메뉴 건너뛰기




Volumn 21, Issue 15, 2010, Pages 2797-2807

Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; GLYCOPROTEIN GP 130; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR ALPHA; INTERLEUKIN RECEPTOR; LEUKEMIA INHIBITORY FACTOR RECEPTOR; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; ONCOSTATIN M RECEPTOR; PROTEIN WSX 1; STAT1 PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG;

EID: 77955106518     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E10-03-0240     Document Type: Article
Times cited : (37)

References (50)
  • 1
    • 2642522073 scopus 로고    scopus 로고
    • Identification of an interleukin-15alpha receptor-binding site on human interleukin-15
    • Bernard, J., et al. (2004). Identification of an interleukin-15alpha receptor-binding site on human interleukin-15. J. Biol. Chem. 279, 24313-24322.
    • (2004) J. Biol. Chem. , vol.279 , pp. 24313-24322
    • Bernard, J.1
  • 2
    • 0038609651 scopus 로고    scopus 로고
    • Hexameric structure and assembly of the interleukin-6/IL-6 α receptor/gp130 complex
    • Boulanger, M. J., Chow, D.-C., .revnova, E. E., and Garcia, K. C. (2003). Hexameric structure and assembly of the interleukin-6/IL-6 α receptor/gp130 complex. Science 300, 2101-2104.
    • (2003) Science , vol.300 , pp. 2101-2104
    • Boulanger, M.J.1    Chow, D.-C.2    Revnova, E.E.3    Garcia, K.C.4
  • 3
    • 0345257344 scopus 로고    scopus 로고
    • Interleukin-21 inhibits dendritic cell activation and maturation
    • Brandt, K., Bulfone-Paus, S., Foster, D. C., and Rückert, R. (2003). Interleukin-21 inhibits dendritic cell activation and maturation. Blood 102, 4090-4098.
    • (2003) Blood , vol.102 , pp. 4090-4098
    • Brandt, K.1    Bulfone-Paus, S.2    Foster, D.C.3    Rückert, R.4
  • 4
    • 0036251154 scopus 로고    scopus 로고
    • Stat proteins and oncogenesis
    • Bromberg, J. (2002). Stat proteins and oncogenesis. J. Clin. Invest. 109, 1139-1142.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1139-1142
    • Bromberg, J.1
  • 6
    • 33645833872 scopus 로고    scopus 로고
    • The interleukin-15/interleukin-15 receptor system as a model for juxtacrine and reverse signaling
    • Bulfone-Paus, S., Bulanova, E., Budagian, V., and Paus, R. (2006). The interleukin-15/interleukin-15 receptor system as a model for juxtacrine and reverse signaling. BioEssays 28, 362-377.
    • (2006) BioEssays , vol.28 , pp. 362-377
    • Bulfone-Paus, S.1    Bulanova, E.2    Budagian, V.3    Paus, R.4
  • 7
    • 17744386517 scopus 로고    scopus 로고
    • Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration
    • Carr, P. D., Gustin, S. E., Church, A. P., Murphy, J. M., Ford, S. C., Mann, D. A., Woltring, D. M., Walker, I., Ollis, D. L., and Young, I. G. (2001). Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration. Cell 104, 291-300.
    • (2001) Cell , vol.104 , pp. 291-300
    • Carr, P.D.1    Gustin, S.E.2    Church, A.P.3    Murphy, J.M.4    Ford, S.C.5    Mann, D.A.6    Woltring, D.M.7    Walker, I.8    Ollis, D.L.9    Young, I.G.10
  • 8
    • 0032984589 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
    • Catlett-Falcone, R., et al. (1999). Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 10, 105-115.
    • (1999) Immunity , vol.10 , pp. 105-115
    • Catlett-Falcone, R.1
  • 9
    • 34047257840 scopus 로고    scopus 로고
    • Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells
    • Chattopadhyay, S., Tracy, E., Liang, P., Robledo, O., Rose-John, S., and Baumann, H. (2007). Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells. J. Biol. Chem. 282, 3014-3026.
