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Volumn 690, Issue 1-2, 2010, Pages 50-56

The inflammatory status of the elderly: The intestinal contribution

Author keywords

Aging; Inflammation; Intestinal mucosa; Microbiota; Probiotics

Indexed keywords

ALPHA INTERFERON; ANTIINFLAMMATORY AGENT; C REACTIVE PROTEIN; INFLUENZA VACCINE; INTERLEUKIN 10; INTERLEUKIN 6; PREBIOTIC AGENT; PROBIOTIC AGENT; SYNBIOTIC AGENT;

EID: 77955271210     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2009.07.011     Document Type: Review
Times cited : (83)

References (98)
  • 2
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • Medzhitov R. Origin and physiological roles of inflammation. Nature 2008, 454(7203):428-435.
    • (2008) Nature , vol.454 , Issue.7203 , pp. 428-435
    • Medzhitov, R.1
  • 3
    • 18844406447 scopus 로고    scopus 로고
    • Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue
    • Ceradini D.J., Gurtner G.C. Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue. Trends Cardiovasc. Med. 2005, 15(2):57-63.
    • (2005) Trends Cardiovasc. Med. , vol.15 , Issue.2 , pp. 57-63
    • Ceradini, D.J.1    Gurtner, G.C.2
  • 4
    • 38849133044 scopus 로고    scopus 로고
    • A calculated response: control of inflammation by the innate immune system
    • Barton G.M. A calculated response: control of inflammation by the innate immune system. J. Clin. Invest. 2008, 118(2):413-420.
    • (2008) J. Clin. Invest. , vol.118 , Issue.2 , pp. 413-420
    • Barton, G.M.1
  • 7
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: a renewed sense of self
    • Matzinger P. The danger model: a renewed sense of self. Science 2002, 296(5566):301-305.
    • (2002) Science , vol.296 , Issue.5566 , pp. 301-305
    • Matzinger, P.1
  • 8
    • 35349016235 scopus 로고    scopus 로고
    • Recognition of microorganisms and activation of the immune response
    • Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature 2007, 449(7164):819-826.
    • (2007) Nature , vol.449 , Issue.7164 , pp. 819-826
    • Medzhitov, R.1
  • 9
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 2001, 1(2):135-145.
    • (2001) Nat. Rev. Immunol. , vol.1 , Issue.2 , pp. 135-145
    • Medzhitov, R.1
  • 10
    • 34248672889 scopus 로고    scopus 로고
    • Antiviral signaling through pattern recognition receptors
    • Kawai T., Akira S. Antiviral signaling through pattern recognition receptors. J. Biochem. 2007, 141(2):137-145.
    • (2007) J. Biochem. , vol.141 , Issue.2 , pp. 137-145
    • Kawai, T.1    Akira, S.2
  • 11
    • 27944453599 scopus 로고    scopus 로고
    • Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
    • Okabe Y., Kawane K., Akira S., et al. Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J. Exp. Med. 2005, 202(10):1333-1339.
    • (2005) J. Exp. Med. , vol.202 , Issue.10 , pp. 1333-1339
    • Okabe, Y.1    Kawane, K.2    Akira, S.3
  • 12
    • 33244472793 scopus 로고    scopus 로고
    • Signalling pathways and molecular interactions of NOD1 and NOD2
    • Strober W., Murray P.J., Kitani A., Watanabe T. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat. Rev. Immunol. 2006, 6(1):9-20.
    • (2006) Nat. Rev. Immunol. , vol.6 , Issue.1 , pp. 9-20
    • Strober, W.1    Murray, P.J.2    Kitani, A.3    Watanabe, T.4
  • 13
    • 33845890803 scopus 로고    scopus 로고
    • Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
    • Mariathasan S., Monack D.M. Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat. Rev. Immunol. 2007, 7(1):31-40.
    • (2007) Nat. Rev. Immunol. , vol.7 , Issue.1 , pp. 31-40
    • Mariathasan, S.1    Monack, D.M.2
  • 14
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon F., Petrilli V., Mayor A., et al. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006, 440(7081):237-241.
    • (2006) Nature , vol.440 , Issue.7081 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3
  • 15
    • 60749104683 scopus 로고    scopus 로고
    • The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
    • Franchi L., Eigenbrod T., Munoz-Planillo R., Nunez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat. Immunol. 2009, 10(3):241-247.
    • (2009) Nat. Immunol. , vol.10 , Issue.3 , pp. 241-247
    • Franchi, L.1    Eigenbrod, T.2    Munoz-Planillo, R.3    Nunez, G.4
  • 16
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • Stetson D.B., Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 2006, 24(1):93-103.
    • (2006) Immunity , vol.24 , Issue.1 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 17
    • 40449097257 scopus 로고    scopus 로고
    • The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
    • Muruve D.A., Petrilli V., Zaiss A.K., et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 2008, 452(7183):103-107.
