CHK2-independent induction of telomere dysfunction checkpoints in stem and progenitor cells

EMBO Reports

Volumn 11, Issue 8, 2010, Pages 619-625

  Nalapareddy, Kodandaramireddy ^a   Choudhury, Aaheli Roy ^a,c   Gompf, Anne ^a   Ju, Zhenyu ^a,b   Ravipati, Satyavani ^a   Leucht, Thomas ^a   Lechel, André ^a   Rudolph, K Lenhard ^a  

^a UNIVERSITY OF ULM   (Germany)

^b BEIJING HOSPITAL   (China)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

CHK2; DNA damage; senescence; stem cells; telomeres

Indexed keywords

CHECKPOINT KINASE 2; PROTEIN P21; PROTEIN P53; CHEK2 PROTEIN, HUMAN; CHEK2 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; TELOMERASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL FUNCTION; CONTROLLED STUDY; GENE DELETION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; LIFESPAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL; TELOMERE; ANIMAL; CELL CYCLE; CYTOLOGY; DNA DAMAGE; FIBROBLAST; GENETICS; INTESTINE; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL AGING; CELL CYCLE; DNA DAMAGE; FIBROBLASTS; HUMANS; INTESTINES; MICE; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; STEM CELLS; TELOMERASE; TELOMERE; CHECKPOINT KINASE 2;

ATAXIA TELANGIECTASIA; MUS;

EID: 77955055801     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2010.83     Document Type: Article

References (29)

1. Barker N et al (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449: 1003-1007
2. Begus-Nahrmann Y et al (2009) p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nat Genet 41: 1138-1143
3. Bi X, Srikanta D, Fanti L, Pimpinelli S, Badugu R, Kellum R, Rong YS (2005) Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proc Natl Acad Sci USA 102: 15167-15172
4. CIP1/WAF1 gene in normal diploid human fibroblasts. Science 277: 831-834
5. Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA (2003) Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361: 393-395
6. Chin L, Artandi SE, Shen Q, Tam A, Lee SL, Gottlieb GJ, Greider CW, De Pinho RA (1999) p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97: 527-538
7. Choudhury AR et al (2007) Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet 39: 99-105
8. D'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, Saretzki G, Carter NP, Jackson SP (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426: 194-198
9. Gire V, Roux P, Wynford-Thomas D, Brondello JM, Dulic V (2004) DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO J 23: 2554-2563
10. Hemann MT, Strong MA, Hao LY, Greider CW (2001) The shortest telomere, Not average telomere length, Is critical for cell viability and chromosome stability. Cell 107: 67-77
11. INK4a. Mol Cell 14: 501-513
12. Hirao A et al (2002) Chk2 is A tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol 22: 6521-6532
13. Hong Y, Stambrook PJ (2004) Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation. Proc Natl Acad Sci USA 101: 14443-14448
14. Ito K et al (2004) Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431: 997-1002
15. Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP (2006) ATM-and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 8: 37-45
16. Ju Z, Jiang H, Jaworski M, Rathinam C, Gompf A, Klein C, Trumpp A, Rudolph KL (2007) Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med 13: 742-747
17. Kirk KE, Harmon BP, Reichardt IK, Sedat JW, Blackburn EH (1997) Block in anaphase chromosome separation caused by A telomerase template mutation. Science 275: 1478-1481
18. Lansdorp PM (2009) Telomeres and disease. EMBO J 28: 2532-2540
19. Liu J et al (2009) Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature 459: 387-392
20. Nalapareddy K, Jiang H, Gutierrez LM, Rudolph KL (2008) Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging\what markers can we use? Exp Gerontol 43: 998-1004
21. Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL (2007) Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447: 725-729
22. Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, DePinho RA (1999) Longevity, Stress response, And cancer in aging telomerase-deficient mice. Cell 96: 701-712
23. Rudolph KL, Millard M, Bosenberg MW, DePinho RA (2001) Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet 28: 155-159
24. Schaetzlein S et al (2007) Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. Cell 130: 863-877
25. Silva E, Tiong S, Pedersen M, Homola E, Royou A, Fasulo B, Siriaco G, Campbell SD (2004) ATM is required for telomere maintenance and chromosome stability during Drosophila development. Curr Biol 14: 1341-1347
26. Takai H et al (2002) Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J 21: 5195-5205
27. Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, De Pinho RA (2003) Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 421: 643-648
28. Wright WE, Shay JW (1992) The two-stage mechanism controlling cellular senescence and immortalization. Exp Gerontol 27: 383-389
29. Zou L, Elledge SJ (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300: 1542-1548