, P. B. Major-histocompatibility-complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4(+) donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenesis. Blood 98, 390-397 (2001).
-
(2001)
Blood
, vol.98
, pp. 390-397
-
-
Jiang, Z.1
Podack, E.2
Levy, P.B.3
-
64
-
-
0028929029
-
The ligands and receptors of the lymphotoxin system
-
Ware, C. F., VanArsdale, T. L., Crowe, P. D. & Browning, J. L. The ligands and receptors of the lymphotoxin system. Curr Top. Microbiol. Immunol. 198, 175-218 (1995).
-
(1995)
Curr. Top. Microbiol. Immunol.
, vol.198
, pp. 175-218
-
-
Ware, C.F.1
VanArsdale, T.L.2
Crowe, P.D.3
Browning, J.L.4
-
66
-
-
0032169208
-
TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T-cell killing of target cells
-
Thomas, W. D. & Hersey, P. TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T-cell killing of target cells. J. Immunol. 161, 2195-2200 (1998).
-
(1998)
J. Immunol.
, vol.161
, pp. 2195-2200
-
-
Thomas, W.D.1
Hersey, P.2
-
67
-
-
0033105638
-
+ T-cell-mediated cytotoxicity
-
+ T-cell-mediated cytotoxicity. J. Immunol. 162, 2639-2647 (1999).
-
(1999)
J. Immunol.
, vol.162
, pp. 2639-2647
-
-
Kayagaki, N.1
-
68
-
-
0025100777
-
Graft-versus-leukemia reactions after bone marrow transplantation
-
Horowitz, M. M. et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 75, 555-562 (1990).
-
(1990)
Blood
, vol.75
, pp. 555-562
-
-
Horowitz, M.M.1
-
69
-
-
0029868846
-
Allogeneic cell therapy with donor peripheral blood cells and recombinant human interleukin-2 to treat leukemia relapse after allogeneic bone marrow transplantation
-
Slavin, S. et al. Allogeneic cell therapy with donor peripheral blood cells and recombinant human interleukin-2 to treat leukemia relapse after allogeneic bone marrow transplantation. Blood 87, 2195-2204 (1996)
-
(1996)
Blood
, vol.87
, pp. 2195-2204
-
-
Slavin, S.1
-
70
-
-
0027537527
-
Delayed infusion of normal donor cells after MHC-matched bone marrow transplantation provides an antileukemia reaction without graft-versus-host disease
-
Johnson, B D., Drobyski, W. R. & Truitt, R. L. Delayed infusion of normal donor cells after MHC-matched bone marrow transplantation provides an antileukemia reaction without graft-versus-host disease. Bone Marrow Transplant 11, 329-336 (1993).
-
(1993)
Bone Marrow Transplant.
, vol.11
, pp. 329-336
-
-
Johnson, B.D.1
Drobyski, W.R.2
Truitt, R.L.3
-
71
-
-
0029014567
-
Adoptive immunotherapy using donor leukocytes following bone marrow transplantation for chronic myeloid leukemia: Is T-cell dose important in determining biological response?
-
Mackinnon, S. et al. Adoptive immunotherapy using donor leukocytes following bone marrow transplantation for chronic myeloid leukemia: is T-cell dose important in determining biological response? Bone Marrow Transplant. 15, 591-594 (1995).
-
(1995)
Bone Marrow Transplant.
, vol.15
, pp. 591-594
-
-
Mackinnon, S.1
-
72
-
-
0028871935
-
CD8-depleted donor lymphocyte infusion as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation
-
Giralt, S. et al. CD8-depleted donor lymphocyte infusion as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation. Blood 86, 4337-4343 (1995).
-
(1995)
Blood
, vol.86
, pp. 4337-4343
-
-
Giralt, S.1
-
73
-
-
20244374668
-
Toxicity and efficacy of defined doses of CD4(+) donor lymphocytes for treatment of relapse after allogeneic bone marrow transplant
-
Alyea, E. P. et al. Toxicity and efficacy of defined doses of CD4(+) donor lymphocytes for treatment of relapse after allogeneic bone marrow transplant. Blood 91, 3671-3680 (1998).
-
(1998)
Blood
, vol.91
, pp. 3671-3680
-
-
Alyea, E.P.1
-
74
-
-
0029115281
-
+ T cells in graft-versus-leukemia activity and engraftment after allogeneic bone marrow transplantation
-
+ T cells in graft-versus-leukemia activity and engraftment after allogeneic bone marrow transplantation. Transplantation 60, 355-361 (1995).
