Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazone-induced closure of the KATP channel and insulin secretion in rats

Diabetologia

Volumn 52, Issue 6, 2009, Pages 1112-1121

  Chang, T J ^a   Chen, W P ^b   Yang, C ^c   Lu, P H ^c   Liang, Y C ^a   Su, M J ^b   Lee, S C ^b   Chuang, L M ^a,b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

AMP activated protein kinase; Insulin secretion; KATP channel; Rosiglitazone; Serine phosphorylation

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; PHOSPHATIDYLINOSITOL 3 KINASE; ROSIGLITAZONE; SERINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOTTING, WESTERN; CELL LINE; CHROMONES; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; HYPOGLYCEMIC AGENTS; IMMUNOPRECIPITATION; INSULIN; ISLETS OF LANGERHANS; KATP CHANNELS; MALE; MORPHOLINES; PHOSPHORYLATION; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RATS, SPRAGUE-DAWLEY; RIBONUCLEOTIDES; SERINE; THIAZOLIDINEDIONES;

EID: 67349132843     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1337-4     Document Type: Article

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