Th1 to Th2 immune deviation facilitates, but does not cause, islet allograft tolerance in mice

Cytokine

Volumn 51, Issue 3, 2010, Pages 311-319

  Zhang, Dong ^a   Sanchez Fueyo, Alberto ^a   Kawamoto, Kensaku ^a   Alexopoulos, Sophoclis P ^a   Zhang, Wensheng ^a   Zheng, Xin Xiao ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Immune regulation; Regulatory T cells; T helper cells; Tolerance; Transplantation

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 IMMUNOGLOBULIN FC FRAGMENT FUSION PROTEIN; IMMUNOMODULATING AGENT; INTERLEUKIN 12 ANTIBODY; INTERLEUKIN 4 IMMUNOGLOBULIN FC FRAGMENT FUSION PROTEIN; UNCLASSIFIED DRUG; CD4 ANTIGEN; CTLA4 PROTEIN, MOUSE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FC RECEPTOR; HYBRID PROTEIN; INTERLEUKIN 12; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; LEUKOCYTE ANTIGEN; MONOCLONAL ANTIBODY;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CHO CELL; CONTROLLED STUDY; DRUG POTENTIATION; ENGRAFTMENT; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HLA MATCHING; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; LOW DRUG DOSE; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH1 CELL; TH2 CELL; ANIMAL; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; MIXED LYMPHOCYTE CULTURE; TIME; TRANSPLANTATION TOLERANCE;

MUS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD4; CELL PROLIFERATION; CTLA-4 ANTIGEN; GRAFT REJECTION; IMMUNOSUPPRESSION; INTERLEUKIN-12; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-4; ISLETS OF LANGERHANS TRANSPLANTATION; LYMPHOCYTE CULTURE TEST, MIXED; MICE; RECEPTORS, FC; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH2 CELLS; TIME FACTORS; TRANSPLANTATION TOLERANCE;

EID: 77955282301     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2010.06.007     Document Type: Article

References (63)