-
(1995)
Transplantation
, vol.60
, pp. 355-361
-
-
Palathumpat, V.1
Dejbakhsh-Jones, S.2
Strober, S.3
-
75
-
-
0033214650
-
A phase I-II clinical trial to evaluate removal of CD4 cells and partial depletion of CD8 cells from donor marrow for HLA-mismatched unrelated recipients
-
Martin, P. J. et al. A phase I-II clinical trial to evaluate removal of CD4 cells and partial depletion of CD8 cells from donor marrow for HLA-mismatched unrelated recipients. Blood 94, 2192-2199 (1999).
-
(1999)
Blood
, vol.94
, pp. 2192-2199
-
-
Martin, P.J.1
-
76
-
-
0032528017
-
+ T-cell depletion does not prevent graft-versus-host disease
-
+ T-cell depletion does not prevent graft-versus-host disease. Transplantation 66, 138-141 (1998).
-
(1998)
Transplantation
, vol.66
, pp. 138-141
-
-
Nagler, A.1
-
77
-
-
0032968981
-
Selective removal of alloreactive cells from haematopoietic stem cell grafts: Graft engineering for GVHD prophylaxis
-
Koh, M. B., Prentice, H. G. & Lowdell, M. W. Selective removal of alloreactive cells from haematopoietic stem cell grafts: graft engineering for GVHD prophylaxis. Bone Marrow Transplant 23, 1071-1079 (1999).
-
(1999)
Bone Marrow Transplant.
, vol.23
, pp. 1071-1079
-
-
Koh, M.B.1
Prentice, H.G.2
Lowdell, M.W.3
-
78
-
-
0033151956
-
Opposing roles of CD28-B7 and CTLA-4-B7 pathways in regulating in vivo alloresponses in murine recipients of MHC disparate T cells
-
Blazar, B. R., Taylor, P. A., Panoskaltsis-Mortari, A., Sharpe, A. H. & Vallera, D. A. Opposing roles of CD28-B7 and CTLA-4-B7 pathways in regulating in vivo alloresponses in murine recipients of MHC disparate T cells. J. Immunol. 162, 6368-6377 (1999).
-
(1999)
J. Immunol.
, vol.162
, pp. 6368-6377
-
-
Blazar, B.R.1
Taylor, P.A.2
Panoskaltsis-Mortari, A.3
Sharpe, A.H.4
Vallera, D.A.5
-
79
-
-
0033519661
-
Transplantation of anergic histoincompatible bone marrow allografts
-
Guinan, E. C. et al. Transplantation of anergic histoincompatible bone marrow allografts N. Engl. J. Med. 340, 1704-1714 (1999).
-
(1999)
N. Engl. J. Med.
, vol.340
, pp. 1704-1714
-
-
Guinan, E.C.1
-
82
-
-
0033826799
-
Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia
-
Molldrem, J. J. et al. Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia. Nature Med. 6, 1018-1023 (2000).
-
(2000)
Nature Med.
, vol.6
, pp. 1018-1023
-
-
Molldrem, J.J.1
-
83
-
-
0030843493
-
HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia
-
Bonini, C. et al. HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 276, 1719-1724 (1997)
-
(1997)
Science
, vol.276
, pp. 1719-1724
-
-
Bonini, C.1
-
84
-
-
0034978248
-
LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation
-
Cooke, K. R. et al. LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation. J. Clin. Invest. 107, 1581-1589 (2001).
-
(2001)
J. Clin. Invest.
, vol.107
, pp. 1581-1589
-
-
Cooke, K.R.1
-
85
-
-
0034641898
-
CD95's deadly mission in the immune system
-
Krammer, P. H. CD95's deadly mission in the immune system. Nature 407, 789-795 (2000).
-
(2000)
Nature
, vol.407
, pp. 789-795
-
-
Krammer, P.H.1
-
86
-
-
0026530828
-
The cDNA structure, expression and chromosomal assignment of the mouse Fas antigen
-
Watanabe-Fukunaga, P. et al. The cDNA structure, expression and chromosomal assignment of the mouse Fas antigen. J. Immunol. 148, 1274-1279 (1992).
