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Volumn 5, Issue 4, 2010, Pages 577-592

Metabolic syndrome is a low-grade systemic inflammatory condition

Author keywords

cytokines; dopamine; exercise; ghrelin; hypothalamus; inflammation; leptin; melanocyte stimulating hormone; metabolic syndrome; neuropeptide Y; nutrition; perilipin; serotonin; synapse; syntaxin

Indexed keywords

ACETYLCHOLINE; ADRENALIN; C REACTIVE PROTEIN; CHOLECYSTOKININ; DOPAMINE; GASTRIC INHIBITORY POLYPEPTIDE; GHRELIN; GLUCAGON LIKE PEPTIDE 1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INSULIN RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LEPTIN; LIPID PEROXIDE; MELANOCORTIN; NEUROPEPTIDE Y; NEUROTRANSMITTER; NITRIC OXIDE; NORADRENALIN; SEROTONIN; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 77954885889     PISSN: 17446651     EISSN: None     Source Type: Journal    
DOI: 10.1586/eem.10.19     Document Type: Review
Times cited : (19)

References (168)
  • 1
    • 0024160877 scopus 로고
    • Banting lecture 1988: Role of insulin resistance in human disease
    • Reaven GM. Banting lecture 1988: role of insulin resistance in human disease. Diabetes 37, 1595-1607 (1988).
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 2
    • 0842277242 scopus 로고    scopus 로고
    • For the conference participants. Definition of metabolic syndrome. NHLBI/AHA conference proceedings
    • Grundy SM, Brewer B Jr, Cleema JI, Smith SC, Lenfant C; for the conference participants. Definition of metabolic syndrome. NHLBI/AHA conference proceedings. Circulation 109, 433-438 (2004).
    • (2004) Circulation , vol.109 , pp. 433-438
    • Grundy, S.M.1    Brewer Jr., B.2    Cleema, J.I.3    Smith, S.C.4    Lenfant, C.5
  • 3
    • 33745725927 scopus 로고    scopus 로고
    • Exercise and inflammation
    • Das UN. Exercise and inflammation. Eur. Heart J. 27, 1385-1386 (2006).
    • (2006) Eur. Heart J. , vol.27 , pp. 1385-1386
    • Das, U.N.1
  • 4
    • 1342285724 scopus 로고    scopus 로고
    • Anti-inflammatory nature of exercise
    • Das UN. Anti-inflammatory nature of exercise. Nutrition 20, 323-326 (2004).
    • (2004) Nutrition , vol.20 , pp. 323-326
    • Das, U.N.1
  • 5
    • 0033532699 scopus 로고    scopus 로고
    • Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation
    • Yamashita N, Hoshida S, Otsu K et al. Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation. J. Exp. Med. 189, 1699-1706 (1999).
    • (1999) J. Exp. Med. , vol.189 , pp. 1699-1706
    • Yamashita, N.1    Hoshida, S.2    Otsu, K.3
  • 6
    • 0242664251 scopus 로고    scopus 로고
    • A perinatal strategy to prevent coronary heart disease
    • Das UN. A perinatal strategy to prevent coronary heart disease. Nutrition 19, 1022-1027 (2002).
    • (2002) Nutrition , vol.19 , pp. 1022-1027
    • Das, U.N.1
  • 7
    • 0038447922 scopus 로고    scopus 로고
    • Plasma concentration of C-reactive protein and the calculated Framingham coronary heart disease risk score
    • Albert MA, Glynn RJ, Ridker PM. Plasma concentration of C-reactive protein and the calculated Framingham coronary heart disease risk score. Circulation 108, 161-165 (2003).
    • (2003) Circulation , vol.108 , pp. 161-165
    • Albert, M.A.1    Glynn, R.J.2    Ridker, P.M.3
  • 8
    • 0036901493 scopus 로고    scopus 로고
    • C-reactive protein predicts progression of atherosclerosis measured as various sites in the arterial tree. The Rotterdam study
    • van der Meer IM, de Maat MPM, Hak AE et al. C-reactive protein predicts progression of atherosclerosis measured as various sites in the arterial tree. The Rotterdam study. Stroke 33, 2750-2755 (2002).
    • (2002) Stroke , vol.33 , pp. 2750-2755
    • Van Der Meer, I.M.1    De Maat Mpm2    Hak, A.E.3
  • 9
    • 0038108728 scopus 로고    scopus 로고
    • C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease. The PRIME study
    • Luc G, Bard J-M, Juhan-Vague I et al. C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease. The PRIME study. Arterioscler. Thromb. Vasc. Biol. 23, 1255-1261 (2003).
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 1255-1261
    • Luc, G.1    Bard, J.-M.2    Juhan-Vague, I.3
  • 10
    • 0042767562 scopus 로고    scopus 로고
    • Inflammation-sensitive plasma proteins are associated with future weight gain
    • Engstrom G, Hedblad B, Stavenow L, Lind P, Janzon L, Lindgarde F. Inflammation-sensitive plasma proteins are associated with future weight gain. Diabetes 52, 2097-2101 (2003).
    • (2003) Diabetes , vol.52 , pp. 2097-2101
    • Engstrom, G.1    Hedblad, B.2    Stavenow, L.3    Lind, P.4    Janzon, L.5    Lindgarde, F.6
  • 11
    • 0037078968 scopus 로고    scopus 로고
    • C-reactive protein - To screen or not to screen
    • Mosca L. C-reactive protein - to screen or not to screen. N. Engl. J. Med. 347, 1615-1617 (2002).
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1615-1617
    • Mosca, L.1
  • 12
    • 0023887261 scopus 로고
    • Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes
    • Castell JV, Gomez-Lechon MJ, David M, Horano T, Kishimoto T, Heinrich PC. Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes. FEBSLett. 232, 347-350 (1988).
    • (1988) FEBSLett. , vol.232 , pp. 347-350
    • Castell, J.V.1    Gomez-Lechon, M.J.2    David, M.3    Horano, T.4    Kishimoto, T.5    Heinrich, P.C.6
  • 13
    • 0035488931 scopus 로고    scopus 로고
    • The relation of markers of inflammation to the development of glucose disorders in the elderly
    • Barzilay JI, Abraham L, Heckbert SR et al. The relation of markers of inflammation to the development of glucose disorders in the elderly. Diabetes 50, 2384-2389 (2001).
    • (2001) Diabetes , vol.50 , pp. 2384-2389
    • Barzilay, J.I.1    Abraham, L.2    Heckbert, S.R.3
  • 14
    • 14944373553 scopus 로고    scopus 로고
    • Plasma adiponectin and insulin resistance in Korean Type 2 diabetes mellitus
    • Kim MJ, Yoo KH, Park HS et al. Plasma adiponectin and insulin resistance in Korean Type 2 diabetes mellitus. Yonsei Med. J. 46, 42-50 (2005).
    • (2005) Yonsei Med. J. , vol.46 , pp. 42-50
    • Kim, M.J.1    Yoo, K.H.2    Park, H.S.3
  • 15
    • 0036178115 scopus 로고    scopus 로고
    • Relation between a diet with a high glycemic load and plasma concentrations of high-sensitivity C-reactive protein in middle-aged women
    • Liu S, Manson JE, Buring JE, Stampfer MJ, Willett WC, Ridker PM. Relation between a diet with a high glycemic load and plasma concentrations of high-sensitivity C-reactive protein in middle-aged women. Am. J. Clin. Nutr. 75, 492-498 (2002).
    • (2002) Am. J. Clin. Nutr. , vol.75 , pp. 492-498
    • Liu, S.1    Manson, J.E.2    Buring, J.E.3    Stampfer, M.J.4    Willett, W.C.5    Ridker, P.M.6
  • 16
    • 0037109184 scopus 로고    scopus 로고
    • Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans. Role of oxidative stress
    • Esposito K, Nappo F, Marfella R et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans. Role of oxidative stress. Circulation 106, 2067-2072 (2002).
    • (2002) Circulation , vol.106 , pp. 2067-2072
    • Esposito, K.1    Nappo, F.2    Marfella, R.3
  • 17
    • 0035658724 scopus 로고    scopus 로고
    • Human aging is associated with altered TNF - A production during hyperglycemia and hyperinsulinemia
    • Kirwan JP, Krishnan RK, Weaver JA, Del Aguila LF, Evans WJ. Human aging is associated with altered TNF-a production during hyperglycemia and hyperinsulinemia. Am. J. Physiol. 281, E1137-E1143 (2001).
    • (2001) Am. J. Physiol. , vol.281
    • Kirwan, J.P.1    Krishnan, R.K.2    Weaver, J.A.3    Del Aguila, L.F.4    Evans, W.J.5
  • 19
    • 0035049305 scopus 로고    scopus 로고
    • Circulating interleukins 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women
    • Fernandez-Real JM, Vayreda M, Richart C et al. Circulating interleukins 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women. J. Clin. Endocrinol. Metab. 86, 1154-1159 (2001).
