High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM- 1 in shear flow

Journal of Immunology

Volumn 162, Issue 2, 1999, Pages 1084-1095

  Chen, Chun ^a   Mobley, James L ^b,d   Dwir, Oren ^a   Shimron, Frida ^a   Grabovsky, Valentin ^a   Lobb, Roy R ^c   Shimizu, Yoji ^b   Alon, Ronen ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c BIOGEN   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; INTEGRIN; VASCULAR CELL ADHESION MOLECULE 1;

ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; CELL ADHESION; CELL SPREADING; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LIGAND BINDING; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; RECEPTOR AFFINITY; SHEAR RATE; T LYMPHOCYTE SUBPOPULATION; VASCULAR ENDOTHELIUM;

EID: 0033556364     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Springer, T. A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301.
2. Butcher, E. C., and L. J. Picker. 1996. Lymphocyte homing and homeostasis. Science 272:60.
3. Lobb, R. R., and M. E. Hemler. 1994. The pathophysiologic role of α4 integrins in vivo. J. Clin. Invest. 94:1722.
4. Gosslar, U., P. Jonas, A. Luz, A. Lifka, D. Naor, A. Hamann, and B. Holzmann. 1996. Predominant role of α4-integrins for distinct steps of lymphoma metastasis. Proc. Natl. Acad. Sci. USA 93:4821.
5. 1-integrins dominate cell traffic of leukemic cells in human bone-marrow stroma. Int. J. Cancer 66:225.
6. Jones, D. A., L. V. McIntire, C. W. Smith, and L. J. Picker. 1994. A two-step adhesion cascade for T cell/endothelial cell interactions under flow conditions. J. Clin. Invest. 94:2443.
7. Alon, R. P. D. Kassner, M. W. Carr, E. B. Finger, M. E. Hemler, and T. A. Springer. 1995. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J. Cell Biol. 128:1243.
8. 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 80:413.
9. 7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: the multistep model confirmed and refined. Immunity 3:99.
10. 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo. J. Exp. Med. 183:1995.
11. Luscinskas, F. W., H. Ding, P. Tan, D. Cumming, T. F. Tedder, and M. E. Gerritsen. 1996. L- and P-selectins, but not CD49d (VLA-4) integrins. mediate monocyte initial attachment to TNF-α-activated vascular endothelium under flow in vitro. J. Immunol. 157:326.
12. 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions. J. Immunol 159: 3929.
13. Konstantopoulos, K., S. Kukreti, C. W. Smith, and L. V. McIntire. 1997. Endothelial P-selectin and VCAM-1 each can function as primary adhesive mechanisms for T cells under conditions of flow. J. Leukocyte Biol. 61:179.
14. Campbell, J. J., S. Qin, K. B. Bacon, C. R. Mackay, and E. C. Butcher. 1996 Biology of chemokine and classical chemoattractant receptors: differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells. J. Cell Biol. 134:255.
15. Chan, P. Y., M. B. Lawrence, M. L. Dustin, L. M. Ferguson, D. E. Golan, and T. A. Springer. 1991. Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2. J. Cell Biol. 115:245.
16. Kucik, D. F., M. L. Dustin, J. M. Miller, and E. J. Brown. 1996. Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes. J. Clin. Invest. 97:2139.
17. Yauch, R. L., D. P. Felscnfeld, S. K. Kraeft, L. B. Chen, M. P. Sheetz, and M. E. Hemler. 1997. Mutational evidence for control of cell adhesion through integrin recruitment, independent of ligand binding. J. Exp. Med. 186:1.
18. Faull, R. J., N. L. Kovach, J. M. Harlan, and M. H. Ginsberg. 1994. Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences. J. Exp. Med. 179:1307.
