-
1
-
-
0037167613
-
Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes
-
Anguiano M., et al. Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes. Biochemistry 2002, 41:11338-11343.
-
(2002)
Biochemistry
, vol.41
, pp. 11338-11343
-
-
Anguiano, M.1
-
2
-
-
33750905657
-
Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages
-
Asuni A.A., et al. Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages. Eur. J. Neurosci. 2006, 24:2530-2542.
-
(2006)
Eur. J. Neurosci.
, vol.24
, pp. 2530-2542
-
-
Asuni, A.A.1
-
3
-
-
0037452779
-
Epitope and isotype specificities of antibodies to beta-amyloid peptide for protection against Alzheimer's disease-like neuropathology
-
Bard F., et al. Epitope and isotype specificities of antibodies to beta-amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proc. Natl Acad. Sci. USA 2003, 100:2023-2028.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 2023-2028
-
-
Bard, F.1
-
4
-
-
11444267243
-
Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD
-
Bayer A.J., et al. Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD. Neurology 2005, 64:94-101.
-
(2005)
Neurology
, vol.64
, pp. 94-101
-
-
Bayer, A.J.1
-
5
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991, 82:239-259.
-
(1991)
Acta Neuropathol.
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
6
-
-
67749122581
-
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease
-
Britschgi M., et al. Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease. Proc. Natl Acad. Sci. USA 2009, 106:12145-12150.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 12145-12150
-
-
Britschgi, M.1
-
7
-
-
0037384333
-
Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid
-
Cribbs D.H., et al. Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. Int. Immunol. 2003, 15:505-514.
-
(2003)
Int. Immunol.
, vol.15
, pp. 505-514
-
-
Cribbs, D.H.1
-
8
-
-
0029937437
-
The canine as an animal model of human aging and dementia
-
Cummings B.J., et al. The canine as an animal model of human aging and dementia. Neurobiol. Aging 1996, 17:259-268.
-
(1996)
Neurobiol. Aging
, vol.17
, pp. 259-268
-
-
Cummings, B.J.1
-
9
-
-
0033549827
-
Long-term clinical efficacy of grass-pollen immunotherapy
-
Durham S.R., et al. Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J. Med. 1999, 341:468-475.
-
(1999)
N Engl J. Med.
, vol.341
, pp. 468-475
-
-
Durham, S.R.1
-
10
-
-
0025216937
-
Lymphokine control of in vivo immunoglobulin isotype selection
-
Finkelman F.D., et al. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 1990, 8:303-333.
-
(1990)
Annu. Rev. Immunol.
, vol.8
, pp. 303-333
-
-
Finkelman, F.D.1
-
11
-
-
0032496922
-
Measurement of IgG, IgM and IgA concentrations in canine serum, saliva, tears and bile
-
German A.J., et al. Measurement of IgG, IgM and IgA concentrations in canine serum, saliva, tears and bile. Vet. Immunol. Immunopathol. 1998, 64:107-121.
-
(1998)
Vet. Immunol. Immunopathol.
, vol.64
, pp. 107-121
-
-
German, A.J.1
-
12
-
-
4644295008
-
Mimotopes of conformational epitopes in fibrillar beta-amyloid
-
Gevorkian G., et al. Mimotopes of conformational epitopes in fibrillar beta-amyloid. J. Neuroimmunol. 2004, 156:10-20.
-
(2004)
J. Neuroimmunol.
, vol.156
, pp. 10-20
-
-
Gevorkian, G.1
-
13
-
-
20944448555
-
Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
-
Gilman S., et al. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 2005, 64:1553-1562.
-
(2005)
Neurology
, vol.64
, pp. 1553-1562
-
-
Gilman, S.1
-
14
-
-
33846101613
-
Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease
-
Golde T.E., et al. Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease. Curr. Alzheimer Res. 2006, 3:421-430.
-
(2006)
Curr. Alzheimer Res.