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 1154-1159
    • Fernandez-Real, J.M.1    Vayreda, M.2    Richart, C.3
  • 20
    • 0035571399 scopus 로고    scopus 로고
    • Blood pressure and inflammation in apparently healthy men
    • Chae CU, Lee RT, Rifai N, Ridker PM. Blood pressure and inflammation in apparently healthy men. Hypertension 38, 399-403 (2001).
    • (2001) Hypertension , vol.38 , pp. 399-403
    • Chae, C.U.1    Lee, R.T.2    Rifai, N.3    Ridker, P.M.4
  • 21
    • 0035052940 scopus 로고    scopus 로고
    • What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women?
    • Brochu M, Tchernof A, Dionne IJ et al. What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women? J. Clin. Endocrinol. Metab. 86, 1020-1025 (2001).
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 1020-1025
    • Brochu, M.1    Tchernof, A.2    Dionne, I.J.3
  • 22
    • 0035824440 scopus 로고    scopus 로고
    • A transgenic model of visceral obesity and the metabolic syndrome
    • Masuzaki H, Paterson J, Shinyama H et al. A transgenic model of visceral obesity and the metabolic syndrome. Science 294, 2166-2170 (2001).
    • (2001) Science , vol.294 , pp. 2166-2170
    • Masuzaki, H.1    Paterson, J.2    Shinyama, H.3
  • 23
    • 3142661851 scopus 로고    scopus 로고
    • 11p-hydroxysteroid dehydrogenase type 1: Genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle
    • Nair S, Lee YH, Lindsay RS et al. 11p-hydroxysteroid dehydrogenase type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle. Diabetologia 47, 1088-1095 (2004).
    • (2004) Diabetologia , vol.47 , pp. 1088-1095
    • Nair, S.1    Lee, Y.H.2    Lindsay, R.S.3
  • 24
    • 14644388141 scopus 로고    scopus 로고
    • Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11p-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone
    • Sandeep TC, Andrew R, Homer N, Andrews RC, Smith K, Walker BR. Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11p-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone. Diabetes 54, 872-879 (2005).
    • (2005) Diabetes , vol.54 , pp. 872-879
    • Sandeep, T.C.1    Andrew, R.2    Homer, N.3    Andrews, R.C.4    Smith, K.5    Walker, B.R.6
  • 25
    • 12144291638 scopus 로고    scopus 로고
    • Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 p-hydroxysteroid dehydrogenase type 1-deficient mice
    • Morton NM, Paterson JM, Masuzaki H et al. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 p-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes 53,931-938 (2004).
    • (2004) Diabetes , vol.53 , pp. 931-938
    • Morton, N.M.1    Paterson, J.M.2    Masuzaki, H.3
  • 26
    • 85047681877 scopus 로고    scopus 로고
    • Regulation of expression of 11p-hydroxysteroid dehydrogenase type 1 in adipose tissue: Tissue-specific induction by cytokines
    • Tomlinson JW, Moore J, Cooper MS et al. Regulation of expression of 11p-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. Endocrinology 142, 1982-1989 (2001).
    • (2001) Endocrinology , vol.142 , pp. 1982-1989
    • Tomlinson, J.W.1    Moore, J.2    Cooper, M.S.3
  • 27
    • 0025282043 scopus 로고
    • Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway
    • Han J, Thompson P, Beutler B. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. J. Exp. Med. 172, 391-394 (1990).
    • (1990) J. Exp. Med. , vol.172 , pp. 391-394
    • Han, J.1    Thompson, P.2    Beutler, B.3
  • 28
    • 24044451713 scopus 로고    scopus 로고
    • Regulation of adiponectin expression in human adipocytes: Effects of adiposity, glucocorticoids, and tumor necrosis factor a
    • Degawa-Yamauchi M, Moss KA, Bovenkerk JE et al. Regulation of adiponectin expression in human adipocytes: effects of adiposity, glucocorticoids, and tumor necrosis factor a. Obes. Res. 13, 662-669 (2005).
    • (2005) Obes. Res. , vol.13 , pp. 662-669
    • Degawa-Yamauchi, M.1    Moss, K.A.2    Bovenkerk, J.E.3
  • 30
    • 0036200250 scopus 로고    scopus 로고
    • Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells
    • Mohanty P, Ghanim H, Hamouda W, Aljada A, Garg R, Dandona P. Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells. Am. J. Clin. Nutr. 75, 767-772 (2002).
    • (2002) Am. J. Clin. Nutr. , vol.75 , pp. 767-772
    • Mohanty, P.1    Ghanim, H.2    Hamouda, W.3    Aljada, A.4    Garg, R.5    Dandona, P.6
  • 31
    • 3142751251 scopus 로고    scopus 로고
    • Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein
    • Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J. Biol. Chem. 279, 30369-30374 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 30369-30374
    • Schulze, P.C.1    Yoshioka, J.2    Takahashi, T.3    He, Z.4    King, G.L.5    Lee, R.T.6
  • 32
    • 20044363264 scopus 로고    scopus 로고
    • The hyperglycemia-induced inflammatory response in adipocytes: The role of reactive oxygen species
    • Lin Y, Berg AH, Iyengar P et al. The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J. Biol. Chem. 280, 4617-4626 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 4617-4626
    • Lin, Y.1    Berg, A.H.2    Iyengar, P.3
  • 33
    • 0036787253 scopus 로고    scopus 로고
    • Is insulin an endogenous cardioprotector?
    • Das UN. Is insulin an endogenous cardioprotector? Crit. Care 6, 389-393 (2002).
    • (2002) Crit. Care , vol.6 , pp. 389-393
    • Das, U.N.1
  • 34
    • 0036479117 scopus 로고    scopus 로고
    • Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-a- induced NF-kB activation and intercellular adhesion molecule-1 expression in endothelial cells
    • Fan J, Frey RS, Rahman A, Malik AB. Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-a- induced NF-kB activation and intercellular adhesion molecule-1 expression in endothelial cells. J. Biol. Chem. 277, 3404-3411 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 3404-3411
    • Fan, J.1    Frey, R.S.2    Rahman, A.3    Malik, A.B.4
  • 35
    • 0037401072 scopus 로고    scopus 로고
    • Vascular smooth muscle cell activation by C-reactive protein
    • Hattori Y, Matsumura M, Kasai K. Vascular smooth muscle cell activation by C-reactive protein. Cardiovasc. Res. 58, 186-195 (2003).
    • (2003) Cardiovasc. Res. , vol.58 , pp. 186-195
    • Hattori, Y.1    Matsumura, M.2    Kasai, K.3
  • 36
    • 0037469261 scopus 로고    scopus 로고
    • C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells
    • Devaraj S, Xu DY, Jialal I. C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells. Circulation 107, 398-404 (2003).
    • (2003) Circulation , vol.107 , pp. 398-404
    • Devaraj, S.1    Xu, D.Y.2    Jialal, I.3
  • 37
    • 85030434746 scopus 로고    scopus 로고
    • Increased oxidative stress in obesity and its impact on metabolic syndrome
    • Furukawa S, Fujita T, Shimabukuro M et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 114, 1752-1761 (2004).
    • (2004) J. Clin. Invest. , vol.114 , pp. 1752-1761
    • Furukawa, S.1    Fujita, T.2    Shimabukuro, M.3
  • 38
    • 33644768153 scopus 로고    scopus 로고
    • Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome
    • Fortuno A, San Jose G, Moreno MU, Beloqui O, Diez J, Zalba G. Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome. Diabetes 55, 209-215 (2006).
    • (2006) Diabetes , vol.55 , pp. 209-215
    • Fortuno, A.1    San Jose, G.2    Moreno, M.U.3    Beloqui, O.4    Diez, J.5    Zalba, G.6
  • 39
    • 0031059059 scopus 로고    scopus 로고
    • Oxidant stress, anti-oxidants and nitric oxide in non- insulin dependent diabetes mellitus
    • Mohan I, Das UN. Oxidant stress, anti-oxidants and nitric oxide in non- insulin dependent diabetes mellitus. Med. Sci. Res. 25, 55-57 (1997).
    • (1997) Med. Sci. Res. , vol.25 , pp. 55-57
    • Mohan, I.1    Das, U.N.2
  • 40
    • 0028223306 scopus 로고
    • Lipid peroxides and essential fatty acids in patients with coronary heart disease
    • Kumar KV, Das UN. Lipid peroxides and essential fatty acids in patients with coronary heart disease. J. Nutr. Med. 4, 33-37 (1994).
    • (1994) J. Nutr. Med. , vol.4 , pp. 33-37
    • Kumar, K.V.1    Das, U.N.2
  • 41
    • 0027989329 scopus 로고
    • Lipid peroxides and essential fatty acids in patients with diabetes mellitus and diabetic nephropathy
    • Das UN, Kumar KV, Mohan IK. Lipid peroxides and essential fatty acids in patients with diabetes mellitus and diabetic nephropathy. J. Nutr. Med. 4, 149-155 (1994).
    • (1994) J. Nutr. Med. , vol.4 , pp. 149-155
    • Das, U.N.1    Kumar, K.V.2    Mohan, I.K.3
  • 42
    • 0027508026 scopus 로고
    • Are free radicals involved in the pathobiology of human essential hypertension?
