α-MSH related peptides: A new class of anti-inflammatory and immunomodulating drugs

Annals of the Rheumatic Diseases

Volumn 66, Issue SUPPL. 3, 2007, Pages

  Luger, Thomas A ^a,b   Brzoska, Thomas ^b,c  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c Dr August Wolff GmbH and Co KG Arzneimittel   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; ALPHA INTERMEDIN DERIVATIVE; BETA INTERMEDIN; CHEMOKINE RECEPTOR; CORTICOTROPIN; GAMMA INTERMEDIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MELANOCORTIN; MELANOCORTIN RECEPTOR;

ANTIINFLAMMATORY ACTIVITY; ASTHMA; CARBOXY TERMINAL SEQUENCE; CELL ACTIVITY; CELL ADHESION; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CONFERENCE PAPER; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; ENCEPHALITIS; ENTERITIS; EYE INFLAMMATION; HUMAN; IMMUNOMODULATION; IRRITANT DERMATITIS; MELANOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SKIN ALLERGY; VASCULITIS;

ALPHA-MSH; ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; BONE DISEASES; CELL ADHESION MOLECULES; CYTOKINES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION; LYMPHOCYTES; MICE; MUTATION; NF-KAPPA B; PRO-OPIOMELANOCORTIN; RECEPTORS, MELANOCORTIN;

EID: 35648982544     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2007.079780     Document Type: Conference Paper

References (38)