    • (2008) Nature , vol.452 , Issue.7183 , pp. 103-107
    • Muruve, D.A.1    Petrilli, V.2    Zaiss, A.K.3
  • 18
    • 33645068450 scopus 로고    scopus 로고
    • Mesenteric lymph nodes at the center of immune anatomy
    • Macpherson A.J., Smith K. Mesenteric lymph nodes at the center of immune anatomy. J. Exp. Med. 2006, 203(3):497-500.
    • (2006) J. Exp. Med. , vol.203 , Issue.3 , pp. 497-500
    • Macpherson, A.J.1    Smith, K.2
  • 19
    • 77955274489 scopus 로고    scopus 로고
    • Education of the mucosal immune system: the role of breast milk during bacterial colonisation of the neonatal intestine
    • E. Mengheri, M. Roselli, M.S. Britti, A. Finamore (Eds.)
    • Schiffrin E.J., Donnet-Hughes A. Education of the mucosal immune system: the role of breast milk during bacterial colonisation of the neonatal intestine. Nutrition and Immunity 2006, 39-51. E. Mengheri, M. Roselli, M.S. Britti, A. Finamore (Eds.).
    • (2006) Nutrition and Immunity , pp. 39-51
    • Schiffrin, E.J.1    Donnet-Hughes, A.2
  • 20
    • 20144372886 scopus 로고    scopus 로고
    • Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72
    • Arvans D.L., Vavricka S.R., Ren H., et al. Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72. Am. J. Physiol. Gastrointest. Liver Physiol. 2005, 288(4):G696-G704.
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.288 , Issue.4
    • Arvans, D.L.1    Vavricka, S.R.2    Ren, H.3
  • 21
    • 0347756655 scopus 로고    scopus 로고
    • Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA
    • Kelly D., Campbell J.I., King T.P., et al. Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat. Immunol. 2004, 5(1):104-112.
    • (2004) Nat. Immunol. , vol.5 , Issue.1 , pp. 104-112
    • Kelly, D.1    Campbell, J.I.2    King, T.P.3
  • 22
    • 0034284803 scopus 로고    scopus 로고
    • Prokaryotic regulation of epithelial responses by inhibition of Ikappa B-alpha ubiquitination
    • Neish A.S., Gewirtz A.T., Zeng H., et al. Prokaryotic regulation of epithelial responses by inhibition of Ikappa B-alpha ubiquitination. Science 2000, 289(5484):1560-1563.
    • (2000) Science , vol.289 , Issue.5484 , pp. 1560-1563
    • Neish, A.S.1    Gewirtz, A.T.2    Zeng, H.3
  • 23
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum S., Paglino J., Eslami-Varzaneh F., et al. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004, 118(2):229-241.
    • (2004) Cell , vol.118 , Issue.2 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3
  • 24
    • 16844386086 scopus 로고    scopus 로고
    • Intestinal epithelial TOLLerance versus inTOLLerance of commensals
    • Cario E., Podolsky D.K. Intestinal epithelial TOLLerance versus inTOLLerance of commensals. Mol. Immunol. 2005, 42(8):887-893.
    • (2005) Mol. Immunol. , vol.42 , Issue.8 , pp. 887-893
    • Cario, E.1    Podolsky, D.K.2
  • 25
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun C.M., Hall J.A., Blank R.B., et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 2007, 204(8):1775-1785.
    • (2007) J. Exp. Med. , vol.204 , Issue.8 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3
  • 26
    • 30744462300 scopus 로고    scopus 로고
    • Regulation of lung injury and repair by Toll-like receptors and hyaluronan
    • Jiang D., Liang J., Fan J., et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat. Med. 2005, 11(11):1173-1179.
    • (2005) Nat. Med. , vol.11 , Issue.11 , pp. 1173-1179
    • Jiang, D.1    Liang, J.2    Fan, J.3
  • 27
    • 44449117540 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factor-1{alpha} modulate lipopolysaccharide-induced dendritic cell activation and function
    • Jantsch J., Chakravortty D., Turza N., et al. Hypoxia and hypoxia-inducible factor-1{alpha} modulate lipopolysaccharide-induced dendritic cell activation and function. J. Immunol. 2008, 180(7):4697-4705.
    • (2008) J. Immunol. , vol.180 , Issue.7 , pp. 4697-4705
    • Jantsch, J.1    Chakravortty, D.2    Turza, N.3
  • 28
    • 64849101844 scopus 로고    scopus 로고
    • Nonresolving inflammation in gp91phox-/- mice, a model of human chronic granulomatous disease, has lower adenosine and cyclic adenosine 5'-monophosphate
    • Rajakariar R., Newson J., Jackson E.K., et al. Nonresolving inflammation in gp91phox-/- mice, a model of human chronic granulomatous disease, has lower adenosine and cyclic adenosine 5'-monophosphate. J. Immunol. 2009, 182(5):3262-3269.
    • (2009) J. Immunol. , vol.182 , Issue.5 , pp. 3262-3269
    • Rajakariar, R.1    Newson, J.2    Jackson, E.K.3
  • 29
    • 30044441094 scopus 로고    scopus 로고
    • Limiting inflammatory responses during activation of innate immunity
    • Han J., Ulevitch R.J. Limiting inflammatory responses during activation of innate immunity. Nat. Immunol. 2005, 6(12):1198-1205.