    • Kumar KV, Das UN. Are free radicals involved in the pathobiology of human essential hypertension? Free Radic. Res. Commun. 19, 59-66 (1993).
    • (1993) Free Radic. Res. Commun. , vol.19 , pp. 59-66
    • Kumar, K.V.1    Das, U.N.2
  • 43
    • 0038100213 scopus 로고    scopus 로고
    • Pathobiology of metabolic syndrome X in obese and non-obese South Asian Indians: Further discussion and some suggestions
    • Das UN. Pathobiology of metabolic syndrome X in obese and non-obese South Asian Indians: further discussion and some suggestions. Nutrition 19, 560-562 (2003).
    • (2003) Nutrition , vol.19 , pp. 560-562
    • Das, U.N.1
  • 44
    • 0035666553 scopus 로고    scopus 로고
    • Is obesity an inflammatory condition?
    • Das UN. Is obesity an inflammatory condition? Nutrition 17, 953-966 (2001).
    • (2001) Nutrition , vol.17 , pp. 953-966
    • Das, U.N.1
  • 45
    • 0036232742 scopus 로고    scopus 로고
    • Obesity, metabolic syndrome X, and inflammation
    • Das UN. Obesity, metabolic syndrome X, and inflammation. Nutrition 18, 430-432 (2002).
    • (2002) Nutrition , vol.18 , pp. 430-432
    • Das, U.N.1
  • 46
    • 0035140336 scopus 로고    scopus 로고
    • The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation
    • Dandona P, Mohanty P, Ghanim H et al. The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. J. Clin. Endocrinol. Metab. 86, 355-362 (2001).
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 355-362
    • Dandona, P.1    Mohanty, P.2    Ghanim, H.3
  • 47
    • 0035017056 scopus 로고    scopus 로고
    • Is insulin an anti-inflammatory molecule?
    • Das UN. Is insulin an anti-inflammatory molecule? Nutrition 17, 409-413 (2001).
    • (2001) Nutrition , vol.17 , pp. 409-413
    • Das, U.N.1
  • 48
    • 0036705908 scopus 로고    scopus 로고
    • Insulin attenuates the systemic inflammatory response
    • Jeschke MG, Einspanier R, Klein D et al. Insulin attenuates the systemic inflammatory response. Mol. Med. 8, 443-450 (2002).
    • (2002) Mol. Med. , vol.8 , pp. 443-450
    • Jeschke, M.G.1    Einspanier, R.2    Klein, D.3
  • 49
    • 0036597085 scopus 로고    scopus 로고
    • The anti-inflammatory and potential anti- atherogenic effect of insulin: A new paradigm
    • Dandona P, Aljada A, Mohanty P. The anti-inflammatory and potential anti- atherogenic effect of insulin: a new paradigm. Diabetologia 45, 924-930 (2002).
    • (2002) Diabetologia , vol.45 , pp. 924-930
    • Dandona, P.1    Aljada, A.2    Mohanty, P.3
  • 51
    • 20944451548 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced leptin synthesis and release are differentially controlled by a-melanocyte-stimulating hormone
    • Mastronardi CA, Srivastava V, Yu WH, Les Dees W, McCann SM. Lipopolysaccharide-induced leptin synthesis and release are differentially controlled by a-melanocyte-stimulating hormone. Neuroimmunomodulation 12, 182-188 (2005).
    • (2005) Neuroimmunomodulation , vol.12 , pp. 182-188
    • Mastronardi, C.A.1    Srivastava, V.2    Yu, W.H.3    Les Dees, W.4    McCann, S.M.5
  • 52
    • 0034757834 scopus 로고    scopus 로고
    • Altered lipid profile, leptin, insulin, and anthropometry in offspring of South Asian immigrants in the United States
    • Kalhan R, Puthawala K, Agarwal S, Amini SB, Kalhan SC. Altered lipid profile, leptin, insulin, and anthropometry in offspring of South Asian immigrants in the United States. Metabolism 50, 1197-1202 (2001).
    • (2001) Metabolism , vol.50 , pp. 1197-1202
    • Kalhan, R.1    Puthawala, K.2    Agarwal, S.3    Amini, S.B.4    Kalhan, S.C.5
  • 53
    • 0034163768 scopus 로고    scopus 로고
    • Insulin attenuates the stimulatory effects of tumor necrosis factor a on 11p-hydroxysteroid dehydrogenase 1 in human adipose stromal cells
    • Handoko K, Yang K, Strutt B, Khalil W, Killinger D. Insulin attenuates the stimulatory effects of tumor necrosis factor a on 11p-hydroxysteroid dehydrogenase 1 in human adipose stromal cells. J. Steroid Biochem. Mol. Biol. 72, 163-168 (2000).
    • (2000) J. Steroid Biochem. Mol. Biol. , vol.72 , pp. 163-168
    • Handoko, K.1    Yang, K.2    Strutt, B.3    Khalil, W.4    Killinger, D.5
  • 54
    • 85047681877 scopus 로고    scopus 로고
    • Regulation of expression of 11p-hydroxysteroid dehydrogenase type 1 in adipose tissue: Tissue-specific induction by cytokines
    • Tomilinson JW, Moore J, Cooper MS et al. Regulation of expression of 11p-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. Endocrinology 142, 1982-1989 (2001).
    • (2001) Endocrinology , vol.142 , pp. 1982-1989
    • Tomilinson, J.W.1    Moore, J.2    Cooper, M.S.3
  • 55
    • 0037177142 scopus 로고    scopus 로고
    • Nitric oxide mediates the anti-apoptotic effect of insulin in myocardial ischemia-reperfusion. The roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation
    • Gao F, Gao E, Yue T-L et al. Nitric oxide mediates the anti-apoptotic effect of insulin in myocardial ischemia-reperfusion. The roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation 105, 1497-1502 (2002).
    • (2002) Circulation , vol.105 , pp. 1497-1502
    • Gao, F.1    Gao, E.2    Yue, T.-L.3
  • 56
    • 0037707568 scopus 로고    scopus 로고
    • Folic acid says NO to vascular diseases
    • Das UN. Folic acid says NO to vascular diseases. Nutrition 19, 686-692 (2003).
    • (2003) Nutrition , vol.19 , pp. 686-692
    • Das, U.N.1
  • 58
    • 9644301873 scopus 로고    scopus 로고
    • Insulin resistance, metabolic syndrome and vascular diseases: Update on mechanistic linkages
    • Leif A, Mather K. Insulin resistance, metabolic syndrome and vascular diseases: update on mechanistic linkages. Can. J. Cardiol. 20(Suppl B), 66B-76B (2004).
    • (2004) Can. J. Cardiol. , vol.20 , Issue.SUPPL. B
    • Leif, A.1    Mather, K.2
  • 59
    • 0031908483 scopus 로고    scopus 로고
    • Evidence for a role of tumor necrosis factor a in disturbances of triglycerides and glucose metabolism predisposing to coronary heart disease
    • Jovinge S, Hamsten A, Tomvall P et al. Evidence for a role of tumor necrosis factor a in disturbances of triglycerides and glucose metabolism predisposing to coronary heart disease. Metabolism 47, 113-118 (1998).
    • (1998) Metabolism , vol.47 , pp. 113-118
    • Jovinge, S.1    Hamsten, A.2    Tomvall, P.3
  • 60
    • 0032963307 scopus 로고    scopus 로고
    • Relationship between plasma leptin levels and the tumor necrosis factor a system in obese subjects
    • Corica F, Allegra A, Corsonello A et al. Relationship between plasma leptin levels and the tumor necrosis factor a system in obese subjects. Int. J. Obes. Relat. Metab. Disord. 23, 355-360 (1999).
    • (1999) Int. J. Obes. Relat. Metab. Disord. , vol.23 , pp. 355-360
    • Corica, F.1    Allegra, A.2    Corsonello, A.3
  • 61
    • 0033817093 scopus 로고    scopus 로고
    • Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men
    • Chu N-F, Spiegelman D, Rifai N et al. Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men. Int. J. Obes. 24, 1085-1092 (2000).
    • (2000) Int. J. Obes. , vol.24 , pp. 1085-1092
    • Chu, N.-F.1    Spiegelman, D.2    Rifai, N.3
  • 62
    • 0042380214 scopus 로고    scopus 로고
    • Altered responses to orexigenic (AGRP, MCH) and anorexigenic (a-MSH, CART) neuropeptides of paraventricular hypothalamic neurons in early postnatally overfed rats
    • Davidowa H, Li Y, Plagemann A. Altered responses to orexigenic (AGRP, MCH) and anorexigenic (a-MSH, CART) neuropeptides of paraventricular hypothalamic neurons in early postnatally overfed rats. Eur. J. Neurosci. 18, 613-621 (2003).
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 613-621
    • Davidowa, H.1    Li, Y.2    Plagemann, A.3
  • 63
    • 1542347160 scopus 로고    scopus 로고
    • Cross-fostering to diabetic rat dams affects early development of mediobasal hypothalamic nuclei regulating food intake, body weight, and metabolism
    • Fahrenkrog S, Harder T, Stolaczyk E et al. Cross-fostering to diabetic rat dams affects early development of mediobasal hypothalamic nuclei regulating food intake, body weight, and metabolism. J. Nutr. 134, 648-654 (2004).
