메뉴 건너뛰기




Volumn 28, Issue 4, 2006, Pages 362-377

The interleukin-15/interleukin-15 receptor system as a model for juxtacrine and reverse signaling

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; JANUS KINASE 1; JANUS KINASE 3; MESSENGER RNA; PROTEIN KINASE SYK; STAT3 PROTEIN; STAT5 PROTEIN; STAT6 PROTEIN; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

EID: 33645833872     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.20380     Document Type: Review
Times cited : (59)

References (102)
  • 1
    • 4344694114 scopus 로고    scopus 로고
    • Ligands working as receptors: Reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system
    • Eissner G, Kolch W, Schneurich P. 2004. Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system. Cytokine Growth Factor Rev 15:353-366.
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 353-366
    • Eissner, G.1    Kolch, W.2    Schneurich, P.3
  • 2
    • 0041669478 scopus 로고    scopus 로고
    • 'Eph'ective signaling: Forward, reverse and crosstalk
    • Murai KK, Pasquale EB. 2003. 'Eph'ective signaling: forward, reverse and crosstalk. J Cell Sci 116:2823-2832.
    • (2003) J Cell Sci , vol.116 , pp. 2823-2832
    • Murai, K.K.1    Pasquale, E.B.2
  • 3
    • 0003735986 scopus 로고    scopus 로고
    • Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, editors. Philadelphia: W.B. Saunders Company
    • th Edition. Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, editors. Philadelphia: W.B. Saunders Company, 2003.
    • (2003) th Edition
  • 4
    • 0347364681 scopus 로고    scopus 로고
    • Membrane-associated IL-1 contributes to chronic synovitis and cartilage destruction in human IL-1 alpha transgenic mice
    • Niki Y, Yamada H, Kikuchi T, Toyama Y, Matsumoto H, et al. 2004. Membrane-associated IL-1 contributes to chronic synovitis and cartilage destruction in human IL-1 alpha transgenic mice. J Immunol 172:577-584.
    • (2004) J Immunol , vol.172 , pp. 577-584
    • Niki, Y.1    Yamada, H.2    Kikuchi, T.3    Toyama, Y.4    Matsumoto, H.5
  • 5
    • 1442306085 scopus 로고    scopus 로고
    • The precursor form of IL-1α is an intracrine proinflamatory activator of transcription
    • Werman A, Werman R, White R, Lee J-K, Werman B, et al. 2004. The precursor form of IL-1α is an intracrine proinflamatory activator of transcription. Proc Natl Acad Sci USA 101:2434-2439.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2434-2439
    • Werman, A.1    Werman, R.2    White, R.3    Lee, J.-K.4    Werman, B.5
  • 6
    • 0034660144 scopus 로고    scopus 로고
    • Reverse signaling through transmembrane TNF confers resistance to lipopolysaccharide in human monocytes and macrophages
    • Eissner G, Kirchner H, Kolch W, Janosch P, Grell M, et al. 2000. Reverse signaling through transmembrane TNF confers resistance to lipopolysaccharide in human monocytes and macrophages. J Immunol 164:6193-6198.
    • (2000) J Immunol , vol.164 , pp. 6193-6198
    • Eissner, G.1    Kirchner, H.2    Kolch, W.3    Janosch, P.4    Grell, M.5
  • 7
    • 0035164182 scopus 로고    scopus 로고
    • Outside-to-inside signal through the membrane TNF-α induces E-selectin (CD62E) expression on activated human CD4+ T cells
    • Harashima S, Horiuchi T, Hatta N, Morita C, Higuchi M, et al. 2001. Outside-to-inside signal through the membrane TNF-α induces E-selectin (CD62E) expression on activated human CD4+ T cells. J Immunol 166:130-136.
    • (2001) J Immunol , vol.166 , pp. 130-136
    • Harashima, S.1    Horiuchi, T.2    Hatta, N.3    Morita, C.4    Higuchi, M.5
  • 8
  • 9
    • 0031570007 scopus 로고    scopus 로고
    • Bidirectional regulation of human B cell responses by CD40-CD40 ligand interactions
    • Miyashita T, McIlraith MJ, Grammer AC, Miura Y, Attrep JF, et al. 1997. Bidirectional Regulation of Human B Cell Responses by CD40-CD40 Ligand Interactions. J Immunol 158:4620-4633.
    • (1997) J Immunol , vol.158 , pp. 4620-4633
    • Miyashita, T.1    McIlraith, M.J.2    Grammer, A.C.3    Miura, Y.4    Attrep, J.F.5
  • 10
    • 0029045255 scopus 로고
    • Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells
    • Stuber E, Neurath M, Calderhead D, Fell HP, Strober W. 1995. Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity 2:507-521.
    • (1995) Immunity , vol.2 , pp. 507-521
    • Stuber, E.1    Neurath, M.2    Calderhead, D.3    Fell, H.P.4    Strober, W.5
  • 11
    • 0032032236 scopus 로고    scopus 로고
    • CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bi-directional signaling
    • Langstein J, Michel J, Fritsche J, Kreutz M, Andereesen R, et al. 1998. CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bi-directional signaling. J Immunol 160:2488-2494.
    • (1998) J Immunol , vol.160 , pp. 2488-2494
    • Langstein, J.1    Michel, J.2    Fritsche, J.3    Kreutz, M.4    Andereesen, R.5
  • 12
    • 0032708836 scopus 로고    scopus 로고
    • Fas ligand: Receptor or ligand
    • Newell MK, Desbarats J. 1999. Fas ligand: receptor or ligand. Apoptosis 4:311-315.
    • (1999) Apoptosis , vol.4 , pp. 311-315
    • Newell, M.K.1    Desbarats, J.2
  • 13
    • 0028790434 scopus 로고
    • CD40 ligand-transduced costimulation of T cells in the development of helper function
    • van Essen D, Kikutani H, Gray D. 1995. CD40 ligand-transduced costimulation of T cells in the development of helper function. Nature 378:620-623.