    • (2005) Nat. Immunol. , vol.6 , Issue.12 , pp. 1198-1205
    • Han, J.1    Ulevitch, R.J.2
  • 30
    • 34250357688 scopus 로고    scopus 로고
    • Resolvin E1 and protectin D1 activate inflammation-resolution programmes
    • Schwab J.M., Chiang N., Arita M., Serhan C.N. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature 2007, 447(7146):869-874.
    • (2007) Nature , vol.447 , Issue.7146 , pp. 869-874
    • Schwab, J.M.1    Chiang, N.2    Arita, M.3    Serhan, C.N.4
  • 31
    • 32944474237 scopus 로고    scopus 로고
    • Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer
    • Karin M., Lawrence T., Nizet V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell 2006, 124(4):823-835.
    • (2006) Cell , vol.124 , Issue.4 , pp. 823-835
    • Karin, M.1    Lawrence, T.2    Nizet, V.3
  • 32
    • 57149104111 scopus 로고    scopus 로고
    • Immune dysregulation and chronic stress among older adults: a review
    • Gouin J.P., Hantsoo L., Kiecolt-Glaser J.K. Immune dysregulation and chronic stress among older adults: a review. Neuroimmunomodulation 2008, 15(4-6):251-259.
    • (2008) Neuroimmunomodulation , vol.15 , Issue.4-6 , pp. 251-259
    • Gouin, J.P.1    Hantsoo, L.2    Kiecolt-Glaser, J.K.3
  • 33
    • 33744477358 scopus 로고    scopus 로고
    • Inflammation, longevity, and cardiovascular diseases: role of polymorphisms of TLR4
    • Candore G., Aquino A., Balistreri C.R., et al. Inflammation, longevity, and cardiovascular diseases: role of polymorphisms of TLR4. Ann. N. Y. Acad. Sci. 2006, 1067:282-287.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1067 , pp. 282-287
    • Candore, G.1    Aquino, A.2    Balistreri, C.R.3
  • 34
    • 67649393351 scopus 로고    scopus 로고
    • Vaccination in the elderly: an immunological perspective
    • Chen W.H., Kozlovsky B.F., Effros R.B., et al. Vaccination in the elderly: an immunological perspective. Trends Immunol. 2009, 30(7):351-359.
    • (2009) Trends Immunol. , vol.30 , Issue.7 , pp. 351-359
    • Chen, W.H.1    Kozlovsky, B.F.2    Effros, R.B.3
  • 35
    • 58149301590 scopus 로고    scopus 로고
    • From bench to bedside and back: the SENIEUR protocol and the efficacy of influenza vaccination in the elderly
    • Trzonkowski P., Mysliwska J., Pawelec G., Mysliwski A. From bench to bedside and back: the SENIEUR protocol and the efficacy of influenza vaccination in the elderly. Biogerontology 2009, 10(1):83-94.
    • (2009) Biogerontology , vol.10 , Issue.1 , pp. 83-94
    • Trzonkowski, P.1    Mysliwska, J.2    Pawelec, G.3    Mysliwski, A.4
  • 36
    • 57949087452 scopus 로고    scopus 로고
    • Molecular inflammation: underpinnings of aging and age-related diseases
    • Chung H.Y., Cesari M., Anton S., et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res. Rev. 2009, 8(1):18-30.
    • (2009) Ageing Res. Rev. , vol.8 , Issue.1 , pp. 18-30
    • Chung, H.Y.1    Cesari, M.2    Anton, S.3
  • 37
    • 42649104802 scopus 로고    scopus 로고
    • Epigenetics, aging, and autoimmunity
    • Yung R.L., Julius A. Epigenetics, aging, and autoimmunity. Autoimmunity 2008, 41(4):329-335.
    • (2008) Autoimmunity , vol.41 , Issue.4 , pp. 329-335
    • Yung, R.L.1    Julius, A.2
  • 38
    • 33846111415 scopus 로고    scopus 로고
    • Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
    • Franceschi C., Capri M., Monti D., et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech. Ageing Dev. 2007, 128(1):92-105.
    • (2007) Mech. Ageing Dev. , vol.128 , Issue.1 , pp. 92-105
    • Franceschi, C.1    Capri, M.2    Monti, D.3
  • 39
    • 0035936802 scopus 로고    scopus 로고
    • Atherosclerosis: the road ahead
    • Glass C.K., Witztum J.L. Atherosclerosis: the road ahead. Cell 2001, 104(4):503-516.
    • (2001) Cell , vol.104 , Issue.4 , pp. 503-516
    • Glass, C.K.1    Witztum, J.L.2
  • 40
    • 20044387026 scopus 로고    scopus 로고
    • IKK-beta links inflammation to obesity-induced insulin resistance
    • Arkan M.C., Hevener A.L., Greten F.R., et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat. Med. 2005, 11(2):191-198.