1. Mosmann T.R., Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989, 7:145.
2. Hsieh C.-S., Macatonia S.E., Tripp C.S., Wolf S.F., O'Garra A., Murphy K.M. Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced Macrophages. Science 1993, 260:547-549.
3. Paul W.E., Seder R.A. Lymphocyte responses and cytokines. Cell 1994, 76:241-251.
4. Scott P., Seder R.A. Selective differentiation of CD4+ T-helper cell subsets. Cur Opin Immunol 1993, 5:391-397.
5. Sher A., Coffman R.L. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Ann Rev Immunol 1992, 10:385-409.
6. Trinchieri G. IL-12, a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995, 13:251-276.
7. Magram J., Connaughton S.E., Warrier R.R. IL-12 deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 1996, 4:471-481.
8. Wu C., Ferrante J., Gately M.K., Magram J. Characterization of IL-12 receptor β1 chain deficient mice: IL-12Rβ1 is an essential component of the functional mouse IL-12 receptor. J Immunol 1997, 159:1658-1665.
9. Willamson E., Garside P., Bradkey J.A., More I.A.R., Mowat A.M. Neutralizing IL-12 during induction of murine acute graft-versus-host disease polarizes the cytokine profile toward a Th2 type alloimmune response and confers long term protection from disease. J Immunol 1997, 159:1208-1215.
10. Li X.C., Zand M.S., Li Y., Zheng X.X., Strom T.B. On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses. J Immunol 1998, 161:2241-2247.
11. Piccotti J.R., Chan S.Y., Goodman R.E., Magram J., Eichwald E.J., Bishop D.K. IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity. J Immunol 1996, 157:1951-1957.
12. Cameron M.J., Arreaza G.A., Zucker P., Censue S.W., Strieter R.M., Chakrabarto S., et al. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in non-obese diabetic mice by potentiation of regulatory T helper-2 cell function. J Immunol 1997, 159:4686-4692.
13. Zheng X.X., Steele A.W., Hancock W.W., Steven A.C., Nickerson P.W., Roy-Chaudhury P., et al. A non-cytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice. J Immunol 1997, 158:4507-4513.
14. Mueller R., Krahl T., Sarvetnick N. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in NOD mice. J Exp Med 1996, 184:1093-1099.
15. Xiao B.G., Bai X.F., Zhang G.X., Link H. Suppression of acute and protracted-relapsong experimental allergic encephalomyelitis by nasal administration of low-dose IL-10 in rats. J Neuroimmunol 1998, 84:230-237.
16. Racke M.K., Bonomo A., Scott D.E., Cannella B., Levine A., Raine C., et al. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med 1994, 180:1961-1966.
17. Horsfall A.C., Butler D.M., Marinova L., Warden P.J., Willams R.O., Maini R.N., et al. Suppression of collagen-induced arthritis by continuous administration of IL-4. J Immunol 1997, 159:5687-5696.
18. Persson S., Mikukowska A., Narula S., O'Garra A., Holmdahl R. Interleukin-10 suppresses the development of collagen type II-induced arthritis and ameliorates sustained arthritis in rats. Scand J Immunol 1996, 44:607-614.
19. Costantinescu C.S., Wysocka M., Hillard B., Ventura E.S., Lavi E., Trinchieri G., et al. Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis. J Immunol 1998, 161:5097-5104.
20. Malfait A.M., Butler D.M., Presky D.H., Maini R.N., Brennan F.M., Feldmann M. Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis. Clin Exp Immunol 1998, 111:377-383.
21. Neurath M.F., Fuss I., Kelsall B.L., Stuber E., Strober W. Antibodies to interleukin-12 abrogate established experimental colitis in mice. J Exp Med 1995, 182:1281-1290.
22. Bugeon L., Cuturi M.-C., Hallet M.-M., Paineau J., Chabannes D., Soulillou J.-P. Peripheral tolerance of an allograft in adult rats- characterization by low interleukin-2 and interferon-γ mRNA levels and by strong accumulation of major histocompatibility complex transcripts in the graft. Transplantation 1992, 54:219-225.
23. Sayegh M.H., Akalin E., Hancock W.W., Russell M.E., Carpenter C.B., Linsley P.S., et al. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 1995, 181:1869-1874.
24. Mottram P.L., Han W.R., Purcell L.J., McKenzie I.F.C., Hancock W.W. Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and IFN-g in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy. Transplantation 1995, 59:559-565.
25. Hancock W.W., Sayegh M.H., Kwok C.A., Weiner H.L., Carpenter C.B. Oral, but not intravenous, alloantigen prevents accelerated allograft rejection by selective intragraft Th2 cell activation. Transplantation 1993, 55:219-225.
26. Fischer Lindahl.K., Wilson D.B. Histocompatibility antigen-activated cytotoxic lymphocytes II. Estimates of frequency and specificity of precursors. J Exp Med 1977, 145:508-522.
27. Teh H.S., Harley E., Phillips R.A., Miller R.G. Quantitative studies on the precursors of cytotoxic lymphocytes I. Characterization of a clonal assay and determination of the size of clonal derived from single precursors. J Immunol 1977, 118:1049-1056.
28. Lin J.X., Migone T.S., Tsang M., Friedmann M., Weatherbee J.A., Zhou L., et al. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 1995, 2:331-339.
