Structure-function studies of interleukin 15 using site-specific mutagenesis, polyethylene glycol conjugation, and homology modeling

Journal of Biological Chemistry

Volumn 272, Issue 4, 1997, Pages 2312-2318

  Pettit, Dean K ^a   Bonnert, Timothy P ^a   Eisenman, June ^a   Srinivasan, Subhashini ^a   Paxton, Ray ^a   Beers, Courtney ^a   Lynch, Dave ^a   Miller, Bob ^a   Yost, Jeff ^a   Grabstein, Kenneth H ^a,b   Gombotz, Wayne R ^a  

^a AMGEN INC   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 15; MACROGOL; RECOMBINANT INTERLEUKIN 15;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; HALF LIFE TIME; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE ACTIVATION; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; INTERLEUKIN-15; INTERLEUKIN-2; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLYETHYLENE GLYCOLS; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15644362966     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.4.2312     Document Type: Article

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