    • (2005) Nat. Med. , vol.11 , Issue.2 , pp. 191-198
    • Arkan, M.C.1    Hevener, A.L.2    Greten, F.R.3
  • 41
    • 0035725929 scopus 로고    scopus 로고
    • Age-related alterations in the inflammatory response to dermal injury
    • Swift M.E., Burns A.L., Gray K.L., DiPietro L.A. Age-related alterations in the inflammatory response to dermal injury. J. Invest. Dermatol. 2001, 117(5):1027-1035.
    • (2001) J. Invest. Dermatol. , vol.117 , Issue.5 , pp. 1027-1035
    • Swift, M.E.1    Burns, A.L.2    Gray, K.L.3    DiPietro, L.A.4
  • 42
    • 19344365992 scopus 로고    scopus 로고
    • Crystal-associated arthritis in the elderly
    • Wise C.M. Crystal-associated arthritis in the elderly. Clin. Geriatr. Med. 2005, 21(3):491-511.
    • (2005) Clin. Geriatr. Med. , vol.21 , Issue.3 , pp. 491-511
    • Wise, C.M.1
  • 43
    • 0028983538 scopus 로고
    • [beta]-Amyloid precursor protein ([beta]-APP) in human gut with special reference to the enteric nervous system
    • Cabal A., onso-Cortina V., Gonzalez-Vazquez L.O., et al. [beta]-Amyloid precursor protein ([beta]-APP) in human gut with special reference to the enteric nervous system. Brain Res. Bull. 1995, 38(5):417-423.
    • (1995) Brain Res. Bull. , vol.38 , Issue.5 , pp. 417-423
    • Cabal, A.1    onso-Cortina, V.2    Gonzalez-Vazquez, L.O.3
  • 44
    • 58149181978 scopus 로고    scopus 로고
    • Fibrillar amyloid-{beta} peptides activate microglia via TLR2: implications for Alzheimer's disease
    • Jana M., Palencia C.A., Pahan K. Fibrillar amyloid-{beta} peptides activate microglia via TLR2: implications for Alzheimer's disease. J. Immunol. 2008, 181(10):7254-7262.
    • (2008) J. Immunol. , vol.181 , Issue.10 , pp. 7254-7262
    • Jana, M.1    Palencia, C.A.2    Pahan, K.3
  • 45
    • 47849085872 scopus 로고    scopus 로고
    • The NALP3 inflammasome is involved in the innate immune response to amyloid-[beta]
    • Halle A., Hornung V., Petzold G.C., et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-[beta]. Nat. Immunol. 2008, 9(8):857-865.
    • (2008) Nat. Immunol. , vol.9 , Issue.8 , pp. 857-865
    • Halle, A.1    Hornung, V.2    Petzold, G.C.3
  • 46
    • 0023950461 scopus 로고
    • Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications
    • Brownlee M., Cerami A., Vlassara H. Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N. Engl. J. Med. 1988, 318(20):1315-1321.
    • (1988) N. Engl. J. Med. , vol.318 , Issue.20 , pp. 1315-1321
    • Brownlee, M.1    Cerami, A.2    Vlassara, H.3
  • 47
    • 34250160687 scopus 로고    scopus 로고
    • RAGE on the toll road?
    • Lin L. RAGE on the toll road?. Cell Mol. Immunol. 2006, 3(5):351-358.
    • (2006) Cell Mol. Immunol. , vol.3 , Issue.5 , pp. 351-358
    • Lin, L.1
  • 48
    • 0034101821 scopus 로고    scopus 로고
    • Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
    • Febbraio M., Podrez E.A., Smith J.D., et al. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. J. Clin. Invest. 2000, 105(8):1049-1056.
    • (2000) J. Clin. Invest. , vol.105 , Issue.8 , pp. 1049-1056
    • Febbraio, M.1    Podrez, E.A.2    Smith, J.D.3
  • 49
    • 57549113882 scopus 로고    scopus 로고
    • Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis
    • Hodgkinson C.P., Laxton R.C., Patel K., Ye S. Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2008, 28(12):2275-2281.
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , Issue.12 , pp. 2275-2281
    • Hodgkinson, C.P.1    Laxton, R.C.2    Patel, K.3    Ye, S.4
  • 50
    • 55049123496 scopus 로고    scopus 로고
    • The clinical significance of gastrointestinal changes with aging
    • Bhutto A., Morley J.E. The clinical significance of gastrointestinal changes with aging. Curr. Opin. Clin. Nutr. Metab. Care 2008, 11(5):651-660.
    • (2008) Curr. Opin. Clin. Nutr. Metab. Care , vol.11 , Issue.5 , pp. 651-660
    • Bhutto, A.1    Morley, J.E.2
  • 51
    • 34347229116 scopus 로고    scopus 로고
    • Chronic subclinical bowel inflammation may explain increased risk of colorectal cancer in obese people 431
    • John B.J., Abulafi A.M., Poullis A., Mendall M.A. Chronic subclinical bowel inflammation may explain increased risk of colorectal cancer in obese people 431. Gut 2007, 56(7):1034-1035.