    • (2004) J. Nutr. , vol.134 , pp. 648-654
    • Fahrenkrog, S.1    Harder, T.2    Stolaczyk, E.3
  • 64
    • 0037059831 scopus 로고    scopus 로고
    • Diffusion of nitric oxide into low density lipoprotein
    • Denicola A, Batthyany C, Lissi E et al. Diffusion of nitric oxide into low density lipoprotein. J. Biol. Chem. 277, 932-936 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 932-936
    • Denicola, A.1    Batthyany, C.2    Lissi, E.3
  • 65
    • 33746698993 scopus 로고    scopus 로고
    • Pyridoxine prevents dysfunction of endothelial cell nitric oxide production in response to low-density lipoprotein
    • Ji Y, Diao J, Han Y et al. Pyridoxine prevents dysfunction of endothelial cell nitric oxide production in response to low-density lipoprotein. Atherosclerosis 188(1), 84-94 (2006).
    • (2006) Atherosclerosis , vol.188 , Issue.1 , pp. 84-94
    • Ji, Y.1    Diao, J.2    Han, Y.3
  • 66
    • 0035011722 scopus 로고    scopus 로고
    • Nutritional factors in the pathobiology of human essential hypertension
    • Das UN. Nutritional factors in the pathobiology of human essential hypertension. Nutrition 17, 337-346 (2001).
    • (2001) Nutrition , vol.17 , pp. 337-346
    • Das, U.N.1
  • 68
    • 0038818552 scopus 로고    scopus 로고
    • Blockade of the rennin-angiotensin system increases adiponectin concentrations in patients with essential hypertension
    • Furuhashi M, Ura N, Higashiura K et al. Blockade of the rennin-angiotensin system increases adiponectin concentrations in patients with essential hypertension. Hypertension 42, 76-81 (2003).
    • (2003) Hypertension , vol.42 , pp. 76-81
    • Furuhashi, M.1    Ura, N.2    Higashiura, K.3
  • 69
    • 36248999741 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors potentiate subthreshold preconditioning through NO and mitoK(ATP) channel
    • Zhang H, Zhang B, Tang BY, Chen YY, Zhu L, Shen YL. Angiotensin- converting enzyme inhibitors potentiate subthreshold preconditioning through NO and mitoK(ATP) channel. Sheng LiXue Bao 57, 453-460 (2005).
    • (2005) Sheng LiXue Bao , vol.57 , pp. 453-460
    • Zhang, H.1    Zhang, B.2    Tang, B.Y.3    Chen, Y.Y.4    Zhu, L.5    Shen, Y.L.6
  • 70
    • 0042863243 scopus 로고    scopus 로고
    • Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice
    • Cook S, Hugli O, Egli M et al. Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. Swiss Med. Wkly 133, 360-363 (2003).
    • (2003) Swiss Med. Wkly , vol.133 , pp. 360-363
    • Cook, S.1    Hugli, O.2    Egli, M.3
  • 71
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Bruning JC, Gautam D, Burks DJ et al. Role of brain insulin receptor in control of body weight and reproduction. Science 289, 2122-2125 (2000).
    • (2000) Science , vol.289 , pp. 2122-2125
    • Bruning, J.C.1    Gautam, D.2    Burks, D.J.3
  • 72
    • 0033600542 scopus 로고    scopus 로고
    • Insulin stimulates both endothelin and nitric oxide activity in the human forearm
    • Cardillo C, Nambi SS, Kilcoyne CM et al. Insulin stimulates both endothelin and nitric oxide activity in the human forearm. Circulation 100, 820-825 (1999).
    • (1999) Circulation , vol.100 , pp. 820-825
    • Cardillo, C.1    Nambi, S.S.2    Kilcoyne, C.M.3
  • 73
    • 1342332361 scopus 로고    scopus 로고
    • Long-chain polyunsaturated fatty acids interact with nitric oxide, superoxide anion, and transforming growth factor-p to prevent human essential hypertension
    • Das UN. Long-chain polyunsaturated fatty acids interact with nitric oxide, superoxide anion, and transforming growth factor-p to prevent human essential hypertension. Eur. J. Clin. Nutr. 58, 195-203 (2004).
    • (2004) Eur. J. Clin. Nutr. , vol.58 , pp. 195-203
    • Das, U.N.1
  • 74
    • 42949103597 scopus 로고    scopus 로고
    • Insulin inhibits tumor necrosis factor - A induction in myocardial ischemia/reperfusion: Role of Akt and endothelial nitric oxide synthase phosphorylation
    • Li J, Zhang H, Wu F et al. Insulin inhibits tumor necrosis factor-a induction in myocardial ischemia/reperfusion: role of Akt and endothelial nitric oxide synthase phosphorylation. Crit. Care Med. 36, 1551-1558 (2008).
    • (2008) Crit. Care Med. , vol.36 , pp. 1551-1558
    • Li, J.1    Zhang, H.2    Wu, F.3
  • 75
    • 0033838158 scopus 로고    scopus 로고
    • Possible beneficial action(s) of glucose-insulin-potassium regimen in acute myocardial infarction and inflammatory conditions: A hypothesis
    • Das UN. Possible beneficial action(s) of glucose-insulin-potassium regimen in acute myocardial infarction and inflammatory conditions: a hypothesis. Diabetologia 43, 1081-1082 (2000).
    • (2000) Diabetologia , vol.43 , pp. 1081-1082
    • Das, U.N.1
  • 76
    • 0035998350 scopus 로고    scopus 로고
    • Insulin and the critically ill
    • Das UN. Insulin and the critically ill. Crit. Care 6, 262-263 (2002).
    • (2002) Crit. Care , vol.6 , pp. 262-263
    • Das, U.N.1
  • 77
    • 0035830040 scopus 로고    scopus 로고
    • Fetal and early life growth and body mass index from birth to early adulthood in 1958 birth cohort: Longitudinal study
    • Parsons TJ, Power C, Manor O. Fetal and early life growth and body mass index from birth to early adulthood in 1958 birth cohort: longitudinal study. BMJ 323, 1331-1335 (2001).
    • (2001) BMJ , vol.323 , pp. 1331-1335
    • Parsons, T.J.1    Power, C.2    Manor, O.3
  • 78
    • 0028287629 scopus 로고
    • Perinatal hyperinsulinism as possible predisposing factor for diabetes mellitus, obesity and enhanced cardiovascular risk in later life
    • Dorner G, Plagemann A. Perinatal hyperinsulinism as possible predisposing factor for diabetes mellitus, obesity and enhanced cardiovascular risk in later life. Horm. Metab. Res. 26, 213-221 (1994).
    • (1994) Horm. Metab. Res. , vol.26 , pp. 213-221
    • Dorner, G.1    Plagemann, A.2
  • 80
    • 0037369617 scopus 로고    scopus 로고
    • Programming lean body mass: A link between birth weight, obesity, and cardiovascular disease?
    • Singhal A, Wells J, Cole TJ, Fewtrell M, Lucas A. Programming lean body mass: a link between birth weight, obesity, and cardiovascular disease? Am. J. Clin. Nutr. 77, 726-730 (2003).
    • (2003) Am. J. Clin. Nutr. , vol.77 , pp. 726-730
    • Singhal, A.1    Wells, J.2    Cole, T.J.3    Fewtrell, M.4    Lucas, A.5
  • 81
    • 0036201174 scopus 로고    scopus 로고
    • Birth weight and body composition in young women: A prospective twin study
    • Loos RJ, Beunen G, Fagard R, Derom C, Vlietinck R. Birth weight and body composition in young women: a prospective twin study. Am. J. Clin. Nutr. 75, 676-682 (2002).
    • (2002) Am. J. Clin. Nutr. , vol.75 , pp. 676-682
    • Loos, R.J.1    Beunen, G.2    Fagard, R.3    Derom, C.4    Vlietinck, R.5
  • 82
    • 45549090953 scopus 로고    scopus 로고
    • Perinatal nutrition and obesity
    • Das UN. Perinatal nutrition and obesity. Br. J. Nutr. 99, 1391-1392 (2008).
    • (2008) Br. J. Nutr. , vol.99 , pp. 1391-1392
    • Das, U.N.1
  • 83
    • 19444384140 scopus 로고    scopus 로고
    • Early origins of obesity: Programming the appetite regulatory system
    • McMillen IC, Adam CL, Muhlhausler BS. Early origins of obesity: programming the appetite regulatory system. J. Physiol. 565, 9-17 (2005).
    • (2005) J. Physiol. , vol.565 , pp. 9-17
    • McMillen, I.C.1    Adam, C.L.2    Muhlhausler, B.S.3
  • 84
    • 0038043228 scopus 로고    scopus 로고
    • Ontogeny of the hypothalamic neuropeptide y system
    • Grove KL, Smith MS. Ontogeny of the hypothalamic neuropeptide Y system. Physiol. Behav. 79, 47-63 (2003).