    • (1995) Nature , vol.378 , pp. 620-623
    • Essen, D.1    Kikutani, H.2    Gray, D.3
  • 14
    • 0035167691 scopus 로고    scopus 로고
    • Enhanced secretion of IFN-gamma by activated Th1 cells occurs via reverse signaling through TNF-related activation-induced cytokine
    • Chen NJ, Huang MW, Hsien SL. 2001. Enhanced secretion of IFN-gamma by activated Th1 cells occurs via reverse signaling through TNF-related activation-induced cytokine. J Immunol 166:270-276.
    • (2001) J Immunol , vol.166 , pp. 270-276
    • Chen, N.J.1    Huang, M.W.2    Hsien, S.L.3
  • 15
    • 17644389199 scopus 로고    scopus 로고
    • TNF/TNFR family members in costimulation of T cell responses
    • Watts TH. 2005. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 23:23-68.
    • (2005) Annu Rev Immunol , vol.23 , pp. 23-68
    • Watts, T.H.1
  • 16
    • 0037114186 scopus 로고    scopus 로고
    • A TNF family member LIGHT transduces costimulatory signals into human T cells
    • Wan X, Zhang J, Luo H, Shi G, Kapnik E, et al. 2002. A TNF family member LIGHT transduces costimulatory signals into human T cells. J Immunol 169:6813-6821.
    • (2002) J Immunol , vol.169 , pp. 6813-6821
    • Wan, X.1    Zhang, J.2    Luo, H.3    Shi, G.4    Kapnik, E.5
  • 17
    • 0033560764 scopus 로고    scopus 로고
    • A casein kinase I motif present in the cytoplasmatic domain of members of the tumor necrosis factor ligand family is implicated in "reverse signaling"
    • Watts AD, Hunt NH, Wanigasekara Y, Bloomfield G, Wallash D, et al. 1999. A casein kinase I motif present in the cytoplasmatic domain of members of the tumor necrosis factor ligand family is implicated in "reverse signaling". EMBO J 18:2119-2126.
    • (1999) EMBO J , vol.18 , pp. 2119-2126
    • Watts, A.D.1    Hunt, N.H.2    Wanigasekara, Y.3    Bloomfield, G.4    Wallash, D.5
  • 18
    • 0028179054 scopus 로고
    • Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
    • Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, et al. 1994. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 264:965-968.
    • (1994) Science , vol.264 , pp. 965-968
    • Grabstein, K.H.1    Eisenman, J.2    Shanebeck, K.3    Rauch, C.4    Srinivasan, S.5
  • 19
    • 0028276796 scopus 로고
    • A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells
    • Burton JD, Bamford RN, Peters C, Grant AJ, Kurys G, et al. 1994. A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci USA 91:4935-4939.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4935-4939
    • Burton, J.D.1    Bamford, R.N.2    Peters, C.3    Grant, A.J.4    Kurys, G.5
  • 20
    • 0025162844 scopus 로고
    • Structural design and molecular evolution of a cytokine receptor superfamily
    • Bazan JF. 1990. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 87:6934-6938.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6934-6938
    • Bazan, J.F.1
  • 21
    • 0642343623 scopus 로고    scopus 로고
    • Genomic structure and chromosomal localization of the human interleukin 15 gene (IL-15)
    • Krause H, Jandrig B, Wenicke C, Bulfone-Paus S, Pohl T, et al. 1996. Genomic structure and chromosomal localization of the human interleukin 15 gene (IL-15). Cytokine 8:667-674.
    • (1996) Cytokine , vol.8 , pp. 667-674
    • Krause, H.1    Jandrig, B.2    Wenicke, C.3    Bulfone-Paus, S.4    Pohl, T.5
  • 23
    • 0036569006 scopus 로고    scopus 로고
    • Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15
    • Briard D, Brouty-Boye D, Azzarone B, Jasmin C. 2002. Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15. J Immunol 168:4326-4632.
    • (2002) J Immunol , vol.168 , pp. 4326-4632
    • Briard, D.1    Brouty-Boye, D.2    Azzarone, B.3    Jasmin, C.4
  • 24
    • 0034663951 scopus 로고    scopus 로고
    • Inhibition of keratinocyte apoptosis by IL-15: A new parameter in the pathogenesis of psoriasis?
    • Ruckert R, Asadullah K, Seifert M, Budagian V, Arnold R, et al. 2000. Inhibition of keratinocyte apoptosis by IL-15: a new parameter in the pathogenesis of psoriasis? J Immunol 165:2240-2250.
    • (2000) J Immunol , vol.165 , pp. 2240-2250
    • Ruckert, R.1    Asadullah, K.2    Seifert, M.3    Budagian, V.4    Arnold, R.5
  • 26
    • 0030032290 scopus 로고    scopus 로고
    • Induction and regulation of IL-15 expression in murine macrophages
    • Doherty TM, Seder RA, Sher A. 1996. Induction and regulation of IL-15 expression in murine macrophages. J Immunol 156:735-741.
    • (1996) J Immunol , vol.156 , pp. 735-741
    • Doherty, T.M.1    Seder, R.A.2    Sher, A.3
  • 27
    • 0035423390 scopus 로고    scopus 로고
    • IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysacchride and promotes dendritic cell activation
    • Mattel F, Schiavoni G, Belardelli F, Tough DF. 2001. IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysacchride and promotes dendritic cell activation. J Immunol 167:1179-1187.