    • (2007) J. Biol. Chem. , vol.282 , pp. 3014-3026
    • Chattopadhyay, S.1    Tracy, E.2    Liang, P.3    Robledo, O.4    Rose-John, S.5    Baumann, H.6
  • 10
    • 0032537503 scopus 로고    scopus 로고
    • Regulation of the type II oncostatin M receptor expression in lung- Derived epithelial cells
    • DOI 10.1016/S0014-5793(98)00643-7, PII S0014579398006437
    • Cichy, J., Rose-John, S., and Pure, E. (1998). Regulation of the Type II OSM receptor expression in human lung-derived epithelial cells. FEBS Lett. 429, 412-416. (Pubitemid 28300403)
    • (1998) FEBS Letters , vol.429 , Issue.3 , pp. 412-416
    • Cichy, J.1    Rose-John, S.2    Pure, E.3
  • 11
    • 0035836645 scopus 로고    scopus 로고
    • Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain
    • Constantinescu, S. N., Keren, T., Socolovsky, M., Nam, H., Henis, Y. I., and Lodish, H. F. (2001). Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain. Proc. Natl. Acad. Sci. USA 98, 4379-4384.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 4379-4384
    • Constantinescu, S.N.1    Keren, T.2    Socolovsky, M.3    Nam, H.4    Henis, Y.I.5    Lodish, H.F.6
  • 12
    • 33644821241 scopus 로고    scopus 로고
    • IL-2 and IL-15 exhibit opposing effects on Fas mediated apoptosis
    • Demirci, G., and Li, X. C. (2004). IL-2 and IL-15 exhibit opposing effects on Fas mediated apoptosis. Cell. Mol. Immunol. 1, 123-128.
    • (2004) Cell. Mol. Immunol. , vol.1 , pp. 123-128
    • Demirci, G.1    Li, X.C.2
  • 13
    • 3242798310 scopus 로고    scopus 로고
    • Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
    • Dillon, S. R., et al. (2004). Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat. Immunol. 5, 752-760.
    • (2004) Nat. Immunol. , vol.5 , pp. 752-760
    • Dillon, S.R.1
  • 14
    • 47949104013 scopus 로고    scopus 로고
    • How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: Lessons from interleukin-15 (IL-15)/IL-15 receptor alpha
    • Duitman, E. H., Orinska, Z., Bulanova, E., Paus, R., and Bulfone-Paus, S. (2008). How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha. Mol. Cell. Biol. 28, 4851-4861.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 4851-4861
    • Duitman, E.H.1    Orinska, Z.2    Bulanova, E.3    Paus, R.4    Bulfone-Paus, S.5
  • 17
    • 85047682496 scopus 로고    scopus 로고
    • Receptor dimerization in GH and erythropoietin action-it takes two to tango, but how?
    • Frank, S. J. (2002). Receptor dimerization in GH and erythropoietin action-it takes two to tango, but how? Endocrinology 143, 2-10.
    • (2002) Endocrinology , vol.143 , pp. 2-10
    • Frank, S.J.1
  • 18
    • 0027958212 scopus 로고
    • Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor
    • Gearing, D. P., Ziegler, S. F., Comeau, M. R., Friend, D., Thoma, B., Cosman, D., Park, L., and Mosley, B. (1994). Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. Proc. Natl. Acad. Sci. USA 91, 1119-1123.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 1119-1123
    • Gearing, D.P.1    Ziegler, S.F.2    Comeau, M.R.3    Friend, D.4    Thoma, B.5    Cosman, D.6    Park, L.7    Mosley, B.8
  • 20
    • 0037178889 scopus 로고    scopus 로고
    • Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling
    • Greiser, J. S., Stross, C., Heinrich, P. C., Behrmann, I., and Hermanns, H. M. (2002). Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling. J. Biol. Chem. 277, 26959-26965.
    • (2002) J. Biol. Chem. , vol.277 , pp. 26959-26965
    • Greiser, J.S.1    Stross, C.2    Heinrich, P.C.3    Behrmann, I.4    Hermanns, H.M.5
  • 23
    • 0030045122 scopus 로고    scopus 로고
    • IL-6 cytokine family and signal transduction: A model of the cytokine system
    • Hibi, M., Nakajima, K., and Hirano, T. (1996). IL-6 cytokine family and signal transduction: a model of the cytokine system. J. Mol. Med. 74, 1-12.
    • (1996) J. Mol. Med. , vol.74 , pp. 1-12
    • Hibi, M.1    Nakajima, K.2    Hirano, T.3
  • 24
    • 23844445451 scopus 로고    scopus 로고
    • Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling
    • Jenkins, B. J., et al. (2005). Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling. Nat. Med. 11, 845-852.
    • (2005) Nat. Med. , vol.11 , pp. 845-852
    • Jenkins, B.J.1
  • 26
    • 0036236631 scopus 로고    scopus 로고
    • Enhanced transgene expression in primitive hematopoietic progenitor cells and embryonic stem cells efficiently transduced by optimized retroviral hybrid vectors
    • Ketteler, R., Glaser, S., Sandra, O., Martens, U. M., and Klingmuller, U. (2002). Enhanced transgene expression in primitive hematopoietic progenitor cells and embryonic stem cells efficiently transduced by optimized retroviral hybrid vectors. Gene Ther. 9, 477-487.