    • (2007) Gut , vol.56 , Issue.7 , pp. 1034-1035
    • John, B.J.1    Abulafi, A.M.2    Poullis, A.3    Mendall, M.A.4
  • 52
    • 37349103420 scopus 로고    scopus 로고
    • The inflammatory status of old age can be nurtured from the intestinal environment
    • Guigoz Y., Doré J., Schiffrin E.J. The inflammatory status of old age can be nurtured from the intestinal environment. Curr. Opin. Clin. Nutr. Metab. Care 2008, 11(1):13-20.
    • (2008) Curr. Opin. Clin. Nutr. Metab. Care , vol.11 , Issue.1 , pp. 13-20
    • Guigoz, Y.1    Doré, J.2    Schiffrin, E.J.3
  • 53
    • 0035124967 scopus 로고    scopus 로고
    • Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles
    • Hopkins M.J., Sharp R., Macfarlane G.T. Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles. Gut 2001, 48(2):198-205.
    • (2001) Gut , vol.48 , Issue.2 , pp. 198-205
    • Hopkins, M.J.1    Sharp, R.2    Macfarlane, G.T.3
  • 54
    • 34247384151 scopus 로고    scopus 로고
    • Intestinal bacteria and ageing
    • Woodmansey E.J. Intestinal bacteria and ageing. J. Appl. Microbiol. 2007, 102(5):1178-1186.
    • (2007) J. Appl. Microbiol. , vol.102 , Issue.5 , pp. 1178-1186
    • Woodmansey, E.J.1
  • 55
    • 67651151152 scopus 로고    scopus 로고
    • The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age
    • Mariat D., Firmesse O., Levenez F., et al. The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol. 2009, 9(1):123.
    • (2009) BMC Microbiol. , vol.9 , Issue.1 , pp. 123
    • Mariat, D.1    Firmesse, O.2    Levenez, F.3
  • 56
    • 44349167059 scopus 로고    scopus 로고
    • Dendritic cells in intestinal immune regulation
    • Coombes J.L., Powrie F. Dendritic cells in intestinal immune regulation. Nat. Rev. Immunol. 2008, 8(6):435-446.
    • (2008) Nat. Rev. Immunol. , vol.8 , Issue.6 , pp. 435-446
    • Coombes, J.L.1    Powrie, F.2
  • 57
    • 43549099743 scopus 로고    scopus 로고
    • The Interleukin-23/Interleukin-17 axis in intestinal inflammation
    • Maloy K.J. The Interleukin-23/Interleukin-17 axis in intestinal inflammation. J. Intern. Med. 2008, 263(6):584-590.
    • (2008) J. Intern. Med. , vol.263 , Issue.6 , pp. 584-590
    • Maloy, K.J.1
  • 59
    • 30744451406 scopus 로고    scopus 로고
    • Effects of aging on the common lymphoid progenitor to pro-B cell transition
    • Min H., Montecino-Rodriguez E., Dorshkind K. Effects of aging on the common lymphoid progenitor to pro-B cell transition. J. Immunol. 2006, 176(2):1007-1012.
    • (2006) J. Immunol. , vol.176 , Issue.2 , pp. 1007-1012
    • Min, H.1    Montecino-Rodriguez, E.2    Dorshkind, K.3
  • 60
    • 2442440593 scopus 로고    scopus 로고
    • Immunogenicity and protective efficacy of influenza vaccination
    • Hannoun C., Megas F., Piercy J. Immunogenicity and protective efficacy of influenza vaccination. Virus Res. 2004, 103(1-2):133-138.
    • (2004) Virus Res. , vol.103 , Issue.1-2 , pp. 133-138
    • Hannoun, C.1    Megas, F.2    Piercy, J.3
  • 61
    • 33744996006 scopus 로고    scopus 로고
    • Why aging T cells fail: implications for vaccination
    • Haynes L., Swain S.L. Why aging T cells fail: implications for vaccination. Immunity 2006, 24(6):663-666.
    • (2006) Immunity , vol.24 , Issue.6 , pp. 663-666
    • Haynes, L.1    Swain, S.L.2
  • 62
    • 0842303113 scopus 로고    scopus 로고
    • Follicular dendritic cells in aging, a " bottle-neck" in the humoral immune response
    • Aydar Y., Balogh P., Tew J.G., Szakal A.K. Follicular dendritic cells in aging, a " bottle-neck" in the humoral immune response. Ageing Res. Rev. 2004, 3(1):15-29.
    • (2004) Ageing Res. Rev. , vol.3 , Issue.1 , pp. 15-29
    • Aydar, Y.1    Balogh, P.2    Tew, J.G.3    Szakal, A.K.4
  • 63
    • 61349097791 scopus 로고    scopus 로고
    • B-cell responses to vaccination at the extremes of age
    • Siegrist C.A., Aspinall R. B-cell responses to vaccination at the extremes of age. Nat. Rev. Immunol. 2009, 9(3):185-194.
    • (2009) Nat. Rev. Immunol. , vol.9 , Issue.3 , pp. 185-194
    • Siegrist, C.A.1    Aspinall, R.2
  • 64
    • 0022585737 scopus 로고
    • Changes in the human thymus during aging
    • Steinmann G.G. Changes in the human thymus during aging. Curr. Top. Pathol. 1986, 75:43-88.