    • (2001) J Immunol , vol.167 , pp. 1179-1187
    • Mattel, F.1    Schiavoni, G.2    Belardelli, F.3    Tough, D.F.4
  • 28
    • 0033562382 scopus 로고    scopus 로고
    • Human monocytes constitutively express membrane-bound, biologically active, and interferon-γ-upregulated interleukin-15
    • Musso T, Calosso L, Zucca M, Millesimo M, Ravarino D, et al. 1999. Human monocytes constitutively express membrane-bound, biologically active, and interferon-γ-upregulated interleukin-15. Blood 93: 3531-3539.
    • (1999) Blood , vol.93 , pp. 3531-3539
    • Musso, T.1    Calosso, L.2    Zucca, M.3    Millesimo, M.4    Ravarino, D.5
  • 29
    • 0032485317 scopus 로고    scopus 로고
    • Interleukin-15, a T-cell growth factor, is expressed in human neural cell lines and tissues
    • Satoh J, Kurohara K, Yukitake M, Kuroda Y. 1998. Interleukin-15, a T-cell growth factor, is expressed in human neural cell lines and tissues. J Neurol Sci 155:170-177.
    • (1998) J Neurol Sci , vol.155 , pp. 170-177
    • Satoh, J.1    Kurohara, K.2    Yukitake, M.3    Kuroda, Y.4
  • 30
    • 0029098563 scopus 로고
    • IL-15: A novel anabolic cytokine for skeletal muscle
    • Quinn LS, Haugk KL, Grabstein KH. 1995. IL-15: a novel anabolic cytokine for skeletal muscle. Endocrinology 136:3669-3672.
    • (1995) Endocrinology , vol.136 , pp. 3669-3672
    • Quinn, L.S.1    Haugk, K.L.2    Grabstein, K.H.3
  • 31
    • 0346752119 scopus 로고    scopus 로고
    • Dendritic cell-derived IL-15 controls the induction of CD8 T cell immune responses
    • Rückert R, Brandt K, Bulanova E, Mirghomizadeh F, Paus R, et al. 2003. Dendritic cell-derived IL-15 controls the induction of CD8 T cell immune responses. Eur J Immunol 33:3493-3503.
    • (2003) Eur J Immunol , vol.33 , pp. 3493-3503
    • Rückert, R.1    Brandt, K.2    Bulanova, E.3    Mirghomizadeh, F.4    Paus, R.5
  • 32
    • 0034730641 scopus 로고    scopus 로고
    • The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15
    • Kurys G, Tagaya Y, Bamford R, Hanover JA, Waldmann TA. 2000. The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15. J Biol Chem 275:30653-30659.
    • (2000) J Biol Chem , vol.275 , pp. 30653-30659
    • Kurys, G.1    Tagaya, Y.2    Bamford, R.3    Hanover, J.A.4    Waldmann, T.A.5
  • 33
    • 0032911060 scopus 로고    scopus 로고
    • Differential intracellular trafficking, secretion and endosomal localization of two IL-15 isoforms
    • Gaggero A, Azzarone B, Andrei C, Mishal Z, Meazza R, et al. 1999. Differential intracellular trafficking, secretion and endosomal localization of two IL-15 isoforms. Eur J Immunol 29:1265-1274.
    • (1999) Eur J Immunol , vol.29 , pp. 1265-1274
    • Gaggero, A.1    Azzarone, B.2    Andrei, C.3    Mishal, Z.4    Meazza, R.5
  • 34
    • 0030047144 scopus 로고    scopus 로고
    • Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines
    • Meazza R, Verdiani S, Biassoni R, Coppolecchia M, Gaggero A, et al. 1996. Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines. Oncogene 12:255-262.
    • (1996) Oncogene , vol.12 , pp. 255-262
    • Meazza, R.1    Verdiani, S.2    Biassoni, R.3    Coppolecchia, M.4    Gaggero, A.5
  • 35
    • 0032506693 scopus 로고    scopus 로고
    • Alternative splicing of mouse IL-15 is due to the use of internal splice site in exon 5
    • Prinz M, Hanisch UK, Kettenmann H, Kirchhoff F. 1998. Alternative splicing of mouse IL-15 is due to the use of internal splice site in exon 5. Brain Res Mol Brain Res 63:155-162.
    • (1998) Brain Res Mol Brain Res , vol.63 , pp. 155-162
    • Prinz, M.1    Hanisch, U.K.2    Kettenmann, H.3    Kirchhoff, F.4
  • 36
    • 0033046593 scopus 로고    scopus 로고
    • The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
    • Waldmann TA, Tagaya Y. 1999. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol 17:19-49.
    • (1999) Annu Rev Immunol , vol.17 , pp. 19-49
    • Waldmann, T.A.1    Tagaya, Y.2
  • 37
    • 0035169507 scopus 로고    scopus 로고
    • Interleukin 15: Biology and relevance to human disease
    • Fehninger TA, Caligiuri MA. 2001. Interleukin 15: biology and relevance to human disease. Blood 97:14-32.
    • (2001) Blood , vol.97 , pp. 14-32
    • Fehninger, T.A.1    Caligiuri, M.A.2
  • 38
    • 0030008255 scopus 로고    scopus 로고
    • Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I R region/IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 mRNA translation
    • Bamford RN, Battiata AP, Burton JD, Sharma H, Waldmann TA. 1996. Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I R region/IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 mRNA translation. Proc Natl Acad Sci USA 93:2897-2902.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2897-2902
    • Bamford, R.N.1    Battiata, A.P.2    Burton, J.D.3    Sharma, H.4    Waldmann, T.A.5
  • 39
    • 0032080666 scopus 로고    scopus 로고
    • The 5′UTR, signal peptide and 3′ coding sequences of IL-15 participate in its multifaceted translational control
    • Bamford RN, DeFilippis AP, Azimi N, Kurys G, Waldmann TA. 1998. The 5′UTR, signal peptide and 3′ coding sequences of IL-15 participate in its multifaceted translational control. J Immunol 160: 4418-4426.
