Behavioral, biochemical, and genetic analysis of iron metabolism in high-intensity blood donors

Transfusion

Volumn 48, Issue 10, 2008, Pages 2197-2204

  Mast, Alan E ^a   Foster, Tisha M ^b   Pinder, Holly L ^b   Beczkiewicz, Craig A ^b   Bellissimo, Daniel B ^b   Murphy, Anthony T ^b   Kovacevic, Steve ^b   Wroblewski, Victor J ^b   Witcher, Derrick R ^b  

^a BLOOD RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FERRITIN; GROWTH DIFFERENTIATION FACTOR 15; HEPCIDIN; HFE PROTEIN; JANUS KINASE 2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLOOD DONOR; CHEMICAL ANALYSIS; CIGARETTE SMOKING; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; FERRITIN BLOOD LEVEL; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; HEMATOCRIT; HEMOCHROMATOSIS; HETEROZYGOSITY; HUMAN; IRON DEFICIENCY; IRON METABOLISM; IRON THERAPY; MALE; NORMAL HUMAN; POLYCYTHEMIA VERA; QUESTIONNAIRE; SEX DIFFERENCE;

ANEMIA, IRON-DEFICIENCY; ANTIMICROBIAL CATIONIC PEPTIDES; BLOOD DONORS; CYTOKINES; FEMALE; FERRITINS; HEMATOCRIT; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IRON; IRON, DIETARY; JANUS KINASE 2; MALE; MEMBRANE PROTEINS; MIDDLE AGED; POLYCYTHEMIA VERA; QUESTIONNAIRES; SMOKING;

EID: 52949104353     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/j.1537-2995.2008.01823.x     Document Type: Article

References (21)

1. Simon TL. Iron, iron everywhere but not enough to donate. Transfusion 2002 42 : 664.
2. Garry PJ, Koehler KM, Simon TL. Iron stores and iron absorption: effects of repeated blood donations. Am J Clin Nutr 1995 62 : 611 20.
3. Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, Dormishian F, Domingo R, Ellis MC, Fullan A, Hinton LM, Jones NL, Kimmel BE, Kronmal GS, Lauer P, Lee VK, Loeb DB, Mapa FA, McClelland E, Meyer NC, Mintier GA, Moeller N, Moore T, Morikang E, Prass CE, Quintana L, Starnes SM, Schatzman RC, Brunke KJ, Drayna DT, Risch NJ, Bacon BR, Wolff RK. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996 13 : 399 408.
4. James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, Lacout C, Garcon L, Raslova H, Berger R, Naceur-Griscelli A, Villeval JL, Constantinescu SN, Casadevall N, Vainchenker W. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005 434 : 1144 8.
5. Murphy AT, Witcher DR, Luan P, Wroblewski VJ. Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry. Blood 2007 110 : 1048 54.
6. Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, Moroney JW, Reed CH, Luban NL, Wang RH, Eling TE, Childs R, Ganz T, Leitman SF, Fucharoen S, Miller JL. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med 2007 13 : 1096 101.
7. Mast AE, Blinder MA, Gronowski AM, Chumley C, Scott MG. Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations. Clin Chem 1998 44 : 45 51.
8. Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annu Rev Nutr 2006 26 : 323 42.
9. Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, Dawkins FW, Acton RT, Harris EL, Gordeuk VR, Leiendecker-Foster C, Speechley M, Snively BM, Holup JL, Thomson E, Sholinsky P. Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med 2005 352 : 1769 78.
10. Steinberg KK, Cogswell ME, Chang JC, Caudill SP, McQuillan GM, Bowman BA, Grummer-Strawn LM, Sampson EJ, Khoury MJ, Gallagher ML. Prevalence of C282Y and H63D mutations in the hemochromatosis (HFE) gene in the United States. JAMA 2001 285 : 2216 22.
11. Barry E, Derhammer T, Elsea SH. Prevalence of three hereditary hemochromatosis mutant alleles in the Michigan Caucasian population. Community Genet 2005 8 : 173 9.
12. Finch CA, Cook JD, Labbe RF, Culala M. Effect of blood donation on iron stores as evaluated by serum ferritin. Blood 1977 50 : 441 7.
13. Simon TL, Garry PJ, Hooper EM. Iron stores in blood donors. JAMA 1981 245 : 2038 43.
14. Simon TL, Hunt WC, Garry PJ. Iron supplementation for menstruating female blood donors. Transfusion 1984 24 : 469 72.
15. Bianco C, Brittenham G, Gilcher RO, Gordeuk VR, Kushner JP, Sayers M, Chambers L, Counts RB, Aylesworth C, Nemo G, Alving B. Maintaining iron balance in women blood donors of childbearing age: summary of a workshop. Transfusion 2002 42 : 798 805.
16. Newman B. Iron depletion by whole-blood donation harms menstruating females: the current whole-blood-collection paradigm needs to be changed. Transfusion 2006 46 : 1667 81.
17. Cafolla A, Dragoni F, Girelli G, Tosti ME, Costante A, Pastorelli D, Bedogni G, Scott S. Folate status in Italian blood donors: relation to gender and smoking. Haematologica 2000 85 : 694 8.
18. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004 306 : 2090 3.
19. Finch C. Regulators of iron balance in humans. Blood 1994 84 : 1697 702.
20. Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood 2006 108 : 3730 5.
21. Piperno A, Girelli D, Nemeth E, Trombini P, Bozzini C, Poggiali E, Phung Y, Ganz T, Camaschella C. Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood 2007 110 : 4096 100.