1. Böhm M, Luger TA, Tobin DJ, Garcia-Borron JC. Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. J Invest Dermatol 2006;126:1966-75.
2. Brzoska T, Luger TA, Abels Ch, Böhm M. α-MSH and related tripeptides. Endocr Rev, In press.
3. Eipper BA, Mains RE. Structure and biosynthesis of pro-adrenocorticotropin/endorphin and related peptides. Endocr Rev 1980;1:1-27.
4. Seidah NG, Benjannet S, Hamelin J, Mamarbachi AM, Basak A, Marcinkiewicz J, et al. The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1. Ann N Y Acad Sci 1999;885:57-74.
5. Haskell-Luevano C, Sawyer TK, Hendrata S, North C, Panahinia L, Stum M, et al. Truncation studies of alpha-melanotropin peptides identify tripeptide analogues exhibiting prolonged agonist bioactivity. Peptides 1996;17:995-1002.
6. Buzzetti R, McLoughlin L, Lavender PM, Clark AJ, Rees LH. Expression of pro-opiomelanocortin gene and quantification of adrenocorticotropic hormone-like immunoreactivity in human normal peripheral mononuclear cells and lymphoid and myeloid malignancies. J Clin Invest 1989;83:733-7.
7. Schioth HB, Muceniece R, Larsson M, Mutulis F, Szardenings M, Prusis P, et al. Binding of cyclic and linear MSH core peptides to the melanocortin receptor subtypes. Eur J Pharmacol 1997;319:369-73.
8. Lam CW, Getting SJ. Melanocortin receptor type 3 as a potential target for anti-inflammatory therapy. Curr Drug Targets Inflamm Allergy 2004;3:311-5.
9. Mugridge KG, Perretti M, Ghiara P, Parente L. Alpha-melanocyte- stimulating hormone reduces interleukin-1 beta effects on rat stomach preparations possibly through interference with a type I receptor. Eur J Pharmacol 1991;197:151-5.
10. Brzoska T, Kalden DH, Scholzen T, Luger TA. Molecular basis of α-MSH/IL-1 antagonism. Ann N Y Acad Sci 1999;885:230-8.
11. Manna SK, Aggarwal BB. α-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kB activation induced by various inflammatory agents. J Immunol 1998;161:2873-80.
12. Moustafa M, Szabo M, Ghanem GE, Morandini R, Kemp EH, MacNeil S, et al. Inhibition of tumor necrosis factor-alpha stimulated NFkappaB/p65 in human keratinocytes by alpha-melanocyte stimulating hormone and adrenocorticotropic hormone peptides. J Invest Dermatol 2002;119:1244-53.
13. Luger TA, Scholzen T, Grabbe S. The role of α-melanocyte stimulating hormone in cutaneous biology. J Invest Dermatol Symp Proc 1997;2:87-93.
14. Manna SK, Sarkar A, Sreenivasan Y. Alpha-melanocyte-stimulating hormone down-regulates CXC receptors through activation of neutrophil elastase. Eur J Immunol 2006;36:754-69.
15. Bhardwaj RS, Schwarz A, Becher E, Mahnke K, Riemann H, Aragane Y, et al. Pro-opiomelanocortin-derived peptides induce IL-10 production in human monocytes. J Immunol 1996;156:2517-21.
16. Redondo P, Garcia-Foncillas J, Okroujnov I, Bandres E. α-MSH regulates interleukin-10 expression by human keratinocytes. Arch Dermatol Res 1998;290:425-8.
17. Bohm M, Eickelmann M, Li Z, Schneider SW, Oji V, Diederichs S, et al. Detection of functionally active melanocortin receptors and evidence for an immunoregulatory activity of alpha-melanocyte-stimulating hormone in human dermal papilla cells. Endocrinology 2005;146: 4635-46.
18. Scholzen TE, Sunderkotter C, Kalden DH, Brzoska T, Fastrich M, Fisbeck T, et al. Alpha-melanocyte stimulating hormone prevents lipopolysaccharide-induced vasculitis by down-regulating endothelial cell adhesion molecule expression. Endocrinology 2003;144:360-70.
19. Bhardwaj RS, Becher E, Mahnke K, Hartmeyer M, Schwarz T, Scholzen T, et al. Evidence for the differential expression of the functional alpha melanocyte stimulating hormone receptor MC-1 on human monocytes. J Immunol 1997;158:3378-84.
20. Andersen GN, Hagglund M, Nagaeva O, Frangsmyr L, Petrovska R, Mincheva-Nilsson L, et al. Quantitative measurement of the levels of melanocortin receptor subtype 1, 2, 3 and 5 and pro-opio-melanocortin peptide gene expression in subsets of human peripheral blood leucocytes. Scand J Immunol 2005;61:279-84.
21. Namba K, Kitaichi N, Nishida T, Taylor AW. Induction of regulatory T cells by the immunomodulating cytokines alpha-melanocyte-stimulating hormone and transforming growth factor-beta2. J Leukoc Biol 2002;72:946- 52.
22. Carotenuto A, Saviello MR, Auriemma L, Campiglia P, Catania A, Novellino E, et al. Structure-function relationships and conformational properties of alpha-MSH(6-13) analogues with candidacidal activity. Chem Biol Drug Des 2007;69:68-74.
23. Catania A, Colombo G, Rossi C, Carlin A, Sordi A, Lonati C, et al. Antimicrobial properties of alpha-MSH and related synthetic melanocortins. Scientific World Journal 2006;6:1241-6.
24. Catania A, Grieco P, Randazzo A, Novellino E, Gatti S, Rossi C, et al. Three-dimensional structure of the alpha-MSH-derived candidacidal peptide [Ac-CKPV]2. J Pept Res 2005;66:19-26.
25. Rheins LA, Cotleur AL, Kleier RS, Hoppenjans WB, Sauder DN, Nordlund JJ. Alpha-melanocyte stimulating hormone modulates contact hypersensitivity responsiveness in C57/BL6 mice. J Invest Dermatol 1989;93:511-7.
26. Grabbe S, Bhardwaj RS, Steinert M, Mahnke K, Simon MM, Schwarz T, et al. Alpha-melanocyte stimulating hormone induces hapten-specific tolerance in mice. J Immunol 1996;156:473-8.
27. Elliott RJ, Szabo M, Wagner MJ, Kemp EH, MacNeil S, Haycock JW. alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells. J Invest Dermatol 2004;122:1010-9.
28. Getting SJ, Schioth HB, Perretti M. Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte- stimulating hormone peptides. J Pharmacol Exp Ther 2003;306:631-7.
29. Luger TA, Scholzen TE, Brzoska T, Bohm M. New insights into the functions of alpha-MSH and related peptides in the immune system. Ann N Y Acad Sci 2003;994:133-40.
30. Slominski A, Wortsman J, Luger T, Paus R, Solomon S. Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 2000;80:979-1020.
31. Raap U, Brzoska T, Sohl S, Path G, Emmel J, Herz U, et al. Alpha-melanocyte-stimulating hormone inhibits allergic airway inflammation. J Immunol 2003;171:353-9.
32. Taylor AW, Yee DG, Nishida T, Namba K. Neuropeptide regulation of immunity. The immunosuppressive activity of alpha-melanocyte-stimulating hormone (alpha-MSH). Ann N Y Acad Sci 2000;917:239-47.
33. Nishida T, Miyata S, Itoh Y, Mizuki N, Ohgami K, Shiratori K, et al. Anti-inflammatory effects of alpha-melanocyte-stimulating hormone against rat endotoxin-induced uveitis and the time course of inflammatory agents in aqueous humor. Int Immunopharmacol 2004;4:1059-66.
34. Ceriani G, Diaz J, Murphree S, Catania A, Lipton JM. The neuropeptide alpha-melanocyte-stimulating hormone inhibits experimental arthritis in rats. Neuroimmunomodulation 1994;1:28-32.
35. Getting SJ, Christian HC, Flower RJ, Perretti M. Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis Rheum 2002;46:2765- 75.
36. Rajora N, Boccoli G, Catania A, Lipton JM. alpha-MSH modulates experimental inflammatory bowel disease. Peptides 1997;18:381-5.
37. Oktar BK, Ercan F, Yegen BC, Alican I. The effect of alpha-melanocyte stimulating hormone on colonic inflammation in the rat. Peptides 2000;21:1271-7.
38. Maaser C, Kannengiesser K, Specht C, Lugering A, Brzoska T, Luger TA, et al. Crucial role of the melanocortin receptor MC1R in experimental colitis. Gut 2006;55:1415-22.