    • (1986) Curr. Top. Pathol. , vol.75 , pp. 43-88
    • Steinmann, G.G.1
  • 65
    • 34548660765 scopus 로고    scopus 로고
    • Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily
    • Colonna-Romano G., Akbar A.N., Aquino A., et al. Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily. Exp. Gerontol. 2007, 42(10):995-1002.
    • (2007) Exp. Gerontol. , vol.42 , Issue.10 , pp. 995-1002
    • Colonna-Romano, G.1    Akbar, A.N.2    Aquino, A.3
  • 67
    • 33744462080 scopus 로고    scopus 로고
    • Human immunosenescence: does it have an infectious component?
    • Pawelec G., Koch S., Franceschi C., Wikby A. Human immunosenescence: does it have an infectious component?. Ann. N. Y. Acad. Sci. 2006, 1067:56-65.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1067 , pp. 56-65
    • Pawelec, G.1    Koch, S.2    Franceschi, C.3    Wikby, A.4
  • 68
    • 0041305837 scopus 로고    scopus 로고
    • Chronic stress and age-related increases in the proinflammatory cytokine IL-6
    • Kiecolt-Glaser J.K., Preacher K.J., MacCallum R.C., et al. Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc. Natl. Acad. Sci. U.S.A. 2003, 100(15):9090-9095.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , Issue.15 , pp. 9090-9095
    • Kiecolt-Glaser, J.K.1    Preacher, K.J.2    MacCallum, R.C.3
  • 69
    • 60549108257 scopus 로고    scopus 로고
    • Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA
    • Agrawal A., Tay J., Ton S., et al. Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA. J. Immunol. 2009, 182(2):1138-1145.
    • (2009) J. Immunol. , vol.182 , Issue.2 , pp. 1138-1145
    • Agrawal, A.1    Tay, J.2    Ton, S.3
  • 70
    • 34249775503 scopus 로고    scopus 로고
    • Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway
    • Agrawal A., Agrawal S., Cao J.N., et al. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J. Immunol. 2007, 178(11):6912-6922.
    • (2007) J. Immunol. , vol.178 , Issue.11 , pp. 6912-6922
    • Agrawal, A.1    Agrawal, S.2    Cao, J.N.3
  • 71
    • 4344648938 scopus 로고    scopus 로고
    • CD14 and toll-like receptor 4: a link between infection and acute coronary events?
    • Arroyo-Espliguero R., Avanzas P., Jeffery S., Kaski J.C. CD14 and toll-like receptor 4: a link between infection and acute coronary events?. Heart 2004, 90(9):983-988.
    • (2004) Heart , vol.90 , Issue.9 , pp. 983-988
    • Arroyo-Espliguero, R.1    Avanzas, P.2    Jeffery, S.3    Kaski, J.C.4
  • 72
    • 58149100407 scopus 로고    scopus 로고
    • The ageing immune system: is it ever too old to become young again?
    • Dorshkind K., Montecino-Rodriguez E., Signer R.A.J. The ageing immune system: is it ever too old to become young again?. Nat. Rev. Immunol. 2009, 9(1):57-62.
    • (2009) Nat. Rev. Immunol. , vol.9 , Issue.1 , pp. 57-62
    • Dorshkind, K.1    Montecino-Rodriguez, E.2    Signer, R.A.J.3
  • 73
    • 4243076298 scopus 로고    scopus 로고
    • Probiotics and prebiotics in the elderly
    • Hamilton-Miller J.M.T. Probiotics and prebiotics in the elderly. Postgrad. Med. J. 2004, 80(946):447-451.
    • (2004) Postgrad. Med. J. , vol.80 , Issue.946 , pp. 447-451
    • Hamilton-Miller, J.M.T.1
  • 74
    • 0036838941 scopus 로고    scopus 로고
    • Effects of prebiotics on the immune response to vaccination in the elderly
    • Bunout D., Hirsch S., de la Maza M.P., et al. Effects of prebiotics on the immune response to vaccination in the elderly. JPEN J. Parenter. Enteral. Nutr. 2002, 26(6):372-376.
    • (2002) JPEN J. Parenter. Enteral. Nutr. , vol.26 , Issue.6 , pp. 372-376
    • Bunout, D.1    Hirsch, S.2    de la Maza, M.P.3
  • 75
    • 0036170747 scopus 로고    scopus 로고
    • Effects of oligosaccharide on the faecal flora and non-specific immune system in elderly people 345
    • Guigoz Y., Rochat F., Perruisseau-Carrier G., et al. Effects of oligosaccharide on the faecal flora and non-specific immune system in elderly people 345. Nutr. Res. 2002, 22:13-25.
    • (2002) Nutr. Res. , vol.22 , pp. 13-25
    • Guigoz, Y.1    Rochat, F.2    Perruisseau-Carrier, G.3
  • 76
    • 37049022798 scopus 로고    scopus 로고
    • Systemic inflammatory markers in older persons: the effect of oral nutritional supplementation with prebiotics
    • Schiffrin E.J., Thomas D.R., Kumar V.B., et al. Systemic inflammatory markers in older persons: the effect of oral nutritional supplementation with prebiotics. J. Nutr. Health Aging 2007, 11(6):475-479.