    • (2003) Physiol. Behav. , vol.79 , pp. 47-63
    • Grove, K.L.1    Smith, M.S.2
  • 85
    • 0028121685 scopus 로고
    • The VMH-dietary obese rat: A new model of non-insulin-dependent diabetes mellitus
    • Axen KV, Li X, Fung K, Sclafani A. The VMH-dietary obese rat: a new model of non-insulin-dependent diabetes mellitus. Am. J. Physiol. 266(3 Pt 2) R921-R928 (1994).
    • (1994) Am. J. Physiol. , vol.266 , Issue.3 PART 2
    • Axen, K.V.1    Li, X.2    Fung, K.3    Sclafani, A.4
  • 86
    • 0028127890 scopus 로고
    • Marked reduction of pancreatic insulin content in male ventromedial hypothalamic-lesioned spontaneously non-insulin-dependent diabetic (Goto-Kakizaki) rats
    • Keno Y, Tokunaga K, Fujioka S et al. Marked reduction of pancreatic insulin content in male ventromedial hypothalamic-lesioned spontaneously non-insulin-dependent diabetic (Goto-Kakizaki) rats. Metabolism 43, 32-37 (1994).
    • (1994) Metabolism , vol.43 , pp. 32-37
    • Keno, Y.1    Tokunaga, K.2    Fujioka, S.3
  • 87
    • 0029125250 scopus 로고
    • Evidence of a physiological role for neuropeptide y in ventromedial hypothalamic lesion-induced hyperphagia
    • Dube MG, Kalra PS, Crowley WR, Kalra SP. Evidence of a physiological role for neuropeptide Y in ventromedial hypothalamic lesion-induced hyperphagia. Brain Res. 690, 275-278 (1995).
    • (1995) Brain Res. , vol.690 , pp. 275-278
    • Dube, M.G.1    Kalra, P.S.2    Crowley, W.R.3    Kalra, S.P.4
  • 88
    • 0029043638 scopus 로고
    • Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats
    • Funahashi T, Shimomura I, Hiraoka H et al. Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats. Biochem. Biophys. Res. Commun. 211, 469-475 (1995).
    • (1995) Biochem. Biophys. Res. Commun. , vol.211 , pp. 469-475
    • Funahashi, T.1    Shimomura, I.2    Hiraoka, H.3
  • 89
    • 0024516638 scopus 로고
    • Increased neuropeptide y concentrations in specific hypothalamic regions of streptozotocin-induced diabetic rats
    • Williams G, Gill JS, Lee YC, Cordoso HM, Okpere BE, Bloom SR. Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozotocin-induced diabetic rats. Diabetes 38, 321-327 (1989).
    • (1989) Diabetes , vol.38 , pp. 321-327
    • Williams, G.1    Gill, J.S.2    Lee, Y.C.3    Cordoso, H.M.4    Okpere, B.E.5    Bloom, S.R.6
  • 90
    • 0030967891 scopus 로고    scopus 로고
    • Microdialysis study of modification of hypothalamic neurotransmitters in streptozotocin-diabetic rats
    • Ohtani N, Ohta M, Sugano T. Microdialysis study of modification of hypothalamic neurotransmitters in streptozotocin-diabetic rats. J. Neurochem. 69, 1622-1628 (1997).
    • (1997) J. Neurochem. , vol.69 , pp. 1622-1628
    • Ohtani, N.1    Ohta, M.2    Sugano, T.3
  • 91
    • 0028243479 scopus 로고
    • Aspects of hypothalamic neuronal systems in VMH lesion-induced obese rats
    • Takahashi A, Ishimaru H, Ikarashi Y, Maruyama Y. Aspects of hypothalamic neuronal systems in VMH lesion-induced obese rats. J. Auton. Nerv. Syst. 48, 213-219 (1994).
    • (1994) J. Auton. Nerv. Syst. , vol.48 , pp. 213-219
    • Takahashi, A.1    Ishimaru, H.2    Ikarashi, Y.3    Maruyama, Y.4
  • 93
    • 10544249465 scopus 로고    scopus 로고
    • Visceral fat accumulation and vascular complications associated with VMH lesioning of spontaneously non-insulin- dependent diabetic GK rat
    • Yoshida S, Yamashita S, Tokunaga K et al. Visceral fat accumulation and vascular complications associated with VMH lesioning of spontaneously non-insulin- dependent diabetic GK rat. Int. J. Obes. Relat. Metab. Disord. 20, 909-916 (1996).
    • (1996) Int. J. Obes. Relat. Metab. Disord. , vol.20 , pp. 909-916
    • Yoshida, S.1    Yamashita, S.2    Tokunaga, K.3
  • 94
    • 47749136255 scopus 로고    scopus 로고
    • Is metabolic syndrome X a disorder of the brain?
    • Das UN. Is metabolic syndrome X a disorder of the brain? Curr. Nutr. Food Sci. 73-108 (2008).
    • (2008) Curr. Nutr. Food Sci. , pp. 73-108
    • Das, U.N.1
  • 95
    • 0030800192 scopus 로고    scopus 로고
    • Recruitment of functional GABAa receptors to postsynaptic domains by insulin
    • Wan Q, Xiong ZG, Man HY et al. Recruitment of functional GABAa receptors to postsynaptic domains by insulin. Nature 388, 686-690 (1997).
    • (1997) Nature , vol.388 , pp. 686-690
    • Wan, Q.1    Xiong, Z.G.2    Man, H.Y.3
  • 96
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Bruning JC, Gautam D, Burks DJ et al. Role of brain insulin receptor in control of body weight and reproduction. Science 289, 2122-2125 (2000).
    • (2000) Science , vol.289 , pp. 2122-2125
    • Bruning, J.C.1    Gautam, D.2    Burks, D.J.3
  • 97
    • 0022510796 scopus 로고
    • Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas
    • Hill JM, Lesniak MA, Pert CB, Roth J. Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas. Neuroscience 17, 1127-1138 (1986).
    • (1986) Neuroscience , vol.17 , pp. 1127-1138
    • Hill, J.M.1    Lesniak, M.A.2    Pert, C.B.3    Roth, J.4
  • 98
    • 0025916854 scopus 로고
    • Insulin and the paraventricular hypothalamus: Modulation of energy balance
    • Menendez JA, Atrens DM. Insulin and the paraventricular hypothalamus: modulation of energy balance. Brain Res. 555, 193-201 (1991).
    • (1991) Brain Res. , vol.555 , pp. 193-201
    • Menendez, J.A.1    Atrens, D.M.2
  • 99
    • 0026523608 scopus 로고
    • Chronic intrahypothalamic infusions of insulin or insulin antibodies alter body weight and food intake in the rat
    • McGowan MK, Andrews KM, Grossman SP. Chronic intrahypothalamic infusions of insulin or insulin antibodies alter body weight and food intake in the rat. Physiol. Behav. 51, 753-766 (1992).
    • (1992) Physiol. Behav. , vol.51 , pp. 753-766
    • McGowan, M.K.1    Andrews, K.M.2    Grossman, S.P.3
  • 100
    • 0036267472 scopus 로고    scopus 로고
    • Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    • Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat. Neurosci. 5, 566-572 (2002).
    • (2002) Nat. Neurosci. , vol.5 , pp. 566-572
    • Obici, S.1    Feng, Z.2    Karkanias, G.3    Baskin, D.G.4    Rossetti, L.5
  • 101
    • 0028924906 scopus 로고
    • Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression
    • Sipols AJ, Baskin DG, Schwartz MW. Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 44, 147-151 (1995).
    • (1995) Diabetes , vol.44 , pp. 147-151
    • Sipols, A.J.1    Baskin, D.G.2    Schwartz, M.W.3
  • 102
    • 0037109670 scopus 로고    scopus 로고
    • The catabolic action of insulin in the brain is mediated by melanocortins
    • Benoit SC, Air EL, Coolen LM et al. The catabolic action of insulin in the brain is mediated by melanocortins. J. Neurosci. 22, 9048-9052 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 9048-9052
    • Benoit, S.C.1    Air, E.L.2    Coolen, L.M.3
  • 103
    • 0034611732 scopus 로고    scopus 로고
    • Central nervous system control of food intake
    • Schwartz MW. Central nervous system control of food intake. Nature 404, 661-671 (2000).
    • (2000) Nature , vol.404 , pp. 661-671
    • Schwartz, M.W.1
  • 104
    • 0037410414 scopus 로고    scopus 로고
    • Leptin in the CNS: Much more than a satiety signal
    • Harvey J, Ashford ML. Leptin in the CNS: much more than a satiety signal. Neuropharmacology 44, 845-854 (2003).
    • (2003) Neuropharmacology , vol.44 , pp. 845-854
    • Harvey, J.1    Ashford, M.L.2
  • 105
    • 12944261926 scopus 로고    scopus 로고
    • Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation
    • Mirshamsi S, Laidlaw HA, Ning K et al. Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation. BMC Neurosci. 54 (2004).