    • (1998) J Immunol , vol.160 , pp. 4418-4426
    • Bamford, R.N.1    Defilippis, A.P.2    Azimi, N.3    Kurys, G.4    Waldmann, T.A.5
  • 40
    • 0030639208 scopus 로고    scopus 로고
    • Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms
    • Onu A, Pohl T, Krause H, Bulfone-Paus S. 1997. Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms. J Immunol 158: 255-262.
    • (1997) J Immunol , vol.158 , pp. 255-262
    • Onu, A.1    Pohl, T.2    Krause, H.3    Bulfone-Paus, S.4
  • 41
    • 11244262365 scopus 로고    scopus 로고
    • A novel autoregulatory mechanism for transcriptional activation of the IL-15 gene by a nonsecretable isoform of IL-15 generated by alternative splicing
    • Nishimura H, Fujimoto A, Tamura N, Yajima T, Wajjwalku W, et al. 2005. A novel autoregulatory mechanism for transcriptional activation of the IL-15 gene by a nonsecretable isoform of IL-15 generated by alternative splicing. FASEB J 19:19-28.
    • (2005) FASEB J , vol.19 , pp. 19-28
    • Nishimura, H.1    Fujimoto, A.2    Tamura, N.3    Yajima, T.4    Wajjwalku, W.5
  • 42
    • 0034718756 scopus 로고    scopus 로고
    • IL-15/IL-15Rα intracellular trafficking in human melanoma cells and signal transduction through the IL-15Rα
    • Pereno R, Giron-Michel J, Gaggero A, Cazes E, Meazza R, et al. 2000. IL-15/IL-15Rα intracellular trafficking in human melanoma cells and signal transduction through the IL-15Rα. Oncogene 19:5153-5162.
    • (2000) Oncogene , vol.19 , pp. 5153-5162
    • Pereno, R.1    Giron-Michel, J.2    Gaggero, A.3    Cazes, E.4    Meazza, R.5
  • 43
    • 0035500282 scopus 로고    scopus 로고
    • Lipopolysaccharide-stimulated or granulocyte-macrophage colony-stimulating factor-stimulated monocytes rapidly express biologically active IL-15 on their cell surface independent of new protein synthesis
    • Neely GG, Robins SM, Amankwah EK, Epelman S, Wong H, et al. 2001. Lipopolysaccharide-stimulated or granulocyte-macrophage colony-stimulating factor-stimulated monocytes rapidly express biologically active IL-15 on their cell surface independent of new protein synthesis. J Immunol 167:5011-5017.
    • (2001) J Immunol , vol.167 , pp. 5011-5017
    • Neely, G.G.1    Robins, S.M.2    Amankwah, E.K.3    Epelman, S.4    Wong, H.5
  • 44
    • 0037219057 scopus 로고    scopus 로고
    • Post-transplant renal tubulitis: The recruitment, differentiation and persistence of intra-epithelial T cells
    • Robertson H, Kirby JA. 2003. Post-transplant renal tubulitis: the recruitment, differentiation and persistence of intra-epithelial T cells. Am J Transplant 3:3-10.
    • (2003) Am J Transplant , vol.3 , pp. 3-10
    • Robertson, H.1    Kirby, J.A.2
  • 45
    • 0028131273 scopus 로고
    • Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of IL-2 receptor
    • Carson WE, Giri JG, Lindemann MJ, Linett ML, Ahdieh M, et al. 1994. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of IL-2 receptor. J Exp Med 180:1395-1403.
    • (1994) J Exp Med , vol.180 , pp. 1395-1403
    • Carson, W.E.1    Giri, J.G.2    Lindemann, M.J.3    Linett, M.L.4    Ahdieh, M.5
  • 46
    • 0028221433 scopus 로고
    • Utilisation of beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15
    • Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein K, et al. 1994. Utilisation of beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J 13:2822-2830.
    • (1994) EMBO J , vol.13 , pp. 2822-2830
    • Giri, J.G.1    Ahdieh, M.2    Eisenman, J.3    Shanebeck, K.4    Grabstein, K.5
  • 47
    • 0029099146 scopus 로고
    • Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor
    • Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, et al. 1995. Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor. EMBO J 14: 3654-3653.
    • (1995) EMBO J , vol.14 , pp. 3654-13653
    • Giri, J.G.1    Kumaki, S.2    Ahdieh, M.3    Friend, D.J.4    Loomis, A.5
  • 48
    • 13344278015 scopus 로고
    • Functional characterization of the human interleukin-15 receptor α chain and close linkage of IL15RA and IL2RA genes
    • Anderson DM, Kumaki S, Ahdieh M, Bertles J, Tometsko M, et al. 1995. Functional characterization of the human interleukin-15 receptor α chain and close linkage of IL15RA and IL2RA genes. J Biol Chem 270:29862-29869.
    • (1995) J Biol Chem , vol.270 , pp. 29862-29869
    • Anderson, D.M.1    Kumaki, S.2    Ahdieh, M.3    Bertles, J.4    Tometsko, M.5
  • 49
    • 0033578642 scopus 로고    scopus 로고
    • Natural splicing of exon 2 of human interleukin-15 receptor α-chain mRNA in shortened form with a distinct pattern of expression
    • Dubois S, Magrangeas F, Lehours P, Raher S, Bernard J, et al. 1999. Natural splicing of exon 2 of human interleukin-15 receptor α-chain mRNA in shortened form with a distinct pattern of expression. J Biol Chem 274:26978-26984.