    • (2007) J. Nutr. Health Aging , vol.11 , Issue.6 , pp. 475-479
    • Schiffrin, E.J.1    Thomas, D.R.2    Kumar, V.B.3
  • 77
    • 55849146633 scopus 로고    scopus 로고
    • Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers
    • Vulevic J., Drakoularakou A., Yaqoob P., et al. Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers. Am. J. Clin. Nutr. 2008, 88(5):1438-1446.
    • (2008) Am. J. Clin. Nutr. , vol.88 , Issue.5 , pp. 1438-1446
    • Vulevic, J.1    Drakoularakou, A.2    Yaqoob, P.3
  • 78
    • 0034946215 scopus 로고    scopus 로고
    • Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes
    • Gill H.S., Rutherfurd K.J., Cross M.L. Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes. J. Clin. Immunol. 2001, 21(4):264-271.
    • (2001) J. Clin. Immunol. , vol.21 , Issue.4 , pp. 264-271
    • Gill, H.S.1    Rutherfurd, K.J.2    Cross, M.L.3
  • 79
    • 33947096460 scopus 로고    scopus 로고
    • Effects of a fermented milk drink containing Lactobacillus casei strain shirota on the human NK-cell activity
    • Takeda K., Okumura K. Effects of a fermented milk drink containing Lactobacillus casei strain shirota on the human NK-cell activity. J. Nutr. 2007, 137(3):791S-793.
    • (2007) J. Nutr. , vol.137 , Issue.3
    • Takeda, K.1    Okumura, K.2
  • 80
    • 0035179295 scopus 로고    scopus 로고
    • Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019
    • Gill H.S., Rutherfurd K.J., Cross M.L., Gopal P.K. Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019. Am. J. Clin. Nutr. 2001, 74(6):833-839.
    • (2001) Am. J. Clin. Nutr. , vol.74 , Issue.6 , pp. 833-839
    • Gill, H.S.1    Rutherfurd, K.J.2    Cross, M.L.3    Gopal, P.K.4
  • 81
    • 0037279208 scopus 로고    scopus 로고
    • Effect of fermented milk containing the probiotic Lactobacillus casei DN-114001 on winter infections in free-living elderly subjects: a randomised, controlled pilot study
    • Turchet P., Laurenzano M., Auboiron S., Antoine J.M. Effect of fermented milk containing the probiotic Lactobacillus casei DN-114001 on winter infections in free-living elderly subjects: a randomised, controlled pilot study. J. Nutr. Health Aging 2003, 7(2):75-77.
    • (2003) J. Nutr. Health Aging , vol.7 , Issue.2 , pp. 75-77
    • Turchet, P.1    Laurenzano, M.2    Auboiron, S.3    Antoine, J.M.4
  • 82
    • 33745500984 scopus 로고    scopus 로고
    • Anti-inflammatory metabolite production in the gut from the consumption of probiotic yogurt containing Bifidobacterium animalis subsp. lactis LKM512
    • Matsumoto M., Benno Y. Anti-inflammatory metabolite production in the gut from the consumption of probiotic yogurt containing Bifidobacterium animalis subsp. lactis LKM512. Biosci. Biotechnol. Biochem. 2006, 70(6):1287-1292.
    • (2006) Biosci. Biotechnol. Biochem. , vol.70 , Issue.6 , pp. 1287-1292
    • Matsumoto, M.1    Benno, Y.2
  • 83
    • 1642451908 scopus 로고    scopus 로고
    • Randomised clinical trial of synbiotic therapy in elective surgical patients
    • Anderson A.D.G., McNaught C.E., Jain P.K., MacFie J. Randomised clinical trial of synbiotic therapy in elective surgical patients. Gut 2004, 53(2):241-245.
    • (2004) Gut , vol.53 , Issue.2 , pp. 241-245
    • Anderson, A.D.G.1    McNaught, C.E.2    Jain, P.K.3    MacFie, J.4
  • 84
    • 22144462827 scopus 로고    scopus 로고
    • Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: a double blind, randomized, controlled trial
    • de Vrese M., Winkler P., Rautenberg P., et al. Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: a double blind, randomized, controlled trial. Clin. Nutr. 2005, 24(4):481-491.
    • (2005) Clin. Nutr. , vol.24 , Issue.4 , pp. 481-491
    • de Vrese, M.1    Winkler, P.2    Rautenberg, P.3
  • 85
    • 54549108771 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases
    • Calder P.C. Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases. Mol. Nutr. Food Res. 2008, 52(8):885-897.
    • (2008) Mol. Nutr. Food Res. , vol.52 , Issue.8 , pp. 885-897
    • Calder, P.C.1
  • 86
    • 0036931477 scopus 로고    scopus 로고
    • Omega-3 fatty acids in inflammation and autoimmune diseases
    • Simopoulos A.P. Omega-3 fatty acids in inflammation and autoimmune diseases. J. Am. Coll. Nutr. 2002, 21(6):495-505.