    • (2002) Gene Ther. , vol.9 , pp. 477-487
    • Ketteler, R.1    Glaser, S.2    Sandra, O.3    Martens, U.M.4    Klingmuller, U.5
  • 27
    • 0012263559 scopus 로고    scopus 로고
    • Seeing the light: Preassembly and ligand-induced changes of the interferon gamma receptor complex in cells
    • Krause, C. D., Mei, E., Xie, J., Jia, Y., Bopp, M. A., Hochstrasser, R. M., and Pestka, S. (2002). Seeing the light: preassembly and ligand-induced changes of the interferon gamma receptor complex in cells. Mol. Cell. Proteom. 1, 805-815.
    • (2002) Mol. Cell. Proteom. , vol.1 , pp. 805-815
    • Krause, C.D.1    Mei, E.2    Xie, J.3    Jia, Y.4    Bopp, M.A.5    Hochstrasser, R.M.6    Pestka, S.7
  • 29
    • 0033548259 scopus 로고    scopus 로고
    • Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
    • DOI 10.1126/science.283.5404.987
    • Livnah, O., Stura, E. A., Middleton, S. A., Johnson, D. L., Jolliffe, L. K., and Wilson, I. A. (1999). Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 283, 987-990. (Pubitemid 29100256)
    • (1999) Science , vol.283 , Issue.5404 , pp. 987-990
    • Livnah, O.1    Stura, E.A.2    Middleton, S.A.3    Johnson, D.L.4    Jolliffe, L.K.5    Wilson, I.A.6
  • 30
    • 33646580769 scopus 로고    scopus 로고
    • The structure of the interleukin-15 alpha receptor and its implications for ligand binding
    • Lorenzen, I., Dingley, A. J., Jacques, Y., and Grotzinger, J. (2006). The structure of the interleukin-15 alpha receptor and its implications for ligand binding. J. Biol. Chem. 281, 6642-6647.
    • (2006) J. Biol. Chem. , vol.281 , pp. 6642-6647
    • Lorenzen, I.1    Dingley, A.J.2    Jacques, Y.3    Grotzinger, J.4
  • 31
    • 0033012030 scopus 로고    scopus 로고
    • An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    • Lutz, M. B., Kukutsch, N., Ogilvie, A. L., Rössner, S., Koch, F., Romani, N., and Schuler, G. (1999). An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223, 77-92.
    • (1999) J. Immunol. Methods , vol.223 , pp. 77-92
    • Lutz, M.B.1    Kukutsch, N.2    Ogilvie, A.L.3    Rössner, S.4    Koch, F.5    Romani, N.6    Schuler, G.7
  • 32
    • 33644975335 scopus 로고    scopus 로고
    • Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma hyperagonist IL-15 x IL-15R alpha fusion proteins
    • Mortier, E., Quemener, A., Vusio, P., Lorenzen, I., Boublik, Y., Grotzinger, J., Plet, A., and Jacques, Y. (2006). Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma hyperagonist IL-15 x IL-15R alpha fusion proteins. J. Biol. Chem. 281, 1612-1619.
    • (2006) J. Biol. Chem. , vol.281 , pp. 1612-1619
    • Mortier, E.1    Quemener, A.2    Vusio, P.3    Lorenzen, I.4    Boublik, Y.5    Grotzinger, J.6    Plet, A.7    Jacques, Y.8
  • 33
    • 0024384644 scopus 로고
    • Preferential heterodimer formation by isolated leucine zippers from fos and jun
    • O'Shea, E. K., Rutkowski, R., Stafford, W. F., and Kim, P. S. (1989). Preferential heterodimer formation by isolated leucine zippers from fos and jun. Science 245, 646-648.
    • (1989) Science , vol.245 , pp. 646-648
    • O'Shea, E.K.1    Rutkowski, R.2    Stafford, W.F.3    Kim, P.S.4
  • 34
    • 49149127436 scopus 로고    scopus 로고
    • STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production
    • Owaki, T., Asakawa, M., Morishima, N., Mizoguchi, I., Fukai, F., Takeda, K., Mizuguchi, J., and Yoshimoto, T. (2008). STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production. J. Immunol. 180, 2903-2911.
    • (2008) J. Immunol. , vol.180 , pp. 2903-2911
    • Owaki, T.1    Asakawa, M.2    Morishima, N.3    Mizoguchi, I.4    Fukai, F.5    Takeda, K.6    Mizuguchi, J.7    Yoshimoto, T.8
  • 35
    • 0029804197 scopus 로고    scopus 로고
    • Functional replacement of cytokine receptor extracellular domains by leucine zippers
    • Patel, N., Herrman, J. M., Timans, J. C., and Katelein, R. A. (1996). Functional replacement of cytokine receptor extracellular domains by leucine zippers. J. Biol. Chem. 271, 30386-30391.