19. Stewart, M. P., C. Cabanas, and N. Hogg. 1996. T cell adhesion to intercellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1. J. Immunol. 156:1810.
20. 1 integrins and promotes adhesion to fibronectin. J. Immunol. 159:3498.
21. 4 cytoplasmic domain. Mol. Biol. Cell 6:661.
22. Mobley, J. L., E. Ennis, and Y. Shimizu. 1996. Isolation and characterization of cell lines with genetically distinct mutations downstream of protein kinase C that result in defective activation-dependent regulation of T cell integrin function. J. Immunol 156:948.
23. Brenner, B., U. Koppenhoefer, C. Weinstock, O. Linderkamp, F. Lang, and E. Gulbins. 1997. Fas-or ceramide-induced apoptosis is mediated by a Rac 1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. J. Biol. Chem. 272:22173.
24. Reinhold, M. I., F. P. Lindberg, G. J. Kersh, P. M. Allen, and E. J. Brown. 1997. Costimulalion of T cell activation by integrin-associated protein (CD47) is an adhesion-dependent, CD28-independent signaling pathway. J. Exp. Med. 185:1.
25. Rock, M. T., W. H. Brooks, and T. L. Roszman. 1997. Calcium-dependent signaling pathways in T cells: potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events. J. Biol. Chem. 272:33377.
26. 2+signaling in Jurkat T lymphocytes. J. Immunol. 158:1618.
27. Sanchez-Madrid, F., M. O. De Landazuri, G. Morago, M. Cebrian, A. Acevedo, and C. Bernabeu. 1986. VLA-3: a novel nolypeptide associated with the VLA molecular complex: cell distribution and biochemical characterization. Eur. J. Immunol. 16:1343.
28. Hemler, M. E., C. Huang, Y. Takada, L. Schwarz, J. L. Strominger, and M. L. Clabby. 1987. Characterization of the cell surface heterodimer VLA-4 and related peptides. J. Biol. Chem. 262:11478.
29. Hemler, M. E., F. Sanchez Madrid, T. J. Flotte, A. M. Krensky, S. J. Burakoff, A. K. Bhan, T. A. Springer, and J. L. Strominger. 1984. Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. J. Immunol. 132:3011.
30. Bazzoni, G., D. T. Shih, C. A. Buck, and M. E. Hemler. 1995. Monoclonal antibody 9EG7 defines a novel β1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J. Biol. Chem. 270:25570.
31. 4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to α4/180 formation. Biochem. J. 313:899
32. Jakcubowski, A., M. D. Rosa, S. Bixler, R. Lobb, and L. C. Burkly. 1995. Vascular cell adhesion molecule (VCAM)-lg fusion protein defines distinct affinity states of the very late antigen-4 (VLA-4) receptor. Cell Adhes. Commun. 3:131.
33. Lobb, R., G. Chi-Rosso, D. Leone, M. Rosa, B. Newman, S. Luhowskyj, L. Osborn, S. Schiffer, C. Benjamin, and I. Dougas. 1991. Expression and functional characterization of a soluble form of vascular cell adhesion molecule 1. Biochem. Biophys. Res. Commun. 178:1498.
34. 2 integrins on T lymphocytes. Immunity 4:179.
35. Finger, E. B., R. E. Bruehl, D. F. Bainton, and T. A. Springer. 1996. A differential role for cell shape in neutrophil tethering and rolling on endothelial selectins under flow. J. Immunol. 157:5085.
36. Lawrence, M. B., and T. A. Springer. 1991. Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 65:859.
37. Abitorabi, M. A., R. K. Pachynski, R. E. Ferrando, M. Tidswell, and D. J. Erle. 1997. Presentation of integrins on leukocyte microvilli: a role for the extracellular domain in determining membrane localization. J. Cell Biol. 139:563.
38. von Andrian, U. H., S. R. Hasslen, R. D. Nelson, S. L. Erlandsen, and E. C. Butcher. 1995. A central role for microvillous receptor presentation in leukocyte adhesion under flow. Cell 82:989.