-
(1992)
J. Immunol.
, vol.148
, pp. 1274-1279
-
-
Watanabe-Fukunaga, P.1
-
87
-
-
13344268993
-
Fas ligand in human serum
-
Tanaka, M. et al. Fas ligand in human serum. Nature Med. 2, 317-322 (1996)
-
(1996)
Nature Med.
, vol.2
, pp. 317-322
-
-
Tanaka, M.1
-
88
-
-
0031785525
-
How do cytotoxic lymphocytes kill their targets?
-
Shresta, S., Pham, C. T., Thomas, D. A., Graubert, T. A. & Ley, T. J. How do cytotoxic lymphocytes kill their targets? Curr. Opin. Immunol. 10, 581-587 (1998).
-
(1998)
Curr. Opin. Immunol.
, vol.10
, pp. 581-587
-
-
Shresta, S.1
Pham, C.T.2
Thomas, D.A.3
Graubert, T.A.4
Ley, T.J.5
-
89
-
-
0034733584
-
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations
-
Siegel, R. M. et al. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science 288, 2354-2357 (2000).
-
(2000)
Science
, vol.288
, pp. 2354-2357
-
-
Siegel, R.M.1
-
90
-
-
0034733682
-
A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling
-
Chan, F. K. et al. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288, 2351-2354 (2000).
-
(2000)
Science
, vol.288
, pp. 2351-2354
-
-
Chan, F.K.1
-
91
-
-
0027946007
-
A null mutation in the perforin gene impairs cytolytic T-lymphocyte and natural-killer-cell-mediated cytotoxicity
-
Lowin, B., Beermann, F., Schmidt, A. & Tschopp, J. A null mutation in the perforin gene impairs cytolytic T-lymphocyte and natural-killer-cell-mediated cytotoxicity. Proc Natl Acad. Sci. USA 91, 11571-11575 (1994).
-
(1994)
Proc Natl Acad. Sci. USA
, vol.91
, pp. 11571-11575
-
-
Lowin, B.1
Beermann, F.2
Schmidt, A.3
Tschopp, J.4
-
92
-
-
0028990676
-
Perforin and lymphocyte-mediated cytolysis
-
Liu, C. C., Persechini, P. M. & Young, J. D. Perforin and lymphocyte-mediated cytolysis. Immunol. Rev. 146, 145-175 (1995).
-
(1995)
Immunol. Rev.
, vol.146
, pp. 145-175
-
-
Liu, C.C.1
Persechini, P.M.2
Young, J.D.3
-
93
-
-
0033523727
-
Inhibition of death receptor signaling by FLICE-inhibitory protein as a mechanism for immune escape of tumors
-
French, L. E. & Tschopp, J. Inhibition of death receptor signaling by FLICE-inhibitory protein as a mechanism for immune escape of tumors. J. Exp. Med. 190, 891-894 (1999).
-
(1999)
J. Exp. Med.
, vol.190
, pp. 891-894
-
-
French, L.E.1
Tschopp, J.2
-
94
-
-
0033656875
-
T-cell subsets mediate graft-versus-myeloid leukemia responses via different cytotoxic mechanisms
-
Hsieh, M. H., Patterson, A. E. & Korngold, R. T-cell subsets mediate graft-versus-myeloid leukemia responses via different cytotoxic mechanisms. Biol. Blood Marrow Transplant. 6, 231-240 (2000).
-
(2000)
Biol. Blood Marrow Transplant.
, vol.6
, pp. 231-240
-
-
Hsieh, M.H.1
Patterson, A.E.2
Korngold, R.3
-
95
-
-
0034721646
-
Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T-cell-induced apoptosis
-
Motyka, B. et al. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T-cell-induced apoptosis. Cell 103, 491-500 (2000).
-
(2000)
Cell
, vol.103
, pp. 491-500
-
-
Motyka, B.1
-
96
-
-
0034564268
-
Cytotoxically impaired transplant recipients can efficiently resist major histocompatibility complex-matched bone marrow allografts
-
Jones, M., Komatsu, M. & Levy, R. B Cytotoxically impaired transplant recipients can efficiently resist major histocompatibility complex-matched bone marrow allografts. Biol. Blood Marrow Transplant 6, 456-464 (2000).
-
(2000)
Biol. Blood Marrow Transplant.
, vol.6
, pp. 456-464
-
-
Jones, M.1
Komatsu, M.2
Levy, R.B.3
|