    • (2004) BMC Neurosci. , vol.54
    • Mirshamsi, S.1    Laidlaw, H.A.2    Ning, K.3
  • 106
    • 0022976996 scopus 로고
    • Intraventricular insulin reduces food intake and body weight of lean but not obese Zucker rats
    • Ikeda H, West DB, Pustek JJ et al. Intraventricular insulin reduces food intake and body weight of lean but not obese Zucker rats. Appetite 7, 381-386 (1986).
    • (1986) Appetite , vol.7 , pp. 381-386
    • Ikeda, H.1    West, D.B.2    Pustek, J.J.3
  • 107
    • 0025804616 scopus 로고
    • Central insulin administration reduces neuropeptide y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats
    • Schwartz MW, Marks J, Sipols AJ et al. Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats. Endocrinology 128, 2645-2647 (1991).
    • (1991) Endocrinology , vol.128 , pp. 2645-2647
    • Schwartz, M.W.1    Marks, J.2    Sipols, A.J.3
  • 108
    • 36248977186 scopus 로고    scopus 로고
    • Metabolic syndrome X is a low-grade systemic inflammatory condition with its origins in the perinatal period
    • Das UN. Metabolic syndrome X is a low-grade systemic inflammatory condition with its origins in the perinatal period. Curr. Nutr. FoodSci. 3, 277-295 (2007).
    • (2007) Curr. Nutr. FoodSci. , vol.3 , pp. 277-295
    • Das, U.N.1
  • 109
    • 0028884712 scopus 로고
    • Insulin and insulin-like growth factor II suppress neuropeptide y release from the nerve terminals in the paraventricular nucleus: A putative hypothalamic site for energy homeostasis
    • Sahu A, Dube MG, Phelps CP, Sninsky CA, Kalra PS, Kalra SP. Insulin and insulin-like growth factor II suppress neuropeptide Y release from the nerve terminals in the paraventricular nucleus: a putative hypothalamic site for energy homeostasis. Endocrinology 136, 5718-5724 (1995).
    • (1995) Endocrinology , vol.136 , pp. 5718-5724
    • Sahu, A.1    Dube, M.G.2    Phelps, C.P.3    Sninsky, C.A.4    Kalra, P.S.5    Kalra, S.P.6
  • 110
    • 0036936565 scopus 로고    scopus 로고
    • Medical and surgical options in the treatment of severe obesity
    • Fisher BL, Schauer P. Medical and surgical options in the treatment of severe obesity. Am. J. Surg 184, 9S-16S (2002).
    • (2002) Am. J. Surg , vol.184
    • Fisher, B.L.1    Schauer, P.2
  • 111
    • 0029130754 scopus 로고
    • Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus
    • Pories WJ, Swanson MS, MacDonald KG et al. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann. Surg. 222, 339-350 (1995).
    • (1995) Ann. Surg. , vol.222 , pp. 339-350
    • Pories, W.J.1    Swanson, M.S.2    MacDonald, K.G.3
  • 112
    • 3042758709 scopus 로고    scopus 로고
    • A surgical model of human Roux-en-Y gastric bypass
    • Meguid MM, Ramos EJB, Suzuki S et al. A surgical model of human Roux-en-Y gastric bypass. J. Gastrointest. Surg. 8, 621-630 (2004).
    • (2004) J. Gastrointest. Surg. , vol.8 , pp. 621-630
    • Meguid, M.M.1    Ejb, R.2    Suzuki, S.3
  • 113
    • 3843118960 scopus 로고    scopus 로고
    • Gene expression profiles post Roux-en-Y gastric bypass
    • Xu Y, Ramos EJB, Middleton F et al. Gene expression profiles post Roux-en-Y gastric bypass. Surgery 136, 246-252 (2004).
    • (2004) Surgery , vol.136 , pp. 246-252
    • Xu, Y.1    Ejb, R.2    Middleton, F.3
  • 114
    • 9144254217 scopus 로고    scopus 로고
    • Neurobiologic changes in the hypothalamus associated with weight loss after gastric bypass
    • Romanova I, Ramos EJB, Xu Y et al. Neurobiologic changes in the hypothalamus associated with weight loss after gastric bypass. J. Am. Coll. Surg. 199, 887-895 (2004).
    • (2004) J. Am. Coll. Surg. , vol.199 , pp. 887-895
    • Romanova, I.1    Ejb, R.2    Xu, Y.3
  • 115
    • 4644226667 scopus 로고    scopus 로고
    • Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: Relationships in obesity
    • Vendrell J, Broch M, Vilarrasa N et al. Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity. Obes. Res. 12, 962-971 (2004).
    • (2004) Obes. Res. , vol.12 , pp. 962-971
    • Vendrell, J.1    Broch, M.2    Vilarrasa, N.3
  • 116
    • 0032854587 scopus 로고    scopus 로고
    • Dopamine induces neutrophil apoptosis through a dopamine D-1 receptor-independent mechanism
    • Sookhai S, Wang JH, McCourt M, O'Connell D, Redmond HP. Dopamine induces neutrophil apoptosis through a dopamine D-1 receptor-independent mechanism. Surgery 126, 314-322 (1999).
    • (1999) Surgery , vol.126 , pp. 314-322
    • Sookhai, S.1    Wang, J.H.2    McCourt, M.3    O'Connell, D.4    Redmond, H.P.5
  • 117
    • 0034279980 scopus 로고    scopus 로고
    • Dopamine attenuates the chemoattractant effect of interleukin-8: A novel role in the systemic inflammatory response syndrome
    • Sookhai S, Wang JH, Winter D, Power C, Kirwan W, Redmond HP. Dopamine attenuates the chemoattractant effect of interleukin-8: a novel role in the systemic inflammatory response syndrome. Shock 14, 295-299 (2000).
    • (2000) Shock , vol.14 , pp. 295-299
    • Sookhai, S.1    Wang, J.H.2    Winter, D.3    Power, C.4    Kirwan, W.5    Redmond, H.P.6
  • 118
    • 33646415114 scopus 로고    scopus 로고
    • Dopamine affects cellular immune functions during polymicrobial sepsis
    • Oberbeck R, Schmitz D, Wilsenack K et al. Dopamine affects cellular immune functions during polymicrobial sepsis. Intens. Care Med. 32, 731-739 (2006).
    • (2006) Intens. Care Med. , vol.32 , pp. 731-739
    • Oberbeck, R.1    Schmitz, D.2    Wilsenack, K.3
  • 119
    • 0035798931 scopus 로고    scopus 로고
    • Brain dopamine and obesity
    • Wang G-J, Volkow ND, Logan J et al. Brain dopamine and obesity. Lancet 357, 354-357 (2001).
    • (2001) Lancet , vol.357 , pp. 354-357
    • Wang, G.-J.1    Volkow, N.D.2    Logan, J.3
  • 120
    • 0018948144 scopus 로고
    • Serotonin and its precursors as modulators of the immunological responsiveness in mice
    • Bliznakov EG. Serotonin and its precursors as modulators of the immunological responsiveness in mice. J. Med. 11, 81-105 (1980).
    • (1980) J. Med. , vol.11 , pp. 81-105
    • Bliznakov, E.G.1
  • 121
    • 0022104388 scopus 로고
    • Changes in the level of serotonin in the brain and immunocompetent organs during the formation of the immune response
    • Mashek K, Devoino LV, Kadletsova O, Idova GV, Morozova NB. Changes in the level of serotonin in the brain and immunocompetent organs during the formation of the immune response. Fiziol Zh SSSR Im IM Sechenova 71, 992-997 (1985).
    • (1985) Fiziol Zh SSSR im im Sechenova , vol.71 , pp. 992-997
    • Mashek, K.1    Devoino, L.V.2    Kadletsova, O.3    Idova, G.V.4    Morozova, N.B.5
  • 122
    • 0024007902 scopus 로고
    • Participation of serotoninergic system in neuroimmunomodulation: Intraimmune mechanisms and the pathways providing an inhibitory effect
    • Devoino L, Morozova N, Cheido M. Participation of serotoninergic system in neuroimmunomodulation: intraimmune mechanisms and the pathways providing an inhibitory effect. Int. J. Neurosci. 40, 111-128 (1988).
    • (1988) Int. J. Neurosci. , vol.40 , pp. 111-128
    • Devoino, L.1    Morozova, N.2    Cheido, M.3
  • 123
    • 36549042025 scopus 로고    scopus 로고
    • Serotonin modulates the oxidative burst of human phagocytes via various mechanisms
    • Ciz M, Komrskova D, Pracharova L et al. Serotonin modulates the oxidative burst of human phagocytes via various mechanisms. Platelets 18, 583-590 (2007).
    • (2007) Platelets , vol.18 , pp. 583-590
    • Ciz, M.1    Komrskova, D.2    Pracharova, L.3
  • 124
    • 35348969860 scopus 로고    scopus 로고
    • Serotonin modulates the cytokine network in the lung: Involvement of prostaglandin E2
    • Menard G, Turmel V, Bissonnette EY. Serotonin modulates the cytokine network in the lung: involvement of prostaglandin E2. Clin. Exp. Immunol. 150, 340-348 (2007).