    • (2002) J. Am. Coll. Nutr. , vol.21 , Issue.6 , pp. 495-505
    • Simopoulos, A.P.1
  • 87
    • 40349100270 scopus 로고    scopus 로고
    • Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus
    • Serhan C.N., Chiang N. Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus. Br. J. Pharmacol. 2008, 153(Suppl. 1):S200-S215.
    • (2008) Br. J. Pharmacol. , vol.153 , Issue.SUPPL. 1
    • Serhan, C.N.1    Chiang, N.2
  • 88
    • 54249105389 scopus 로고    scopus 로고
    • Nutrition and age-associated inflammation: implications for disease prevention
    • Meydani S.N., Wu D. Nutrition and age-associated inflammation: implications for disease prevention. J. Parenter. Enteral. Nutr. 2008, 32(6):626-629.
    • (2008) J. Parenter. Enteral. Nutr. , vol.32 , Issue.6 , pp. 626-629
    • Meydani, S.N.1    Wu, D.2
  • 89
    • 31544434227 scopus 로고    scopus 로고
    • Nutritional status predicts primary subclasses of T cells and the lymphocyte proliferation response in healthy older women
    • Molls R.R., Ahluwalia N., Mastro A.M., et al. Nutritional status predicts primary subclasses of T cells and the lymphocyte proliferation response in healthy older women. J. Nutr. 2005, 135(11):2644-2650.
    • (2005) J. Nutr. , vol.135 , Issue.11 , pp. 2644-2650
    • Molls, R.R.1    Ahluwalia, N.2    Mastro, A.M.3
  • 90
    • 35248887619 scopus 로고    scopus 로고
    • Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses
    • Maggini S., Wintergerst E.S., Beveridge S., Hornig D.H. Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br. J. Nutr. 2007, 98(Suppl. 1):S29-S35.
    • (2007) Br. J. Nutr. , vol.98 , Issue.SUPPL. 1
    • Maggini, S.1    Wintergerst, E.S.2    Beveridge, S.3    Hornig, D.H.4
  • 91
    • 49749097901 scopus 로고    scopus 로고
    • Zinc-gene interaction related to inflammatory/immune response in ageing
    • Mocchegiani E., Malavolta M. Zinc-gene interaction related to inflammatory/immune response in ageing. Genes Nutr. 2008, 3(2):61-75.
    • (2008) Genes Nutr. , vol.3 , Issue.2 , pp. 61-75
    • Mocchegiani, E.1    Malavolta, M.2
  • 92
    • 55949122981 scopus 로고    scopus 로고
    • The influence of selenium on immune responses
    • Hoffmann P.R., Berry M.J. The influence of selenium on immune responses. Mol. Nutr. Food Res. 2008, 52(11):1273-1280.
    • (2008) Mol. Nutr. Food Res. , vol.52 , Issue.11 , pp. 1273-1280
    • Hoffmann, P.R.1    Berry, M.J.2
  • 93
    • 33947119626 scopus 로고    scopus 로고
    • Gut microbiota: mining for therapeutic potential
    • O'Hara A.M., Shanahan F. Gut microbiota: mining for therapeutic potential. Clin. Gastroenterol. Hepatol. 2007, 5(3):274-284.
    • (2007) Clin. Gastroenterol. Hepatol. , vol.5 , Issue.3 , pp. 274-284
    • O'Hara, A.M.1    Shanahan, F.2
  • 94
    • 27644441511 scopus 로고    scopus 로고
    • Milk casein-based diet containing TGF-{beta} controls the inflammatory reaction in the HLA-B27 transgenic rat model
    • Schiffrin E.J., Yousfi M.E., Faure M., et al. Milk casein-based diet containing TGF-{beta} controls the inflammatory reaction in the HLA-B27 transgenic rat model. J. Parenter. Enteral. Nutr. 2005, 29(Suppl. 4):S141-S150.
    • (2005) J. Parenter. Enteral. Nutr. , vol.29 , Issue.SUPPL. 4
    • Schiffrin, E.J.1    Yousfi, M.E.2    Faure, M.3
  • 95
    • 34547751351 scopus 로고    scopus 로고
    • Oral tolerance: is it all retinoic acid?
    • von Boehmer H. Oral tolerance: is it all retinoic acid?. J. Exp. Med. 2007, 204(8):1737-1739.
    • (2007) J. Exp. Med. , vol.204 , Issue.8 , pp. 1737-1739
    • von Boehmer, H.1
  • 97
    • 48849107455 scopus 로고    scopus 로고
    • A rewrites the ABCs of oral tolerance
    • Strober W., Vitamin A rewrites the ABCs of oral tolerance. Mucosal Immunol. 2008, 1(2):92-95.
    • (2008) Mucosal Immunol. , vol.1 , Issue.2 , pp. 92-95
    • Strober, W.1    Vitamin2
  • 98
    • 33847328456 scopus 로고    scopus 로고
    • Nutritional factors and immunological ageing
    • Lesourd B. Nutritional factors and immunological ageing. Proc. Nutr. Soc. 2006, 65(3):319-325.
    • (2006) Proc. Nutr. Soc. , vol.65 , Issue.3 , pp. 319-325
    • Lesourd, B.1


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