Visceral fat accumulation and vascular complications associated with VMH lesioning of spontaneously non-insulin-dependent diabetic GK rat

International Journal of Obesity

Volumn 20, Issue 10, 1996, Pages 909-916

  Yoshida, S ^a   Yamashita, S ^a   Tokunaga, K ^a   Yamane, M ^a   Shinohara, E ^a   Keno, Y ^a   Nishida, M ^a   Kotani, K ^a   Shimomura, I ^a   Kobayashi, H ^a   Nakamura, T ^a   Miyagawa, J ^a   Kameda Takemura, K ^a   Odaka, H ^b   Ikeda, H ^b   Matsuzawa, Y ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Diabetes mellitus; GK rat; Macroangiopathy; Microangiopathy; Visceral fat; VMH (ventromedial hypothalamus)

Indexed keywords

ALBUMIN; GLUCOSE; INSULIN; LIPID; PROTEIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY WEIGHT; CONTROLLED STUDY; DESCENDING AORTA; DIABETIC MICROANGIOPATHY; FOOD INTAKE; GLOMERULUS BASEMENT MEMBRANE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; MALE; MESENTERY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RAT; SUBCUTANEOUS FAT; TIME; TRIACYLGLYCEROL BLOOD LEVEL; URINARY EXCRETION;

ADIPOSE TISSUE; ANIMALS; AORTA, THORACIC; ARTERIOSCLEROSIS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; EATING; GLYCOSURIA; HYPOTHALAMUS, MIDDLE; INSULIN; LIPIDS; MALE; OBESITY; PANCREAS; RATS; RATS, MUTANT STRAINS; RATS, WISTAR; VISCERA;

ANIMALIA; GLOMERULUS; RATTUS NORVEGICUS;