, vol.3
, pp. 421-430
-
-
Golde, T.E.1
-
15
-
-
0027324838
-
Use of novel adjuvants and delivery systems to improve the humoral and cellular immune response to malaria vaccine candidate antigens
-
Gordon D.M. Use of novel adjuvants and delivery systems to improve the humoral and cellular immune response to malaria vaccine candidate antigens. Vaccine 1993, 11:591-593.
-
(1993)
Vaccine
, vol.11
, pp. 591-593
-
-
Gordon, D.M.1
-
16
-
-
0026597063
-
Alzheimer's disease: the amyloid cascade hypothesis
-
Hardy J.A., Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992, 256:184-185.
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
17
-
-
0032410562
-
Visual-discrimination learning ability and beta-amyloid accumulation in the dog
-
Head E., et al. Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiol. Aging 1998, 19:415-425.
-
(1998)
Neurobiol. Aging
, vol.19
, pp. 415-425
-
-
Head, E.1
-
18
-
-
0034594462
-
Region-specific age at onset of beta-amyloid in dogs
-
Head E., et al. Region-specific age at onset of beta-amyloid in dogs. Neurobiol. Aging 2000, 21:89-96.
-
(2000)
Neurobiol. Aging
, vol.21
, pp. 89-96
-
-
Head, E.1
-
19
-
-
33644920371
-
Immunization with fibrillar Abeta(1-42) in young and aged canines: antibody generation and characteristics, and effects on CSF and brain Abeta
-
Head E., et al. Immunization with fibrillar Abeta(1-42) in young and aged canines: antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine 2006, 24:2824-2834.
-
(2006)
Vaccine
, vol.24
, pp. 2824-2834
-
-
Head, E.1
-
20
-
-
43649096717
-
A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta
-
Head E., et al. A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta. J. Neurosci. 2008, 28:3555-3566.
-
(2008)
J. Neurosci.
, vol.28
, pp. 3555-3566
-
-
Head, E.1
-
21
-
-
0036853548
-
Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease
-
Hock C., et al. Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease. Nat. Med. 2002, 8:1270-1275.
-
(2002)
Nat. Med.
, vol.8
, pp. 1270-1275
-
-
Hock, C.1
-
22
-
-
0038100154
-
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
-
Hock C., et al. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron 2003, 38:547-554.
-
(2003)
Neuron
, vol.38
, pp. 547-554
-
-
Hock, C.1
-
23
-
-
47149112621
-
Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
-
Holmes C., et al. Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 2008, 372:216-223.
-
(2008)
Lancet
, vol.372
, pp. 216-223
-
-
Holmes, C.1
-
24
-
-
0029742199
-
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
-
Hsiao K., et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996, 274:99-102.
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
-
25
-
-
0034700471
-
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
-
Janus C., et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 2000, 408:979-982.
-
(2000)
Nature
, vol.408
, pp. 979-982
-
-
Janus, C.1
-
26
-
-
36749078121
-
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
-
Kayed R., et al. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener. 2007, 2:18.
-
(2007)
Mol Neurodegener.
, vol.2
, pp. 18
-
-
Kayed, R.1
-
27
-
-
0141596080
-
The dog genome: survey sequencing and comparative analysis
-
Kirkness E.F., et al. The dog genome: survey sequencing and comparative analysis. Science 2003, 301:1898-1903.
-
(2003)
Science
, vol.301
, pp. 1898-1903
-
-
Kirkness, E.F.1
-
28
-
-
42249088234
-
Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
-
Kool M., et al. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J. Exp. Med. 2008, 205:869-882.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 869-882
-
-
Kool, M.1
-
29
-
-
24644458809
-
Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies
-
Lee M., et al. Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies. Ann. Neurol. 2005, 58:430-435.
-
(2005)
Ann. Neurol.
, vol.58
, pp. 430-435
-
-
Lee, M.1
-
30
-
-
3042692322
-
Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet
-
Lemere C.A., et al. Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet. Am. J. Pathol. 2004, 165:283-297.
-
(2004)
Am. J. Pathol.