    • (1999) J Biol Chem , vol.274 , pp. 26978-26984
    • Dubois, S.1    Magrangeas, F.2    Lehours, P.3    Raher, S.4    Bernard, J.5
  • 50
    • 0038561082 scopus 로고    scopus 로고
    • Mast cells express novel functional interleukin-15 receptor α isoforms
    • Bulanova E, Budagian V, Orinska Z, Krause H, Paus R, et al. 2003. Mast cells express novel functional interleukin-15 receptor α isoforms. J Immunol 170:5045-5055.
    • (2003) J Immunol , vol.170 , pp. 5045-5055
    • Bulanova, E.1    Budagian, V.2    Orinska, Z.3    Krause, H.4    Paus, R.5
  • 51
    • 0032425822 scopus 로고    scopus 로고
    • Isoforms sorting and the creation of intracellular compartments
    • Gunning P, Weinberger R. 1998. Isoforms sorting and the creation of intracellular compartments. Auu Rev Cell Develop Biol 14:339-372.
    • (1998) Auu Rev Cell Develop Biol , vol.14 , pp. 339-372
    • Gunning, P.1    Weinberger, R.2
  • 52
    • 0032876816 scopus 로고    scopus 로고
    • Death deflected: IL-15 inhibits TNFα-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-ISRo chain
    • Bulfone-Paus S, Bulanova E, Pohl T, Budagian V, Dürkop H, et al. 1999. Death deflected: IL-15 inhibits TNFα-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-ISRo chain. FASEB J 13:1575-1585.
    • (1999) FASEB J , vol.13 , pp. 1575-1585
    • Bulfone-Paus, S.1    Bulanova, E.2    Pohl, T.3    Budagian, V.4    Dürkop, H.5
  • 53
    • 0029811474 scopus 로고    scopus 로고
    • Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells
    • Tagaya Y, Burton JD, Miyamoto Y, Waldmann TA. 1996. Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells. EMBO J 15:4928-4939.
    • (1996) EMBO J , vol.15 , pp. 4928-4939
    • Tagaya, Y.1    Burton, J.D.2    Miyamoto, Y.3    Waldmann, T.A.4
  • 54
    • 33645816631 scopus 로고    scopus 로고
    • The IL-15Rα chain signals through association with Syk in human B cells
    • Bulanova E, Budagian V, Pohl T, Krause H, Dürkop H, et al. 2001. The IL-15Rα chain signals through association with Syk in human B cells. J Immunol 170:5045-5055.
    • (2001) J Immunol , vol.170 , pp. 5045-5055
    • Bulanova, E.1    Budagian, V.2    Pohl, T.3    Krause, H.4    Dürkop, H.5
  • 55
    • 29244436892 scopus 로고    scopus 로고
    • A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cells death control
    • Budagian V, Bulanova E, Orinska Z, Thon L, Mamat U, et al. 2005. A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cells death control. EMBO J 24:4260-4270.
    • (2005) EMBO J , vol.24 , pp. 4260-4270
    • Budagian, V.1    Bulanova, E.2    Orinska, Z.3    Thon, L.4    Mamat, U.5
  • 56
    • 3042826228 scopus 로고    scopus 로고
    • Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: Importance of the IL-15Rα chain
    • Ratthe C, Girard D. 2004. Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Rα chain. J Leukoc Biol 76:162-168.
    • (2004) J Leukoc Biol , vol.76 , pp. 162-168
    • Ratthe, C.1    Girard, D.2
  • 57
    • 0029115522 scopus 로고
    • Tyrosine phosphorylation and activation of STAT 5, STAT 3, and Janus kinases by interleukin 2 and 15
    • Johnston JA, Bacon CM, Finbloom DS, Rees RC, Kaplan D, et al. 1995. Tyrosine phosphorylation and activation of STAT 5, STAT 3, and Janus kinases by interleukin 2 and 15. Proc Natl Acad Sci USA 92:8705-8709.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8705-8709
    • Johnston, J.A.1    Bacon, C.M.2    Finbloom, D.S.3    Rees, R.C.4    Kaplan, D.5
  • 58
    • 4644367922 scopus 로고    scopus 로고
    • Natural soluble interleukin-15Rα is generated by cleavage that involves the tumor necrosis factor-α-converting enzyme (TACE/ADAM 17)
    • Budagian V, Bulanova E, Orinska Z, Ludwig A, Rose-John S, et al. 2004. Natural soluble interleukin-15Rα is generated by cleavage that involves the tumor necrosis factor-α-converting enzyme (TACE/ADAM 17). J BiOl Chem 279:40368-40375.
    • (2004) J BiOl Chem , vol.279 , pp. 40368-40375
    • Budagian, V.1    Bulanova, E.2    Orinska, Z.3    Ludwig, A.4    Rose-John, S.5
  • 59
    • 3242776039 scopus 로고    scopus 로고
    • Natural, proteolytic release of a soluble form of human IL-15 receptor α-chain that behaves as a specific, high affinity IL-15 antagonist
    • Mortier E, Bernard J, Plet A, Jacques Y. 2004. Natural, proteolytic release of a soluble form of human IL-15 receptor α-chain that behaves as a specific, high affinity IL-15 antagonist. J Immunol 173:1681-1688.
    • (2004) J Immunol , vol.173 , pp. 1681-1688
    • Mortier, E.1    Bernard, J.2    Plet, A.3    Jacques, Y.4
  • 61
    • 0030239647 scopus 로고    scopus 로고
    • Two distinct stimulus-dependent pathways lead to production of soluble murine interleukin-4 receptor
    • Blum H, Wolf M, Enssle K, Rollinghoff M, Gessner A. 1996. Two distinct stimulus-dependent pathways lead to production of soluble murine interleukin-4 receptor. J Immunol 157:1846-1853.
