Oral tolerance: Is it all retinoic acid?

Journal of Experimental Medicine

Volumn 204, Issue 8, 2007, Pages 1737-1739

  Von Boehmer, Harald ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

CATALYSIS; CELL HOMING; DENDRITIC CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; T LYMPHOCYTE;

ANIMALS; ANTIGEN PRESENTATION; CELL DIFFERENTIATION; DENDRITIC CELLS; FORKHEAD TRANSCRIPTION FACTORS; GASTROINTESTINAL TRACT; HUMANS; IMMUNE TOLERANCE; LIGANDS; MODELS, BIOLOGICAL; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, RETINOIC ACID; TRANSFORMING GROWTH FACTOR BETA; TRETINOIN;

EID: 34547751351     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20071251     Document Type: Review

References (19)

1. Faria, A.M., and H.L. Weiner. 1999. Oral tolerance: mechanisms and therapeutic applications. Adv. Immunol. 73:153-264.
2. + regulatory T cells via a TGF-β- and retinoic acid-dependent mechanism. J. Exp. Med. 204:1757-1764.
3. Sun, C.-M., J. Hall, R.B. Blank, N. Bouladoux, M. Oukka, J.R. Mora, and Y. Belkaid. 2007. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204:1775-1785.
4. Benson, M.J., K. Pino-Lagos, M. Rosemblatt, and R.J. Noelle. 2007. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J. Exp. Med. 204:1765-1774.
5. Mora, J.R., M.R. Bono, N. Manjunath, W. Weninger, L.L. Cavanagh, M. Rosemblatt, and U.H. von Andrian. 2003. Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature. 424:88-93.
6. Butcher, E.C., M. Williams, K. Youngman, L. Rott, and M. Briskin. 1999. Lymphocyte trafficking and regional immunity. Adv. Immunol. 72:209-253.
7. Wurbel, M.A., J.M. Philippe, C. Nguyen, G. Victorero, T. Freeman, P. Wooding, A. Miazek, M.G. Mattei, M. Malissen, B.R. Jordan, et al. 2000. The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. Eur. J. Immunol. 30:262-271.
8. Iwata, M., A. Hirakiyama, Y. Eshima, H. Kagechika, C. Kato, and S.Y. Song. 2004. Retinoic acid imprints gut-homing specificity on T cells. Immunity. 21:527-538.
9. Khattri, R., T. Cox, S.A. Yasayko, and F. Ramsdell. 2003. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4:337-342.
10. von Boehmer, H. 2005. Mechanisms of suppression by suppressor T cells. Nat. Immunol. 6:338-344.
11. Apostolou, I., and H. von Boehmer. 2004. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199:1401-1408.
12. Kretschmer, K., I. Apostolou, D. Hawiger, K. Khazaie, M.C. Nussenzweig, and H. von Boehmer. 2005. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 6:1219-1227.
13. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198:1875-1886.
14. Floess, S., J. Freyer, C. Siewert, U. Baron, S. Olek, J. Polansky, K. Schlawe, H.D. Chang, T. Bopp, E. Schmitt, et al. 2007. Epigenetic control of the fxp3 locus in regulatory T cells. PLoS Biol. 5:e38.
15. Li, Y., Y. Hashimoto, A. Agadir, H. Kagechika, and X. Zhang. 1999. Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells. J. Biol. Chem. 274:15360-15366.
16. Fisher, G.J., H.S. Talwar, J. Lin, P. Lin, F. McPhillips, Z. Wang, X. Li, Y. Wan, S. Kang, and J.J. Voorhees. 1998. Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo. J. Clin. Invest. 101:1432-1440.
17. Wu, Y., M. Borde, V. Heissmeyer, M. Feuerer, A.D. Lapan, J.C. Stroud, D.L. Bates, L. Guo, A. Han, S.F. Ziegler, et al. 2006. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell. 126:375-387.
18. Marson, A., K. Kretschmer, G.M. Frampton, E.S. Jacobsen, J.K. Polansky, K.D. MacIsaac, S.S. Levine, E. Fraenkel, H. von Boehmer, and R.A. Young. 2007. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature. 445:931-935.
19. Winau, F., G. Hegasy, R. Weiskirchen, S. Weber, C. Cassan, P.A. Sieling, R.L. Modlin, R.S. Liblau, A.M. Gressner, and S.H. Kaufmann. 2007. Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Immunity. 26:117-129.