39. Chen, S., R. Akin, R. Fuhlbrigge, and T. A. Springer. 1997. Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins. Proc. Natl. Acad. Sci. USA 94:3172.
40. Moore, K. L., K. D. Patel, R. E. Bruehl, F. Li, D. A. Johnson, H. S. Lichenstein, R. D. Cummings, D. F. Bainton, and R. P. McEver. 1095. P-selectin glycoprotein ligand-l mediates rolling of human neutrophils on P-selectin. J. Cell Biol. 128: 661.
41. Humphries, M. J., A. Komoriya, S. K. Akiyama, K. Olden, and K. M. Yamada. 1987. Identification of two distinct regions of the type III connecting segment of human plasma fibronectin that promote cell type-specific adhesion. J. Biol Chem. 262:6886.
42. Wang, J. H., R. B. Pepinsky, T. Stehle, J. H. Liu, M. Karpusas, B. Browning, and L. Osborn. 1995. The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-α4 integrin interaction. Proc. Natl. Acad. Sci. USA 92:5714.
43. Lalor, P. F., J. M. Clements, R. Pigott, M. J. Humphries, J. H. Spragg, and G. B. Nash. 1997. Association between receptor density, cellular activation, and transformation of adhesive behavior of flowing lymphocytes binding to VCAM-1. Eur. J. Immunol. 27:1422.
44. Berg, E. L., M. K. Robinson, R. A. Warnock, and E. C. Butcher. 1991. The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor. J. Cell Biol. 114:343.
45. Masumoto, A., and M. E. Hemler. 1993. Multiple activation states of VLA-4: mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1. J. Biol. Chem. 268:228.
46. O'Toole, T. E., Y. Katagiri, R. J. Faull, K. Peter, R. Tamura, V. Quaranta, J. C. Loftus, S. J. Shattil, and M. H. Ginsberg. 1994. Integrin cytoplasmic domains mediate inside-out signal transduction. J. Cell Biol. 124:1047.
47. Stewart, M., M. Thiel, and N. Hogg. 1995. Leukocyte integrins. Curr. Opin. Cell Biol. 7:690.
48. 1) integrin receptors on T cells. Nature 345:250.
49. Chan, B. M., J. G. Wong. A. Rao, and M. E. Hemler. 1991. T cell receptor-dependent, antigen-specific stimulation of a murine T cell clone induces a transient. VLA protein-mediated binding to extracellular matrix. J. Immunol. 147: 398.
50. 1 integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is confomationally responsive to ligand. J. Biol. Chem. 270:28740.
51. Diamond, M. S., and T. A. Springer. 1993. A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen. J. Cell Biol. 120:545.
52. Lollo, B. A., K. W. Chan, E. M. Hanson, V. T. Moy, and A. A. Brian. 1993. Direct evidence for two affinity states for lymphocyte function-associated antigen I on activated T cells. J. Biol. Chem. 268:21693
53. FAK) in human T cells. J. Exp. Med. 182:2079.
54. Zhang, Z., K. Vuori, H. Wang, J. C. Reed, and E. Ruoslahti. 1996. Integrin activation by R-ras. Cell 85:61.
55. Hughes, P. E., M. W. Renshaw, M. Pfaff, J. Forsyth, V. M. Keivens, M. A. Schwartz, and M. H. Ginsberg. 1997. Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell 88:521.
56. 2 integrin avidity by chemoattractants in eosinophils. Proc. Natl. Acad. Sci. USA 93:10939.
57. 1 integrin. Nature 356:63.
58. Laudanna, C., J. J. Campbell, and E. C. Butcher. 1996. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins. Science 271:981.
59. Calabresi, P. A., L. R. Tranquill, J. M. Damhrosia, L. A. Stone, H. Maloni, C. N. Bash, J. A. Frank, and H. F. McFarland. 1997. Increases in soluble VCAM-1 correlate with a decrease in MRI lesions in multiple sclerosis treated with interferon β-1b. Ann. Neurol. 41:669.