    • (1996) J Immunol , vol.157 , pp. 1846-1853
    • Blum, H.1    Wolf, M.2    Enssle, K.3    Rollinghoff, M.4    Gessner, A.5
  • 62
    • 0034663825 scopus 로고    scopus 로고
    • TNF-induced shedding of TNF receptors in human polymorphonuclear leukocytes: Role of the 55-kDa TNF receptor and involvement of a membrane-bound and non-matrix metalloproteinase
    • Dri P, Gasparini C, Menegazzi R, Cramer R, Alberi L, et al. 2000. TNF-induced shedding of TNF receptors in human polymorphonuclear leukocytes: role of the 55-kDa TNF receptor and involvement of a membrane-bound and non-matrix metalloproteinase. J Immunol 165: 2165-2172.
    • (2000) J Immunol , vol.165 , pp. 2165-2172
    • Dri, P.1    Gasparini, C.2    Menegazzi, R.3    Cramer, R.4    Alberi, L.5
  • 63
    • 0042237924 scopus 로고    scopus 로고
    • The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion
    • Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, et al. 2003. The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood 102:1186-1195.
    • (2003) Blood , vol.102 , pp. 1186-1195
    • Hundhausen, C.1    Misztela, D.2    Berkhout, T.A.3    Broadway, N.4    Saftig, P.5
  • 64
    • 0032103993 scopus 로고    scopus 로고
    • Soluble IL-15 receptor α-chain administration prevents murine collagen-induced arthritis: A role for IL-15 in development of antigen-induced immunopathology
    • Ruchatz H, Leung BP, Wei XQ. McInnes IB, Liew FY. 1998. Soluble IL-15 receptor α-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology. J Immunol 160:5654-5660.
    • (1998) J Immunol , vol.160 , pp. 5654-5660
    • Ruchatz, H.1    Leung, B.P.2    Wei, X.Q.3    McInnes, I.B.4    Liew, F.Y.5
  • 65
    • 0034665543 scopus 로고    scopus 로고
    • Selective blockade of IL-15 by soluble IL-15 receptor α-chain enhances cardiac allograft survival
    • Smith SG, Bolton EM, Ruchatz H, Wei X, Liew FY, et al. 2000. Selective blockade of IL-15 by soluble IL-15 receptor α-chain enhances cardiac allograft survival. J Immunol 165:3444-3450.
    • (2000) J Immunol , vol.165 , pp. 3444-3450
    • Smith, S.G.1    Bolton, E.M.2    Ruchatz, H.3    Wei, X.4    Liew, F.Y.5
  • 66
    • 0035399559 scopus 로고    scopus 로고
    • The Sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo
    • Wei X, Orchardson M, Gracie JA, Leung BP, Gao B, et al. 2001. The Sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo. J Immunol 167:277-282.
    • (2001) J Immunol , vol.167 , pp. 277-282
    • Wei, X.1    Orchardson, M.2    Gracie, J.A.3    Leung, B.P.4    Gao, B.5
  • 67
    • 17844369481 scopus 로고    scopus 로고
    • Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo
    • Rückert R, Brandt K, Braun A, Hoymann H-G, Herz U, et al. 2005. Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo. J Immunol 174:5507-5515.
    • (2005) J Immunol , vol.174 , pp. 5507-5515
    • Rückert, R.1    Brandt, K.2    Braun, A.3    Hoymann, H.-G.4    Herz, U.5
  • 68
    • 2442605821 scopus 로고    scopus 로고
    • Interleukin-6 biology is coordinated by membrane bound and soluble receptors
    • Rose-John S. 2003. Interleukin-6 biology is coordinated by membrane bound and soluble receptors. Acta Biochem Pol 50:603-611.
    • (2003) Acta Biochem Pol , vol.50 , pp. 603-611
    • Rose-John, S.1
  • 69
    • 33644975335 scopus 로고    scopus 로고
    • Soluble IL-15Rα sushi as a selective and potent agonist of IL-15 action through IL-15Rβ/γ: Hyper agonist IL-15-IL-15Rα fusion proteins
    • Mortier E, Quemener A, Vusio P, Lorenzen I, Boublik Y, et al. 2006. Soluble IL-15Rα sushi as a selective and potent agonist of IL-15 action through IL-15Rβ/γ: hyper agonist IL-15-IL-15Rα fusion proteins. J Biol Chem 281:1612-1619.
    • (2006) J Biol Chem , vol.281 , pp. 1612-1619
    • Mortier, E.1    Quemener, A.2    Vusio, P.3    Lorenzen, I.4    Boublik, Y.5
  • 70
    • 11244261160 scopus 로고    scopus 로고
    • ADAMs: Key components in EGFR signaling and development
    • Blobel CP. 2005. ADAMs: key components in EGFR signaling and development. Nat Rev Mol Cell Biol 6:32-43.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 32-43
    • Blobel, C.P.1
  • 71
    • 0035102242 scopus 로고    scopus 로고
    • Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: Implication for immunotherapy
    • Waldmann TA, Dubois S, Tagaya Y. 2001. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implication for immunotherapy. Immunity 14:105-110.
    • (2001) Immunity , vol.14 , pp. 105-110
    • Waldmann, T.A.1    Dubois, S.2    Tagaya, Y.3
  • 74
    • 19344368323 scopus 로고    scopus 로고
    • The role of interleukin-15 receptor α: Trans-presentation, receptor component or both?
    • Schluns KS, Stoklasek T, Lefrançois L. 2005. The role of interleukin-15 receptor α: trans-presentation, receptor component or both? Int J Biochem Cell Biol 37:1567-1571.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 1567-1571
    • Schluns, K.S.1    Stoklasek, T.2    Lefrançois, L.3
  • 75
    • 0042266738 scopus 로고    scopus 로고
    • Breakdown of peripheral T-cell tolerance by chronic interleukin-15 elevation
    • Maekawa Y, Tsukumo S, Okada H, Kishihara K, Yasutomo K. 2003. Breakdown of peripheral T-cell tolerance by chronic interleukin-15 elevation. Transplantation 76:415-420.