    • (2007) Clin. Exp. Immunol. , vol.150 , pp. 340-348
    • Menard, G.1    Turmel, V.2    Bissonnette, E.Y.3
  • 125
    • 68149122350 scopus 로고    scopus 로고
    • 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo
    • Muller T, Durk T, Blumental B et al. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS ONE 4, E6453 (2009).
    • (2009) PLoS ONE , vol.4
    • Muller, T.1    Durk, T.2    Blumental, B.3
  • 126
    • 33750327836 scopus 로고    scopus 로고
    • 5-hydroxytryptamine induces mast cell adhesion and migration
    • Kushnir-Sukhov NM, Gilfillan AM, Coleman JW et al. 5-hydroxytryptamine induces mast cell adhesion and migration. J. Immunol. 177, 6422-6432 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 6422-6432
    • Kushnir-Sukhov, N.M.1    Gilfillan, A.M.2    Coleman, J.W.3
  • 127
    • 58149192147 scopus 로고    scopus 로고
    • Neuropeptide y is expressed by rat mononuclear blood leukocytes and strongly down-regulated during inflammation
    • Holler J, Zakrzewicz A, Kaufmann A et al. Neuropeptide Y is expressed by rat mononuclear blood leukocytes and strongly down-regulated during inflammation. J. Immunol. 181, 6906-6912 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 6906-6912
    • Holler, J.1    Zakrzewicz, A.2    Kaufmann, A.3
  • 128
    • 33750959354 scopus 로고    scopus 로고
    • Neuropeptide y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch
    • Dimitrijevic M, Stanojevic S, Mitic S et al. Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch. Peptides 27, 3208-3215 (2006).
    • (2006) Peptides , vol.27 , pp. 3208-3215
    • Dimitrijevic, M.1    Stanojevic, S.2    Mitic, S.3
  • 129
    • 56049125933 scopus 로고    scopus 로고
    • The anti-inflammatory effect of neuropeptide y (NPY) in rats is dependent on dipeptidyl peptidase 4 (DP4) activity and age
    • Dimitrijevic M, Stanojevic S, Mitic S et al. The anti-inflammatory effect of neuropeptide Y (NPY) in rats is dependent on dipeptidyl peptidase 4 (DP4) activity and age. Peptides 29, 2179-2187 (2008).
    • (2008) Peptides , vol.29 , pp. 2179-2187
    • Dimitrijevic, M.1    Stanojevic, S.2    Mitic, S.3
  • 130
    • 53249142340 scopus 로고    scopus 로고
    • Targeted deletion of neuropeptide y (NPY) modulates experimental colitis
    • Chandrasekharan B, Bala V, Kolachala VL et al. Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis. PLoS ONE 3, E3304 (2008).
    • (2008) PLoS ONE , vol.3
    • Chandrasekharan, B.1    Bala, V.2    Kolachala, V.L.3
  • 131
    • 0030560659 scopus 로고    scopus 로고
    • Differential effects of gastrin-releasing peptide, neuropeptide Y, somatostatin and vasoactive intestinal peptide on interleukin-1 p, interleukin-6 and tumor necrosis factor - A production by whole blood cells from healthy young and old subjects
    • Hernanz A, Tato E, De la Fuente M, de Miguel E, Arnalich F. Differential effects of gastrin-releasing peptide, neuropeptide Y, somatostatin and vasoactive intestinal peptide on interleukin-1 p, interleukin-6 and tumor necrosis factor-a production by whole blood cells from healthy young and old subjects. J. Neuroimmunol. 71, 25-30 (1996).
    • (1996) J. Neuroimmunol. , vol.71 , pp. 25-30
    • Hernanz, A.1    Tato, E.2    De La Fuente, M.3    De Miguel, E.4    Arnalich, F.5
  • 132
    • 0034003336 scopus 로고    scopus 로고
    • Effect of cytokines on hypothalamic neuropeptide y release in vitro
    • King PJ, Widdowson PS, Doods H, Williams G. Effect of cytokines on hypothalamic neuropeptide Y release in vitro. Peptides 21, 143-146 (2000).
    • (2000) Peptides , vol.21 , pp. 143-146
    • King, P.J.1    Widdowson, P.S.2    Doods, H.3    Williams, G.4
  • 134
    • 42949146633 scopus 로고    scopus 로고
    • Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin
    • Lopez M, Lage R, Saha AK et al. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab. 7, 389-399 (2008).
    • (2008) Cell Metab. , vol.7 , pp. 389-399
    • Lopez, M.1    Lage, R.2    Saha, A.K.3
  • 135
    • 3242749843 scopus 로고    scopus 로고
    • Ghrelin inhibits leptin- and activation- induced proinflammatory cytokine expression by human monocytes and T cells
    • Dixit VD, Schaffer EM, Pyle RS et al. Ghrelin inhibits leptin- and activation- induced proinflammatory cytokine expression by human monocytes and T cells. J. Clin. Invest. 114, 57-66 (2004).
    • (2004) J. Clin. Invest. , vol.114 , pp. 57-66
    • Dixit, V.D.1    Schaffer, E.M.2    Pyle, R.S.3
  • 136
    • 68249101621 scopus 로고    scopus 로고
    • Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats
    • Wu R, Dong W, Qiang X et al. Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats. Crit. Care Med. 37, 2421-2426 (2009).
    • (2009) Crit. Care Med. , vol.37 , pp. 2421-2426
    • Wu, R.1    Dong, W.2    Qiang, X.3
  • 137
    • 77950008727 scopus 로고    scopus 로고
    • TNF-A and ghrelin: Opposite effects on immune system, metabolism and mental health
    • Himmerch H, Sheldrick AJ. TNF-a and ghrelin: opposite effects on immune system, metabolism and mental health. Protein Pept. Lett. 17(2), 186-196 (2010).
    • (2010) Protein Pept. Lett. , vol.17 , Issue.2 , pp. 186-196
    • Himmerch, H.1    Sheldrick, A.J.2
  • 138
    • 34247640178 scopus 로고    scopus 로고
    • Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve
    • Wu R, Dong W, Cui X et al. Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve. Ann. Surg. 245, 480-486 (2007).
    • (2007) Ann. Surg. , vol.245 , pp. 480-486
    • Wu, R.1    Dong, W.2    Cui, X.3
  • 139
    • 35648982544 scopus 로고    scopus 로고
    • A-MSH related peptides: A new class of anti-inflammatory and immunomodulating drugs
    • Luger TA, Brzoska T. a-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Ann. Rheum. Dis. 66(Suppl. 3), 52-55 (2007).
    • (2007) Ann. Rheum. Dis. , vol.66 , Issue.SUPPL. 3 , pp. 52-55
    • Luger, T.A.1    Brzoska, T.2
  • 140
    • 44849128371 scopus 로고    scopus 로고
    • The diminishment of experimental autoimmune encephalomyelitis (EAE) by neuropeptide a-melanocyte stimulating hormone (a-MSH) therapy
    • Taylor AW, Kitaichi N. The diminishment of experimental autoimmune encephalomyelitis (EAE) by neuropeptide a-melanocyte stimulating hormone (a-MSH) therapy. Brain Behav. Immun. 22, 639-646 (2008).
    • (2008) Brain Behav. Immun. , vol.22 , pp. 639-646
    • Taylor, A.W.1    Kitaichi, N.2
  • 141
    • 56949087765 scopus 로고    scopus 로고
    • Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway
    • Pavlov VA, Parrish WR, Rosas-Ballina M et al. Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway. Brain Behav. Immun. 23, 41-45 (2009).
    • (2009) Brain Behav. Immun. , vol.23 , pp. 41-45
    • Pavlov, V.A.1    Parrish, W.R.2    Rosas-Ballina, M.3
  • 142
    • 37249057800 scopus 로고    scopus 로고
    • Acetylcholinesterase and butyrylcholinesterase as possible markers of low-grade systemic inflammation
    • Das UN. Acetylcholinesterase and butyrylcholinesterase as possible markers of low-grade systemic inflammation. Med. Sci. Monit. 13, RA214-RA221 (2007)
    • (2007) Med. Sci. Monit. , vol.13
    • Das, U.N.1
  • 143
    • 67650501700 scopus 로고    scopus 로고
    • The cholinergic anti-inflammatory pathway: Towards innovative treatment of rheumatoid arthritis
    • Van Maanen MA, Vervoordeldonk MJ, Tak PP. The cholinergic anti-inflammatory pathway: towards innovative treatment of rheumatoid arthritis. Nat. Rev. Rheumatol. 5, 229-232 (2009).
    • (2009) Nat. Rev. Rheumatol. , vol.5 , pp. 229-232
    • Van Maanen, M.A.1    Vervoordeldonk, M.J.2    Tak, P.P.3
  • 144
    • 33745885021 scopus 로고    scopus 로고
    • High serum high-sensitivity C-reactive protein concentrations are associated with relative cardiac sympathetic overactivity during the early morning period in Type 2 diabetic patients with metabolic syndrome
    • Aso Y, Wakabayashi S, Nakano T, Yamamoto R, Takebayashi K, Inukai T. High serum high-sensitivity C-reactive protein concentrations are associated with relative cardiac sympathetic overactivity during the early morning period in Type 2 diabetic patients with metabolic syndrome. Metabolism 55, 1014-1021 (2006).