29. Strom T.B., Roy Chaudhury P., Manfro R., Zheng X.X., Nickerson P.W., Wood K., et al. The Thl/Th2 paradigm and the allograft response. Curr Opin Immunol 1996, 8:688-693.
30. Zheng X.X., Li X.C., Noguchi M., Li Y., Strom T.B. T-helper 1 and T-helper 2 paradigm in the acquisition of peripheral graft tolerance. Curr Opin Organ Transpl 2000, 5:42-48.
31. Li X.C., Strom T.B., Turka L.A., Wells A.D. T cell death and transplantation tolerance. Immunity 2001, 14:407-416.
32. Kishimoto K., Sandner S., Imitola J., Sho M., Li Y., Langmuir P.B., et al. Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance. J Clin Invest 2002, 109:1471-1479.
33. Zheng X.X., Sanchez-Fueyo A., Sho M., Domenig C., Sayegh M.H., Strom T.B. Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance. Immunity 2003, 19:503-514.
34. Zheng X.X., Sanchez-Fueyo A., Domenig C., Strom T.B. The balance of deletion and regulation in allograft tolerance. Immunol Rev 2003, 196:75-84.
35. Zheng X.X., Steele A.W., Nickerson P.W., Steurer W., Steiger J., Strom T.B. Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation. J Immunol 1995, 154:5590-5600.
36. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65:55-63.
37. Burstein H.J., Tepper R.I., Leder P., Abbas A.K. Humoral immune functions in IL-4 transgenic mice. J Immunol 1991, 147:2950-2956.
38. Sanchez-Fueyo A., Tian J., Picarella D., Domenig C., Zheng X.X., Sabatos C.A., et al. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol 2003, 4:1093-1101.
39. Steurer W., Nickerson P.W., Steele A.W., Steiger J., Zheng X.X., Strom T.B. Ex vivo coating of islet cell allografts with murine CTLA4/Fc promotes graft tolerance. J Immunol 1995, 155:1165-1174.
40. Sanchez-Fueyo A., Weber M., Domenig C., Strom T.B., Zheng X.X. Tracking the immunoregulatory mechanisms active during allograft tolerance. J Immunol 2002, 168:2274-2281.
41. Sho M., Yamada A., Najafian N., Salama A.D., Harada H., Sandner S.E., et al. Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25(+) cells, and the alloreactive T cell clone size. J Immunol 2002, 169:3744-3751.
42. Kishimoto K., Dong V.M., Issazadeh S., Fedoseyeva E.V., Waaga A.M., Yamada A., et al. The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo. J Clin Invest 2000, 106:63-72.
43. Zhou P., Szot G.L., Guo Z., Kim O., He G., Wang J., et al. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol 2000, 165:5580-5587.
44. Maurik A., Herber M., Wood K.J., Jones N.D. Cutting edge: CD4(+)CD25(+) alloantigen-specific immunoregulatory cells that can prevent CD8(+) T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. J Immunol 2002, 169:5401-5404.
45. Graca L., Cobbold S.P., Waldmann H. Identification of regulatory T cells in tolerated allografts. J Exp Med 2002, 195:1641-1646.
46. Kingsley C.I., Karim M., Bushell A.R., Wood K.J. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 2002, 168:1080-1086.
47. Yamazaki S., Iyoda T., Tarbell K., Olson K., Velinzon K., Inaba K., et al. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med 2003, 198:235-247.
48. McHugh R.S., Shevach E.M. The role of suppressor T cells in regulation of immune responses. J Allergy Clin Immunol 2002, 110:693-702.
49. Shimizu J., Yamazaki S., Takahashi T., Ishida Y., Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002, 3:135-142.
50. - regulatory T cells. Proc Natl Acad Sci USA 2002, 99:13031-13036.
51. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector T(H)17 and regulatory T cells. Nature 2006.
52. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 1995, 16:34-38.
53. Abbas A.K., Murphy K.M., Sher A. Functional diversity of helper T lymphocytes. Nature 1996, 383:787-793.
54. Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005, 6:1133-1141.
55. + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003, 198:1875-1886.
56. Groux H. Type 1 T-regulatory cells: their role in the control of immune responses. Transplantation 2003, 75:8S-12S.
57. Zhang Z.X., Yang L., Young K.J., DuTemple B., Zhang L. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med 2000, 6:782-789.
58. Zhang D., Yang W., Degauque N., Tian Y., Mikita A., Zheng X.X. New differentiation pathway for double-negative regulatory T-cells that regulates the magnitude of immune responses. Blood 2007, 109:4071-4079.
59. Ouaked N., Mantel P.Y., Bassin C., Burgler S., Siegmund K., Akdis C.A., et al. Regulation of the foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1. J Immunol 2009, 182:1041-1049.
60. + mRNA expression and induces Th2 dominance in the microenvironment of cutaneous squamous cell carcinoma in organ transplant recipients. J Immunother 2010, 33:538-546.
61. Schmidt-Weber C.B., Blaser K. New insights into the mechanisms of allergen-specific immunotherapy. Curr Opin Allergy Clin Immunol 2005, 5:525-530.
62. Schmidt-Weber C.B., Blaser K. The role of the FOXP3 transcription factor in the immune regulation of allergic asthma. Curr Allergy Asthma Rep 2005, 5:356-361.
63. Mantel P.Y., Kuipers H., Boyman O., Rhyner C., Ouaked N., Ruckert B., et al. GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells. PLoS Biol 2007, 5:e329.