    • (2003) Transplantation , vol.76 , pp. 415-420
    • Maekawa, Y.1    Tsukumo, S.2    Okada, H.3    Kishihara, K.4    Yasutomo, K.5
  • 76
    • 0034651023 scopus 로고    scopus 로고
    • Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma
    • Tinhofer I, Marschitz I, Henn T, EgIe A, Greil R. 2000. Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma. Blood 95:610-618.
    • (2000) Blood , vol.95 , pp. 610-618
    • Tinhofer, I.1    Marschitz, I.2    Henn, T.3    Egie, A.4    Greil, R.5
  • 77
    • 0031841871 scopus 로고    scopus 로고
    • Interleukin-15 activates proinflammatory and antimicrobial functions in polymorphonuclear cells
    • Musso T, Colosso L, Zucca M, Millesimo M, Piliti M, et al. 1998. Interleukin-15 activates proinflammatory and antimicrobial functions in polymorphonuclear cells. Infect Immunol 66:2640-2647.
    • (1998) Infect Immunol , vol.66 , pp. 2640-2647
    • Musso, T.1    Colosso, L.2    Zucca, M.3    Millesimo, M.4    Piliti, M.5
  • 78
    • 2642631748 scopus 로고    scopus 로고
    • Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans
    • Vasquez N, Walsh TJ, Friedman D, Chanock SJ, Lyman CA. 1998. Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans. Infect Immun 66:145-150.
    • (1998) Infect Immun , vol.66 , pp. 145-150
    • Vasquez, N.1    Walsh, T.J.2    Friedman, D.3    Chanock, S.J.4    Lyman, C.A.5
  • 79
    • 0034610970 scopus 로고    scopus 로고
    • Reversible defects in natural killer and memory CDS T cell lineage in interleukin-15 deficient mice
    • Kennedy MK, Glaccum M, Brown SN, Butz EA, Viney JL, et al. 2000. Reversible defects in natural killer and memory CDS T cell lineage in interleukin-15 deficient mice. J Exp Med 191:771-780.
    • (2000) J Exp Med , vol.191 , pp. 771-780
    • Kennedy, M.K.1    Glaccum, M.2    Brown, S.N.3    Butz, E.A.4    Viney, J.L.5
  • 80
    • 0032211699 scopus 로고    scopus 로고
    • IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
    • Lodolce JP, Boone DL, Chai S, Swain RE, Dassopoulos T, et al. 1998. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9:669-676.
    • (1998) Immunity , vol.9 , pp. 669-676
    • Lodolce, J.P.1    Boone, D.L.2    Chai, S.3    Swain, R.E.4    Dassopoulos, T.5
  • 81
    • 0037460058 scopus 로고    scopus 로고
    • Interleukin (IL)-15Rα-deficient natural killer cells survive in normal but not IL-15Rα-deficient mice
    • Koka R, Burkett PR, Chien M, Chai S, Chan F, et al. 2003. Interleukin (IL)-15Rα-deficient natural killer cells survive in normal but not IL-15Rα-deficient mice. J Exp Med 197:977-984.
    • (2003) J Exp Med , vol.197 , pp. 977-984
    • Koka, R.1    Burkett, P.R.2    Chien, M.3    Chai, S.4    Chan, F.5
  • 82
    • 0037124341 scopus 로고    scopus 로고
    • Interleukin 15 is required for proliferation of virus-specific memory CDs T cells
    • Becher TC, Wherry EJ, Boone D, Murali-Krishna K, Antia R, et al. 2002. Interleukin 15 is required for proliferation of virus-specific memory CDs T cells. J Exp Med 195:1541-1548.
    • (2002) J Exp Med , vol.195 , pp. 1541-1548
    • Becher, T.C.1    Wherry, E.J.2    Boone, D.3    Murali-Krishna, K.4    Antia, R.5
  • 83
    • 0034002818 scopus 로고    scopus 로고
    • Interleukin-15 and its impact on neutrophil function
    • Cassatella MA, McDonald PP. 2000. Interleukin-15 and its impact on neutrophil function. Curr Opin Hematol 7:174-177.
    • (2000) Curr Opin Hematol , vol.7 , pp. 174-177
    • Cassatella, M.A.1    McDonald, P.P.2
  • 84
    • 8944235345 scopus 로고    scopus 로고
    • Role of IL-15, IL-2, and their receptors in the development of T cell alveolitis in pulmonary sarcoidosis
    • Agostini C, Trentin L, Facco M, Sancetta R, Cerutti A, et al. 1996. Role of IL-15, IL-2, and their receptors in the development of T cell alveolitis in pulmonary sarcoidosis. J Immunol 157:910-918.
    • (1996) J Immunol , vol.157 , pp. 910-918
    • Agostini, C.1    Trentin, L.2    Facco, M.3    Sancetta, R.4    Cerutti, A.5
  • 85
    • 0031038352 scopus 로고    scopus 로고
    • Interleukin-15 triggers the proliferation and cytotoxicity of granular lymphocytes in patients with lymphoproliferative disease of granular lymphocytes
    • Zambello R, Facco M, Trentin L, Sancetta R, Tassinari C, et al. 1997. Interleukin-15 triggers the proliferation and cytotoxicity of granular lymphocytes in patients with lymphoproliferative disease of granular lymphocytes. Blood 89:201-211.
    • (1997) Blood , vol.89 , pp. 201-211
    • Zambello, R.1    Facco, M.2    Trentin, L.3    Sancetta, R.4    Tassinari, C.5
  • 86
    • 0035102242 scopus 로고    scopus 로고
    • IL-15Rα recycles and presents IL-15 in trans to neighboring cells
    • Waldmann TA, Dubois S, Tagaya Y. 2001. IL-15Rα recycles and presents IL-15 in trans to neighboring cells. Immunity 14:105-110.
