Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6-independent phenotype by murine plasmacytomas and hybridomas

Blood

Volumn 96, Issue 10, 2000, Pages 3514-3521

  Rawat, Rashmi ^a   Rainey, G Jonah ^a   Thompson, Cynthia D ^a   Frazier Jessen, Michelle R ^a   Brown, Robert T ^a   Nordan, Richard P ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6; STAT3 PROTEIN;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; CONTROLLED STUDY; DNA FLANKING REGION; GENE ACTIVATION; HYBRIDOMA; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PHENOTYPE; PLASMACYTOMA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0034669993     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.10.3514     Document Type: Article

References (51)

1. Gp130 and the interleukin-6 family of cytokines
2. Interleukin-6 in biology and medicine
3. Molecular biology and immunology of interleukin-6
4. T cell derived IL-6 is differentially required for antigen-specific antibody secretion by primary and secondary B cells
5. A macrophage-derived factor required by plasmacytomas for survival and proliferation in vitro
6. Growth of primary plasmacytomas in the mineral oil-conditioned peritoneal environment
7. The requirement of an adherent cell substratum for the growth of developing plasmacytoma cells in vivo
8. Role of the macrophage-derived hybridoma growth factor in the in vitro and in vivo proliferation of newly formed B cell hybridomas
9. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
10. Interleukin-6 in human multiple myeloma
11. Interleukin-6 family of cytokines and gp130
12. Signaling through the hematopoietic cytokine receptors
13. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
14. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
15. Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level
16. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
17. Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome
18. Jak-STAT signaling induced by the v-abl oncogene
19. Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase
20. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
21. Characterization of a recombinant murine interleukin-6: Assignment of disulfide bonds
22. An acute phase response factor/NF-kappa B site downstream of the junB gene that mediates responsiveness to interleukin-6 in a murine plasmacytoma
23. DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma
24. Growth regulatory pathways in myeloma: Evidence for autocrine oncostatin M expression
25. Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130
26. Establishment and characterization of a CHO cell line producing a secreted form of human ciliary neurotrophic factor: Neuroprotective effects of the recombinant protein
27. Interleukin-6 antisense oligonucleotides inhibit the growth of human myeloma cell lines
28. Autocrine growth factors and tumourigenic transformation
29. Intracellular interleukin 6 mediates platelet-derived growth factor- induced proliferation of nontransformed cells
30. IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade
31. Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3
32. A common nuclear signal transduction pathway activated by growth factor and cytokine receptors
33. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
34. Stat3 as an oncogene
35. Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs
36. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
37. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: Involvement of STAT3 in anti-apoptosis
38. Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6
39. Stat3 activation is required for cellular transformation by v-src
40. Stat3 activation by Src induces specific gene regulation and is required for cell transformation
41. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
42. Activation of STAT transcription factors in oncogenic tyrosine kinase signaling
43. Jaks and STATs: Biological implications
44. Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
45. STAT3 is required for the gp130-mediated full activation of the c-myc gene
46. STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition
47. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
48. Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients
49. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells
50. Proliferation of adult T cell leukemia/lymphoma chits is associated with the constitutive activation of JAK/STAT proteins
51. STATs in oncogenesis