, vol.165
, pp. 283-297
-
-
Lemere, C.A.1
-
31
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
Lesne S., et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006, 440:352-357.
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesne, S.1
-
32
-
-
34248160486
-
Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice
-
Lin C.Y., et al. Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice. Diabetes 2007, 56:1324-1332.
-
(2007)
Diabetes
, vol.56
, pp. 1324-1332
-
-
Lin, C.Y.1
-
33
-
-
0032888131
-
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
-
Lue L.F., et al. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am. J. Pathol. 1999, 155:853-862.
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 853-862
-
-
Lue, L.F.1
-
34
-
-
0036852750
-
Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis
-
McLaurin J., et al. Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis. Nat. Med. 2002, 8:1263-1269.
-
(2002)
Nat. Med.
, vol.8
, pp. 1263-1269
-
-
McLaurin, J.1
-
35
-
-
33749020837
-
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host
-
Meyer-Luehmann M., et al. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science 2006, 313:1781-1784.
-
(2006)
Science
, vol.313
, pp. 1781-1784
-
-
Meyer-Luehmann, M.1
-
36
-
-
0028331373
-
Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks
-
Milgram N.W., et al. Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks. Behav. Neurosci. 1994, 108:57-68.
-
(1994)
Behav. Neurosci.
, vol.108
, pp. 57-68
-
-
Milgram, N.W.1
-
37
-
-
0036819096
-
Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy
-
Milgram N.W., et al. Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy. Neurosci. Biobehav. Rev. 2002, 26:679-695.
-
(2002)
Neurosci. Biobehav. Rev.
, vol.26
, pp. 679-695
-
-
Milgram, N.W.1
-
38
-
-
0025908356
-
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
-
Mirra S.S., et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991, 41:479-486.
-
(1991)
Neurology
, vol.41
, pp. 479-486
-
-
Mirra, S.S.1
-
39
-
-
84984755327
-
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
Morgan D., et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 2000, 408:982-985.
-
(2000)
Nature
, vol.408
, pp. 982-985
-
-
Morgan, D.1
-
40
-
-
0034213718
-
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation
-
Mucke L., et al. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J. Neurosci. 2000, 20:4050-4058.
-
(2000)
J. Neurosci.
, vol.20
, pp. 4050-4058
-
-
Mucke, L.1
-
41
-
-
34547672881
-
Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization
-
Necula M., et al. Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization. Biochemistry 2007, 46:8850-8860.
-
(2007)
Biochemistry
, vol.46
, pp. 8850-8860
-
-
Necula, M.1
-
42
-
-
10744230547
-
Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization
-
Orgogozo J.M., et al. Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 2003, 61:46-54.
-
(2003)
Neurology
, vol.61
, pp. 46-54
-
-
Orgogozo, J.M.1
-
43
-
-
0028945939
-
Sequence of the dog immunoglobulin alpha and epsilon constant region genes
-
Patel M., et al. Sequence of the dog immunoglobulin alpha and epsilon constant region genes. Immunogenetics 1995, 41:282-286.
-
(1995)
Immunogenetics
, vol.41
, pp. 282-286
-
-
Patel, M.1
-
44
-
-
4644250248
-
Measurement of immunoglobulin concentrations in the feces of healthy dogs
-
Peters I.R., et al. Measurement of immunoglobulin concentrations in the feces of healthy dogs. Clin. Diagn. Lab. Immunol. 2004, 11:841-848.
-
(2004)
Clin. Diagn. Lab. Immunol.
, vol.11
, pp. 841-848
-
-
Peters, I.R.1
-
45
-
-
36248941497
-
Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice
-
Petrushina I., et al. Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice. J. Neurosci. 2007, 27:12721-12731.
-
(2007)
J. Neurosci.
, vol.27
, pp. 12721-12731
-
-
Petrushina, I.1
-
46
-
-
40449086748
-
Progress in the active immunotherapeutic approach to Alzheimer's disease: clinical investigations into AN1792-associated meningoencephalitis
-
Pride M., et al. Progress in the active immunotherapeutic approach to Alzheimer's disease: clinical investigations into AN1792-associated meningoencephalitis. Neurodegener. Dis. 2008, 5:194-196.