    • (1996) J. Biol. Chem. , vol.271 , pp. 30386-30391
    • Patel, N.1    Herrman, J.M.2    Timans, J.C.3    Katelein, R.A.4
  • 38
    • 0034669993 scopus 로고    scopus 로고
    • Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6 independent phenotype by murine plasmacytomas and hybridomas
    • Rawat, R., Rainey, G. J., Thompson, C. D., Frazier-Jessen, M. R., Brown, R. T., and Nordan, R. P. (2000). Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6 independent phenotype by murine plasmacytomas and hybridomas. Blood 96, 3514-3521.
    • (2000) Blood , vol.96 , pp. 3514-3521
    • Rawat, R.1    Rainey, G.J.2    Thompson, C.D.3    Frazier-Jessen, M.R.4    Brown, R.T.5    Nordan, R.P.6
  • 40
    • 0033548048 scopus 로고    scopus 로고
    • Erythropoietin receptor activation by a ligand-induced conformation change
    • Remy, I., Wilson, I. A., and Michnick, S. W. (1999). Erythropoietin receptor activation by a ligand-induced conformation change. Science 283, 990-993.
    • (1999) Science , vol.283 , pp. 990-993
    • Remy, I.1    Wilson, I.A.2    Michnick, S.W.3
  • 42
    • 0037434888 scopus 로고    scopus 로고
    • The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane
    • Schuster, B., Meinert, W., Rose-John, S., and Kallen, K.-J. (2003). The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane. FEBS Lett. 538, 113-116.
    • (2003) FEBS Lett. , vol.538 , pp. 113-116
    • Schuster, B.1    Meinert, W.2    Rose-John, S.3    Kallen, K.-J.4
  • 43
    • 4944250270 scopus 로고    scopus 로고
    • Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy
    • Selander, K. S., Li, L., Watson, L., Merrell, M., Dahmen, H., Heinrich, P. C., Muller-Newen, G., and Harris, K. W. (2004). Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy. Cancer Res. 64, 6924-6933.
    • (2004) Cancer Res. , vol.64 , pp. 6924-6933
    • Selander, K.S.1    Li, L.2    Watson, L.3    Merrell, M.4    Dahmen, H.5    Heinrich, P.C.6    Muller-Newen, G.7    Harris, K.W.8
  • 44
    • 22444442637 scopus 로고    scopus 로고
    • Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor
    • Skiniotis, G., Boulanger, M. J., Garcia, K. C., and Walz, T. (2005). Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nat. Struct. Mol. Biol. 12, 545-551.
    • (2005) Nat. Struct. Mol. Biol. , vol.12 , pp. 545-551
    • Skiniotis, G.1    Boulanger, M.J.2    Garcia, K.C.3    Walz, T.4
  • 45
    • 50249158577 scopus 로고    scopus 로고
    • Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex
    • Skiniotis, G., Lupardus, P. J., Martick, M., Walz, T., and Garcia, K. C. (2008). Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Mol. Cell 31, 737-748.
    • (2008) Mol. Cell , vol.31 , pp. 737-748
    • Skiniotis, G.1    Lupardus, P.J.2    Martick, M.3    Walz, T.4    Garcia, K.C.5
  • 47
    • 0030890718 scopus 로고    scopus 로고
    • gp130 and the interleukin-6 family of cytokines
    • Taga, T., and Kishimoto, T. (1997). gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 15, 797-819.
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 797-819
    • Taga, T.1    Kishimoto, T.2
  • 49
    • 70350455062 scopus 로고    scopus 로고
    • The beta-secretase enzyme BACE in health and Alzheimer's disease: Regulation, cell biology, function, and therapeutic potential
    • Vassar, R., Kovacs, D. M., Yan, R., and Wong, P. C. (2009). The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. J. Neurosci. 29, 12787-12794.
    • (2009) J. Neurosci. , vol.29 , pp. 12787-12794
    • Vassar, R.1    Kovacs, D.M.2    Yan, R.3    Wong, P.C.4
  • 50
    • 27944505913 scopus 로고    scopus 로고
    • Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors
    • Wang, X., Rickert, M., and Garcia, K. C. (2005). Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science 310, 1159-1163.
    • (2005) Science , vol.310 , pp. 1159-1163
    • Wang, X.1    Rickert, M.2    Garcia, K.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.