EID: 10544249465     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S. Contribution of intraabdominal fat accumulation to the impairment of glucose and lipid metabolism Metabolism 1987; 36: 57-59.
2. Kanai H et al. Close correlation of intraabdominal fat accumulation to hypertension in obese women Hypertension 1990; 16: 484-490.
3. Nakamura T et al. Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men Atherosclerosis 1994; 107: 239-246.
4. Goto Y, Kakizaki M, Masaki N. Spontaneous diabetes produced by selective breeding of normal Wistar rats Proc Jpn Acad 1975; 51: 80-85.
5. Goto Y, Kakizaki M, Masaki N. Production of spontaneous diabetic rats by repetition of selective breeding Tohoku J Exp Med 1976; 119: 85-90.
6. Goto Y, Kakizaki M. The spontaneous-diabetes rat: a model of insulin dependent diabetes mellitus Proc Jpn Acad 1981; 57: 381-384.
7. Goto Y et al. Development of diabetes in the non-obese NIDDM rat (GK rat) Adv Exp Med Biol 1988; 246: 29-31.
8. Keno Y et al. Marked reduction of pancreatic insulin content in male ventromedial hypothalamic lesioned spontaneously non-insulin-dependent diabetic (Goto-Kakizaki) rats Metabolism 1994; 43: 1-5.
9. Tokunaga K, Fukushima M, Kemnitz JW, Bray GA. Comparison of ventromedial and paraventricular lesions in rats that become obese Am J Physiol 1986; 251: R1221-R1227.
10. Tokunaga K, Bray GA, Matsuzawa Y. Improved yield of obese rats using a double coordinate system to locate the ventromedial and paraventricular nucleus Brain Res Bull 1993; 32: 191-194.
11. Kobatake T et al. Metabolic improvements associated with a reduction of abdominal visceral fat caused by a new a-glucosidase inhibitor, AO-128, in Zucker fatty rats Int J Obes 1989; 13: 147-154.
12. Krotkiewski M, Björntorp P. The effect of progesterone and of insulin administration on regional adipose tissue cellularity in the rat Acta Physiol Scand 1976; 96: 122-127.
13. Mogan CR, Lazarow A. Immunoassay of insulin using a two-antibody system Proc Soc Exp Biol Med 1962; 110: 29-32.
14. Portha B, Picon L, Rosselin G. Chemical diabetes in the adult rat as the spontaneous evolution of neonatal diabetes Diabetologia 1979; 17: 371-377.
15. Goto Y, Kakizaki M. The spontaneous diabetes rat: a model of non insulin dependent diabetes mellitus Proc Jpn Acad 1981; 57: 381-384.
16. Goto Y et al. GK rats as a model of nonobese, non-insulin-dependent diabetes: selective breeding over 35 generations. In: Shafrir E, Renold AE (eds). Frontiers in Diabetes Research. Lessons From Animal Diabetes. II. Libbey: London 1988; pp 301-303.
17. Kimura K et al. Impaired insulin secretion in the spontaneous diabetes rats Tohoku J Exp Med 1982; 137: 453-459.
18. Portha B et al. B-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type 2 diabetes Diabetes 1991; 40: 486-491.
19. Portha B et al. Glucose refractoriness of pancreatic β-cells in rat models of non-insulin dependent diabetes Diabete Metab 1994; 20: 108-115.
20. Sugiyama Y et al. Role of hepatic insulin sensitivity in development of hyperglycemia of spontaneously diabetic GK rats J Jpn Diab Soc 1989; 32: 593-599.
21. Hughes SJ, Suzuki K, Goto Y. The role of islet secretory function in the development of diabetes in the GK Wistar rat Diabetologia 1994; 37: 863-870.
22. Farese RV et al. Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats Proc Natl Acad Sci USA 1994; 91: 11040-11044.
23. Bray GA, York DA. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis Physiol Rev 1979; 59: 719-780.
24. Suzuki K, Goto Y. Non-insulin-dependent diabetic Goto-Kakizaki (GK) rats Progress in Diabetes Mellitus Research 1987; 22: 211-217(in Japanese).
25. Inoue S et al. The changes of glucose tolerance induced by VMH lesion in spontaneously non-insulin-dependent diabetic GK (Goto-Kakizaki) rat Tounyoubyou-Doubutsu 1987; 1: 142-145(in Japanese).
26. Lealy JL, Cooper HE, Deal DA, Weir GC. Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion J Clin Invest 1986; 77: 908-915.
27. Inoue S. Animal models of obesity: Hypothalamic lesions. In: Björntorp P, Brodoff BN (eds). Obesity 1992, JB Lippincott Co. pp 266-277.
28. Matsuzawa Y et al. Pathophysiology and pathogenesis of visceral fat obesity Ann New York Acad Sci 1993; 676: 270-278.
29. Shimomura I et al. Marked reduction of acyl-CoA synthetase activity and mRNA in intra-abdominal visceral fat by physical exercise Am J Physiol 1993; 265: E44-E50.
30. Tokunaga K et al. PVN-lesioned obese rats maintain ambulatory activity and its circadian rhythm Brain Res Bull 1991; 26: 393-396.
31. Hogan S, Coscine DV, Himms-Hagen J. Brown adipose tissue of rats with obesity-inducing ventromedial hypothalamic lesions Am J Physiol 1982; 243: E338-E 344.
32. Hartman AD, Christ DW. Effect of cell size, age and anatomical location on the lipolytic response of adipocytes Life Sci 1978; 22: 1087-1096.
33. Ostman J, Arner P, Engfeldt P, Kager L. Regional differences in the control of lipolysis in human adipose tissue Metabolism 1979; 28: 1198-1205.
34. Rebuffé-Scrive M, Andersson B, Olbe L, Bjorntorp P. Metabolism of adipose tissue in intraabdominal depots of non-obese men and women Metabolism 1989; 38: 453-458.
35. Kissebah AH, Peiris AN. Biology of regional body fat distribution: relationship to non-insulin-dependent diabetes mellitus Diabetes Metab Rev 1989; 5: 83-109.
36. Björntorp P. Abdominal obesity and the development of NIDDM Diabetes Metab Rev 1988; 4: 615-622.
37. Foley JE. Rationale and application of fatty acid oxidation inhibitors in treatment of diabetes mellitus Diabetes Care 1992; 15: 773-784.
38. Björntorp P. 'Portal' adipose tissue as a generater of risk factors for cardiovascular disease and diabetes Arteriosclerosis 1990; 10: 493-496.
39. Yagihashi S, Goto Y, Kakizaki M, Kaseda N. Thickening of glomerular basement membrane in spontaneously diabetic rats Diabetologia 1978; 15: 309-312.
40. Armstrong ML, Heistad DD. Animal models of atherosclerosis Atherosclerosis 1990; 85: 15-23.