-
(2008)
Neurodegener. Dis.
, vol.5
, pp. 194-196
-
-
Pride, M.1
-
47
-
-
0026465192
-
A two-signal model for regulation of immunoglobulin isotype switching
-
Purkerson J., Isakson P. A two-signal model for regulation of immunoglobulin isotype switching. FASEB J. 1992, 6:3245-3252.
-
(1992)
FASEB J.
, vol.6
, pp. 3245-3252
-
-
Purkerson, J.1
Isakson, P.2
-
48
-
-
0029842232
-
The IgG isotypes of specific antibodies in patients with American cutaneous leishmaniasis; relationship to the cell-mediated immune response
-
Rodriguez V., et al. The IgG isotypes of specific antibodies in patients with American cutaneous leishmaniasis; relationship to the cell-mediated immune response. Parasite Immunol. 1996, 18:341-345.
-
(1996)
Parasite Immunol.
, vol.18
, pp. 341-345
-
-
Rodriguez, V.1
-
49
-
-
33645809555
-
Molecular characterization of immunoglobulin D in mammals: immunoglobulin heavy constant delta genes in dogs, chimpanzees and four old world monkey species
-
Rogers K.A., et al. Molecular characterization of immunoglobulin D in mammals: immunoglobulin heavy constant delta genes in dogs, chimpanzees and four old world monkey species. Immunology 2006, 118:88-100.
-
(2006)
Immunology
, vol.118
, pp. 88-100
-
-
Rogers, K.A.1
-
50
-
-
0036780877
-
Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning
-
Schenk D. Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning. Nat. Rev. Neurosci. 2002, 3:824-828.
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, pp. 824-828
-
-
Schenk, D.1
-
51
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D., et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999, 400:173-177.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
-
52
-
-
34247092861
-
Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice
-
Seabrook T.J., et al. Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice. Neurobiol. Aging 2007, 28:813-823.
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 813-823
-
-
Seabrook, T.J.1
-
53
-
-
0029784838
-
Amyloid beta-protein and the genetics of Alzheimer's disease
-
Selkoe D.J. Amyloid beta-protein and the genetics of Alzheimer's disease. J. Biol. Chem. 1996, 271:18295-18298.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 18295-18298
-
-
Selkoe, D.J.1
-
54
-
-
39649101710
-
Developing preventive therapies for chronic diseases: lessons learned from Alzheimer's disease
-
Selkoe D.J. Developing preventive therapies for chronic diseases: lessons learned from Alzheimer's disease. Nutr. Rev. 2007, 65:S239-S243.
-
(2007)
Nutr. Rev.
, vol.65
-
-
Selkoe, D.J.1
-
55
-
-
0001181116
-
Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics
-
Selkoe D.J., Schenk D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu. Rev. Pharmacol. Toxicol. 2003, 43:545-584.
-
(2003)
Annu. Rev. Pharmacol. Toxicol.
, vol.43
, pp. 545-584
-
-
Selkoe, D.J.1
Schenk, D.2
-
56
-
-
0035839298
-
Cloning and characterization of cDNAs encoding four different canine immunoglobulin gamma chains
-
Tang L., et al. Cloning and characterization of cDNAs encoding four different canine immunoglobulin gamma chains. Vet. Immunol. Immunopathol. 2001, 80:259-270.
-
(2001)
Vet. Immunol. Immunopathol.
, vol.80
, pp. 259-270
-
-
Tang, L.1
-
57
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh D.M., et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002, 416:535-539.
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
-
58
-
-
0036669881
-
Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition
-
Walsh D.M., et al. Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem. Soc. Trans. 2002, 30:552-557.
-
(2002)
Biochem. Soc. Trans.
, vol.30
, pp. 552-557
-
-
Walsh, D.M.1
|