    • (2006) Metabolism , vol.55 , pp. 1014-1021
    • Aso, Y.1    Wakabayashi, S.2    Nakano, T.3    Yamamoto, R.4    Takebayashi, K.5    Inukai, T.6
  • 145
    • 33744996917 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits LPS-induced IL-1p production in cultured rat astrocytes
    • Iwai T, Ito S, Tanimitsu K, Udagawa S, Oka J. Glucagon-like peptide-1 inhibits LPS-induced IL-1p production in cultured rat astrocytes. Neurosci. Res. 55, 352-360 (2006).
    • (2006) Neurosci. Res. , vol.55 , pp. 352-360
    • Iwai, T.1    Ito, S.2    Tanimitsu, K.3    Udagawa, S.4    Oka, J.5
  • 146
    • 48949088649 scopus 로고    scopus 로고
    • Anti-proliferative effect of pro-inflammatory cytokines in cultured p cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition: Protective role of glucagon-like peptide-1
    • Blandino-Osano M, Perez-Arana G, Mellado-Gil JM, Segundo C, Aguilar- Diosdado M. Anti-proliferative effect of pro-inflammatory cytokines in cultured p cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition: protective role of glucagon-like peptide-1. J. Mol. Endocrinol. 41, 35-44 (2008).
    • (2008) J. Mol. Endocrinol. , vol.41 , pp. 35-44
    • Blandino-Osano, M.1    Perez-Arana, G.2    Mellado-Gil, J.M.3    Segundo, C.4    Aguilar- Diosdado, M.5
  • 147
    • 62749133510 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation
    • Kim SJ, Nian C, Doudet DJ, McIntosh CH. Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Diabetes 58, 641-651 (2009).
    • (2009) Diabetes , vol.58 , pp. 641-651
    • Kim, S.J.1    Nian, C.2    Doudet, D.J.3    McIntosh, C.H.4
  • 148
    • 61649116369 scopus 로고    scopus 로고
    • Pro-inflammatory effect of leptin on peripheral blood mononuclear cells of patients with ankylosing spondylitis
    • Park MC, Chung SJ, Park YB, Lee SK. Pro-inflammatory effect of leptin on peripheral blood mononuclear cells of patients with ankylosing spondylitis. Joint Bone Spine 76, 170-175 (2009).
    • (2009) Joint Bone Spine , vol.76 , pp. 170-175
    • Park, M.C.1    Chung, S.J.2    Park, Y.B.3    Lee, S.K.4
  • 149
    • 64549104642 scopus 로고    scopus 로고
    • High-fat diet induces apoptosis of hypothalamic neurons
    • Moraes JC, Coope A, Morari J et al. High-fat diet induces apoptosis of hypothalamic neurons. PLoS ONE 4, E5045 (2009).
    • (2009) PLoS ONE , vol.4
    • Moraes, J.C.1    Coope, A.2    Morari, J.3
  • 150
    • 66149118129 scopus 로고    scopus 로고
    • Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet
    • Posey KA, Clegg DJ, Printz RL et al. Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am. J. Physiol. Endocrinol. Metab. 296, E1003-E1012 (2009).
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296
    • Posey, K.A.1    Clegg, D.J.2    Printz, R.L.3
  • 151
    • 24944438230 scopus 로고    scopus 로고
    • Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
    • De Souza CT, Araujo EP, Bordin S et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146, 4192-4199 (2005).
    • (2005) Endocrinology , vol.146 , pp. 4192-4199
    • De Souza, C.T.1    Araujo, E.P.2    Bordin, S.3
  • 152
    • 26844436564 scopus 로고    scopus 로고
    • Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve
    • Luyer MD, Greve JW, Hadfoune M, Jacobs JA, Dejong CH, Buurman WA. Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. J. Exp. Med. 202, 1023-1029 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 1023-1029
    • Luyer, M.D.1    Greve, J.W.2    Hadfoune, M.3    Jacobs, J.A.4    Dejong, C.H.5    Buurman, W.A.6
  • 153
    • 0035140336 scopus 로고    scopus 로고
    • The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation
    • Dandona P, Mohanty P, Ghanim H et al. The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. J. Clin. Endocrinol. Metab. 86, 355-362 (2001).
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 355-362
    • Dandona, P.1    Mohanty, P.2    Ghanim, H.3
  • 154
    • 33750300106 scopus 로고    scopus 로고
    • Modulation of vagal afferent excitation and reduction of food intake by leptin and cholecystokinin
    • Peters JH, Simasko SM, Ritter RG. Modulation of vagal afferent excitation and reduction of food intake by leptin and cholecystokinin. Physiol. Behav. 89, 477-485 (2006).
    • (2006) Physiol. Behav. , vol.89 , pp. 477-485
    • Peters, J.H.1    Simasko, S.M.2    Ritter, R.G.3
  • 155
    • 4344675633 scopus 로고    scopus 로고
    • Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy
    • Ueno N, Dube MG, Inui A, Kalra PS, Kalra SP. Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy. Endocrinology 145, 4176-4184 (2004).
    • (2004) Endocrinology , vol.145 , pp. 4176-4184
    • Ueno, N.1    Dube, M.G.2    Inui, A.3    Kalra, P.S.4    Kalra, S.P.5
  • 156
    • 33751214825 scopus 로고    scopus 로고
    • Ghrelin increases neuropeptide y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures
    • Goto M, Arima H, Watanabe M et al. Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures. Endocrinology 147(11), 5102-5109 (2006).
    • (2006) Endocrinology , vol.147 , Issue.11 , pp. 5102-5109
    • Goto, M.1    Arima, H.2    Watanabe, M.3
  • 157
    • 33746780697 scopus 로고    scopus 로고
    • The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykininergic motor neurones
    • Bassil AK, Dass NB, Sanger GJ. The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykininergic motor neurones. Eur. J. Pharmacol. 544(1-3), 146-152 (2006).
    • (2006) Eur. J. Pharmacol. , vol.544 , Issue.1-3 , pp. 146-152
    • Bassil, A.K.1    Dass, N.B.2    Sanger, G.J.3
  • 158
    • 33745151403 scopus 로고    scopus 로고
    • Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity
    • Uno K, Katagiri H, Yamada T et al. Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science 312, 1656-1659 (2006).
    • (2006) Science , vol.312 , pp. 1656-1659
    • Uno, K.1    Katagiri, H.2    Yamada, T.3
  • 159
    • 0034713266 scopus 로고    scopus 로고
    • Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
    • Borovikova LV, Ivanova S, Zhang M et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405, 458-462 (2000).
    • (2000) Nature , vol.405 , pp. 458-462
    • Borovikova, L.V.1    Ivanova, S.2    Zhang, M.3
  • 161
    • 33845541048 scopus 로고    scopus 로고
    • Attenuation of insulin-evoked responses in brain networks controlling appetite and reward in insulin resistance. The cerebral basis for impaired control of food intake in metabolic syndrome?
    • Anthony K, Reed LJ, Dunn J T et al. Attenuation of insulin-evoked responses in brain networks controlling appetite and reward in insulin resistance. The cerebral basis for impaired control of food intake in metabolic syndrome? Diabetes 55, 2986-2992 (2006).
    • (2006) Diabetes , vol.55 , pp. 2986-2992
    • Anthony, K.1    Reed, L.J.2    Dunn, J.T.3
  • 162
    • 33750591273 scopus 로고    scopus 로고
    • Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats
    • Flores MBS, Fernandes MFA, Ropello ER et al. Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats. Diabetes 55, 2554-2561 (2006).
    • (2006) Diabetes , vol.55 , pp. 2554-2561
    • Mbs, F.1    Mfa, F.2    Ropello, E.R.3
  • 163
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura S, Manabe I, Nagasaki M et al CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 15, 914-921 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 914-921
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3
  • 164
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesity-associated insulin resistance through immunotherapy
    • Winer S, Chan Y, Paltser G et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat. Med. 15, 921-930 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 921-930
    • Winer, S.1    Chan, Y.2    Paltser, G.3
  • 165
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feurer M, Herrero L, Cipolletta D et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 15, 930-940 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 930-940
    • Feurer, M.1    Herrero, L.2    Cipolletta, D.3
  • 167
    • 0036908984 scopus 로고    scopus 로고
    • Is metabolic syndrome X an inflammatory condition?
    • Das UN. Is metabolic syndrome X an inflammatory condition? Exp. Biol. Med. 227, 989-997 (2002).
    • (2002) Exp. Biol. Med. , vol.227 , pp. 989-997
    • Das, U.N.1
  • 168
    • 0036232742 scopus 로고    scopus 로고
    • Obesity, metabolic syndrome X, and inflammation
    • Das UN. Obesity, metabolic syndrome X, and inflammation. Nutrition 18, 430-432 (2002).
    • (2002) Nutrition , vol.18 , pp. 430-432
    • Das, U.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.