    • (2001) Immunity , vol.14 , pp. 105-110
    • Waldmann, T.A.1    Dubois, S.2    Tagaya, Y.3
  • 87
    • 9144269943 scopus 로고    scopus 로고
    • Follicular dendritic cells produce IL-15 that enhances germinal center B cello proliferation in membrane-bound form
    • Park C-S, Yoon S-O, Armitage RJ, Choi YS. 2004. Follicular dendritic cells produce IL-15 that enhances germinal center B cello proliferation in membrane-bound form. J Immunol 173:6676-6683.
    • (2004) J Immunol , vol.173 , pp. 6676-6683
    • Park, C.-S.1    Yoon, S.-O.2    Armitage, R.J.3    Choi, Y.S.4
  • 88
    • 4644288343 scopus 로고    scopus 로고
    • Murine dendritic cells require IL-15Ra to prime NK cells
    • Koka R, Burkett P, Chien M, Chai S, Boone DL, et al. 2004. Murine dendritic cells require IL-15Ra to prime NK cells. J Immunol 173:3594-3598.
    • (2004) J Immunol , vol.173 , pp. 3594-3598
    • Koka, R.1    Burkett, P.2    Chien, M.3    Chai, S.4    Boone, D.L.5
  • 89
    • 11244255868 scopus 로고    scopus 로고
    • Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance
    • Kobayashi H, Dubois S, Sato N, Sabzevari H, Sakai Y, et al. 2005. Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance. Blood 105:721-727.
    • (2005) Blood , vol.105 , pp. 721-727
    • Kobayashi, H.1    Dubois, S.2    Sato, N.3    Sabzevari, H.4    Sakai, Y.5
  • 90
    • 9144241114 scopus 로고    scopus 로고
    • Transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15Rα by the same cells
    • Sandau MM, Schluns KS, Lefrançois L, Jameson SC. 2004. Transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15Rα by the same cells. J Immunol 173:6537-6541.
    • (2004) J Immunol , vol.173 , pp. 6537-6541
    • Sandau, M.M.1    Schluns, K.S.2    Lefrançois, L.3    Jameson, S.C.4
  • 91
    • 27144446158 scopus 로고    scopus 로고
    • Membrane-bound and soluble IL-15/IL-15Rα complexes display differential signaling and functions on human haematopoietic progenitors
    • Giron-Michel J, Guiliani M, Fogli M, Brouty-Boye D, Ferrini S, et al. 2005. Membrane-bound and soluble IL-15/IL-15Rα complexes display differential signaling and functions on human haematopoietic progenitors. Blood 106:2302-2310.
    • (2005) Blood , vol.106 , pp. 2302-2310
    • Giron-Michel, J.1    Guiliani, M.2    Fogli, M.3    Brouty-Boye, D.4    Ferrini, S.5
  • 93
    • 1642344614 scopus 로고    scopus 로고
    • Monocytes surface-bound IL-15 can function as an activating receptor and participate in reverse signaling
    • Neely GG, Epelman S, Ma LL, Colaruso P, Hofler CJ, et al. 2004. Monocytes surface-bound IL-15 can function as an activating receptor and participate in reverse signaling. J Immunol 172:4225-4234.
    • (2004) J Immunol , vol.172 , pp. 4225-4234
    • Neely, G.G.1    Epelman, S.2    Ma, L.L.3    Colaruso, P.4    Hofler, C.J.5
  • 94
    • 2642522073 scopus 로고    scopus 로고
    • Identification of an interleukin-15Ralpha receptor-binding site on human interleukin-15
    • Bernard J, Harb C, Mortier E, Quemener A, Meloen RH, et al. 2004. Identification of an interleukin-15Ralpha receptor-binding site on human interleukin-15. J Biol Chem 279:24313-24322.
    • (2004) J Biol Chem , vol.279 , pp. 24313-24322
    • Bernard, J.1    Harb, C.2    Mortier, E.3    Quemener, A.4    Meloen, R.H.5
  • 95
  • 96
    • 0030022275 scopus 로고    scopus 로고
    • The role of IL-15 in T-cell migration and activation in rheumatoid arthritis
    • McInnes IB, al-Mughales J, Field M, Leung BP, Huang FP, et al. 1996. The role of IL-15 in T-cell migration and activation in rheumatoid arthritis. Nat Med 2:175-182.
    • (1996) Nat Med , vol.2 , pp. 175-182
    • McInnes, I.B.1    Al-Mughales, J.2    Field, M.3    Leung, B.P.4    Huang, F.P.5
  • 97
    • 0034176003 scopus 로고    scopus 로고
    • IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production
    • Liu Z, Geboes K, Colpaert S, D'Haens GR, Rutgeerts P, et al. 2000. IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production. J Immunol 164:3608-3615.
    • (2000) J Immunol , vol.164 , pp. 3608-3615
    • Liu, Z.1    Geboes, K.2    Colpaert, S.3    D'Haens, G.R.4    Rutgeerts, P.5
  • 101
    • 0343183719 scopus 로고    scopus 로고
    • Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayed-type hypersensitivity
    • Kim YS, Maslinski W, Zheng XX, Stevens AC, Li XC, et al. 1998. Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayed-type hypersensitivity. J Immunol 160:5742-5748.
    • (1998) J Immunol , vol.160 , pp. 5742-5748
    • Kim, Y.S.1    Maslinski, W.2    Zheng, X.X.3    Stevens, A.C.4    Li, X.C.5
  • 102
    • 4444372681 scopus 로고    scopus 로고
    • Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases
    • Waldmann TA. 2004. Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases. Arthritis Res Ther 6: 174-177.
    • (2004) Arthritis Res Ther , vol.6 , pp. 174-177
    • Waldmann, T.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.